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sbaofnc · SBANC Talk: Spina Bifida Association of NC Members
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Spina Bifida & stem cells   Message List  
Reply | Forward Message #37 of 415 |
This is not great, hard info and I will get something better for you,
but this does at least show that the door is open for possibility
This q&a can be found on www.pbs.org:

4.24.01 Mark Glazer asked:
When do you anticipate stem cell research will result in an
effective treatment for spinal cord injuries in humans?

McDonald's response:
This is always a difficult question and the answer is that no one
knows the answer. However, I can approximate the issues for
you. There are a set of standards required to demonstrate safety
and efficacy in human trials and this process typically takes a
decade. In the case of stem cells, more basic science work is
required before attempts at clinical trials. The tremendous need
and lack of potential alternatives, which are present in SCI, are
factors that can accelerate the pace. Other key factors are
national funding levels (resources) and governmental
commitment (right now human stem cell work is being
hampered because of the latter).

Of the regenerative strategies, some will be more doable than
others- recreating neural circuits is one of the most difficult.
Remyelination may be one of the most doable.

4.24.01 Devin Waggoner asked:
It seems as though the emphasis thus far is on people who
have sustained a spinal cord injury later in life. Is it probable that
these techniques will help people such as myself who have the
congenital defect Spina Bifida?

McDonald's response:
Good question. Yes. Strategies to repair the injured cord can
also apply to congenital defects such as spina bifida. For the
other readers, let me explain what spina bifida is. Spina bifida
occulta is a benign form where there are only vertebrae defects,
typically in the arches surrounding the cord (occurs in 5% of the
population), and no associated neurological defects. Spina
bifida occurs because of incomplete closure of the neural tube
during early embryo development. This occurs at the ends of the
spinal cord (near the head and near the sacrum). Defects can
range from simple cutaneous lesions, such as a hairy mole, a
pilonidal sinus, a dermal sinus, telangiectasia, or a
subcutaneous lipoma to severe defects including a double
spinal cord, tethered spinal cord associated with loss of function
in the lower body.

Repair strategies will also be applicable to such congenital
disorders, but the problems are somewhat different than with
trauma, but largely similar.




Fri Jun 7, 2002 12:01 am

curesnow
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This is not great, hard info and I will get something better for you, but this does at least show that the door is open for possibility This q&a can be found...
curesnow
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Jun 7, 2002
12:03 am
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