The following research is a big plus for those who aren't
yet taking large amounts of Vitamin D per day.

It means you can start and get major protection from Cancer.

http://www.sciencedaily.com/releases/2009/02/090204172437.htm

This study shows that it's never too late to start. Could resveratrol
have a similar effect?

http://www.pnas.org/content/106/4/1255.abstract

http://www.sciencedaily.com/releases/2009/02/090203081624.htm

Ray Kurzweil co-authored Fantastic Voyage, which in my opinion is the
best book written to date on life extension. A revised edition should
be released later this year.


Google and Nasa back new school for futurists
By David Gelles in San Francisco

Published: February 3 2009 05:02 | Last updated: February 3 2009 05:02

Google and Nasa are throwing their weight behind a new school for
futurists in Silicon Valley to prepare scientists for an era when
machines become cleverer than people.

The new institution, known as "Singularity University", is to be
headed by Ray Kurzweil, whose predictions about the exponential pace
of technological change have made him a controversial figure in
technology circles.

EDITOR'S CHOICE
Tech Blog: Tales from Topographic Oceans - Oct-17In depth: Browser
battles - Sep-03Google and Nasa's backing demonstrates the growing
mainstream acceptance of Mr Kurzweil's views, which include a claim
that before the middle of this century artificial intelligence will
outstrip human beings, ushering in a new era of civilisation.

To be housed at Nasa's Ames Research Center, a stone's-throw from the
Googleplex, the Singularity University will offer courses on
biotechnology, nano-technology and artificial intelligence.

The so-called "singularity" is a theorised period of rapid
technological progress in the near future. Mr Kurzweil, an American
inventor, popularised the term in his 2005 book "The Singularity is
Near".

Proponents say that during the singularity, machines will be able to
improve themselves using artificial intelligence and that smarter-
than-human computers will solve problems including energy scarcity,
climate change and hunger.

Yet many critics call the singularity dangerous. Some worry that a
malicious artificial intelligence might annihilate the human race.

Mr Kurzweil said the university was launching now because many
technologies were approaching a moment of radical advancement. "We're
getting to the steep part of the curve," said Mr Kurzweil. "It's not
just electronics and computers. It's any technology where we can
measure the information content, like genetics."

The school is backed by Larry Page, Google co-founder, and Peter
Diamandis, chief executive of X-Prize, an organisation which provides
grants to support technological change.

"We are anchoring the university in what is in the lab today, with an
understanding of what's in the realm of possibility in the future,"
said Mr Diamandis, who will be vice-chancellor. "The day before
something is truly a breakthrough, it's a crazy idea."

Despite its title, the school will not be an accredited university.
Instead, it will be modelled on the International Space University in
Strasbourg, France, the interdisciplinary, multi-cultural school that
Mr Diamandis helped establish in 1987.
Copyright The Financial Times Limited 2009

Special Report

Lots Of Unanswered Questions After CBS 60 Minutes Report. 
Is An Anti-Aging Pill Still Beyond Reach? 

“If scientists are right, we may soon be taking a pill that will give us a decade or two of healthy old age.” – Morley Safer, CBS 60 MINUTES, January 25, 2009

In 1991 CBS 60 MINUTES first exposed the world to The French Paradox, the fact the red wine-drinking French live longer and are healthier, exhibiting a 30% reduction in mortality from heart disease compared to western countries, despite their high-fat, high-calorie diet.  The 60 MINUTES report caused a temporary shortage in red wine at the time.  

But there will be no shortage of red wine this time – researchers interviewed on 60 MINUTES said it would take 1000 bottles of red wine to produce the same life-prolonging effects they achieved in the animal laboratory.   But were 60 MINUTES reporters misled?

Alert viewers are sending emails, inquiring online about the inconsistencies in CBS’ 60 MINUTES report about resveratrol (rez-vair-ah-trawl), the red wine molecule that is fast becoming a household word, even if few can pronounce it. 

The most glaring discrepancy was the bottle of resveratrol pills shown on air.  A picture of the bottle, provided by the pharmaceutical company interviewed by 60 MINUTES, has been captured and reproduced below.  It’s not a drug at all.

Notice its label says “dietary supplement” and “250 mg per capsule” on the label.   This is not the SRT501 5000 mg plain resveratrol “drug” (microencapsulated, stabilized, emulsified) that was first used in human clinical trials (see side-by-side photos).  It’s difficult to know whether the label shown on 60 MINUTES was just made up for television viewing, or is an actual product on the drawing board by the pharmaceutical company. 

Why would a drug company, whose scientific experts claim 1000 bottles of red wine, (providing ~1000 milligrams of resveratrol) would be needed to produce a beneficial response in humans, make a pill that provides 1/4th that amount? 

