Hi guys,

Sorry to reply late for your celebration, and thank you very much.

Now I am in Japan to re-start PhD course in neuropharmacology,
which I left without degree before JICA volunteer in Manus.
Also I will join a diploma course in the tropical medicine in Nagasaki,
for only 3 months (June-Aug.).
Contact me if you have a plan to come to Nagasaki while I am there,
or Tokyo after Aug.

By the way, I will be on TV about PNG HIV/AIDS documentary.
as a interpreter, not a presenter though.
TV crew went to Wewak, Mt Hagen and POM last month.
to have interviewed some doctors and Health ministar etc.
It will be worth while watching if you are in Japan.
I am sure it will raise tremendous fund through UNICEF in PNG.
28-29 / May / 2007, 8am-10am, Fuji TV

TOKSAVE tasol!

Mail: rt173cm67kg@yahoo.co.jp
Mobile: 090-9847-0987
Mobile mail¡§tamakiraita@softbank.ne.jp

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

thanks for the infor

--- mol william <w_mol2003@...> wrote:

>
> Raita Tamaki,
>
>
>   wanted me to post this message to the forum but
> somehow he couldn't so he asked me to post it for
> him. Below is the message.
>
>   Hi guys,
>
> Sorry to reply late for your celebration, and thank
> you very much.
>
> Now I am in Japan to re-start PhD course in
> neuropharmacology,
> which I left without degree before JICA volunteer in
> Manus.
> Also I will join a diploma course in the tropical
> medicine in Nagasaki,
> for only 3 months (June-Aug.).
> Contact me if you have a plan to come to Nagasaki
> while I am there,
> or Tokyo after Aug.
>
> By the way, I will be on TV about PNG HIV/AIDS
> documentary.
> as a interpreter, not a presenter though.
> TV crew went to Wewak, Mt Hagen and POM last month.
> to have interviewed some doctors and Health ministar
> etc.
> It will be worth while watching if you are in Japan.
> I am sure it will raise tremendous fund through
> UNICEF in PNG.
> 28-29 / May / 2007, 8am-10am, Fuji TV
>
> TOKSAVE tasol!
>
> Mail:        rt173cm67kg@...
> Mobile:      090-9847-0987
> Mobile mail¡§tamakiraita@...
>
>
>
>
> ---------------------------------
> Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
>


Rodney Itaki



___________________________________________________________
The all-new Yahoo! Mail goes wherever you go - free your email address from your
Internet provider. http://uk.docs.yahoo.com/nowyoucan.html

Hi guys,

Sorry to reply late for your celebration, and thank you very much.

Now I am in Japan to re-start PhD course in neuropharmacology,
which I left without degree before JICA volunteer in Manus.
Also I will join a diploma course in the tropical medicine in Nagasaki,
for only 3 months (June-Aug.).
Contact me if you have a plan to come to Nagasaki while I am there,
or Tokyo after Aug.

By the way, I will be on TV about PNG HIV/AIDS documentary.
as a interpreter, not a presenter though.
TV crew went to Wewak, Mt Hagen and POM last month.
to have interviewed some doctors and Health ministar etc.
It will be worth while watching if you are in Japan.
I am sure it will raise tremendous fund through UNICEF in PNG.
28-29 / May / 2007, 8am-10am, Fuji TV

TOKSAVE tasol!

Mail:        rt173cm67kg@...
Mobile:      090-9847-0987
Mobile mail¡§tamakiraita@...

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

Valid point Poyap,

Somebody told me, 'everything one can think of can be
achieved or be done, if not now later'.

Many years ago somebody said, 'we could go to the moon'
and pople thought he was a psycho. Now it is possible.

Many things Leonardo da Vinci thought of & drew are now
being invented. For example, he thought of the principles
of vertical take-off & landing aircraft; the helicopter,
in 1493 (See picture of airscrew below). In 14th September
1939 (446 years later), Igor Sikorsky (see photo below),
successfully built & flew the first helicopter. He named
it,
Vought-Sikorsky 300 (see picture below).

In this world, In regards to thought, I think we can
simply classify people into 4 groups:

1. People who don't think & don't do anything
2. People who don't think but do things
3. People who think but don't do things
4. People who think & do things

Which one are you? Think!

William

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

Valid point Poyap,

Somebody told me, 'everything one can think of can be
achieved or be done, if not now later'.

Many years ago somebody said, 'we could go to the moon'
and pople thought he was a psycho. Now it is possible.

Many things Leonardo da Vinci thought of & drew are now
being invented. For example, he thought of the principles
of vertical take-off & landing aircraft; the helicopter,
in 1493 (See picture of airscrew below). In 14th September
1939 (446 years later), Igor Sikorsky (see photo below),
successfully built & flew the first helicopter. He named
it,
Vought-Sikorsky 300 (see picture below).

In this world, In regards to thought, I think we can
simply classify people into 4 groups:

1. People who don't think & don't do anything
2. People who don't think but do things
3. People who think but don't do things
4. People who think & do things

Which one are you? Think!

William

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

Actually Moses who you "thought" gave that comment on technicality was infact willie and not me.  This is a clear example of how "mass thought" can get derailled and a false believe, disillusion perpetuated,  how the original thought can get twisted, modified from one individual to another and at the end the the original idea, thought is unrecognisable from the original, just like mercury.

