> I was reading through the posts and came across the
> following message (#57650). This is an interesting
> post which has info from Dr. Nase and another group
> member. It is concerning cromolyn sodium, which is
> an ingredient in the nasal spay Nasalcrom. My
> question is when nasalcrom is taken, does it only
> affect the nose and nasal passages, or does the
> medication make its way thought the rest of
> the body helping other areas as well? Thanks.

Virtually nil, see the study below. Oral cromolyn
sodium is also very poorly absorbed, about 5% in a
rat.

Logan


Mast cell stabilizers.

Otolaryngol Head Neck Surg. 1992 Dec;107(6 Pt
2):841-4.
King HC.

The precise mode of action of the well-studied
cromolyn sodium and the newer nedocromil sodium has
not been completely elucidated. Because the drugs do
not pass the cell membrane and enter the cell, they
are virtually not metabolized, do not exert a systemic
action, and therefore are associated with only minimal
systemic toxicity. To be effective either drug must be
applied topically and directly to the nasal mucosa.
Proper contact with the nasal mucosa is essential for
efficacy; in patients with nasal congestion and
secretions, vasoconstrictors or saline lavages are
indicated before cromolyn or nedocromil use. Both
products are highly effective in patients who have
IgE-mediated allergic rhinitis but must be
administered prophylactically before exposure to an
allergen to prevent development of the allergic event.
Neither drug is effective in vasomotor rhinitis,
exercise-induced rhinitis, or in the management of
nasal polyps. Correct diagnosis is essential before
therapy.


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