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Reply | Forward Message #340 of 384 |
Re: [pngdoctors-cme] Iron & Infection


I have found a paper regarding the inhibiton of bacterial
growth by iron starvation in vitro (attached file).

A study done in Sydney, Australia, using the bacteria,
Helicobacter pylori & published in Nov. 2003.

Iron starvation inhibits growth in the 'exponential'
growth phase but not in the 'stationary' growth phase.

Does this mean that iron depletion is more effective in
acute infection when growth of bacteria is high
(exponential phase)?

I think iron chelators that work specifically & locally
may be more beneficial than hepcidin or its analogues that
inhibits absorption of iron from the guts.

Any other ideas?

Thanks!

William

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Thu May 17, 2007 7:20 am

molwillie
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Message #340 of 384 |
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Hello friends, Just tok save ken olsem PNG.j.sci.technol.eng is accepting manuscripts. The journal scope is very broad covering life sciences (including ...
Rodney Itaki
londari2000
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May 8, 2007
12:17 am

Poyap, interesting topic & good summary there. We have discussed it briefly before. Anyway, I would like to ask: as you said, it is one of the body's defence ...
mol william
molwillie
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May 16, 2007
11:32 am

Thanks Willie, I haven't come across any papers demonstrating the affectivness of iron depletion in controlling microorganisms - in vitro, but I am pretty sure...
Poyap James Rooney
pojaroo
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May 16, 2007
11:21 pm

I have found a paper regarding the inhibiton of bacterial growth by iron starvation in vitro (attached file). A study done in Sydney, Australia, using the...
mol william
molwillie
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May 17, 2007
7:20 am

In what clinical situation can a localised/specific iron chelation be utalised Willie. Just wondering!!. The postualtion being put forward (in regards to...
Poyap James Rooney
pojaroo
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May 17, 2007
9:17 am

"In what clinical situation can a localised/specific iron chelation be utalised Willie." Well, Poyap, that is something to think about! I mean something that...
mol william
molwillie
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May 17, 2007
12:23 pm
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