 

Anyway, ......  Noken tingting tumas....JUST DO IT!! as in the Nike Ad.  Enjoy you thoughts!!, but don't dwell in thought for too long without doing something, a good mix of thought and ACTION is health, too much of one and not the other is not good.

 

poyap

moses wiau <mouwiau04@yahoo.com.au> wrote:

Poyap,

 

As technical as one would get, where did one obtain  the thought of being technical? Is not thought the very essence that drives the greatest computer- brain,etc...which controls our very being like emotions;relatioships;intelligence;etc..These are the inherent qualities that define what/who we are as humans...

Well, it was nice to gauge constructive views. Hope to discuss further stimulating topic on the forum.

 

Cheers

 

Moses
mol william <w_mol2003@yahoo.co.jp> wrote:

Poyap! that's a great & complete summary on lead. May help
as a reference.

Moses, yeah! as you know very well I am more technical
then you. That is simply because thought is a very complex
& abstract topic.

Cheers!

William

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

---

How would you spend $50,000 to create a more sustainable environment in Australia? Go to Yahoo!7 Answers and share your idea.

---

How would you spend $50,000 to create a more sustainable environment in Australia? Go to Yahoo!7 Answers and share your idea.

Poyap,

 

As technical as one would get, where did one obtain  the thought of being technical? Is not thought the very essence that drives the greatest computer- brain,etc...which controls our very being like emotions;relatioships;intelligence;etc..These are the inherent qualities that define what/who we are as humans...

Well, it was nice to gauge constructive views. Hope to discuss further stimulating topic on the forum.

 

Cheers

 

Moses
mol william <w_mol2003@yahoo.co.jp> wrote:

Poyap! that's a great & complete summary on lead. May help
as a reference.

Moses, yeah! as you know very well I am more technical
then you. That is simply because thought is a very complex
& abstract topic.

Cheers!

William

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

---

How would you spend $50,000 to create a more sustainable environment in Australia? Go to Yahoo!7 Answers and share your idea.

Poyap! that's a great & complete summary on lead. May help
as a reference.

Moses, yeah! as you know very well I am more technical
then you. That is simply because thought is a very complex
& abstract topic.

Cheers!

William

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

Poyap! that's a great & complete summary on lead. May help
as a reference.

Moses, yeah! as you know very well I am more technical
then you. That is simply because thought is a very complex
& abstract topic.

Cheers!

William





--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

Hi Pou,

 

Good to know about Mercury...

 

I hope you are fine in Melbourne.

 

Cheers

 

Moses

Poyap <pojaroo@yahoo.com.au> wrote:

Hi all - here is a liklik story about Mercury, hope you can get
through it in one sitting.

Mercury is a very interesting substance. I remeber as a kid finding
a small bottle of mercury in an old workshop and finding myself
facinated by it. It was like water yet very heavy, it shined like
the other metals I was familiar with but flowed. I use to play around
with it in may hands, rolled it around on the floor, pick it up with
a magnet and did many other things to satisfy my curiousity. Little
did I know the potential danger I was exposing myself to, and may it
did affect me somehow, who knows??

Anually, the atmosphere and surface of the earth is exposed to about
36,000 tonns of mercury. The single largest source of mercury is the
natural outgassing from granite rock (about 30,000 tonns)-not too
sure about this process, if our mining collegue can enlighten us.
The metal fillings used in dentistry is made of mixtures of metals
containing mercury (amalgam). Some studies have shown high levels of
mercury in the blood of people with amalgam dental fillings, but the
general consensus is that they are safe.

The mining industry uses mercury to extract gold and other minerals
from the raw material as outline beautifully by VB. Great effort
should be made to dispose of the waste products of mineral
extraction. When this is not done mercury and other toxic substance
can pollute and contaminate the environment and cause serious health
problems in animals and humans.

Mercury can take different forms each having a different level of
toxicity. Basically there are three different forms as outline
belowed in order of toxicity:

1) Elemental ("natural") mercury (Hg 0) - this is essentially non
toxic,this what we find in the dental amalgams.

2) When exposed to other modifying (oxidising) chemicals elemental
mercury (Hg 0) can be ionised to Hg2+ --> this is more toxic then
Hg 0.

3) Further modification forms the very toxic forms (the alkyl Hg).

SO HOW DOES THE INOCENT ELEMENTAL MERCURY Hg 0 GET CORRUPTED??

a) In industry, the chemical modification of Hg 0 to Hg 2+ is
frequently accomplished by exposing Hg 0 to a strong oxidants
such as chlorine.

b) Hg 0 can also be bioconverted to both Hg2+ and alkyl Hg by
microorganism that exist in the human gut and in the bottom
sediments of rivers and lakes.

These modified and now toxic forms of mercury accumulate in the
acquatic food chain and reach their highest concentration in the
large fish. Humans in turn acquire them by eating these fish.

HOW DOES MERCURY AFFECT HUMAN HEALTH??

Mercury toxicity can be expressed in three ways.

