For Everyone,
The following is some recent private email with a person who says he has been a
Registered Nurse for many years. He's always been very positive about this
treatment/cure, and has had enough medical knowledge to see through the lame
claims and gross disinformation being put out about DMSO, and about this
treatment/cure, by peanut-gallery liars.
I hope this helps.
God Bless, ITN & IDFN,
Dave Fleming ----TEXT OF EMAILS FOLLOWS, (in reverse chronological order)----

Dave Fleming wrote:
Hi, David,
It's good to hear from you, since you've always been so positive and helpful. I
do remember our past private email.
Thank you for your update, of your situation.
Am sorry to hear of your problem(s), and as you no doubt know, since you have
worked in the health field for so long, I have to refer you to your doctor.
Is there any chance that you could send me
any info on his opinion(s), in this matter?
This would be most helpful to all the rosaceans
who will use this med in the future, since
I'm trying to compile that sort of authoritative
"doctors' opinions", for that purpose.

To some degree, as you know, we are in "uncharted territory" here. Although we
have all the data from the FDA approval of these two "drugs", (i.e. DMSO and
fluconazole/Diflucan), we do seem to be dealing with a complex situation,
especially since it involves the human face, and all the psychological
ramifications that that implies.
In other words, if your "problem" were on some part of your body concealed by
clothing, you would most likely never be concerned enough to send me your
present question(s).

With all that as preface, what do we know?
1) This med, (either 1% or 10%), has virtually no effect on "healthy" skin.

2) This med, (both 1% and 10%), appears to deeply "attack" rosaceous skin, with
subsequent "cascade effects" and healing to a state that is improved from the
"original disease state".

3) There seems to be some sort of cascade "immunological response" effect
involved/caused/triggered by this med, (both the 1% and the 10%), which causes
the "effects" of the med application to go on for much longer time periods than
one would expect from the direct effect(s) of the med alone; this time period
certainly lasts at least one month, and may go on for months, before the
"healing" is completed, (from that one application of the med).
It seems to me that new, healthy skin has to "grow" from underneath, replacing
and "pushing up" all the skin with the "dead rosacea causing entity" in it. As
this slow growth occurs, "symptoms" seem to be caused, by the very gradual
"sloughing off" of the old skin containing the "dead rosacea causing entity".

(4) To make matters much more complicated, each subsequent application of the
med appears to "kill" more of the "rosacea causing entity", layer, by layer, by
layer, until the skin is returned to a healthy, non-rosaceous condition. I
believe that the "rosacea causing entity" may "hide" in the sinus cavities in
the face, which cannot be reached by any medication in the blood, but is
penetrated and reached by the [DMSO + 10% fluconazole].

So what am I led to offer you, as my opinion in your situation?
Well, David, I admit that I am sort of like a "bulldog" in this matter, and I'm
inclined to offer "excuses" for this "treatment/cure", (since it is a cure, in
my opinion).

In that vein, my first thought, is that you seem to be using this med as a
"treatment", and you are watching the "symptoms", rather than the "disease".
Let's refer to my "General Directions" as at:
http://groups.yahoo.com/group/rosacea-cure/message/210
I state that you should wait from ONE TO FOUR WEEKS, between applications of the
med. I could have easily made that from ONE TO TWO MONTHS, to be more
conservative, but I leave it to each rosacean, to know what level of "effects"
they are willing/able to deal with.

You have chosen the lesser limit of one week between med applications, for a
long, long, long time. This may have "built up" effects of this healing process
that need more time than you are giving them, to be "completed", before you
apply more med every week.
I also recommend that ideally, multiple applications of the med be applied at
one time, with a long "waiting" period for healing, between, with no med
applications. In other words, it takes at least 10 or 15 minutes for an
application of the med to be absorbed, so several applications would have to
take at least an hour or two, to apply; then more than a month of "waiting"
might be needed, to assess the healing effects of this multiple application of
the med.

It appears that you have never tried that, so I guess that that is what I might
recommend for you to try, with your doctor's advice and consent. But FIRST, you
might want to WAIT ONE OR TWO MONTHS, without any med applications, to try to
assess whether your "problems" improve, WITHOUT ANY APPLICATION OF THE MED.

Your SD may complicate the matter, but don't ask me about that, because this
"bulldog" is inclined to believe that [DMSO + fluconazole] may very likely be
the best "treatment" for SD!!!

I admit that this "waiting" can take an "infinite" amount of patience,
especially if you are fighting other symptoms as well, such as those from SD,
Acne Vulgaris, etc.

Another very important aspect of my "bulldog" attitude about this, is that I
know that certain types of "damage", (which was caused by the rosacea but did
not completely "show", before getting rid of the rosacea), may remain, AFTER
this treatment/cure is COMPLETED. In my case, it has been a couple of minor
purple veins left on the left side of my nose, but I have received just a couple
of "complaints/statements" that there might be "pinkness" left, AFTER this CURE.

