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Hello Kirshner,
A very interesting patent was issued last week, #7,553,661, covering the use of
mesenchymal stem cells as antigen presenting cells. In order to induce antigen
presenting function the cells are stimulated with interferon gamma. Uses for
this patent may include tolerogenic vaccines.
Patent #7,553,663 granted to Blasticon covers the treatment of liver failure
using hepatocytes generated from dedifferentiated monocytes. This IP seems a
little related to with Opexa is working on. It will be interesting to see
whether there will be any interactions between these companies.
Noteworthy publications last week included a paper by Herr et al demonstrating
that apoptotic bodies induce macrophages to secrete angiogenic factors...this
makes us wonder...could we simply just use extracorporeal ozonization or
photopheresis to achieve angiogenesis clinically? People in the alternative
medicine community have been saying this for decades now.



Stromal antigen-presenting cells and use thereof


Patent Number: 7,553,661
Assignee | Inventor
Mesenchymal stem cells are known to possess a variety of immune modulatory
activities such as suppression of allogeneic responses, as well as induction of
T regulatory cells. Mechanisms include expression of IDO and HLA-G.
Mesenchymal stem cells...[Read More]
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Apoptotic Cells Secrete Angiogenic Factors
Saturday June 27th, 2009 @ 03:54:59 EST
It is a medical mystery why approaches such as extracorporeal ozone therapy or
even photopheresis seem to have therapeutic effects in certain situations. One
possibility is that stressing of cells outside of the body causes formation of
apoptotic bodies, with the apoptotic bodies having a therapeutic...[Read More]
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RECENTLY ADDED PATENTS

Dedifferentiated, programmable stem cells of monocytic origin, and their
production and use (7,553,663)
Assignee | Inventor | Ask a question OR leave your comments


Stromal antigen-presenting cells and use thereof (7,553,661)
Assignee | Inventor | Ask a question OR leave your comments


Directed in vitro differentiation of marrow stromal cells into neural cell
progenitors (7,547,545)
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Progenitor cells from wharton's jelly of human umbilical cord (7,547,546)
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Methods for identifying factors for differentiating definitive endoderm
(7,541,185)
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Method of generating human retinal progenitors from embryonic stem cells
(7,541,186)
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Growth and differentiation of adult muscle stem cells with activators or
inhibitors of Wnt signaling (7,541,183)
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Angiogenically effective unit dose of FGF-2 and method of use (7,541,333)
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Stem cells and their use in transplantation (7,537,756)
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Method of expanding undifferentiated hemopoietic stem cells (7,534,609)
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