1) Mercury changes the structure of many essential proteins in the
body, from collagen in skin to important enzymes for normal
functioning of the body, this change in protein structure render
these proteins dysfunctional and incabale of doing their jobs
(detail are beyond the scope of this summary).

2) Protein structure modification makes them suseptable to
autoimmune destruction as the bodies immune system no longer
recognised them as self, and mounts an attack against them.

3) The most toxic form of mercury the alkyl mercuries can easily
penetrate into the central nervous system causing brain damage.
Unborn children are also affected as mercury freely passes from
the mother to the fetus.

TOUGH LESSONS THE WORLD HAS LEARNT ABOUT MERCURY.
Much of what is known about the health effects of mercury has been
gained from investigations of the 1951 to 1963 industrial dumping of
Hg waste into the Minamata Bay, Japan. Fish in Minamata bay became
heavily ladened with Hg and humans around the area who relied on
these fish for protein in turn became intoxicated. The symptoms and
signs of heavy mercury intoxication included:

Ataxia - unsteady gait
impaired speech - slurred
visual field contriction
hearing loss
psychotic changes

Collectively, these symptoms have become to be known as Minamata
disease.

THE ANALYSIS OF MERCURY.
The analysis of blood, urine and hair for mercury levels is used to
determine exposure. Blood and urine levels correlate well with the
degree of toxicity.

Significant exposure is indicated when blood mercury levels
> 50micrograms (if exposure is the the alkyl mercuries)
> 200micrograms (if exposure is to Hg 2+ form).

THE WHO SAFTY STANDARD FOR DAILY EXPOSURE OF Hg IS 45Micrograms PER
DAY WITH A DAILY URINARY EXCRETION EXCEEDING 50Micrograms/DAY
INDICATING SIGNIFICANT EXPOSURE>>>>.

Treatment of mercury includes the administration of penicilamine
which binds mercury and mobilises it for quicker excretion.
Treatment is monitored by urinary mercury excretion.

......................................................................

We should continue to educate ourselve and the public regarding the
issue of toxic metals in relation to the mining industry

The points I want to stress here are:

1) We need to know what form of mercury are our people exposed to in
order to stratify them into appropriate risk levels, and
determine wheather or not treatment is needed.

2) To determine this, samples need to be taken from fish and other
aquatic animals in the area.

3) If it is found that levels of alkyl mercury in these fish are
high it would indicate the same in humans and would further
suggest that the general exposure of the environment has been
going for some time.

4) If the people around the area are intoxicated ((Minamata
disease), do they deserve treatment and if so who is to pay for
their treatment.

Cheers
poyap

---

How would you spend $50,000 to create a more sustainable environment in Australia? Go to Yahoo!7 Answers and share your idea.

Hi all - here is a liklik story about Mercury, hope you can get
through it in one sitting.

Mercury is a very interesting substance. I remeber as a kid finding
a small bottle of mercury in an old workshop and finding myself
facinated by it. It was like water yet very heavy, it shined like
the other metals I was familiar with but flowed. I use to play around
with it in may hands, rolled it around on the floor, pick it up with
a magnet and did many other things to satisfy my curiousity. Little
did I know the potential danger I was exposing myself to, and may it
did affect me somehow, who knows??

Anually, the atmosphere and surface of the earth is exposed to about
36,000 tonns of mercury. The single largest source of mercury is the
natural outgassing from granite rock (about 30,000 tonns)-not too
sure about this process, if our mining collegue can enlighten us.
The metal fillings used in dentistry is made of mixtures of metals
containing mercury (amalgam). Some studies have shown high levels of
mercury in the blood of people with amalgam dental fillings, but the
general consensus is that they are safe.

The mining industry uses mercury to extract gold and other minerals
from the raw material as outline beautifully by VB. Great effort
should be made to dispose of the waste products of mineral
extraction. When this is not done mercury and other toxic substance
can pollute and contaminate the environment and cause serious health
problems in animals and humans.

Mercury can take different forms each having a different level of
toxicity. Basically there are three different forms as outline
belowed in order of toxicity:

1) Elemental ("natural") mercury (Hg 0) - this is essentially non
toxic,this what we find in the dental amalgams.

2) When exposed to other modifying (oxidising) chemicals elemental
mercury (Hg 0) can be ionised to Hg2+ --> this is more toxic then
Hg 0.

3) Further modification forms the very toxic forms (the alkyl Hg).

SO HOW DOES THE INOCENT ELEMENTAL MERCURY Hg 0 GET CORRUPTED??

a) In industry, the chemical modification of Hg 0 to Hg 2+ is
frequently accomplished by exposing Hg 0 to a strong oxidants
such as chlorine.

b) Hg 0 can also be bioconverted to both Hg2+ and alkyl Hg by
microorganism that exist in the human gut and in the bottom
sediments of rivers and lakes.

These modified and now toxic forms of mercury accumulate in the
acquatic food chain and reach their highest concentration in the
large fish. Humans in turn acquire them by eating these fish.

HOW DOES MERCURY AFFECT HUMAN HEALTH??

Mercury toxicity can be expressed in three ways.

1) Mercury changes the structure of many essential proteins in the
body, from collagen in skin to important enzymes for normal
functioning of the body, this change in protein structure render
these proteins dysfunctional and incabale of doing their jobs
(detail are beyond the scope of this summary).

