natural_prostate_treatments : Messages : 15896-15909 of 16765

#15896

From: shel litt <shellitt@...>
Date: Mon Jul 6, 2009 1:32 pm
Subject: resveratrol produces longevity and can kill cancer (??) - (longevinex)

shellitt

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Send Email

Has anyone here tried Longevinex? (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)

-Shel

Subject: Dose determines whether resveratrol
produces longevity or kills cancer
All followers of resveratrol science take note! In
the study abstract below, researchers describe how
resveratrol affects the cell cycle, that is,
cellular events leading to its division and
duplication (replication). The S-phase (synthesis
phase) of the cell cycle is when DNA synthesis or
replication occurs.

In modest doses, resveratrol causes the S-phase cell
cycle to proceed in slow gear, giving more time for
DNA to be repaired, producing longevity. In mega-
doses, resveratrol accelerates the S-phase cell
cycle and increases cellular death, thus inducing
mutated tumor cells to die (apoptosis).

Advice to consume mega-dose resveratrol (more than
300 mg) appears to be ill advised. Other studies
confirm that mega-dose resveratrol (as little as 360
milligrams for a 160 lb human) shortened the lives
of laboratory animals on a standard calorie diet.

The widespread false notion that the equivalent of
1000 glasses of red wine is needed to produce the
same effect as pure resveratrol in the laboratory
should be dismissed. It has been shown that 3-5
glasses of red wine, providing 180-300 mg of daily
polyphenolic molecules (resveratrol, quercetin,
ferulic acid, malvidin, catechin, kaempferol, gallic
acid) produces unusual health and longevity in
French wine-drinking populations. Copyright 2009
Bill Sardi, Resveratrol Partners LLC

For the full text of this report, email Bill Sardi at
bsardi@...

British Journal Pharmacology 2009 Jun 25. [Epub
ahead of print]

Induction of a reversible, non-cytotoxic S-phase
delay by resveratrol: implications for a mechanism
of lifespan prolongation and cancer protection.
Zhou R, Fukui M, Choi HJ Zhu BT.
Department of Pharmacology, Toxicology and
Therapeutics, School of Medicine, University of
Kansas Medical Center, Kansas City, KS, USA.

Background and purpose: Resveratrol (RES) has been
shown to prolong lifespan and prevent cancer
formation. At present, the precise cellular
mechanisms of RES actions are still not clearly
understood, and this is the focus of this study.
Experimental approach: Using human hepatocellular
carcinoma-derived HepG2 cells as a model, we studied
RES-induced changes in cell growth, cell cycle
progression and apoptosis (death). Key results:

RES at lower concentrations induced a strong but
reversible S-phase delay and mild DNA synthesis
inhibition, yet without causing apoptotic or
necrotic cell death.
At high concentrations, RES induced apoptosis (cell
death), which is mainly mediated by the
mitochondrial pathway.
Overall, RES was a relatively weak apoptotic agent.
Mechanistically, MEK inhibition was identified as an
important early signalling event for RES-induced
apoptosis. In comparison, activation of CDK2 and
checkpoint kinase 2, and inhibition of
phosphatidylinositol 3'-kinase/Akt signalling
pathway contributed to the induction by RES of a
reversible, non-cytotoxic S-phase delay. Conclusion
and implications: It is hypothesized that the
induction of a non-cytotoxic S-phase delay may
represent a useful mechanistic strategy for lifespan
prolongation and cancer prevention. When cell cycles
are selectively slowed down in the S phase, it would
cumulatively increase the total lifespan of an
organism if the total numbers of cell divisions of a
given organism are assumed to remain basically
constant. Likewise, when cells proceed through the
cell cycles at a reduced pace during DNA
replication, it may allow cells more time to repair
the damaged DNA, and thereby reduce the chances for
mutagenesis and tumor initiation.

Longevinex�
457 W. Allen Ave. Suite 117
San Dimas, CA 91773
http://www.longevinex.com
http://www.longevinexadvantage.com
(866) 405-4000

If you wish to be removed from our mailing list,
please click here.

=====================================================
For info on managing your subscription: http://ppml-info.org/welcome.html
Need more help? Send email to: prostate-request@...