I believe that most rosaceans cured by [DMSO + 10% fluconazole] will NOT have
any significant problem with "damage" such as "veins" or "pinkness" left in
healthy skin, but I mention this here as a worst-scenario coverage.

Now how in the world can I claim that rosacea, which is known as a "pinkness" of
the skin, has been cured, if the skin is "pink", AFTER the rosacea is cured???
Well, it's simple to me, because I believe that it is self-evident and obvious
that any "pinkness" left AFTER [DMSO + 10% fluconazole] has "killed" the ROOT
CAUSE of the rosacea, would be in the same "category" as the minor purple veins
on my nose, (sort of as "scars/damage" left by the rosacea's years, and even
decades of "damage" done).

My conclusion, is that these "scars" can only be "treated" successfully, AFTER
the rosacea has FIRST been cured by the lengthy applications of [DMSO + 10%
fluconazole]. I'm not a dermatologist, but even the laser/IPL that I think of
as the most primitive, horrific "butchery", when it is used on
rosacea/rhinophyma, MIGHT be appropriate when dealing with strictly "cosmetic"
problems, of healthy skin.
Or dermatologists may know many other means of decreasing the appearance of
purple veins such as mine, or the "pinkness" of healthy skin.

So, to sum up, David, you should listen to me ONLY with your doctor's advice and
consent.
I believe you have simply underestimated the longer-lasting effects of the 10%
med, as compared to the 1% med.
Also, I believe that you have not recognized that some of your "symptoms" may
actually be caused by the "sloughing off" of already "dead rosaceous skin".
For one example, the "itching" you mention may be what I call a "healing itch",
which is caused by the growth of new healthy skin, and is a "positive" itch,
like that under a scab that is healing. It may annoy you, but in my opinion it
is not the same "negative" character as is a different, non-healing "irritation
itch".

For another example, I had small "bumps" on my forehead, (and some on my
cheeks), which I now believe were not "disease symptoms" but were part of this
"sloughing off" process, which can take at least one month, (OR MORE), to be
"finished". In most cases, the "bumps" were not inflamed in any way, so they
could not technically be called "papules".
Seeing this, we are tempted to apply more med, but in fact we may be better off
waiting for all of the effects of our last application of the med to be
"completed", before applying more med.

When all is said and done, if this "rosacea" were on some part of our body
concealed by clothing, we'd just keep piling on the med, and that would be OK.
The cure would be accomplished, perhaps sooner, (or perhaps not, since cascade
effects which take time seem to be involved). But to minimize "unsightliness",
we need to wait to fully allow the benefits from one (multiple) application of
the med, before we apply it again. "Dryness", "bumps", "healing itches", and
other "effects" of this healing may be mistaken for "disease symptoms", tempting
us to apply the med more often than is best, for the optimum daily "appearance"
of our face.

There is also another aspect of this situation, involving the non-curative
anti-inflammation characteristic of the DMSO, which I posted at:
http://groups.yahoo.com/group/rosacea-cure/message/225
You might consider studying this post carefully, to decide how it might also
apply to your situation.

We also have to really resist the temptation to "pick at" or "scratch" the kind
of "dry skin bumps" and itching, peeling skin that may occur. ALSO, I STILL
BELIEVE THAT THE "CREME" THAT I RECOMMEND IN MY "DIRECTIONS" SHOULD BE USED, TO
"BLEND IN" THE PEELING SKIN, AND TO SOOTH THE SKIN, DURING THE RATHER LONG
HEALING PROCESS. THIS "CREME" IS MENTIONED, IN r-c message #210.

PERHAPS/MAYBE other types of "cremes" would also accomplish this job, such as
those being marketed by Brady Barrows, in his "Diary" of his use of this med.
He says a lot of good things about the healing effects he experienced with this
med, even though he finally states that it did not "cure" his rosacea. Call me
a cock-eyed optimist, but I still hope that Brady will "come to his God's
full-truth senses" in the future, and state the full truth clearly, about this
[DMSO + 10% fluconazole] treatment/CURE. His "Diary", (and his link to rather
ambiguous, positively smiling self-photos), are at:
http://www.rosacea-control.com/html/diary2.html

So, I think that your "mind-set" has been more on "symptoms", than on curing the
disease.
You are not alone in this tendency.
I cautioned Brady Barrows in private email, because I could see that he was
misinterpreting the effects of the med, and applying it too often, (as in r-c
message #225).
For another example, I stopped applying the med too soon, and found months later
that there was still some stinging upon application of the med, even though I
did not have rosacea symptoms. And I especially point out this reality, at the
end of my "Directions" in r-c message #210.
And there appears to be a wide "spectrum" of TYPES of "infestation", with some
more resistant to this med than others. I have found that the most serious,
such as rhinophyma, appear to be most quickly cured by this med. Some types of
"infestations", which occur on parts of the body other than the face, seem to be
very "stealthy", being almost undetectable until this med is applied, and more
resistant to a complete cure, even though they are 95% "killed" by this med;
perhaps with months of daily treatment, they may be finally cured 100%.