2) Protein structure modification makes them suseptable to
autoimmune destruction as the bodies immune system no longer
recognised them as self, and mounts an attack against them.

3) The most toxic form of mercury the alkyl mercuries can easily
penetrate into the central nervous system causing brain damage.
Unborn children are also affected as mercury freely passes from
the mother to the fetus.

TOUGH LESSONS THE WORLD HAS LEARNT ABOUT MERCURY.
Much of what is known about the health effects of mercury has been
gained from investigations of the 1951 to 1963 industrial dumping of
Hg waste into the Minamata Bay, Japan. Fish in Minamata bay became
heavily ladened with Hg and humans around the area who relied on
these fish for protein in turn became intoxicated. The symptoms and
signs of heavy mercury intoxication included:

Ataxia - unsteady gait
impaired speech - slurred
visual field contriction
hearing loss
psychotic changes

Collectively, these symptoms have become to be known as Minamata
disease.

THE ANALYSIS OF MERCURY.
The analysis of blood, urine and hair for mercury levels is used to
determine exposure. Blood and urine levels correlate well with the
degree of toxicity.

Significant exposure is indicated when blood mercury levels
> 50micrograms (if exposure is the the alkyl mercuries)
> 200micrograms (if exposure is to Hg 2+ form).

THE WHO SAFTY STANDARD FOR DAILY EXPOSURE OF Hg IS 45Micrograms PER
DAY WITH A DAILY URINARY EXCRETION EXCEEDING 50Micrograms/DAY
INDICATING SIGNIFICANT EXPOSURE>>>>.

Treatment of mercury includes the administration of penicilamine
which binds mercury and mobilises it for quicker excretion.
Treatment is monitored by urinary mercury excretion.

......................................................................

We should continue to educate ourselve and the public regarding the
issue of toxic metals in relation to the mining industry

The points I want to stress here are:

1) We need to know what form of mercury are our people exposed to in
order to stratify them into appropriate risk levels, and
determine wheather or not treatment is needed.

2) To determine this, samples need to be taken from fish and other
aquatic animals in the area.

3) If it is found that levels of alkyl mercury in these fish are
high it would indicate the same in humans and would further
suggest that the general exposure of the environment has been
going for some time.

4) If the people around the area are intoxicated ((Minamata
disease), do they deserve treatment and if so who is to pay for
their treatment.

Cheers
poyap

Hi all - here is a liklik story about Mercury, hope you can get
through it in one sitting.

Mercury is a very interesting substance.  I remeber as a kid finding
a small bottle of mercury in an old workshop and finding myself
facinated by it.  It was like water yet very heavy, it shined like
the other metals I was familiar with but flowed. I use to play around
with it in may hands, rolled it around on the floor, pick it up with
a magnet and did many other things to satisfy my curiousity.  Little
did I know the potential danger I was exposing myself to, and may it
did affect me somehow, who knows??

Anually, the atmosphere and surface of the earth is exposed to about
36,000 tonns of mercury.  The single largest source of mercury is the
natural outgassing from granite rock (about 30,000 tonns)-not too
sure about this process, if our mining collegue can enlighten us.
The metal fillings used in dentistry is made of mixtures of metals
containing mercury (amalgam).  Some studies have shown high levels of
mercury in the blood of people with amalgam dental fillings, but the
general consensus is that they are safe.

The mining industry uses mercury to extract gold and other minerals
from the raw material as outline beautifully by VB.  Great effort
should be made to dispose of the waste products of mineral
extraction.  When this is not done mercury and other toxic substance
can pollute and contaminate the environment and cause serious health
problems in animals and humans.

Mercury can take different forms each having a different level of
toxicity.  Basically there are three different forms as outline
belowed in order of toxicity:

1)  Elemental ("natural") mercury (Hg 0)  - this is essentially non
     toxic,this what we find in the dental amalgams.

2)  When exposed to other modifying (oxidising) chemicals elemental
     mercury (Hg 0) can be ionised to Hg2+ --> this is more toxic then
     Hg 0.

3)  Further modification forms the very toxic forms (the alkyl Hg).

SO HOW DOES THE INOCENT ELEMENTAL MERCURY Hg 0 GET CORRUPTED??

a)  In industry, the chemical modification of Hg 0 to Hg 2+ is
     frequently accomplished by exposing Hg 0 to a strong oxidants
     such as chlorine.

b)  Hg 0 can also be bioconverted to both Hg2+ and alkyl Hg by
     microorganism that exist in the human gut and in the bottom
     sediments of rivers and lakes.

These modified and now toxic forms of mercury accumulate in the
acquatic food chain and reach their highest concentration in the
large fish.  Humans in turn acquire them by eating these fish.

HOW DOES MERCURY AFFECT HUMAN HEALTH??

Mercury toxicity can be expressed in three ways.

1)  Mercury changes the structure of many essential proteins in the
     body, from collagen in skin to important enzymes for normal
     functioning of the body,  this change in protein structure render
     these proteins dysfunctional and incabale of doing their jobs
     (detail are beyond the scope of this summary).

