Hello members, There are more then 4000 known inherited disorders, which lack effective therapy, by conventional medicines. There is one infant in every 100 ...
Good informations,carry on. With best wishes, ... -- Anand Chaudhary Deptt of Rasa Shastra (Ayurvedic Pharmaceutics) Faculty of Ayuveda Institute of Medical...
Hello members, Most of us do not suffer any harmful effects from our defective genes because we carry two copies of nearly all genes, one derived from our ...
Dear Anand Sir,  Thanks a lot for the encouraging words. In future we will witness that gene therapy will be revealed as an most promising treatment for...
Dear members, In the early 1970s, scientists proposed "gene surgery" for treating inherited diseases caused by faulty genes. The idea was to take out the ...
Dear Dr Swapnil, Gene therapy has been found useful in plants and also in domestic animals. But gene therapy in man raises many ethical issues. However if gene...
Hello Anupama mam,  You have correctly pointed out that gene therapy is effective in plants and animals. Before approving gene therapy as an treatment...
Dear members, Potential approaches currently available to gene therapy: * Correction of a mutated gene. * Addition of normal gene to replace the function of...
Hello members, Below are the differentiating features of Gene replacement therapy vs Corrective gene therapy: Gene replacement therapy (Gene augmentation) ...
Dear members, SOMATIC GENE THERAPY vs GERM THERAPY. SOMATIC GENE THERAPY GERM THERAPY 1. Genes are introduced into somatic cells Changes are confined to the ...
Good morning members, [:)] Gene therapy potentially represents one of the most important developments to occur in medicine, but before this can be realized ...
Hello Dr Swapnil and all the members, I would like to list some of the factors that have kept gene therapy away from becoming an effective treatment for...
Dear Dr Swapnil,  As you have pointed,gene therapy is a novel concept for delivery of genetic materials, which can be used for the treatment of inherited...
Dear Dr. Swapnil: I am also attaching a review article from "GUT" titled, "The Promise and potential hazards of adenovirus gene therapy". Apart from issues...
Good Morning Geer Sir,  Yes, there are many hazards of gene therapy. Though started in 1980's, gene therapy is still in it's infancy. There is always the...
Hello members, [:)] Delivery of gene is very important and tidious process in gene therapy. Lots of precautions and expertization is needed. Hallmarks of the...
Dear members, [:)] Viruses are obligate intra-cellular parasites, designed through the course of evolution to infect cells, often with great specificity to a ...
Hello members, [:)] Features of some common viral vectors: Adenovirus vector: The life cycle does not normally involve integration into the host genome, rather...
Hello Everybody, Dr. Geer has rightly pointed out to the limitations of gene therapy which probably is the reason why it has not yet achieved a defined ...
Hello members,  Dr. Smita Sontakke mam quoted an exellent example of the successful gene therapy. Presently researchs are conducted in each and every...
Dear members, Viral vectors induce an immunological response to some degree & may have safety risks (such as insertional mutagenesis & toxicity problems). ...
Dear members, It is very difficult, rather impossible, to reverse or repair mutation once it occurs. Here is the technique which is used to repair mutation: ...
Dear Dr. Swapnil: You seem to be in possession of vast stores of invaluable, interesting and useful information on gene therapy, thanks for the same. Well...
Dear Friends,  As Dr Swapnil has mentioned in his posting, gene therapy remains a very powerful theme of molecular medicine.It holds promise for diseases...
Dear Dr Swapnil, In popular culture In the TV series Dark Angel gene therapy is mentioned as one of the practices performed on transgenics and their surrogate...
Good morning members, Approximately half of all current clinical gene therapy research relates to its use in cancer. The first gene transfer experiment to be...
Hello members, In addition to DNA vaccines, there is considerable interest in the potential of gene therapy for HIV infection. Some 10% of all clinical gene...
Dear members, It is estimated that as of today around 1,340 gene therapy clinical trials have been completed, or are ongoing or been approved worldwide. Gene...
Hello Friends, Swapnil is certainly doing a fantastic job. As mentioned in his latest post the Human Genome Project and other international efforts have...
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