__________ Information fr�n ESET NOD32 Antivirus, version av virussignaturdatabas 4217 (20090704) __________

Meddelandet har kontrollerats av ESET NOD32 Antivirus.

http://www.esetscandinavia.com

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#15897

From: Arthur Terwilliger <atwigant@...>
Date: Mon Jul 6, 2009 1:53 pm
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

atwigant

Offline

Send Email

Shel

I have been taking Longevinex for about 4 years. One capsule per day. It is hard to objectively determine the effects of this supplement as it is with many supplements. However, subjectively, I have not seen any evidence that it has improved my pca/psa situation. As far as my overall health, I feel much better and younger then my 70 years would indicate. Maybe this has helped. I also take many supplements and have been for good part of my life. It is hard to put a number on any one supplement.

Art T

From: shel litt <shellitt@...>
To: hope <HOPE-list@yahoogroups.com>
Cc: PC-ACT@yahoogroups.com
Sent: Monday, July 6, 2009 9:32:25 AM
Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

Has anyone here tried Longevinex? (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)

-Shel

Subject: Dose determines whether resveratrol
produces longevity or kills cancer
All followers of resveratrol science take note! In
the study abstract below, researchers describe how
resveratrol affects the cell cycle, that is,
cellular events leading to its division and
duplication (replication) . The S-phase (synthesis
phase) of the cell cycle is when DNA synthesis or
replication occurs.

In modest doses, resveratrol causes the S-phase cell
cycle to proceed in slow gear, giving more time for
DNA to be repaired, producing longevity. In mega-
doses, resveratrol accelerates the S-phase cell
cycle and increases cellular death, thus inducing
mutated tumor cells to die (apoptosis).

Advice to consume mega-dose resveratrol (more than
300 mg) appears to be ill advised. Other studies
confirm that mega-dose resveratrol (as little as 360
milligrams for a 160 lb human) shortened the lives
of laboratory animals on a standard calorie diet.

The widespread false notion that the equivalent of
1000 glasses of red wine is needed to produce the
same effect as pure resveratrol in the laboratory
should be dismissed. It has been shown that 3-5
glasses of red wine, providing 180-300 mg of daily
polyphenolic molecules (resveratrol, quercetin,
ferulic acid, malvidin, catechin, kaempferol, gallic
acid) produces unusual health and longevity in
French wine-drinking populations. Copyright 2009
Bill Sardi, Resveratrol Partners LLC

For the full text of this report, email Bill Sardi at
bsardi@...

British Journal Pharmacology 2009 Jun 25. [Epub
ahead of print]

Induction of a reversible, non-cytotoxic S-phase
delay by resveratrol: implications for a mechanism
of lifespan prolongation and cancer protection.
Zhou R, Fukui M, Choi HJ Zhu BT.
Department of Pharmacology, Toxicology and
Therapeutics, School of Medicine, University of
Kansas Medical Center, Kansas City, KS, USA.

Background and purpose: Resveratrol (RES) has been
shown to prolong lifespan and prevent cancer
formation. At present, the precise cellular
mechanisms of RES actions are still not clearly
understood, and this is the focus of this study.
Experimental approach: Using human hepatocellular
carcinoma-derived HepG2 cells as a model, we studied
RES-induced changes in cell growth, cell cycle
progression and apoptosis (death). Key results:

RES at lower concentrations induced a strong but
reversible S-phase delay and mild DNA synthesis
inhibition, yet without causing apoptotic or
necrotic cell death.
At high concentrations, RES induced apoptosis (cell
death), which is mainly mediated by the
mitochondrial pathway.
Overall, RES was a relatively weak apoptotic agent.
Mechanistically, MEK inhibition was identified as an
important early signalling event for RES-induced
apoptosis. In comparison, activation of CDK2 and
checkpoint kinase 2, and inhibition of
phosphatidylinosito l 3'-kinase/Akt signalling
pathway contributed to the induction by RES of a
reversible, non-cytotoxic S-phase delay. Conclusion
and implications: It is hypothesized that the
induction of a non-cytotoxic S-phase delay may
represent a useful mechanistic strategy for lifespan
prolongation and cancer prevention. When cell cycles
are selectively slowed down in the S phase, it would
cumulatively increase the total lifespan of an
organism if the total numbers of cell divisions of a
given organism are assumed to remain basically
constant. Likewise, when cells proceed through the
cell cycles at a reduced pace during DNA
replication, it may allow cells more time to repair
the damaged DNA, and thereby reduce the chances for
mutagenesis and tumor initiation.