2)  Protein structure modification makes them suseptable to
     autoimmune destruction as the bodies immune system no longer
     recognised them as self, and mounts an attack against them.

3)  The most toxic form of mercury the alkyl mercuries can easily
     penetrate into the central nervous system causing brain damage.
     Unborn children are also affected as mercury freely passes from
     the mother to the fetus.

TOUGH LESSONS THE WORLD HAS LEARNT ABOUT MERCURY.
Much of what is known about the health effects of mercury has been
gained from investigations of the 1951 to 1963 industrial dumping of
Hg waste into the Minamata Bay, Japan.  Fish in Minamata bay became
heavily ladened with Hg and humans around the area who relied on
these fish for protein in turn became intoxicated.  The symptoms and
signs of heavy mercury intoxication included:

Ataxia - unsteady gait
impaired speech - slurred
visual field contriction
hearing loss
psychotic changes

Collectively, these symptoms have become to be known as Minamata
disease.

THE ANALYSIS OF MERCURY.
The analysis of blood, urine and hair for mercury levels is used to
determine exposure.  Blood and urine levels correlate well with the
degree of toxicity.

Significant exposure is indicated when blood mercury levels
> 50micrograms (if exposure is the the alkyl mercuries)
> 200micrograms (if exposure is to Hg 2+ form).

THE WHO SAFTY STANDARD FOR DAILY EXPOSURE OF Hg IS 45Micrograms PER
DAY WITH A DAILY URINARY EXCRETION EXCEEDING 50Micrograms/DAY
INDICATING SIGNIFICANT EXPOSURE>>>>.

Treatment of mercury includes the administration of penicilamine
which binds mercury and mobilises it for quicker excretion.
Treatment is monitored by urinary mercury excretion.

......................................................................

We should continue to educate ourselve and the public regarding the
issue of toxic metals in relation to the mining industry

The points I want to stress here are:

1)  We need to know what form of mercury are our people exposed to in
     order to stratify them into appropriate risk levels, and
     determine wheather or not treatment is needed.

2)  To determine this, samples need to be taken from fish and other
     aquatic animals in the area.

3)  If it is found that levels of alkyl mercury in these fish are
     high it would indicate the same in humans and would further
     suggest that the general exposure of the environment has been
     going for some time.

4)  If the people around the area are intoxicated ((Minamata
     disease), do they deserve treatment and if so who is to pay for
     their treatment.

Cheers
poyap

"In what clinical situation can a localised/specific
iron chelation be utalised Willie."

Well, Poyap, that is something to think about! I mean
something that is given systemically but can act more
locally where the inflammation is to inhibit the
availabillity of iron. I guess it is a problem of drug
design & delievery systems-a problem for the
pharmacologists

Good analagee,... but the 'country's innocent, citizens
may also be starved to death' because of the generalized
anemia, especially as you know if there are other medical
problems, especially cardio-respiratory conditions etc.

As I know innate immunity is the frontline line, mainly
nonspecific defence against invaders.

Probably, we could say, that this system protects from
further infection & also to suppress the growth of already
invading bugs. But not totally effective in completely
clearing the bugs.

Dendritic cells are also component of the innate immunty.
As I have mentioned several times before, OK-432 or killed
bacteria have been used to activate them to keep them more
alert than usual to effectively & quickly attack any bugs
& even cancer cells. It is said, that they have a certain
degree of specificity too. Hepcidin system is another
component of the innate immunity that tries to minimise
infection.

Broadly speaking, is it the innate immunity or the
adaptive (more specific & effective, but slower) immunity
we should utillize to control infection? That means
specific vaccines/vacination.

Any other views?

William

--------------------------------------
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http://pr.mail.yahoo.co.jp/toolbar/

I have found a paper regarding the inhibiton of bacterial
growth by iron starvation in vitro (attached file).

A study done in Sydney, Australia, using the bacteria,
Helicobacter pylori & published in Nov. 2003.

Iron starvation inhibits growth in the 'exponential'
growth phase but not in the 'stationary' growth phase.

Does this mean that iron depletion is more effective in
acute infection when growth of bacteria is high
(exponential phase)?

I think iron chelators that work specifically & locally
may be more beneficial than hepcidin or its analogues that
inhibits absorption of iron from the guts.

Any other ideas?

Thanks!

William

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

I have found a paper regarding the inhibiton of bacterial
growth by iron starvation in vitro (attached file).

A study done in Sydney, Australia, using the bacteria,
Helicobacter pylori & published in Nov. 2003.

Iron starvation inhibits growth in the 'exponential'
growth phase but not in the 'stationary' growth phase.

Does this mean that iron depletion is more effective in
acute infection when growth of bacteria is high
(exponential phase)?

I think iron chelators that work specifically & locally
may be more beneficial than hepcidin or its analogues that
inhibits absorption of iron from the guts.

Any other ideas?

Thanks!

William

--------------------------------------
Easy + Joy + Powerful = Yahoo! Bookmarks x Toolbar
http://pr.mail.yahoo.co.jp/toolbar/

Poyap, interesting topic & good summary there.

