I have found a paper regarding the inhibiton of bacterial
growth by iron starvation in vitro (attached file).
A study done in Sydney, Australia, using the bacteria,
Helicobacter pylori & published in Nov. 2003.
Iron starvation inhibits growth in the 'exponential'
growth phase but not in the 'stationary' growth phase.
Does this mean that iron depletion is more effective in
acute infection when growth of bacteria is high
(exponential phase)?
I think iron chelators that work specifically & locally
may be more beneficial than hepcidin or its analogues that
inhibits absorption of iron from the guts.
Any other ideas?
Thanks!
William
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