When first researching Rosacea I also ran across this fact - I read
that only antibiotics that worked against gram negative bacteria were
helpful for rosacea - reason unknown.
HUMMM
--- In rosacea-support@yahoogroups.com, "nurse_artist"
<nurse_artist@...> wrote:
>
> See the below study, which indicates Demodex is the carrier. I
thought this excerpt was pretty interesting: "typical treatment for
rosacea
> initially includes oral antibiotics that destroy B. oleronius.
> Interestingly, he said, antibiotics that are not harmful to these
> bacteria generally are not effective in the management of rosacea. "
> -Artist
>
>
> The role of bacterial antigen(s) in the etiology and persistence of
> papulopustular bacteria.
> Dr. Kevin Kavanagh, Department of Biology, National University of
> Ireland - Maynooth, and Dr. Frank Powell, consultant dermatologist,
> Mater Misericordiae Hospital, Dublin.
>
> Bacteria associated with microscopic mites known as Demodex
> folliculorum may play a role in the development of papulopustular
> (subtype 2) rosacea, according to the results of a study funded by a
> National Rosacea Society grant and reported at the 2004 annual
meeting
> of the Society for Investigative Dermatology.
>
> In the completed study, Dr. Kevin Kavanagh and colleagues found that
> the bacterium Bacillus oleronius stimulated an immune system
response,
> inducing high levels of T-cell proliferation, in 79 percent of
> patients with subtype 2 rosacea, compared with only 29 percent of
> patients without the disorder. T-cell proliferation induces an
> inflammatory response, evident as papules and pustules.
>
> "This indicates that the Bacillus bacteria found in the Demodex mite
> produce an antigen that could be responsible for the tissue
> inflammation associated with papulopustular rosacea," Dr. Kavanagh
> said.
>
> The researchers located the bacteria in Demodex folliculorum, which
> are normal inhabitants of human skin. Because these microorganisms
> often occur in much greater numbers in patients with rosacea,
> researchers have long theorized that they may play a part in the
> development of the disorder.
>
> The researchers offered several possibilities that may explain how
> Demodex and bacteria interact to cause inflammation in rosacea. The
> Demodex mites may carry the pathogenic bacteria into areas of the
face
> susceptible to the changes of rosacea, so that the increased mite
> density in rosacea patients may result in a higher density of
bacteria
> that produce the papules and pustules. Alternatively, Demodex mites
> may be attracted to an area of facial skin rich in these bacteria
and
> increase in numbers in this "fertile territory."
>
> Another possibility is that the mites in rosacea patients are
infected
> with these bacteria, which in turn produce stimulatory antigens that
> trigger the disorder in susceptible patients.
>
> Dr. Kavanagh noted that the potential role for bacteria in causing
> papulopustular rosacea is supported by the fact that typical
treatment
> for rosacea initially includes oral antibiotics that destroy B.
> oleronius. Interestingly, he said, antibiotics that are not harmful
to
> these bacteria generally are not effective in the management of
> rosacea.
>
> Moreover, the possibility that antigens may play a role in disease
> processes has been demonstrated in other disorders. For example,
> antigens produced by Streptococcus and Staphylococcus bacteria have
> been linked with such disorders as psoriasis, food poisoning and
toxic
> shock syndrome.
>
> Dr. Kavanagh and his colleagues are now developing antibodies
against
> the antigen produced by B. oleronius to confirm its presence on the
> faces of patients with papulopustular rosacea and to define its
> relationship with Demodex mites.
>
>
>
> --- In rosacea-support@yahoogroups.com, Matthew I <mtthw_i@> wrote:
> >
> > Did a little more research. Unfortunately without more background
> knowledge it's only speculation, but seems to be heading somewhere.
> >
> > There is a gram negative bacteria found within the Demodex Mite
> called Bacillus Oleronius.
> >
> >
> > The following is an article on LLLT and Gram Negative Bacteria. It
> mentions two other types of Bacteria, being the Gram Negative
> Pseudomonas aeruginosa and the Gram Positive Staphylococcus aureus.
> >
> > They classify the difference as follows. Gram-negative bacteria
are
> those that do not retain crystal violet dye in the Gram staining
> protocol. Gram-positive bacteria will retain the dark blue dye after
> an alcohol wash, whereas Gram-negative bacteria do not. In a Gram
> stain test, a counterstain is added after the crystal violet, which
> colors all Gram-negative bacteria a red or pink color. The test
itself
> is useful in classifying two distinctly different types of bacteria
> based on structural differences in their cell walls.
> >
> > Here is a quote…
> >
> > "All energy densities of Ar ion laser showed a proliferative
effect
> on Pseudomonas aeruginosa and inhibitory effect on Staphylococcus
> aureus. Similarly, SHG Nd:YAG and He-Ne lasers with chosen energy
> densities were again proliferating for Pseudomonas aeruginosa and
> inhibitory for Staphylococcus aureus"
> >
> > http://www.springerlink.com/content/e072158g52487462/
> >
> > This shows that LLLT definitely has an affect on Gram-Negative/
> Positive bacteria.
> >
> > Unfortunately you have to purcahse the article to see it in its
> entirety. If you look at the google search though it mentions
> something about Gram negative Bacteria with higher amounts of
> porphyrins, so it gives a teaser to possibly releasing some
> information there.
> >
> > http://www.google.com.au/search?hl=en&q=gram-
> negative+bacteria+respiratory+chain+porphyrin&meta=
> >
> >
> > This article mentions Bacillus, Porphyrin and respiratory chain
but
> there was soo much medical jargon it was hard to put it all
together.
> Maybe Dan could decipher this one for us if he has a spare minute?
> >
> > http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=197023
> >
> >
> > This article from the Rosacea Archives relates a possible cause to
> Bacillus Oleronius also.
> >
> > http://www.rosacea.org/press/archive/20040503.php
> >
> > Hmm, All I can add is that LLLT definitely has an affect on
> bacteria. But for Bacillus Oleronius specifically though, I am
> unsure.
> >
> > Matt.
> >
> > -------------------------------------------------------------
> >
> > Matt wrote: "I did some quick googling but couldn't find what the
> demodex mite uses for its respiratory chain."
> >
> > Hi Matt,
> >
> > Thanks for your contribution to the discussion on this topic,
which
> was of course rather more detailed than the snippet above. ;)
> >
> > I wonder if anyone else might like to take up the challenge and
> locate a study with this information? You never know, someone might
> have a bit of time on their hands and want to demonstrate their
> superior abilities with search engines. No harm in cautious
optimism,
> is there? :)
> >
> > Kind regards,
> >
> > Aurelia
> >
> > Send instant messages to your online friends http://au.messenger.
> yahoo.com
> >
> > [Non-text portions of this message have been removed]
> >
>