Longevinex�
457 W. Allen Ave. Suite 117
San Dimas, CA 91773
http://www.longevinex.com/
http://www.longevin exadvantage. com
(866) 405-4000

If you wish to be removed from our mailing list,
please click here.

============ ========= ========= ========= ========= =====
For info on managing your subscription: http://ppml-info.org/welcome.html
Need more help? Send email to: prostate-request@ listserv. acor.org

__________ Information fr�n ESET NOD32 Antivirus, version av virussignaturdataba s 4217 (20090704) __________

Meddelandet har kontrollerats av ESET NOD32 Antivirus.

http://www.esetscandinavia.com/

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#15898

From: Patrick OShea <pjoshea13@...>
Date: Mon Jul 6, 2009 4:49 pm
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

pjoshea13

Offline

Send Email

Shel,

I have used it (I recently ran out). I have never been convinced that regular resveratrol is particularly bioavailable. Seemed to me that Longevinex, although expensive, might almost be cheaper than other brands because of increased bioavailability. I started out on 1 cap as a replacement for the 4-6 LEF caps I had been taking. I moved to 4 caps when I read that a higher dose was necessary for apoptosis.

One study, though, had me worried. It seems that at a dose required to kill cancer cells, Longevinex might actually increase mortality. A healthy organ is in a homeostatic state in terms of cells. Apoptosis & cell division must balance. When the organ is under attack, there is a danger that cell death will race ahead of replacement. However, the obligatory response to such an event is activation of NFkB, which is anti-apoptotic. Resveratrol is just one of a number of polyphenols that can inhibit NFkB activation. Whatever the reason, it seems that increased mortality was due to an unusually high rate of apoptosis during events that did not particularly affect controls.

The obvious concern to the PCa population is what might happen during a mild heart attack. I raised this issue with Sardi. I said that it seemed that I should be taking 4 caps to fight PCa - but was that a safe dose? He replied that, unless fighting active cancer, take a low dose (1-2 caps). It's a non-reply, but clear enough.

During the year that I was on Longevinex, my PSA continued to rise, but at a slow rate. I can't say what Longevinex did for me, since I take a lot of other stuff. When I shifted to 4 caps, I foolishly omitted to have a baseline PSA test.

If you are in good health (apart from PCa), it might be interesting to see what effect 4 caps has on PSA in a 1-2 month period. I would discontinue Longevinex during times when the body is suffering from viral or bacterial insult - & upon experiencing any medical emergency.

-Patrick

Dx04 @ 56 (DRE nodule 2002) |bPSA 3.3 (0.8 when nodule found)| GS=4+3, RP - no LN, no SV, but PSA nadir-0.3. DT=3 months Salvage RT 2005. Again, nadir=0.3. No HB. +AM

--- On Mon, 7/6/09, shel litt <shellitt@...> wrote:

From: shel litt <shellitt@...>
Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)
To: "hope" <HOPE-list@yahoogroups.com>
Cc: PC-ACT@yahoogroups.com
Date: Monday, July 6, 2009, 9:32 AM

Has anyone here tried Longevinex? (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)

-Shel

Subject: Dose determines whether resveratrol
produces longevity or kills cancer
All followers of resveratrol science take note! In
the study abstract below, researchers describe how
resveratrol affects the cell cycle, that is,
cellular events leading to its division and
duplication (replication) . The S-phase (synthesis
phase) of the cell cycle is when DNA synthesis or
replication occurs.

In modest doses, resveratrol causes the S-phase cell
cycle to proceed in slow gear, giving more time for
DNA to be repaired, producing longevity. In mega-
doses, resveratrol accelerates the S-phase cell
cycle and increases cellular death, thus inducing
mutated tumor cells to die (apoptosis).

Advice to consume mega-dose resveratrol (more than
300 mg) appears to be ill advised. Other studies
confirm that mega-dose resveratrol (as little as 360
milligrams for a 160 lb human) shortened the lives
of laboratory animals on a standard calorie diet.

The widespread false notion that the equivalent of
1000 glasses of red wine is needed to produce the
same effect as pure resveratrol in the laboratory
should be dismissed. It has been shown that 3-5
glasses of red wine, providing 180-300 mg of daily
polyphenolic molecules (resveratrol, quercetin,
ferulic acid, malvidin, catechin, kaempferol, gallic
acid) produces unusual health and longevity in
French wine-drinking populations. Copyright 2009
Bill Sardi, Resveratrol Partners LLC

For the full text of this report, email Bill Sardi at
bsardi@...