Is mega-dose resveratrol needed to prolong human life -- to achieve maximum lifespan -- as drug company researchers say?  They don’t need longevity pills in France.  Their traditionally made, dark, aged red wine confers super-longevity like that found in no other country.   Examine the following chart:

Roger Corder, author of THE WINE DIET and professor of experimental therapeutics at the William Harvey Research Institute in England, says resveratrol couldn’t possibly be responsible for the health benefits derived from wine since a 5-ounce glass of wine might provide just 1 mg of resveratrol.  It is the total polyphenolic (iron-binding) molecules, or about 60 mg per 5-ounce glass, that is responsible for the unusual health of wine drinkers. 

Almost magically, low-doses of an array of molecules found in red wine (resveratrol, quercetin, catechin, kaempferol, gallic acid, ferulic acid) appear to work better than mega-dose resveratrol alone.  A recent genomic study bears this out. 

Researchers affiliated with the University of Wisconsin conducted a global gene array study comparing calorie restriction, plain resveratrol and a uniquely patented array of molecules (resveratrol, quercetin, IP6 rice bran) found in Longevinex®.  At doses of resveratrol 17-320 times lower than prior studies, Longevinex® activated 9-fold more longevity genes than plain resveratrol or a calorie restricted diet.  [Experimental Gerontology 2008 Sept; 43(9):859-66] 

But again, something was amiss in the 60 MINUTES report.  University-based researchers interviewed on 60 MINUTES were adept at showing how calorie restriction was working in primates (monkeys), but these very same researchers conducted the above gene array study and apparently never told CBS reporter Morley Safer that a nutriceutical matrix (Longevinex®) far exceeds the genomic effect produced by plainresveratrol or a limited calorie diet.  The public was deprived of hearing about a major breakthrough in longevity science.

The point of a well designed red wine pill is to provide about the same quantity of mineral-controlling molecules provided in 3-to-5 glasses of red wine, or about 180-300 mg, without the alcohol, sugar, calories and sulfite preservatives, at a cost that ~5-6 times less than wine.  A $6 bottle of wine would cost ~3-5 a day to provide health benefits.  The cost of Longevinex®, a red wine pill designed to provide the equivalent amount of molecules found in 3-5 glasses of wine, is less than $1 per day.

Are the researchers intentionally misleading consumers, holding them off from taking resveratrol as a dietary supplement and telling them to wait for their stronger yet more expensive resveratrol-like drug?  In earlier pronouncements, drug company spokespersons said resveratrol will take a back seat to more potent “new chemical entities” and the company never plans to introduce an anti-aging pill but rather to match resveratrol with an anti-diabetic drug or a statin cholesterol-lowering drug to treat disease. 

The drug company claims it has stronger molecules that will activate the Sirtuin1 longevity gene, by 1000-fold, but these synthetic molecules are unproven, have never been used in humans, and already the drug company has switched from one of these so-called “new chemical entities” (SRT1720) to another (SRT2104) with no explanation as to why.

Furthermore, while drug company researchers said “we have a pill that can mimic the effects of a calorie restricted diet,” and were bragging on television that their resveratrol pill prolonged the life of laboratory mice, there was a big asterisk attached to that statement.  The researchers were referring to a 2006 study published in Nature Magazine where mice were fed a 60% fat-calorie diet.  But in 2008, a follow-up report published in the journal Cell Metabolism, this time conducted among mice fed a standard fat-calorie diet (25%), showed mega-dose resveratrol (360 and 1565 mg) shortened the lifespan of mice.  The higher dose produced a shorter lifespan.  [Cell Metabolism 2008 Aug; 8(2):157-68]  It’s best to stick with red wine, or low doses in dietary supplements as found in red wine, preferably from an array of molecules rather than just resveratrol.

Mr. Safer ended the 60 MINUTES report by saying: “Everybody from plastic surgeons to snake oil salesmen have been promising a ticket to eternal youth for some time.  So the prospect of a prescription pill that could trigger a longevity gene sounds too good to be true. ….  It’s a pill that diets for you, a pill that activates the survival gene … a highly concentrated form of resveratrol, a virtual vineyard of healthy living,” added Safer. 

The script read well.  It captured the attention of millions.  Yet the 60 MINUTES report was riddled with omissions, apparent intentional distortions and exaggerations.  If CBS’ Morley Safer only knew.

Mr. Safer seemed ready for the pill.  He ended the 60 MINUTES report this way:  “The question is, when do WE get this pill?” 

