Hi Dan,

Yeah that confirms a few things.

When i was trying to find whether B.Oleronius contained naturally occuring
Porphyrins, I couldn't find any matches, so did a quick search to find if other
Negative Gram bacteria contained Porphyrins, but it seems to vary.

I think it is established that the production of singlet oxygen produced by the
light reacting with the porphyrin is destructive to the bacteria, However I
cannot locate if porphyrin is naturally occuring in B.Oleronius. Any ideas
there?

Yeah i share your concern about the statement that had the words "Proliferative"
and "Pseudomonas aeruginosa" in the same sentence. With consideration to the
fact that it is apparently an opportunistic bacteria that thrives in burns,
wounds and cuts.

http://textbookofbacteriology.net/pseudomonas.html

One of the major marketed uses of LED therapy is for wound healing. If it could
possibly have a proliferative affect on some form of gram negative bacteria this
could be a problem.

Matt.

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Hi Matt,

Thanks for posting this info. I found it very interesting,
particularly since most articles I've read haven't mentioned naturally
occuring porphyrins in bacteria, but rather concentrate on application
of additional porphyric substances in addition to light therapy.

I couldn't dig up too much more that helped explain this, but here's
an article discussing light therapy (mostly laser, but again, I don't
think the light source is all that important here) and porphyrins.
It explains pretty well how they work together, namely, "Light energy
is absorbed by bacterial porphyrins, triggering production of toxic
singlet oxygen which damages or destroys the bacteria":

http://www.shorelas er.com/LaserAcne Rx.html

So with your articles and other suggesting that certain bacterial seem
to have naturally occuring porphyrins, potentially light therapy can
be antibacterial for these bacteria even without the use of additional
photoactive substances (like ALA, etc).

Along these lines, the only thing that worries me is the statement
"all energy densities of Ar ion laser showed a proliferative effect on
Pseudomonas aeruginosa".

Does this sort of answer your questions? If not, let me know and
I'll take another stab at answering...

Thanks again...

Dan

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