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Tramadol can impair thinking and the physical abilities required for driving or operating machinery.

Tramadol should be avoided in patients intoxicated with alcohol, hypnotics, and narcotics. Large doses of tramadol administered with alcohol or anesthetic agents can impair breathing.

Tramadol can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants, such as Elavil.

Do not crush the tramadol tablet. This medicine is for oral (by mouth) use only.

Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhlation or injection can cause life-threatening side effects, overdose, or death.

Tramadol may be taken every 4-6 hours as needed. If you take too much tramadol, you may experience serious side effects.Ask your doctor about the maximum number of tablets that you may take for each dose or for a 24-hour period.

These drugs may slow your breathing or increase drowsiness when used together with tramadol.

Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhlation or injection can cause life-threatening side effects, overdose, or death.