- Copyright 2009 Resveratrol Partners LLC, not for posting on other websites.

http://www.telegraph.co.uk/earth/wildlife/4357829/Immortal-jellyfish-swarming-ac\
ross-the-world.html

A depressing approach from Stanford:

http://news-service.stanford.edu/news/2009/january14/med-aging-011409.html

I don't know about you but I'm going to do everything
in my power to live as long as possible, because I do
not want to know what is on the other side, frankly...
My responsibility to my family, relatives, in-laws
and co-workers takes precedence over any personal
death-wish that a decaying society may wish to infuse
me with, which I refuse.

Something neat from Aubrey de Grey gives hope:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=423155

And the remarkable interview of Sinclair and
Bush's misguided Medieval adviser Leon Kass:

http://realserver.bu.edu:8080/ramgen/w/b/wbur/storage/2004/01/theconnection_0106\
_2.rm

When Kass said we're not supposed to want to live
longer but instead live out our need for life through
our children, well, at that point I knew Bush was in
the 1500's or earlier as far as his science and thought
were concerned.

I will never vote for a mid-America candidate again, ever.
It is primitive thinking that goes on there. Inert, opaque,
vague, controlling, dogmatic, and inexact.

Stuart

Slightly off topic but good information:

http://www.physorg.com/news152344736.html

Very interesting article:

http://www.technologyreview.com/biomedicine/22023/page1/

I wouldn't want to live to be 100 in this world. In the
world I grew up in where three generations of each family
saw each other every week and ate at the same table,
I'd want to live in that age.

The problem is that it takes two generations to turn a
rotten society around. Two ... if you're lucky. Well,
we've got Gen-Y now in their twenties and they are
the end product of decadent, spoiled capitalism.
They CANNOT turn the ship around. Maybe their
children can.

I don't know if you observe very old people much. I
mean people older than 80. Most of them don't look
like they're having much fun. I would rather measure
my life by the LIFE IN MY YEARS RATHER THAN
THE YEARS IN MY LIFE. I'd rather have another
two good decades and then call it a day.

Until then, I plan to live life to the hilt.

In an article published early online on January 21, 2009 in the
Proceedings of the National Academy of Sciences, researchers from
Brown University in Rhode Island, the University of Chicago, and the
University of Connecticut Health Center report that a mutation that
extends the lifespan of fruit flies works by limiting free radicals
and the damage they cause. Free radicals are highly reactive cellular
byproducts that damage tissue and contribute to many of the signs of
aging.

Professor Stephen Helfand of Brown's Department of Molecular Biology,
Cell Biology and Biochemistry and his associates sought to determine
the life-extending mechanism of a mutation named "Indy" (which stands
for "I'm not dead yet"), that he first discovered in 2000. Flies with
the Indy mutation have double the average life span as those without
it (70 versus 35 days). Dr Helfand's team compared gene expression in
Indy flies and normal flies throughout their lives and determined
that the mutation significantly limits the production of free
radicals known as reactive oxygen species via reduced expression of
genes involved in generating energy, without decreasing the overall
level of energy (as assessed by measuring adenosine triphosphate
levels) within the cell. Accordingly, protein carbonyls, a measure of
free radical damage to proteins, were lower in the mitochondrial
protein of Indy flies.

"There are very few, if any, interventions that are known to
dramatically extend healthy lifespan," Dr Helfand
stated. "Understanding how � the Indy mutation alters the metabolic
state of the fruit fly would allow someone to come up with
pharmacological interventions that could mimic it and give you the
benefit of genetic manipulation without having to do genetics."

Overall, a pretty good segment on Resveratrol
on tonight's 60 Minutes seventeen years after
the French Paradox aired...

Morley Safer was his usual skeptical self
with sardonic wit (excellent characteristics
for a news anchor/reporter to have and
Morley is pretty seasoned.)

I was, of course, disappointed to see it so
centralized/dependent on the medical angle
however,

Why we have to have PhD's and MD's
force-feeding us to believe anything is
pretty sad... since the medical profession
is one of the most backward on earth
as far as accepting substantive improvement
rapidly. Many millions have died through the
centuries for its snail's pace of internalizing
change. Certainly, nowadays, with the implied
threat of litigation hanging over every physician's
head, true help is being often withheld for fear
of a lawsuit.

Also, no mention was made, as far as I could
tell, of overdosing on Resveratrol (>100mg/day)
which could lead to serious health consequences,
including death apparently.

No mention was made that some people have
reported that on 100mg/day of Resveratrol
an extreme hyper-reaction, extreme nervousness
and agitation -- many people do not want to live
that way or be seen like that... I have a close friend
and he has a close friend who had that reaction...
and ceased resveratrol immediately upon confirming
the above personal observations of each other, preferring
instead a laid-back persona/presentation. Both are
tenured professors and in the scientific field (computer science.)