We have discussed it briefly before. Anyway, I would like
to ask: as you said, it is one of the body's defence
mechanisms to rid or at least control the growth of
invading pathogens. In chronic infections despite all
these mechanisms, the infection still persists. So my
question is; how effective is this 'anemia' in controlling
infection. Have you come across some papers that prove
clearly using in vitro experiments, its effectiveness.

Infact, it would be possible to do such experiment in
vitro. Culture, say any pathogen (TB bacteria etc.) &
apply different amount of iron & also deplete iron & study
the bugs' growth patterns. I know there are some culture
medium rich in blood or iron (blood agar etc.).

The value of hepcidin agonists as a therapy is very
interesting, but what do you think about the
non-specificness. I mean hepacidin agonist would reduce
iron absorption from the gut so the entire body is
depleted of iron & not only the invading bugs.

Any other thoughts on this interesting topic?

William

--------------------------------------
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http://pr.mail.yahoo.co.jp/toolbar/

Poyap, interesting topic & good summary there.

We have discussed it briefly before. Anyway, I would like
to ask: as you said, it is one of the body's defence
mechanisms to rid or at least control the growth of
invading pathogens. In chronic infections despite all
these mechanisms, the infection still persists. So my
question is; how effective is this 'anemia' in controlling
infection. Have you come across some papers that prove
clearly using in vitro experiments, its effectiveness.

Infact, it would be possible to do such experiment in
vitro. Culture, say any pathogen (TB bacteria etc.) &
apply different amount of iron & also deplete iron & study
the bugs' growth patterns. I know there are some culture
medium rich in blood or iron (blood agar etc.).

The value of hepcidin agonists as a therapy is very
interesting, but what do you think about the
non-specificness. I mean hepacidin agonist would reduce
iron absorption from the gut so the entire body is
depleted of iron & not only the invading bugs.

Any other thoughts on this interesting topic?

William





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Hello friends,

Just tok save ken olsem PNG.j.sci.technol.eng is accepting manuscripts.

The journal scope is very broad covering life sciences (including
clinical medicine), physical sciences, social sciences, technology and
engineering.

I have created a blog - http://pngjscitech.wordpress.com/ to publish
the abstracts. This blog is to fascilitate discussion between readers
and authors of articles published by the journal. Some of the titles
recieved so far have been put up so visit the journal blog and have a
look.

So askim i go out ken lon supportim journal and submit a manuscript.
Original research, reviews on current topics, book reviews, comments
and letters are welcomed.

regards

ri

Raita, omedeto gozaimasu. Well done.

ri

How Slow Can You Go?

Ensure delivery by adding ECGCase@... to your address book.

Please click here if you are unable to access the diagnosis page.

BACKGROUND

A 66-year-old man presents to the Emergency Department (ED) with chest pain and shortness of breath that started several hours ago as he was cleaning his porch. His chest pain is dull in quality and radiates to his neck and arms, and when asked to rate the severity of the pain, he indicates a 5 in a range from 1 to 10 (with 10 being the worst). The chest pain is not associated with diaphoresis, nausea, or vomiting. The patient also had exertional weakness for 4 days. He denies having dizziness, lightheadedness, or loss of consciousness.

The patient underwent a 3-vessel coronary artery bypass 8 years ago. Since then, he has had stable angina that occurs approximately once a month. His medical history is also clinically significant for hyperlipidemia, hypertension, and poorly controlled insulin-dependent diabetes mellitus. His medication regimen includes hydrochlorothiazide, insulin, isosorbide dinitrate, simvastatin, aspirin, and sublingual nitroglycerin as needed. The patient smokes 2 packs of cigarettes per day. The review of systems yields unremarkable findings.

The patient is afebrile but appears uncomfortable. The cardiovascular examination reveals bradycardia. His heart rate is 39 bpm and regular, his blood pressure is 130/53 mm Hg, and his respiratory rate is 18 breaths per minute. His first and second heart sounds are normal. No murmur or gallop is present. Except for evidence of his previous surgery, his other physical findings are normal.

The patient’s laboratory results are normal except for mildly elevated troponin I levels. An ECG is obtained (see Image 1).

What is the diagnosis?

CASE DIAGNOSIS

What is the diagnosis?
Click here for the answer

HINT

Identify the P waves.

Authors:
Salyka Sengsayadeth,
Resident,
Internal Medicine,
Vanderbilt University

Ehab S. Kasasbeh, MD,
Resident,
Department of Internal Medicine,
James H. Quillen College of Medicine,
East Tennessee State University

Ryland P. Byrd, Jr, MD,
Chief of Pulmonary Medicine,
Medical Director of Respiratory Therapy,
Quillen Mountain Home Veterans Affairs Medical Center,
Professor,
Department of Internal Medicine,
Division of Pulmonary Diseases and Critical Care Medicine,
James H. Quillen College of Medicine,
East Tennessee State University

eMedicine Editors:
Erik D. Schraga, MD,
Department of Emergency Medicine,
Kaiser Permanente,
Santa Clara Medical Center, Calif

Rick G. Kulkarni, MD,
Assistant Professor,
Yale School of Medicine,
Section of Emergency Medicine,
Department of Surgery,
Attending Physician,
Medical Director,
Department of Emergency Services,
Yale-New Haven Hospital, Conn

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Sorry, Rodney, didn't seem to realize. Just copy & pasted,
if you don't mind.

