There are more then 4000 known inherited disorders, which lack effective therapy, by conventional medicines. There is one infant in every 100 infants, that has been seen to be suffering form some or the other genetic defect. Larger numbers of genetic disorders are associated with liver (where numerous liver specific enzymes catalyze complex metabolic processes) and with haematopoietic organ (bone marrow). Very few genetic disorders can be cured. Current methods of treatment genetic diseases are mostly symptomatic treatments and in certain cases congenital abnormalities are corrected by surgery.
Symptomatic treatments when analyzed on the basis of life, increased reproductive abilities and social acceptance show very low rate success. It is completely successful in 26 genetic diseases (40% of the total) and moderately useless in rest. Apart from the low rate of success the other problems with symptomatic treatments currently practiced are:
High cost of treatment.
Continuous treatment throughout the life.
Dangers of transmission of AIDS and others during blood transfusion.
High iron contents after repeated blood transfusion in thalasemic patients as side effects.
Hello members, I am Dr. Swapnil Jaiswal, post graduate student in Pharmacology Dept., GMC Nagpur. I am extremely thankful to our inspiring teacher Dr. Vijay ...
Hello members, There are more then 4000 known inherited disorders, which lack effective therapy, by conventional medicines. There is one infant in every 100 ...
Good informations,carry on. With best wishes, ... -- Anand Chaudhary Deptt of Rasa Shastra (Ayurvedic Pharmaceutics) Faculty of Ayuveda Institute of Medical...
Hello members, Most of us do not suffer any harmful effects from our defective genes because we carry two copies of nearly all genes, one derived from our ...
Dear Anand Sir,  Thanks a lot for the encouraging words. In future we will witness that gene therapy will be revealed as an most promising treatment for...
Dear members, In the early 1970s, scientists proposed "gene surgery" for treating inherited diseases caused by faulty genes. The idea was to take out the ...
Dear Dr Swapnil, Gene therapy has been found useful in plants and also in domestic animals. But gene therapy in man raises many ethical issues. However if gene...
Hello Anupama mam,  You have correctly pointed out that gene therapy is effective in plants and animals. Before approving gene therapy as an treatment...
Dear members, Potential approaches currently available to gene therapy: * Correction of a mutated gene. * Addition of normal gene to replace the function of...
Hello members, Below are the differentiating features of Gene replacement therapy vs Corrective gene therapy: Gene replacement therapy (Gene augmentation) ...
Dear members, SOMATIC GENE THERAPY vs GERM THERAPY. SOMATIC GENE THERAPY GERM THERAPY 1. Genes are introduced into somatic cells Changes are confined to the ...
Good morning members, [:)] Gene therapy potentially represents one of the most important developments to occur in medicine, but before this can be realized ...
Hello Dr Swapnil and all the members, I would like to list some of the factors that have kept gene therapy away from becoming an effective treatment for...
Dear Dr Swapnil,  As you have pointed,gene therapy is a novel concept for delivery of genetic materials, which can be used for the treatment of inherited...
Dear Dr. Swapnil: I am also attaching a review article from "GUT" titled, "The Promise and potential hazards of adenovirus gene therapy". Apart from issues...
Good Morning Geer Sir,  Yes, there are many hazards of gene therapy. Though started in 1980's, gene therapy is still in it's infancy. There is always the...
Having problems with message search?
Offline 
Send Email