Last, members of the CRS Caloric Restriction Society,
shown in the episode,  looked very ill to me, dangerously
thin, emaciated, almost like prison-camp-detainees. I don't think
I'd want to go that route...

Stuart

www.telegraph.co.uk/news/newstopics/howaboutthat/4283619/Memory-pill-that-could-\
help-with-exam-revision-could-be-available-soon.html

http://www.sciencedaily.com/releases/2009/01/090116123129.htm

Scientists Discover Gene Responsible For Brain's Aging

ScienceDaily (Jan. 18, 2009) � Will scientists one day be able to slow
the aging
of the brain and prevent diseases such as Alzheimer's and Parkinson's?
Perhaps --
at least once the genetic coding associated with neuronal degeneration
has been unraveled.

According to a new study published in The Journal of Neuroscience, a
research team
from the Universit� de Montr�al, Maisonneuve-Rosemont Hospital and Lawrence
Berkeley National Laboratory has taken a giant step in this direction by
identifying
a gene that controls the normal and pathological aging of neurons in the
central
nervous system: Bmi1.

The primary risk factor for diseases such as macular degeneration,
Parkinson's and
Alzheimer's is age. Although many researchers have sought to better
understand the
genetics and pathophysiology of these diseases, few studies have focused
on the
basic molecular mechanisms that control neuronal aging.

Dr. Gilbert Bernier, of the Universit� de Montr�al and Maisonneuve-Rosemont
Hospital, led a team that identified a mutation in mice that
dramatically accelerates
the process of aging in the brain and the eye. The new study reveals
that neurons
in the retina and cerebral cortex require a gene called Bmi1 to prevent
activation
of the p53 pathway and the accumulation of free radicals.

"Overall, we have now established that the Bmi1 gene is a direct
regulator of cell
aging in brain and retinal neurons of mammals through its action on the
defense
mechanisms against free radicals," says Dr. Bernier.

The article is the work of Dr. Gilbert Bernier in collaboration with
Wassim Chatoo,
Mohammed Abdouh, Jocelyn David, Marie-Pier Champagne, Jos� Ferreira from
the Universit� de Montr�al and Maisonneuve-Rosemont Hospital with Francis
Rodier from the Lawrence Berkeley National Laboratory, San Francisco, U.S.

http://www.lef.org/news/LefDailyNews.htm?NewsID=7761&Section=Aging

http://www.breitbart.com/article.php?id=D95F59B00&show_article=1

http://news.bbc.co.uk/2/hi/health/7803619.stm

In light of the recent question over whether red wine resveratrol pills
actually deliver on their promise to prolong human life, the following
was sent to a critical reviewer.

*IN DEFENSE OF A RED WINE RESVERATROL PILL*

*Sandy Szwarc/ Junk Food Science*

Your report at Junk Food Science regarding resveratrol piils is an
honest attempt to provide consumers with a critical review.
http://junkfoodscience.blogspot.com/2008/12/living-longer-with-resveratrol.html

However, may I add some things for you to think about.

First, Thomas Walle's work should be discredited.  It is misleading and
sponsored by a drug company.
It is obvious from other studies that systemic effects are produced by
resveratrol.  Its effects are not limited to the gut.  Yes, free
(unbound) resveratrol is not commonly found in the blood circulation.
Once it reaches the liver it is conjugated with glucuronate or sulfate,
which are detox molecules.  The res/glucuronate conjugate is too large
to pass through cell walls and influence genetic machinery.  However,
glucuronidase is an enzyme that is abundant at sites of inflammation,
infection and malignancy and it free resveratrol to be delivered at the
right time and place.

http://www.ncbi.nlm.nih.gov/pubmed/19114588?

http://www.ncbi.nlm.nih.gov/pubmed/15349955?

Second, we cannot call for longevity studies in humans, this is
impractical.  99-year studies would be required.  So researchers are
forced to use animals.  Even 3-4 year mouse studies are costly.  Yes,
some human trials are on the way, but would only prove what has already
been observed in animals, they are profoundly healthier, but may die
sooner.  This is a bit of a paradox (explained below).  Gene array
testing may serve as a valid shortcut to longevity studies (see more
below).

http://www.ncbi.nlm.nih.gov/pubmed/11238786?

http://www.ncbi.nlm.nih.gov/pubmed/10906510?

http://www.ncbi.nlm.nih.gov/pubmed/10464095?

