This has nothing to do with stem cells but I found it very interesting.
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AFP/File – A rat walks through a pipe. Paralysed rats whose spinal cords had
been severed from their brains were …
by Marlowe Hood – Sun Sep 20, 3:20 pm ET
PARIS (AFP) – Paralysed rats whose spinal cords had been severed from their
brains were made to run again using a technique that scientists say can work for
people, according to a study released Sunday.
Consistent electrical stimulation and drugs enabled the rats to walk on their
hind legs on a treadmill -- bearing the full weight of the body -- within a week
of being paralysed.
With the addition of physical therapy, the rodents were able after several weeks
to walk and run without stumbling for up to 30 minutes, reported the study,
published in the journal Nature Neuroscience.
Remarkably, the animals could adjust their movements in response to stimuli
despite the lack of signals to and from the brain: when the treadmill was
reversed, for example, the rats walked backwards.
"This means that the spinal network is almost capable of cognitive processing,"
explained Gregoire Courtine, a professor at Zurich University.
"It can understand that the external world is changing, and interpret this
information to modify the way it activates muscle," he told AFP by phone.
Earlier studies had shown that nerve networks in the spinal cord can produce
limited motion in the muscles independent of the brain or sensory organs.
But this is the first time that researchers have been able to restore normal or
nearly normal functions.
"We can optimise the use of the circuitry in the spinal cord to the point where
the animals can sustain full weight-bearing locomotion," said Courtine.
"In some cases they actually walked with more consistent locomotive patterns
than non-injured animals."
The next step is to develop devices that can be implanted inside the body.
"We are now designing neuro-prostheses, arrays of electrodes that fit like a
second skin between the vertebrae and the spinal cord," Courtine explained.
A strip measuring three centimetres (1.2 inches) long and one hundredth of a
centimetre thick, the device is described as "minimally invasive" because it
does not penetrate into the spinal cord.
Courtine and colleagues are currently testing the neuro-prostheses on rats, and
expect to have an interface for humans within four years.
The new technique is designed to help patients with incomplete but severe
injuries, such as those who cannot walk independently.
"For these people, it is highly likely that this approach will improve their
function," he said.
The mix of electrical stimulation and physical therapy may be enough to restore
significant mobility in many patients, but the addition of drugs "would be
extremely beneficial," he added.
In the rat experiments, the researchers injected so-called serotonergic
agonists, a compound that mimics the effect of the neurotransmitter serotonin
and activates receptors in the central and peripheral nervous system.
There are approximately a quarter of a million persons with serious spinal cord
injuries in the United States, according to the Foundation for Spinal Cord
Injury, Prevention, Care and Cure. Other sources estimate the total worldwide at
2.5 million.
Nearly half of all spinal cord injuries are caused by automobile accidents, and
more than half occur among young people between 16 and 30 years old.