Thanks! Helen,

for the update & guidlines, will consider it. There is an
interesting point, I would like to bring up!

As we know, the incidence & prevelance of cancer in
developed countries are higher than in underdeveloped
countries. Infectious diseases are the exact opposite. In
normal, healthy persons a certain amount of exposure to
bacteria etc. (pathogens) don't exactly make us sick but
activate our innate immunity or keeps it alert & active.

Innate immunity is nonspecific but the frontline battlers,
while adaptive immunity comes later on and are more
specific in attacking a certain pathogen.

Certain cells within the Innate immunity who has the
potential to quickly recognise pathogens as well as
deformed body cells (that have the potential to turn into
cancer cells), surveillance our system, regularly &
removes them. Thus, the thoery is that if you have a real
active innate immunty, then your chances of cancer
developement is low. (well, there are other factors also).

The Japanese has gone 1 step further. OK-432 or Picibanil
is prepared from bacteria that resides in our pharynx
(throat) by treating them with heat & penicillin (Chugai
pharmaceuticals) . The cells are dead but their structures
are intact. It is then injected intravenously, into
terminal cancer patients. Research has found that it has
prolonged their survival compared to control groups.

There are other uses of OK-432 but won't mention it now.

So if our inert immunity is active then the chances of
developing cancer is low (I haven't come accross any
research that has proven this theory yet. The above use is
not prevention but a kind of treatment).

Finally, remember THIS IS ONLY A THEORY!

William

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No idea yet! But Rodney, probably around that time
(September 10). Soon they will call for papers via their
home page.

Anyone know the contacts of the organising committee?

William

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Does anyone know the exact date for the symposium in POM this year?

I am thinking maby around September 10 but not sure.

ri

Great idea PJ,
JT
>>> "Poyap" <pojaroo@...> 05/04/2007 5:23 pm >>>
Thanks John, I think just as nearly all the other problems being
faced by PNG right now, the answer is for us PNGeans, to SAY NO!!!!,
this is not good enough for me, this is not good enough for my
children and my people and stop compromising.  "Evil prospers when
good people do nothing".....bible verse don't know where exactly but
some of you may know.  It is about time the "GOOD PEOPLE" stop hiding
in their shells, get out, and do something....

On this particular issue, I think that it should come from the fifth,
the imeptus should come from the RMO themselve and the fifthyear
medical students, they should get together form an association, the
Medical Students already have one and that should continue to the RMO
years...they should push for NO RMO to start work until all the
beuracratic red tape is finalised and they are on the payroll, only
then should they start..  we should encourage them to do just that.

.....
..
.
..
Apinun now
Poyap
--- In pngdoctors-cme@yahoogroups.com, moses taram <mtaram_76@...>
wrote:
>
> Thanks John for raising this issue of concern.
>   This chronic problem has been experienced also by resident
medical imaging technologist, laboratory technologists, dental
therapists, and pharmacists for over 10 years now.
>   As the saying goes, one can learn from a mistake, but the
greatest mistake one can make is not learning from it.. What is
happening to NDOH - HR, or the government?
>   Mi lusim olsem long yupla..
>   Moses Taram..
>
> John Tonar <John.Tonar@...> wrote:
>           Ladies and Gentleman,
>
> I failed to understand year after year, residents were left to fan
for themselves when they resume their residency training. They do not
need a protest or strike to let Dr Mann come down to address them.
>
> When I started my residency on the 6th Jan 1997 in Lae, we went
without pay for 6-8 weeks. DOH gave the same old reason. We (Manape,
Urakoko, A. Ame) had to physically called into personel officer - to
get some attention.
>
> That was 10 years ago!...system failure?
>
> DOH : Resident Doctors Scenario
>
> You plant a geniune apple seed, got the plant up. sunshine, water
etc. Saw the first fruit on its way to maturity. Instead of continued
care to obtain the ultimum content; energy and sweetness, instead you
grab a bush knife and slash it in half.
>
> This is unthinkable.
>
> I sympathised with our RMO in PNG...I was given the same plate 10
years ago.
>
> Just a concern only.
>
> Is there any way we can discuss to improve this scenario? over to
the forum
>
> JT
>
>
>
>
>
>
>  Send instant messages to your online friends
http://au.messenger.yahoo.com
>

Thanks John, I think just as nearly all the other problems being
faced by PNG right now, the answer is for us PNGeans, to SAY NO!!!!,
this is not good enough for me, this is not good enough for my
children and my people and stop compromising.  "Evil prospers when
good people do nothing".....bible verse don't know where exactly but
some of you may know.  It is about time the "GOOD PEOPLE" stop hiding
in their shells, get out, and do something....

On this particular issue, I think that it should come from the fifth,
the imeptus should come from the RMO themselve and the fifthyear
medical students, they should get together form an association, the
Medical Students already have one and that should continue to the RMO
years...they should push for NO RMO to start work until all the
beuracratic red tape is finalised and they are on the payroll, only
then should they start..  we should encourage them to do just that.