Third, the positive health benefits of red wine molecules like
resveratrol are observed and repeatedly demonstrated in animal studies
and by epidemiology ONLY in relatively lower doses and when an array of
molecules are employed.  Aged, dark red wine provides ~60 mg of
polyphenolic molecules (resveratrol, quercetin, catechin, gallic acid,
kaempferol, ferulic acid, etc) per 5 oz glass of wine.  A U-shaped
consumption curve is revealed.  Abstainers and over-imbibers exhibit no
benefits.  Consumers of 3-5 glasses of red wine, providing ~180-300 mg
of total polyphenols, exhibit profound and repeated health benefits,
i.e. 30% reduced cardiac mortality among French red wine drinkers.

http://www.ncbi.nlm.nih.gov/pubmed/8814971?

http://www.ncbi.nlm.nih.gov/pubmed/12965884?

Resveratrol appears to exert profound beneficial effects are very low
concentrations.

http://www.ncbi.nlm.nih.gov/pubmed/18234130?

The beneficial effects of red wine molecules are additive:

http://www.ncbi.nlm.nih.gov/pubmed/15740983?

Fourth, there are synergistic effects observed when polyphenolic
molecules are combined.

http://www.ncbi.nlm.nih.gov/pubmed/19053873?

http://www.ncbi.nlm.nih.gov/pubmed/18495457?

http://www.ncbi.nlm.nih.gov/pubmed/18433793?

http://www.ncbi.nlm.nih.gov/pubmed/16935024?

http://www.ncbi.nlm.nih.gov/pubmed/16310197?

http://www.ncbi.nlm.nih.gov/pubmed/15670891?

http://www.ncbi.nlm.nih.gov/pubmed/12888656?

http://www.ncbi.nlm.nih.gov/pubmed/11743756?

Fifth, lower doses of resveratrol appear to genomically mimic calorie
restriction:

http://www.ncbi.nlm.nih.gov/pubmed/18523577

Sixth, it has been shown that relatively lower doses of resveratrol when
combined in a matrix of mineral-chelating molecules exerts a far greater
genomic effect than plain resveratrol.  (I am commercially involved with
this product, Longevinex).  At a dose of resveratrol 17-320 times lower
than prior studies, a resveratrol/quercetin/rice bran IP6
matrix significantly affected 1711 genes, but only 225 genes as plain
resveratrol alone.

http://www.ncbi.nlm.nih.gov/pubmed/18657603?

Seventh, the molecules in red wine are known TNF inhibitors.  There are
many other natural molecules that are TNF inhibitors (vitamin E, fish
oil, vitamin C, curcumin, etc.).  Over-inhibition of TNF is associated
with increased risk for lymphoma.

http://www.ncbi.nlm.nih.gov/pubmed/18360633?

http://www.ncbi.nlm.nih.gov/pubmed/17654504?

The animals in the 2008 Cell Metabolism study did not live as long on
360 mg or 1565 mg human equivalent of resveratrol compared to a standard
calorie diet alone.  The animals tended to die of lymphoma.

http://www.ncbi.nlm.nih.gov/pubmed/18599363?

I believe it was the over-inhibition of TNF that shortened the lives of
these lab animals.  Dosage would then be critical in achieving health
benefits, as over-inhibition of TNF may be deleterious.

Eighth, relatively lower doses of resveratrol (175-350 mg human
equivalent) appear to protect the heart from damage should a heart
attack occur, while larger doses (often provided in some mega-dose
resveratrol supplements) may worsen the area damaged (scarred) by a
heart attack (1750-3500 mg human equivalent).  Mega-dose resveratrol is
more appropriate to induce apoptosis, such as for cancer therapy.

http://www.ncbi.nlm.nih.gov/pubmed/18789672?

Ninth, provision of mega-doses of the molecules in red wine, as well as
in bran, as mineral chelators, may induce anemia and resultant side
effects.  For example, resveratrol is a copper chelator and copper is
needed for collagen synthesis.  Achilles tendonitis is commonly reported
among users of mega-dose resveratrol and may be due to weak collagen.
Resveratrol and other mineral chelating molecules are not appropriate
for menstruating females, growing children, or known anemics.

The beneficial effects of red wine may be safely replicated in a pill
that provides a modest dose (180-300 mg) of red wine polyphenols or
other mineral-chelating molecules, as provided in 3-5 glasses of aged,
dark, red wine, and such a pill eliminates the hazards posed by alcohol,
excess calories, sugar, heavy metals and sulfite preservatives found in
wine.  Such a pill would also be far more affordable than 3-5 glasses of
red wine.

