PFPC Daily - June 23, 2005

Colakoglu O, Tankurt E, Unsal B, Ugur F, Kupelioglu A, Buyrac Z,
Akpinar Z - Toxic hepatitis associated with paroxetine" Int J Clin
Pract 59(7):861-2(2005)

Summary: Hepatotoxicity is a rare complication of paroxetine, a
selective serotonin reuptake inhibitor. Regarded as safe in
therapeutic use, there have been reports of cases of severe hepatic
dysfunction with gross elevations of transaminase levels that may be
related to this drug. We report here severe adverse cholestatic and
hepatocellular injury in a patient taking paroxetine probably due to
an immune-mediated hypersensitivity reaction.