British Journal Pharmacology 2009 Jun 25. [Epub
ahead of print]

Induction of a reversible, non-cytotoxic S-phase
delay by resveratrol: implications for a mechanism
of lifespan prolongation and cancer protection.
Zhou R, Fukui M, Choi HJ Zhu BT.
Department of Pharmacology, Toxicology and
Therapeutics, School of Medicine, University of
Kansas Medical Center, Kansas City, KS, USA.

Background and purpose: Resveratrol (RES) has been
shown to prolong lifespan and prevent cancer
formation. At present, the precise cellular
mechanisms of RES actions are still not clearly
understood, and this is the focus of this study.
Experimental approach: Using human hepatocellular
carcinoma-derived HepG2 cells as a model, we studied
RES-induced changes in cell growth, cell cycle
progression and apoptosis (death). Key results:

RES at lower concentrations induced a strong but
reversible S-phase delay and mild DNA synthesis
inhibition, yet without causing apoptotic or
necrotic cell death.
At high concentrations, RES induced apoptosis (cell
death), which is mainly mediated by the
mitochondrial pathway.
Overall, RES was a relatively weak apoptotic agent.
Mechanistically, MEK inhibition was identified as an
important early signalling event for RES-induced
apoptosis. In comparison, activation of CDK2 and
checkpoint kinase 2, and inhibition of
phosphatidylinosito l 3'-kinase/Akt signalling
pathway contributed to the induction by RES of a
reversible, non-cytotoxic S-phase delay. Conclusion
and implications: It is hypothesized that the
induction of a non-cytotoxic S-phase delay may
represent a useful mechanistic strategy for lifespan
prolongation and cancer prevention. When cell cycles
are selectively slowed down in the S phase, it would
cumulatively increase the total lifespan of an
organism if the total numbers of cell divisions of a
given organism are assumed to remain basically
constant. Likewise, when cells proceed through the
cell cycles at a reduced pace during DNA
replication, it may allow cells more time to repair
the damaged DNA, and thereby reduce the chances for
mutagenesis and tumor initiation..

Longevinex�
457 W. Allen Ave. Suite 117
San Dimas, CA 91773
http://www.longevin ex.com
http://www.longevin exadvantage. com
(866) 405-4000

If you wish to be removed from our mailing list,
please click here.

============ ========= ========= ========= ========= =====
For info on managing your subscription: http://ppml- info.org/ welcome.html
Need more help? Send email to: prostate-request@ listserv. acor.org

__________ Information fr�n ESET NOD32 Antivirus, version av virussignaturdataba s 4217 (20090704) __________

Meddelandet har kontrollerats av ESET NOD32 Antivirus.

http://www.esetscan dinavia.com

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#15899

From: shel litt <shellitt@...>
Date: Mon Jul 6, 2009 6:54 pm
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

shellitt

Offline

Send Email

Patrick,

thanks for reply.

1 or 2 pills is too little; 4 pills is too much.

how about taking 3 longevinex per day? sounds about right? i read somewhere that 3 pills /day is proper dose for PCa guys.

my health is good, all my test scores excellent,- except for psa. my only pathology is anxiety when meeting urologists.

-shel

--- On Mon, 7/6/09, Patrick OShea <pjoshea13@...> wrote:

From: Patrick OShea <pjoshea13@...>
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)
To: natural_prostate_treatments@yahoogroups.com
Date: Monday, July 6, 2009, 12:49 PM

Shel,

I have used it (I recently ran out). I have never been convinced that regular resveratrol is particularly bioavailable. Seemed to me that Longevinex, although expensive, might almost be cheaper than other brands because of increased bioavailability. I started out on 1 cap as a replacement for the 4-6 LEF caps I had been taking. I moved to 4 caps when I read that a higher dose was necessary for apoptosis.

One study, though, had me worried. It seems that at a dose required to kill cancer cells, Longevinex might actually increase mortality. A healthy organ is in a homeostatic state in terms of cells. Apoptosis & cell division must balance. When the organ is under attack, there is a danger that cell death will race ahead of replacement. However, the obligatory response to such an event is activation of NFkB, which is anti-apoptotic. Resveratrol is just one of a number of polyphenols that can inhibit NFkB activation. Whatever the reason, it seems that increased mortality was due to an unusually high rate of apoptosis during events that did not particularly affect controls.