Bill Sardi, Resveratrol Partners LLC, dba LONGEVINEX



------------------------------------------------------------------------
New year...new news. Be the first to know what is making headlines
<http://www.aol.com/?ncid=emlcntaolcom00000026>.

http://www.nola.com/news/index.ssf/2008/12/george_francis_oldest_man_in_n.html

--Stuart
___
Sent via Treo 700p using  SnapperMail  2.4.1.01 on the EVDO REV-A Verizon
Wireless Network.

  ..... Forwarded Message .......
From: Stuart Cracraft <cracraft@...>
To: forumpoint@yahoogroups.com
Date: Sat, 27 Dec 2008 15:15:24 -0800
Subj: [forumpoint] Fwd: Modest doses of resveratrol suggested for longevity 
seekers



--Stuart
___
Sent via Treo 700p using  SnapperMail  2.4.1.01 on the EVDO REV-A Verizon
Wireless Network.

  ..... Forwarded Message .......
From: BSardi@...
To: gerrygawne@...
Date: Sat, 27 Dec 2008 12:09:45 EST
Subj: Modest doses of resveratrol suggested for longevity seekers

For Immediate Release



Longevity Seekers Advised To Consume Modest Doses of Red Wine Molecules In
Dietary Supplements (Longevinex®) Rather Than Mega-Dose Resveratrol Alone



San Dimas, CA (Dec. 27, 2008) - According to the latest science, resveratrol
pill users are best advised to consume modest doses resveratrol plus an array of
antioxidant molecules as typically provided in 3 to 5 glasses of aged, red wine,
rather than resveratrol alone.



The most recent study shows mega-dose resveratrol alone fails to prolong the
life of laboratory mice.  In fact, mega-doses shortened the life of animals
compared to a standard calorie diet with no resveratrol. [Cell Metabolism. 2008
Aug; 8:157-68]



While resveratrol (rez-vair-ah-trol), an antioxidant molecule concentrated in
red wine (about 1 milligram per glass), is touted for its health properties,
partially explaining the French Paradox (why French wine drinkers have cardiac
mortality rates 30% lower than North Americans despite their high-calorie,
high-fat diets), it is not the sole molecule responsible for longevity, says
Bill Sardi, spokesperson for Longevinex®, a leading brand of resveratrol
dietary supplement.



The total array of red wine molecules found in the best red wine, about 60
milligrams per 5-ounce glass, or 180-300 milligrams in 3 to 5 glasses, is the
suggested healthy dosage range, says Sardi.



Consistently, studies show modest doses of red wine lower mortality rates over
abstention or over-consumption.  [American Journal Epidemiology 1986 Sep;
124(3):481-9]  Red wine pills offer the advantage of no alcohol, no calories or
sulfite preservatives.



Cause of shortened lifespan



The negative effect upon lifespan with mega-dose resveratrol may emanate from
over-inhibition of tumor necrosis factor (TNF), an inflammatory factor. 
Excessive TNF leads to inflammation, while too little impairs the immune system,
says Sardi.



“We know that over-inhibition of TNF in humans increases the risk for lymphoma
(cancer that originates in lymphocytes, a type of white blood cell),” says
Sardi.  [Therapeutics Clinical Risk Management 2007 Jun; 3(2):245-58]  “When
laboratory mice were given mega-dose resveratrol they did not live as long and
largely succumbed to lymphoma.  Resveratrol is a known TNF inhibitor,” adds
Sardi.  [Biochemical and Biophysical Research Communications 2008 May 2;
369(2):471-7]



Confusing dosage advice



While longevity seekers have been hearing a lot about resveratrol in the past
four years, since an Ivy League university discovered it activated a longevity
gene known as Sirtuin 1, advice concerning dosage has been confusing at times.



A 2006 mouse study suggested consumers would have to drink about 750 to 1500
bottles of red wine a day to live longer (24 milligrams per kilogram of body
weight), but the longevity effect was only demonstrated among mice engorged with
a fat-laden diet (60% fat calories vs. 35% for the typical human diet), which
isn’t a real-world example.



When the data on mice fed a standard calorie diet were analyzed and published in
2008 [Cell Metabolism. 2008 Aug; 8(2):157-68], ultra-high dose resveratrol (360
mg and 1565 mg, human equivalent dosage) actually stunted the lifespan of mice. 
So the public has been misled concerning dosage since 2006 [Nature 2006 Nov 16;
444:337-42], and may have never heard about the 2008 report, says Sardi.



Lower dose resveratrol accompanied by an array of other small molecules may be
superior to resveratrol alone.  According to a mouse study conducted by
Longevinex®, published in the September 2008 issue of Experimental Gerontology
[2008 Sept; 43(9):859-66], far more longevity genes were activated in heart
tissue by Longevinex (9-fold more) than plain resveratrol, at a dose that was
17-320 times lower than doses used in prior studies.



