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I came across this article that mentions ivermectin as a treatment
for rosacea.
The Management of Rosacea. By: Rebora, A.. American Journal of
Clinical Dermatology, 2002, Vol. 3 Issue 7, p489, 8p; Abstract:
Rosacea is a multiphasic disease which is associated with flushing,
erythrosis, papulopustular rosacea and phymas; each phase is likely
to have its own treatment. Flushing is better prevented rather than
treated, and its etiology investigated. â-Blockers, atenolol in
particular, are worthy of prophylactic trials examining their
efficacy in treating the flushing associated with rosacea.
Currently, clonidine is the only drug available for the treatment of
flushing. Treatment for erythrosis includes topical and systemic
therapies. Metronidazole 1% cream and azelaic acid 20% cream have
been reported to reduce the severity score of erythema. The systemic
treatment of erythrosis is based on the association of Helicobacter
pylori with rosacea. However, this role is still being debated.
Eradication of H. pylori can be achieved using a triple therapy
regimen lasting 1 to 2 weeks [omeprazole and a combination of two
antibacterials (a choice from clarithromycin, metronidazole or
amoxicillin)]. Both the flashlamp-pumped long-pulse dye laser and
the potassium-titanyl-phosphate laser may be used in the treatment
of facial telangiectases. Both systemic and topical remedies may be
used to treat the papulopustules of rosacea. Systemic treatment
includes metronidazole, doxycycline, minocycline, clarithromycin and
isotretinoin, while topical treatment is based on metronidazole
cream and gel. The presence of Demodex folliculorum is important in
the inflammatory reaction, whether it is pathogenetic or not.
Crotamiton 10% cream or permethrin 5% cream may be useful
medications for papulopustular rosacea, although they are rarely
successful in eradicating D. folliculorum. Oral or topical
ivermectin may also be useful in such cases. Ocular involvement is
common in patients with cutaneous rosacea and can be treated with
orally administered or topical antibacterials. Once rhinophyma
starts to be evident, the only way to correct it is by aggressive
dermatosurgical procedures....
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