The obvious concern to the PCa population is what might happen during a mild heart attack. I raised this issue with Sardi. I said that it seemed that I should be taking 4 caps to fight PCa - but was that a safe dose? He replied that, unless fighting active cancer, take a low dose (1-2 caps). It's a non-reply, but clear enough.

During the year that I was on Longevinex, my PSA continued to rise, but at a slow rate. I can't say what Longevinex did for me, since I take a lot of other stuff. When I shifted to 4 caps, I foolishly omitted to have a baseline PSA test.

If you are in good health (apart from PCa), it might be interesting to see what effect 4 caps has on PSA in a 1-2 month period. I would discontinue Longevinex during times when the body is suffering from viral or bacterial insult - & upon experiencing any medical emergency.

-Patrick

Dx04 @ 56 (DRE nodule 2002) |bPSA 3.3 (0.8 when nodule found)| GS=4+3, RP - no LN, no SV, but PSA nadir-0.3. DT=3 months Salvage RT 2005. Again, nadir=0.3. No HB. +AM

--- On Mon, 7/6/09, shel litt <shellitt@yahoo. com> wrote:

From: shel litt <shellitt@yahoo. com>
Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)
To: "hope" <HOPE-list@yahoogrou ps.com>
Cc: PC-ACT@yahoogroups. com
Date: Monday, July 6, 2009, 9:32 AM

Has anyone here tried Longevinex? (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)

-Shel

Subject: Dose determines whether resveratrol
produces longevity or kills cancer
All followers of resveratrol science take note! In
the study abstract below, researchers describe how
resveratrol affects the cell cycle, that is,
cellular events leading to its division and
duplication (replication) . The S-phase (synthesis
phase) of the cell cycle is when DNA synthesis or
replication occurs.

In modest doses, resveratrol causes the S-phase cell
cycle to proceed in slow gear, giving more time for
DNA to be repaired, producing longevity. In mega-
doses, resveratrol accelerates the S-phase cell
cycle and increases cellular death, thus inducing
mutated tumor cells to die (apoptosis).

Advice to consume mega-dose resveratrol (more than
300 mg) appears to be ill advised. Other studies
confirm that mega-dose resveratrol (as little as 360
milligrams for a 160 lb human) shortened the lives
of laboratory animals on a standard calorie diet.

The widespread false notion that the equivalent of
1000 glasses of red wine is needed to produce the
same effect as pure resveratrol in the laboratory
should be dismissed. It has been shown that 3-5
glasses of red wine, providing 180-300 mg of daily
polyphenolic molecules (resveratrol, quercetin,
ferulic acid, malvidin, catechin, kaempferol, gallic
acid) produces unusual health and longevity in
French wine-drinking populations. Copyright 2009
Bill Sardi, Resveratrol Partners LLC

For the full text of this report, email Bill Sardi at
bsardi@...

British Journal Pharmacology 2009 Jun 25. [Epub
ahead of print]

Induction of a reversible, non-cytotoxic S-phase
delay by resveratrol: implications for a mechanism
of lifespan prolongation and cancer protection.
Zhou R, Fukui M, Choi HJ Zhu BT.
Department of Pharmacology, Toxicology and
Therapeutics, School of Medicine, University of
Kansas Medical Center, Kansas City, KS, USA.

Background and purpose: Resveratrol (RES) has been
shown to prolong lifespan and prevent cancer
formation. At present, the precise cellular
mechanisms of RES actions are still not clearly
understood, and this is the focus of this study.
Experimental approach: Using human hepatocellular
carcinoma-derived HepG2 cells as a model, we studied
RES-induced changes in cell growth, cell cycle
progression and apoptosis (death). Key results:

RES at lower concentrations induced a strong but
reversible S-phase delay and mild DNA synthesis
inhibition, yet without causing apoptotic or
necrotic cell death.
At high concentrations, RES induced apoptosis (cell
death), which is mainly mediated by the
mitochondrial pathway.
Overall, RES was a relatively weak apoptotic agent.
Mechanistically, MEK inhibition was identified as an
important early signalling event for RES-induced
apoptosis. In comparison, activation of CDK2 and
checkpoint kinase 2, and inhibition of
phosphatidylinosito l 3'-kinase/Akt signalling
pathway contributed to the induction by RES of a
reversible, non-cytotoxic S-phase delay. Conclusion
and implications: It is hypothesized that the
induction of a non-cytotoxic S-phase delay may
represent a useful mechanistic strategy for lifespan
prolongation and cancer prevention. When cell cycles
are selectively slowed down in the S phase, it would
cumulatively increase the total lifespan of an
organism if the total numbers of cell divisions of a
given organism are assumed to remain basically
constant. Likewise, when cells proceed through the
cell cycles at a reduced pace during DNA
replication, it may allow cells more time to repair
the damaged DNA, and thereby reduce the chances for
mutagenesis and tumor initiation..