There is a little more info I can offer you.
A higher concentration of this med has become available, but I don't know if it
is better or not. From Michael Roberge, RPh, it is [DMSO + 50% fluconazole],
which costs $277.00 for 15 ml. At some future time, I intend to try it on the
inside of my nose, if the "infestation" does not improve with my current, very
seldom treatment using the 10% med on Q-tips.

Perhaps more importantly, I have done some "research" on my own. Since 1998
when this med was first prescribed, it was made with a 100% concentration of
DMSO, (which is normally labeled as 99% DMSO, because DMSO absorbs some water
from the humidity in the air).
I have known since about June 2003, that a 90% concentration of DMSO, (i.e. 10%
water/90% DMSO), is the most efficient "transporter" of substances into the
bloodstream, as determined by 1985, using DMSO with morphine, and measuring the
blood serum levels of the morphine. This statement is found under the Heading,
"B. Membrane Transport", at:
http://dmso.org/articles/information/herschler.htm

Recently, since I'm still treating my hand and the inside of my nose, I decided
to add 10% distilled water to my [DMSO + 10% fluconazole], to make [10%
water/90% DMSO + 10% fluconazole]. So I measured 1.5 ml of distilled water,
(not an easy task, without the correct laboratory equipment pipette), into one
of my used 15 ml bottles, and filled it up with 13.5 ml of the [DMSO + 10%
fluconazole]. This gave me 15 ml of Rx made with 10% water/90% DMSO
concentration, + 10% fluconazole.

I've only had less than a month to "assess" this med, (made with 10% water/90%
DMSO), on my hand and inside my nose, so I am unable to say whether it is better
or not.

I believe that it may be better.
It seems to cause a little more "pinkness" for a day or two, and it seems to
create a greater "drying" effect, which in my opinion is better.
Logically speaking, it should produce a higher blood serum level of [DMSO +
fluconazole], and thereby have more effective "whole body effects", which might
even get rid of or "disarm" such things as the "polyps" that later turn into
colon cancer, (which I admit is a "stretch", but I have my reasons for believing
this may be true).

Whether this [10% water/90% DMSO + 10% fluconazole] is better for rosacea is
another question. As you know, it can take months to come to any clear opinion
about something this hard to assess. But you might try it. But IF it IS more
effective, you MAY have to wait even LONGER, between med applications, to allow
the cascade healing effects to be "completed/finished". :-)
I hope this helps.
God Bless, ITN & IDFN,
Dave Fleming
X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X=X

Date: Wed, 23 Mar 2005 23:23:21 -0600
From: "David"
To: Dave Fleming <fulltruth40@...>
Subject: 10% Fluconazole no longer helping ????

Dave,
I have corresponded with you before, but it has been a while.
I am quite concerned and would like your input.
I have used DMSO/Fluconazole for quite some time. I started over a year ago
with the 1% solution that I had made locally by my compounding pharmacy. It
contained the 200mg Ibuprofen like the original formula. I had great results.
I only had to use it weekly at first, then I decreased to every two weeks. My
skin condition had been great until recently.

I took your advise and ordered from the pharmacy you recommended Compounded
Solutions in Pharmacy and got the 10% fluconazole DMSO solution. I agree with
what you told me before, that it does not burn quite as much as the 1% solution
but my skin is far worse.

It took me a while to figure out what was going on.
I started using the 10% solution weekly, and it took the full time to get over
the dryness caused by the solution.
I now have returned to my original condition, red, scaly, itching, with pimples
on the center of my forehead, both cheeks, and very slightly on the chin. I can
cover it with concealer easily, but it was gone for a long time.
I do not seem to be getting the results from the 10% solution that I got from
1%.
I don't know if the 10% solution contains the ibuprofen or not, as it does not
say on the bottle.
I just know it no longer seems to help.
I searched my bathroom closet and found Metrogel and have used it for three
days and the redness is greatly improved. I still have this itching sensation,
that comes and goes. I am quite disappointed as I paid $102 plus shipping for
the 10% Fluconazole DMSO solution, and it doesn't seem to help.

What is your impression here and what should I do.
As I am sure you know, I have an element of seborrheic dermatitis on my face and
in the edge of my hairline (forehead area). I know that Rosacea and Seborrheic
dermatitis seem to be common together, but it seems to be what starts the
redness in the firstplace.

I know you won't remember our prior conversations, as you most likely hear from
many, but my rosacea, I think, was causes by steroid creams that I was given by
my dermatologist for the seborrheic dermatitis. I certainly would appreciate
your advise, as you have been such a great help in the past.
Sincerely,
David


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