For Everyone,
Corrected [rosacea-cure] message #267 is being reposted, (as #269), because I
many months ago misread the info in [rosacea-cure] message #170.
For a very long time, I have believed that 25 "GRAMS" of fluconazole will
dissolve in "ONE MILLILITER" of alcohol.
I read it wrong....
Only 25 "MILLIGRAMS" of fluconazole dissolves in "ONE MILLILITER" of alcohol at
room temperature.
The source quoted in r-c message #170 is authoritative: the International
Journal of Pharmaceutical Compounding, vol. 2, No. 4 July/August 1998, page 299
However, even a reliable source HAS TO BE READ CORRECTLY!!! :-I
So, my extrapolation of this "25 mg/ml alcohol" info to how much fluconazole
will dissolve in DMSO, is MOOT, because [DMSO + 10% fluconazole] is already FOUR
TIMES HIGHER THAN 25 mg, at 100 mg per ml of DMSO.
I'm currently working to find out exactly how much fluconazole will dissolve in
one ml of DMSO, at room temperature.

I believe that this figure has become much more important, with the radical
decrease in the price of fluconazole that has occurred. And the fact that I
found that the 10% med is more effective than the 1% med, is very important to
this question.
The curative effectiveness may or may not increase at higher than 10%
percentages of fluconazole, but we will never determine this, without trying
higher percentages, (and also trying [10% water/90% DMSO], as the base).

This info is either in some extremely obscure "chart", somewhere, or has NEVER
EVEN BEEN DETERMINED!!!
So I will be trying to determine how much fluconazole will dissolve in one ml of
DMSO at room temperature.
And to make this question even more extensive, we also need to know how much
fluconazole will dissolve in one ml of [10% water/90% DMSO], at room
temperature.

The best "off-hand guess" I have obtained, is that (PERHAPS!) no more than 500
mg of fluconazole will dissolve in one milliliter of DMSO, at room temperature.

IF THIS GUESS IS TRUE, it would make [DMSO + 50% fluconazole] the highest
percentage possible.
So, all my "facts" about this "dissolvability", in [rosacea-cure] message #267,
were not based in fact, but in my misreading of the info in the article posted
at:
http://groups.yahoo.com/group/rosacea-cure/message/170
, from the International Journal of Pharmaceutical Compounding, vol. 2, No. 4
July/August 1998, page 299

My apology for the mistake, but from such acorn mistakes, mighty, useful oaks
may grow. :-D

Message #267 will soon be deleted, and is replaced by the corrected message
#269.
God Bless, ITN & IDFN,
Dave Fleming


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