Longevinex�
457 W. Allen Ave. Suite 117
San Dimas, CA 91773
http://www.longevin ex.com
http://www.longevin exadvantage. com
(866) 405-4000

If you wish to be removed from our mailing list,
please click here.

============ ========= ========= ========= ========= =====
For info on managing your subscription: http://ppml- info.org/ welcome.html
Need more help? Send email to: prostate-request@ listserv. acor.org

__________ Information fr�n ESET NOD32 Antivirus, version av virussignaturdataba s 4217 (20090704) __________

Meddelandet har kontrollerats av ESET NOD32 Antivirus.

http://www.esetscan dinavia.com

Reply | Forward

#15900

From: Donald Lytton <dhlytton@...>
Date: Tue Jul 7, 2009 10:42 pm
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

donaldlytton

Offline

Send Email

Hi Shel. Your e-mail reminded me of something.

I posted this e mail 12/9/08.

"Hi : I had a prostatectomy in 1991 and they didn't get all the cancer out. I started on PC Spes when it came out and now I'm on Prostasol from Medpro. My strategy is to let my PSA drift slightly up to keep my testostrone at a reasonable amount ( betwwen 500 and 600).

Last spring my PSA was 1.1 on 5 to 6 Prostasol capsules per week. I stayed on this amount and expected my PSA to drift up to 1.3 to 1.5. Much to my surprise, my Psa, taken on Nov. 26, 2008 was undetectable. I went back to the lab to check my testosterone and Vitamin D. My testosterone was only 38 and my Vitamin D was 73.9 ng/ml. I take 2000IUs of Vit. D per day.

It didn't make any sense that my testosterone should be so low on the same dosage of Prostasol. It's possible that since I'm 78 I'm producing less testerone.

I'm only going to take 2 prostasol capsules per week and see what happens in 3 months.

If anyone has an explanation, I'd love to hear it. Don Lytton"

Since then, I've dropped it to two per week and then one per week and it is still undetectable. I'm now taking one capsule evry other week and I'll report the results in 2 months.

I thought it might be the Vitamin D, as I had been taking Longevinex for about a year earlier with no unusual results. But about the middle of September 2008 ( 2 months before my Nov 26 PSA test), I started taking a supplement called Triveratrol Plus sold by Dr. Julian Whitaker.

Each capsule contains 150mg Aloe Vera extract, 100mg tumeric extract, 50mg trans resveratrol extract from Japanese knotwood root and 40 mg red wine polyphenols from grapes. I take two per day.

I have no idea whether it's the Triveratrol Plus that's causing my undetectable PSA, or maybe it's combination with Vit D. Or it could be a fluke. Unfortunately, you can't prove anything with one person's data. I thought I'd throw this information into the mix. Don

From: shel litt <shellitt@...>
Reply-To: natural_prostate_treatments@yahoogroups.com
Date: Mon, 6 Jul 2009 06:32:25 -0700 (PDT)
To: hope <HOPE-list@yahoogroups.com>
Cc: PC-ACT@yahoogroups.com
Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

Has anyone here tried Longevinex? (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)

-Shel

Subject: Dose determines whether resveratrol
produces longevity or kills cancer
All followers of resveratrol science take note! In
the study abstract below, researchers describe how
resveratrol affects the cell cycle, that is,
cellular events leading to its division and
duplication (replication). The S-phase (synthesis
phase) of the cell cycle is when DNA synthesis or
replication occurs.

In modest doses, resveratrol causes the S-phase cell
cycle to proceed in slow gear, giving more time for
DNA to be repaired, producing longevity. In mega-
doses, resveratrol accelerates the S-phase cell
cycle and increases cellular death, thus inducing
mutated tumor cells to die (apoptosis).