.....
..
.
..
Apinun now
Poyap
--- In pngdoctors-cme@yahoogroups.com, moses taram <mtaram_76@...>
wrote:
>
> Thanks John for raising this issue of concern.
>   This chronic problem has been experienced also by resident
medical imaging technologist, laboratory technologists, dental
therapists, and pharmacists for over 10 years now.
>   As the saying goes, one can learn from a mistake, but the
greatest mistake one can make is not learning from it.. What is
happening to NDOH - HR, or the government?
>   Mi lusim olsem long yupla..
>   Moses Taram..
>
> John Tonar <John.Tonar@...> wrote:
>           Ladies and Gentleman,
>
> I failed to understand year after year, residents were left to fan
for themselves when they resume their residency training. They do not
need a protest or strike to let Dr Mann come down to address them.
>
> When I started my residency on the 6th Jan 1997 in Lae, we went
without pay for 6-8 weeks. DOH gave the same old reason. We (Manape,
Urakoko, A. Ame) had to physically called into personel officer - to
get some attention.
>
> That was 10 years ago!...system failure?
>
> DOH : Resident Doctors Scenario
>
> You plant a geniune apple seed, got the plant up. sunshine, water
etc. Saw the first fruit on its way to maturity. Instead of continued
care to obtain the ultimum content; energy and sweetness, instead you
grab a bush knife and slash it in half.
>
> This is unthinkable.
>
> I sympathised with our RMO in PNG...I was given the same plate 10
years ago.
>
> Just a concern only.
>
> Is there any way we can discuss to improve this scenario? over to
the forum
>
> JT
>
>
>
>
>
>
>  Send instant messages to your online friends
http://au.messenger.yahoo.com
>

Ladies and Gentleman,

I failed to understand year after year, residents were left to fan for themselves when they resume their residency training. They do not need a protest or strike to let Dr Mann come down to address them.

When I started my residency on the 6th Jan 1997 in Lae, we went without pay for 6-8 weeks. DOH gave the same old reason. We (Manape, Urakoko, A. Ame) had to physically called into personel officer - to get some attention.

That was 10 years ago!...system failure?

DOH : Resident Doctors Scenario

You plant a geniune apple seed, got the plant up. sunshine, water etc. Saw the first fruit on its way to maturity. Instead of continued care to obtain the ultimum content; energy and sweetness, instead you grab a bush knife and slash it in half.

This is unthinkable.

I sympathised with our RMO in PNG...I was given the same plate 10 years ago.

Just a concern only.

Is there any way we can discuss to improve this scenario? over to the forum

JT

Send instant messages to your online friends http://au.messenger.yahoo.com

JT, thank you for bringing this up.

We had the same problem too.

Something is DEFINITLY WRONG here. I do not have much
information on the process of getting new RMO on the
payroll.

If anyone know, lets discuss this issue.

ri

--- John Tonar <John.Tonar@...>
wrote:

> Ladies and Gentleman,
>
> I failed to understand year after year, residents
> were left to fan for themselves when they resume
> their residency training. They do not need a protest
> or strike to let Dr Mann come down to address them.
>
> When I started my residency on the 6th Jan 1997 in
> Lae, we went without pay for 6-8 weeks. DOH gave the
> same old reason. We (Manape, Urakoko, A. Ame) had to
> physically called into personel officer - to get
> some attention.
>
> That was 10 years ago!...system failure?
>
> DOH : Resident Doctors Scenario
>
> You plant a geniune apple  seed, got the plant up.
> sunshine, water etc. Saw the first fruit on its way
> to maturity. Instead of continued care to obtain the
> ultimum content; energy and sweetness, instead you
> grab a bush knife and slash it in half.
>
> This is unthinkable.
>
> I sympathised with our RMO in PNG...I was given the
> same plate 10 years ago.
>
> Just a concern only.
>
> Is there any way we can discuss to improve this
> scenario? over to the forum
>
> JT
>
>
>




___________________________________________________________
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Internet provider. http://uk.docs.yahoo.com/nowyoucan.html

Ladies and Gentleman,

I failed to understand year after year, residents were left to fan for
themselves when they resume their residency training. They do not need a protest
or strike to let Dr Mann come down to address them.

When I started my residency on the 6th Jan 1997 in Lae, we went without pay for
6-8 weeks. DOH gave the same old reason. We (Manape, Urakoko, A. Ame) had to
physically called into personel officer - to get some attention.

That was 10 years ago!...system failure?

DOH : Resident Doctors Scenario

You plant a geniune apple  seed, got the plant up. sunshine, water etc. Saw the
first fruit on its way to maturity. Instead of continued care to obtain the
ultimum content; energy and sweetness, instead you grab a bush knife and slash
it in half.

This is unthinkable.

I sympathised with our RMO in PNG...I was given the same plate 10 years ago.

Just a concern only.

Is there any way we can discuss to improve this scenario? over to the forum

JT

Guys, you all remember Dr Udayan Ray, who once the chemical patholoy
lecture at UPNG. He is now the clinicl chemistry director at Hobart.
PJ, is that correct?

He has kindly agreed to be an editor and reviewer for the PNG JSTE.
Willie has also kindly accepted the invitation to a reviewer as well.
If any of you guys are interested, let me know.

ri