Synergism found



“A synergistic effect has been demonstrated with the array of antioxidant
molecules provided in Longevinex®, compared to resveratrol alone,” says
Sardi.  Other studies also corroborate that resveratrol works better when
accompanied by other molecules, at lower doses.  [Journal Medicinal Food 2008
Dec; 11:773-83; Translational Oncology 2008 March; 1:19-27; Life Science 2008
May 7; 82: 1032-9]



Sardi says longevity seekers often demand human lifespan studies, not realizing
such a study would be impractical, taking 100 years to complete.  Mouse
longevity studies take about 3-4 years and cost more than a million dollars, so
more economical gene array studies are performed and compared against a calorie
restricted diet, which is a known intervention that prolongs life in all life
forms.  Longevinex® also sponsored an unpublished study showing it activated
far more genes in brain tissue than plain resveratrol.



Longevinex® is a patent-applied-for matrix providing 250 milligrams of
gene-controlling molecules (resveratrol, quercetin, rice bran IP6, ferulic acid,
vitamin D), and is currently the only resveratrol-based dietary supplement to
have been successfully studied in humans.  Researchers at Appalachian State
University found Longevinex® had superior antioxidant and anti-inflammatory
action among endurance athletes compared to green tea molecules or quercetin
alone.



Longevinex® is microencapsulated for stability and long-term shelf life, and is
micronized to enhance absorption.  Longevinex® contains no alcohol.  Longevity
seekers are invited to visit the website at www.longevinex.com  ####








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One site keeps you connected to all your email: AOL Mail, Gmail, and Yahoo Mail.
Try it now.


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Yahoo! Groups Links

http://online.wsj.com/article/SB123025446150734561.html?mod=googlenews_wsj

http://www.msnbc.msn.com/id/28369049/

Just get off your feet, lay down, close your eyes
and stay in bed, horizontal, for 8 hours, nightly,
the rest of your life.

Add resveratrol and you have a good situation!

In a study that adds evidence to what chocolate lovers, tea drinkers,
and wine aficionados have been claiming for years, A. David Smith of
the University of Oxford in England and his colleagues have
demonstrated that these foods do appear to be good for the brain.

Writing in the December, 2008 issue of the Journal of Nutrition, Dr
Smith and his associates describe their study of 2,031 men and women
aged 70 to 74 recruited from the Hordaland Health Study in Norway.
Responses to dietary questionnaires were analyzed for the intake of
wine, tea, and chocolate--common dietary items that are high in
flavonoids. Cognitive evaluation included six tests of memory and
learning.

Subjects who reported consuming wine, chocolate or tea had
significantly better average cognitive test scores and than
nonconsumers. The risk of performing poorly on the cognitive tests
decreased as a greater number of the three foods were consumed, with
a 64 to 74 percent reduction in the risk of poor test performance
associated with the intake of all three compared to the risk
experienced by those who did not consume these foods.

In their discussion of the possible effects of these foods upon the
brain, the authors note that wine drinkers have been shown to have a
lower risk of dementia compared with nondrinkers, cocoa is a rich
source of flavonoids which have antioxidant benefits, and green tea
polyphenol intake has been correlated with a reduction in cognitive
impairment.

"In a population-based study, we showed that intake of flavonoid-rich
food, including chocolate, wine, and tea, is associated with better
performance across several cognitive abilities and that the
associations are dose dependent," the authors conclude. "We suggest
that further studies should directly examine the flavonoid status and
take into account other bioactive dietary substances in these foods."

For those having cancer already, this looks like a real find:

http://www.computerworld.com/action/article.do?command=viewArticleBasic&articleI\
d=9124182&source=NLT_PM

For those wishing to prevent it, I outlined the approach last night.

It bears repeating: "red wine (1 glass daily) and/or
resveratrol supplementation in amounts of 50mg to 100mg daily)
leads to inhibition and prevention of breast cancer
(as well as many other cancers):

   http://www.newswise.com/articles/view/542194/

   http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=19919

It is a stronger inhibitor than exercise or diet (and far, far easier than
control of either of those.)

The literature is literally now OVERFLOWING with enormous numbers
of studies that point in the same direction as the above. You can
review them for yourself if you wish at www.pubmed.org by
searching on the keyword "resveratrol".

There are 2555 pro-resveratrol articles there. That's hard research
backing up one of nature's very few miracle molecules, one of the
very few that is far more powerful than most man-created molecules.
I get mine at www.longevinex.com, which also happens to be the BEST
formulation.