Advice to consume mega-dose resveratrol (more than
300 mg) appears to be ill advised. Other studies
confirm that mega-dose resveratrol (as little as 360
milligrams for a 160 lb human) shortened the lives
of laboratory animals on a standard calorie diet.

The widespread false notion that the equivalent of
1000 glasses of red wine is needed to produce the
same effect as pure resveratrol in the laboratory
should be dismissed. It has been shown that 3-5
glasses of red wine, providing 180-300 mg of daily
polyphenolic molecules (resveratrol, quercetin,
ferulic acid, malvidin, catechin, kaempferol, gallic
acid) produces unusual health and longevity in
French wine-drinking populations. Copyright 2009
Bill Sardi, Resveratrol Partners LLC

For the full text of this report, email Bill Sardi at
bsardi@... <http://us.mc343.mail.yahoo.com/mc/compose?to=bsardi@...>

British Journal Pharmacology 2009 Jun 25. [Epub
ahead of print]

Induction of a reversible, non-cytotoxic S-phase
delay by resveratrol: implications for a mechanism
of lifespan prolongation and cancer protection.
Zhou R, Fukui M, Choi HJ Zhu BT.
Department of Pharmacology, Toxicology and
Therapeutics, School of Medicine, University of
Kansas Medical Center, Kansas City, KS, USA.

Background and purpose: Resveratrol (RES) has been
shown to prolong lifespan and prevent cancer
formation. At present, the precise cellular
mechanisms of RES actions are still not clearly
understood, and this is the focus of this study.
Experimental approach: Using human hepatocellular
carcinoma-derived HepG2 cells as a model, we studied
RES-induced changes in cell growth, cell cycle
progression and apoptosis (death). Key results:

RES at lower concentrations induced a strong but
reversible S-phase delay and mild DNA synthesis
inhibition, yet without causing apoptotic or
necrotic cell death.
At high concentrations, RES induced apoptosis (cell
death), which is mainly mediated by the
mitochondrial pathway.
Overall, RES was a relatively weak apoptotic agent.
Mechanistically, MEK inhibition was identified as an
important early signalling event for RES-induced
apoptosis. In comparison, activation of CDK2 and
checkpoint kinase 2, and inhibition of
phosphatidylinositol 3'-kinase/Akt signalling
pathway contributed to the induction by RES of a
reversible, non-cytotoxic S-phase delay. Conclusion
and implications: It is hypothesized that the
induction of a non-cytotoxic S-phase delay may
represent a useful mechanistic strategy for lifespan
prolongation and cancer prevention. When cell cycles
are selectively slowed down in the S phase, it would
cumulatively increase the total lifespan of an
organism if the total numbers of cell divisions of a
given organism are assumed to remain basically
constant. Likewise, when cells proceed through the
cell cycles at a reduced pace during DNA
replication, it may allow cells more time to repair
the damaged DNA, and thereby reduce the chances for
mutagenesis and tumor initiation.

Longevinex�
457 W. Allen Ave. Suite 117
San Dimas, CA 91773
http://www.longevinex.com <http://www.longevinex.com/>
http://www.longevinexadvantage.com <http://www.longevinexadvantage.com/>
(866) 405-4000

If you wish to be removed from our mailing list,
please click here.

=====================================================
For info on managing your subscription: http://ppml-info.org/welcome.html
Need more help? Send email to: prostate-request@... <http://us.mc343.mail.yahoo.com/mc/compose?to=prostate-request@...>

__________ Information fr�n ESET NOD32 Antivirus, version av virussignaturdatabas 4217 (20090704) __________

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Reply | Forward

#15901

From: "tinycamera1" <DavidCohen99@...>
Date: Wed Jul 8, 2009 2:30 am
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

tinycamera1

Offline

Send Email

Donald:



I had the same experience.  The new QP+ seems to be 3 times more potent.  I only

take one every couple weeks.



David





--- In natural_prostate_treatments@yahoogroups.com, Donald Lytton <dhlytton@...>

wrote:

>

> Hi Shel.  Your e-mail reminded me of something.

>

> I posted this e mail 12/9/08.

>

> "Hi :  I had a prostatectomy in 1991 and they didn't get all the cancer out.

> I started on PC Spes when it came out and now I'm on Prostasol from Medpro.

> My strategy is to let my PSA drift slightly up to keep my testostrone at a

> reasonable amount ( betwwen 500 and 600).

