"VEGF receptor-ligand binding may contribute to the vascular changes and
cellular
infiltration that occurs in rosacea." This was the conclusion of a research
paper
published in the British Journal of Ophthalmology (Feb 2007) entitled:

Expression of vascular endothelial growth factor and its receptors in rosacea.
Smith JR, Lanier VB, Braziel RM, Falkenhagen KM, White C, Rosenbaum JT.
Br J Ophthalmol. 2007 Feb;91(2):226-9

Vascular endothelial growth factor (VEGF) is vasoactive and has inflammatory
activities
and according to Wikipedia "is an important signaling protein involved in both
vasculogenesis (the de novo formation of the embryonic circulatory system) and
angiogenesis (the growth of blood vessels from pre-existing vasculature). As its
name implies, VEGF activity has been mostly studied on cells of the vascular
endothelium,
although it does have effects on a number of other cell types (e.g. stimulation
monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ).
In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell
migration. VEGF is also a vasodilator and increases microvascular permeability
and
was originally referred to as vascular permeability factor."

We may hear more about treatment targeting VEGF factors for rosacea.

Sources:

http://tinyurl.com/3cpu3w
http://en.wikipedia.org/wiki/VEGF

Brady
group owner