Stuart

P.S. This is the last e-mail you will receive on this specific subject
from me for a long time. I've had my say. It's up to you to care for
yourselves!!!!

And don't forget: it slows neuron decay/loss in the brain, ameliorates
plaque (those two contribute to Alzheimer's, Senility, Parkinson's
and other brain-wasting/damage diseases), and is one of the most
strongly pro-cardia (heart) approaches in the world. It's a wonder
you can even buy it without some doctor overcharging you for an
opinion! I'm surprised the government hasn't banned it, frankly.

Have a great Winter Solstice all.

Longevinex® Bulletin:  Resveratrol Eradicates Brain Plaque Associated With Senility (animal study)

 

Researchers at the Weill Medical College of Cornell University report that dietary supplementation with the red wine molecule resveratrol (rez-vair-ah-trawl) dramatically reduces plaque formation in animal brains, surprisingly without activating the Sirtuin1 gene. 

 

Oral resveratrol produced large reductions in brain plaque in the hypothalamus (-90%), striatum (-89%), and medial cortex (-48%) sections of the brain.  Previously, studies had shown that direct injection of resveratrol into brain tissues reduces degeneration and prevents learning impairment.  This study shows that oral doses of resveratrol may reduce beta amyloid plaque associated with aging changes in the brain.  Researchers theorize that one mechanism for plaque eradication is the ability of resveratrol to chelate (remove) copper.  [Neurochemistry International, Nov. 8, 2008 early online]

 

 

 

 

 

 

Plaque counts

 

 

 

 

Percent plaque area

 

 

 

 

 

 

Abstract:  Neurochemistry International   2008 Nov 8. [Epub ahead of print]

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.

Karuppagounder  SS, Pinto JT, Xu  H, Chen LH, Beal  MF, Gibson GE.

Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Ave., White Plains, NY 10605, United States.

Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses a wide range of biological effects. Since resveratrol's properties seem ideal for treating neurodegenerative diseases, its ability to diminish amyloid plaques was tested. Mice were fed clinically feasible dosages of resveratrol for forty-five days. Neither resveratrol nor its conjugated metabolites were detectable in brain. Nevertheless, resveratrol diminished plaque formation in a region specific manner. The largest reductions in the percent area occupied by plaques were observed in medial cortex (-48%), striatum (-89%) and hypothalamus (-90%). The changes occurred without detectable activation of SIRT-1 or alterations in APP processing. However, brain glutathione declined 21% and brain cysteine increased 54%. The increased cysteine and decreased glutathione may be linked to the diminished plaque formation. This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against beta-amyloid induced neuronal damage.

Longevinex® Bulletin:  Resveratrol Eradicates Brain Plaque Associated With Senility (animal study)

 

Researchers at the Weill Medical College of Cornell University report that dietary supplementation with the red wine molecule resveratrol (rez-vair-ah-trawl) dramatically reduces plaque formation in animal brains, surprisingly without activating the Sirtuin1 gene. 

 

Oral resveratrol produced large reductions in brain plaque in the hypothalamus (-90%), striatum (-89%), and medial cortex (-48%) sections of the brain.  Previously, studies had shown that direct injection of resveratrol into brain tissues reduces degeneration and prevents learning impairment.  This study shows that oral doses of resveratrol may reduce beta amyloid plaque associated with aging changes in the brain.  Researchers theorize that one mechanism for plaque eradication is the ability of resveratrol to chelate (remove) copper.  [Neurochemistry International, Nov. 8, 2008 early online]

 

 

 

 

 

 

Plaque counts

 

 

 

 

Percent plaque area

 

 

 

 

 

 

Abstract:  Neurochemistry International   2008 Nov 8. [Epub ahead of print]

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.

Karuppagounder  SS, Pinto JT, Xu  H, Chen LH, Beal  MF, Gibson GE.

Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Ave., White Plains, NY 10605, United States.

Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses a wide range of biological effects. Since resveratrol's properties seem ideal for treating neurodegenerative diseases, its ability to diminish amyloid plaques was tested. Mice were fed clinically feasible dosages of resveratrol for forty-five days. Neither resveratrol nor its conjugated metabolites were detectable in brain. Nevertheless, resveratrol diminished plaque formation in a region specific manner. The largest reductions in the percent area occupied by plaques were observed in medial cortex (-48%), striatum (-89%) and hypothalamus (-90%). The changes occurred without detectable activation of SIRT-1 or alterations in APP processing. However, brain glutathione declined 21% and brain cysteine increased 54%. The increased cysteine and decreased glutathione may be linked to the diminished plaque formation. This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against beta-amyloid induced neuronal damage.