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>From: jw-allergy-mailer@...
>To: <ctdeshmukh@...>
>Subject: Journal Watch Allergy/Asthma Alert for August 2, 2007
>Date: Thu, 2 Aug 2007 16:27:23 -0700
>
>
>Welcome to Journal Watch Allergy / Asthma Alerts
>
>
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>
>ALLERGY / ASTHMA for August 2, 2007
>
> . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
>
>A Controlled Clinical Trial of Steroids for Bronchiolitis
>[General Medicine | Summary and Comment | Free]
>
>One dose of oral dexamethasone was no different than placebo.
> By Howard Bauchner, MD
> July 26, 2007
> Covering: Corneli HM et al. N Engl J Med 2007 Jul 26; 357:331-9
> http://general-medicine.jwatch.org/cgi/content/full/2007/726/1?q=etoc
>
> . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
>
>A Controlled Clinical Trial of Steroids for Bronchiolitis
>[Pediatrics and Adolescent Medicine | Summary and Comment | Free]
>
>One dose of oral dexamethasone was no different from placebo.
> By Howard Bauchner, MD
> July 25, 2007
> Covering: Corneli HM et al. N Engl J Med 2007 Jul 26; 357:331-9
> http://pediatrics.jwatch.org/cgi/content/full/2007/725/1?q=etoc
>
> . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
>
>Antibiotic Use Early in Life Increases Risk for Asthma
>[Pediatrics and Adolescent Medicine | Summary and Comment | Free]
>
>This population-based study confirms previous studies that found an
>association between antibiotic use and development of childhood asthma.
> By F. Bruder Stapleton, MD
> July 18, 2007
> Covering: Kozyrskyj AL et al. Chest 2007 Jun 131:1753-9
> http://pediatrics.jwatch.org/cgi/content/full/2007/718/1?q=etoc
>
> . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
>
>The Childhood Atopic Dermatitis Impact Scale: CADIS Comes of Age
>[Dermatology | Summary and Comment | Free]
>
>This subjective parental assessment tool yielded results that were
>comparable to and more easily obtained than SCORAD system assessments.
> By Mary Wu Chang, MD
> July 13, 2007
> Covering: Chamlin SL et al. Arch Dermatol 2007 Jun 143:768-72
> http://dermatology.jwatch.org/cgi/content/full/2007/713/1?q=etoc
>
> . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
>
>Mycophenolate Mofetil for Childhood Atopic Dermatitis
>[Dermatology | Summary and Comment | Subscription Required]
>
>MMF may be costly, but it appears to be an effective, alternative
>immunosuppressive agent for severe pediatric atopic dermatitis.
> By Jeffrey P. Callen, MD
> July 13, 2007
> Covering: Heller M et al. Br J Dermatol 2007 Jul 157:127-32
> http://dermatology.jwatch.org/cgi/content/full/2007/713/4?q=etoc
>
>
>_______________________________________________________________________
>
>FREE FULL-TEXT ARTICLE
>
>Summary and Comment
>
>A Controlled Clinical Trial of Steroids for Bronchiolitis
>One dose of oral dexamethasone was no different than placebo.
>
>
>
>Bronchiolitis is the leading cause of hospitalization among infants in the
>U.S. Use of steroids for infants with bronchiolitis remains controversial
>because of the lack of high-quality, sufficiently powered studies. In a
>multisite double-blind clinical trial, researchers randomized 600 infants
>(age range, 212 months) who presented to an emergency department with no
>prior history of wheezing and a clinical picture consistent with
>moderate-to-severe bronchiolitis to receive either a single dose of oral
>dexamethasone (1 mg/kg) or placebo. The primary outcome was hospitalization
>4 hours after drug administration.
>
>The admission rate was virtually identical in the steroid and placebo
>groups (39.7% and 41.0%, respectively). No differences emerged in subgroup
>analyses of infants who were positive for respiratory syncytial virus,
>those younger than 6 months, or those with a history of eczema or family
>history of asthma. Length of stay for hospitalized infants and subsequent
>admissions in the 7 days after the intervention were similar in the two
>groups.
>
>Comment: This likely represents the definitive study of the use of steroids
>for infants with bronchiolitis in the ambulatory care setting. For infants
>with no history of wheeze, steroids convey no benefit. These results are
>consistent with a recent American Academy of Pediatrics guideline, which
>indicated that corticosteroids should not be used to treat bronchiolitis
>routinely.
>
> Howard Bauchner, MD
>
>Published in Journal Watch General Medicine July 26, 2007 Citation(s):
>
>Corneli HM et al. A multicenter, randomized, controlled trial of
>dexamethasone for bronchiolitis. N Engl J Med 2007 Jul 26; 357:331-9.
>(Subscription may be required) (Free)
>
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