Oral Metronidazole Indications -- it does not have a direct effect
on demodex

Symptomatic Trichomoniasis: Metronidazole is indicated for the
treatment of symptomatic trichomoniasis in females and males when
the presence of the trichomonad has been confirmed by appropriate
laboratory procedures (wet smears and/or cultures).

Asymptomatic Trichomoniasis: Metronidazole is indicated in the
treatment of asymptomatic females when the organism is associated
with endocervicitis, cervicitis or cervical erosion. Since there is
evidence that presence of the trichomonad can interfere with
accurate assessment of abnormal cytological smears, additional
smears should be performed after eradication of the parasite.



Treatment of Asymptomatic Consorts: T. vaginalis infection is a
venereal disease. Therefore, asymptomatic sexual partners of treated
patients should be treated simultaneously if the organism has been
found to be present, in order to prevent reinfection of the partner.
The decision as to whether to treat an asymptomatic male partner who
has a negative culture or one for whom no culture has been attempted
is an individual one. In making this decision, it should be noted
that there is evidence that a woman may become reinfected if her
consort is not treated. Also, since there can be considerable
difficulty in isolating the organism from the asymptomatic male
carrier negative smears and cultures cannot be relied upon in this
regard. In any event, the consort should be treated with
metronidazole in cases of reinfection.

Amebiasis: Metronidazole is indicated in the treatment of acute
intestinal amebiasis (amebic dysentery) and amebic liver abscess. In
amebic liver abscess, metronidazole therapy does not obviate the
need for aspiration or drainage of pus.

Anaerobic Bacterial Infections: Metronidazole is indicated in the
treatment of serious infections caused by susceptible anaerobic
bacteria. Indicated surgical procedures should be performed in
conjunction with metronidazole therapy. In a mixed aerobic and
anaerobic infection, antimicrobials appropriate for the treatment of
the aerobic infection should be used in addition to metronidazole.

In the treatment of most serious anaerobic infections, the
intravenous form of metronidazole is usually administered initially.
This may be followed by oral therapy with metronidazole at the
discretion of the physician.

Intra-Abdominal Infections, including peritonitis, intra-abdominal
abscess, and liver abscess, caused by Bacteroides species, including
the B. fragilis group, (B. fragilis, B. distasonis, B. ovatus, B.
thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium
species, Peptococcus niger, and Peptostreptococcus species.

Skin and Skin Structure Infections caused by Bacteroides species
including the B. fragilis group, Clostridium species, Peptococcus
niger, Peptostreptococcus species, and Fusobacterium species.

Gynecologic Infections, including endometritis, endomyometritis,
tubo-ovarian abscess, and postsurgical vaginal cuff infection,
caused by Bacteroides species including the B. fragilis group,
Clostridium species, Peptococcus niger and Peptostreptococcus
species.

Bacterial Septicemia caused by Bacteroides species including the B.
fragilis group and Clostridium species.

Bone and Joint Infections, as adjunctive therapy, caused by
Bacteroides species, including the B. fragilis group

Central Nervous System (CNS) infection, including meningitis and
brain abscess, caused by Bacteroides species, including the B.
fragilis group.

Lower Respiratory Tract Infections, including pneumonia, empyema,
and lung abscess, caused by Bacteroides species including the B.
fragilis group.

Endocarditis caused by Bacteroides species including the B. fragilis
group.


DOSAGE AND ADMINISTRATION