Mary ("marybmorehead") wrote that her doctor wouldn't prescribe Stromectol
without seeing the full studies. "I would like to specifically take these
studies to her once they are published. So I am wondering when the time
comes where these studies will be published -- can we see them on Pub Med?"


Hi Mary.

In the meantime, there are a few older studies on Pub Med, but not
necessarily referring to rosacea. A search for ivermectin and demodex brings
up 10, and it looks as if 6 of them are about humans. Here are a few, but
note that in the last one ivermectin didn't work while oral metronidazole
did!

Kind regards,

Aurelia

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1: J Am Acad Dermatol. 1999 Nov;41(5 Pt 1):775-7.

Treatment of rosacea-like demodicidosis with oral ivermectin and topical
permethrin cream.

Forstinger C, Kittler H, Binder M.
Department of Dermatology, Division of General Dermatology, University of
Vienna Medical School, Austria.

A 32-year-old man presented with a chronic rosacea-like dermatitis of the
facial skin and the eyelids. The skin disorder had been present for 4 years
and was unresponsive to multiple previous treatment attempts. Skin scrapings
and a histologic examination of a biopsy specimen from the affected area
revealed the presence of numerous Demodex mites. The patient was treated
with oral ivermectin and subsequent topical permethrin resulting in complete
and rapid clearing of the folliculitis. We believe that this case supports
the view that Demodex mites may be pathogenic when they are present in large
numbers. Oral treatment with 200 microg/kg ivermectin with subsequent weekly
topical permethrin showed impressive treatment efficacy in a case refractory
to conventional treatment.

Publication Types: Case Reports

PMID: 10534645 [PubMed - indexed for MEDLINE]
------------------------------------------

1: Dermatology. 2002;205(4):394-7.

Ivermectin-responsive Demodex infestation during human immunodeficiency
virus infection. A case report and literature review.

Aquilina C, Viraben R, Sire S.
Service de Dermato-Venereologie, Hopital La Grave, Place Lange, Toulouse,
France. aquilina.c@...

http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=drm05394

We report the case of a 56-year-old HIV-seropositive man who presented a
facial Demodex infection developed 2 months after initiation of highly
active antiretroviral therapy. The Demodex infection was confirmed by
scrapings and histopathologic examination and by the dramatic response to
antiparasitic treatment with oral ivermectin associated with 5% permethrin
cream. Copyright 2002 S. Karger AG, Basel

Publication Types: Case Reports Review Review of Reported Cases

PMID: 12444338 [PubMed - indexed for MEDLINE]
------------------------------------------

1: J Am Acad Dermatol. 2003 Nov;49(5 Suppl):S272-4.Related Articles, Links

Demodex abscesses: clinical and therapeutic challenges.

Schaller M, Sander CA, Plewig G.
Department of Dermatology and Allergology, University of Munich, Germany.
Martin.Schaller@...

A 53-year-old man had a 6-week history of confluent erythematous papules,
pustules, and abscesses of the face initially limited to the right
nasolabial fold. Histologic investigation revealed a perifollicular
infiltrate with lymphocytes, histiocytes, and many Demodex folliculorum
mites. A large number of mites were seen in skin scrapings. The skin
manifestations progressed and persisted for the following 5 years and were
unresponsive to numerous antiparasitic treatments, including repeated oral
administration of ivermectin and external application of lindane,
permethrin, and benzoyl benzoate. Therapy with oral administration of 250 mg
metronidazole 3 times a day for 2 weeks resulted in rapid and lasting
recovery. Demodex folliculitis remains a diagnostic and therapeutic
challenge. Antiparasitic therapies used against lice or scabies may fail in
control of D folliculorum mites. In the presence of clinical and microscopic
findings typical of Demodex folliculitis or abscesses, treatment failure
with acaricidal agents does not exclude the diagnosis. Oral metronidazole
seems to work in the management of this chronic mite infestation.

Publication Types: Case Reports

PMID: 14576651 [PubMed - indexed for MEDLINE]
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