Ian,

I am leaving on the 4th of August and will be in POM
for the Symposium. You have my support.

Email me with the details and I will see where I can
help.

regards

rodney
--- ian garbett <ian_garbett@...> wrote:

> Dear friends
>
> I have now left the UK en route back to PNG.
>
> I was thrilled with the new members on the
> site..welcome...and the great news of Dr Clement
> Malau being appointed as health secretary!
>
> I will be arriving in Port Moresby for the
> conference on September 1st.
>
> I wanted to create a satellite meeting during the
> week of the symposium to gather all those
> interstested in cancer with a view to holding a
> national cancer conference, like the one in Lae in
> 2001.
>
> So I wanted to invite anyone who is going and is
> interested to help organise that..please get in
> touch..
>
> Really looking forward to meeting as many of you
> as possible in person on mosbi
>
> stay well
>
> Ian
>
> rodney itaki <londari2000@...> wrote:
> yeah willing. very interesting work. Can
> you put more details on the pics? Might use them
> for presentations.
>
> 10x
>
> Poyap James Rooney <pojaroo@...> wrote:
> Thanks Willie very interesting,
> unfortunately my work computer has a filter that
> doesn't allow me to view these photo. Sound like
> you are having fun.
>
> poyap
>
> mol william <w_mol2003@...> wrote:
>
> Stem cells are hot topics of modern, medical,
> scientific
> research. Various methods of cloning & preparation
> of stem
> cells has been developed. However, the ultimate goal
> of
> such research is to achieve tissue and/or organ
> regeneration in vivo or in vitro. To do that we have
> to
> precisely guide the differentiation (fate) of the
> stem
> cells, otherwise they would become useless tissues
> (teratomas) or dangerous tissues (cancers). The
> mechanisms
> or the factors that guide or determine cell
> differentiation is complex. However, to simply we
> could
> say:
>
> 1. A cell's interaction with the extracellular
> matrix via
> adhesion molecules
> 2. Cell-cell interaction also via adhesion molecules
> 3. The concentration & the precise timingly release
> of
> soluble factors into the extracellular space & the
> precise
> interraction with their ligands (receptors) of which
> their
> expression is regulated precisely resulting in
> communication between cells & guides normal cell
> differentiation.
>
> A stem cell becomes a certain cell because of the:
> 1. Expression of certain combination of markers
> 2. Has certain function (releases certain factors or
> produces certain proteins, or has highly specialized
> function-nerves)
> 3. May or may not have a distinct cell morphology to
> the
> originally, transfered stem cell
>
> Interesting, a cell in a certain part of the body
> has a
> system of knowing its exact location and how to
> interract
> to it. This is achieved by the regulated expression
> patterns of HOX gene complexes
> (http://en.wikipedia.org/wiki/Homeobox). Also of
> interest
> when a cell is removed & grown in the lab, for a
> certain
> period of time, the cells:
> 1. lose their cell markers (identity)
> 2. May loose their function & even morphology
> 3. The pattern of HOX gene expression is lost or
> becomes
> very different to that of the original in vivo
> pattern
>
> This simply means the cell has become a totally
> different
> cell because of the different environment, without
> the
> influence of other cells & the factors they produce.
> Such
> cells cannot be transfered back to the body because
> of the
> risk of rejection, infection & cancer formation.
> Current
> technology cannot totally overcome these problems
> yet. So,
> the alternative thing to do could be to directly
> transfer
> stem cells to the body & try to guide their
> differentiation (fate). However, this is currently
> in its
> experimental stage.
>
> When a stem cell is transfered, first they have to
> be
> labelled with a dye (eg. DiI). Second, transfered
> using
> various surgical methods (injection, attached to
> artificial collagen & applied etc.). Third, a biopsy
> is
> done to visualize the labelled cells & to prove that
> it
> poses the markers (immunohistochemistry) of the
> cells it
> is suppose to differentiate to.
>
> There is a controversy that sometimes the transfered
> stem
> cells don't just differentiate into the desired cell
> type
> (trans-differentiation) but they fuse with the
> local,
> residing adult cells, making the procedure of stem
> cell
> transfer a useless one because no new cell or tissue
> will
> be formed (no tissue regeneration). After cell
> fusion, the
> dye in the labelled stem cells will be shared
> between the
> 2 cells & then the final cell will also poses the
> markers
> of the adult cell, making the in vivo study a
> confusing
> one.
>
> Finally, it would be simpler to do cell fusion
> studies
> between stem & adult cells in the lab first (in
> vitro) &
> then apply the knowledge to guide cell
> trans-differentiation in vivo.
>
> With that I have put 3 photo albums of the my
> practice
> labelling of rat bone marrow cells & follow-up of
> morphological changes the cells have undergone over
> several days, using DiI in the CME, photo section.
> The
> cell marker studies has not been done. The cells can
> be
> labelled like this & then transfered back to the
> animal
> (eg. rat). DiI is a red dye that stains cell
> membrane &
> cytosol. Hoechst is a green dye that stains only the
> nucleus. These dyes are visualized only using a
> fluorescent microscope.
>
> Thanks!
>
> William Mol
>
> (Sapporo, Japan)
>
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=== message truncated ===


Rodney Itaki


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