>

> Last spring my PSA was 1.1 on 5 to 6 Prostasol capsules per week.  I stayed

> on this amount and expected my PSA to drift up to 1.3 to 1.5.  Much to my

> surprise, my Psa, taken on Nov. 26, 2008 was undetectable.  I went back to

> the lab to check my testosterone and Vitamin D.  My testosterone was only 38

> and my Vitamin D was 73.9 ng/ml. I take 2000IUs of Vit. D per day.

>

> It didn't make any sense that my testosterone should be so low on the same

> dosage of Prostasol.  It's possible that since I'm 78 I'm producing less

> testerone.

>

> I'm only going to take 2 prostasol capsules per week and see what happens in

> 3 months.

>

> If anyone has an explanation, I'd love to hear it.  Don Lytton"

>

> Since then, I've dropped it to two per week and then one per week and it is

> still undetectable.  I'm now taking one capsule evry other week and I'll

> report the results in 2 months.

>

> I thought it might be the Vitamin D, as I had been taking Longevinex for

> about a year earlier with no unusual results.  But about the middle of

> September 2008 ( 2 months before my Nov 26 PSA test), I started taking a

> supplement called Triveratrol Plus sold by Dr. Julian Whitaker.

>

> Each capsule contains 150mg Aloe Vera extract, 100mg tumeric extract, 50mg

> trans resveratrol extract from Japanese knotwood root and 40 mg red wine

> polyphenols from grapes.  I take two per day.

>

> I have no idea whether it's the Triveratrol Plus that's causing my

> undetectable PSA, or maybe it's combination with Vit D.  Or it could be a

> fluke.  Unfortunately, you can't prove anything with one person's data.  I

> thought I'd throw this information into the mix.  Don

>

>

>

>

>

> From: shel litt <shellitt@...>

> Reply-To: natural_prostate_treatments@yahoogroups.com

> Date: Mon, 6 Jul 2009 06:32:25 -0700 (PDT)

> To: hope <HOPE-list@yahoogroups.com>

> Cc: PC-ACT@yahoogroups.com

> Subject: [NTPC  Yahoo Group] resveratrol produces longevity and can kill

> cancer (??) - (longevinex)

>

>

>

>

>

> Has anyone here tried Longevinex?  (i was told by someone long ago that Dr

> Myers recommends it, but cannot recall context.)

>

> -Shel

>

> Subject: Dose determines whether resveratrol

> produces longevity or kills cancer

> All followers of resveratrol science take note! In

> the study abstract below, researchers describe how

> resveratrol affects the cell cycle, that is,

> cellular events leading to its division and

> duplication (replication). The S-phase (synthesis

> phase) of the cell cycle is when DNA synthesis or

> replication occurs.

>

> In modest doses, resveratrol causes the S-phase cell

> cycle to proceed in slow gear, giving more time for

> DNA to be repaired, producing longevity. In mega-

> doses, resveratrol accelerates the S-phase cell

> cycle and increases cellular death, thus inducing

> mutated tumor cells to die (apoptosis).

>

> Advice to consume mega-dose resveratrol (more than

> 300 mg) appears to be ill advised. Other studies

> confirm that mega-dose resveratrol (as little as 360

> milligrams for a 160 lb human) shortened the lives

> of laboratory animals on a standard calorie diet.

>

> The widespread false notion that the equivalent of

> 1000 glasses of red wine is needed to produce the

> same effect as pure resveratrol in the laboratory

> should be dismissed. It has been shown that 3-5

> glasses of red wine, providing 180-300 mg of daily

> polyphenolic molecules (resveratrol, quercetin,

> ferulic acid, malvidin, catechin, kaempferol, gallic

> acid) produces unusual health and longevity in

> French wine-drinking populations. Copyright 2009

> Bill Sardi, Resveratrol Partners LLC

>

> For the full text of this report, email Bill Sardi at

> bsardi@... <http://us.mc343.mail.yahoo.com/mc/compose?to=bsardi@...>

>

>

> British Journal Pharmacology 2009 Jun 25. [Epub

> ahead of print]

>

>

>

> Induction of a reversible, non-cytotoxic S-phase

> delay by resveratrol: implications for a mechanism

> of lifespan prolongation and cancer protection.

> Zhou R, Fukui M, Choi HJ Zhu BT.

> Department of Pharmacology, Toxicology and

> Therapeutics, School of Medicine, University of

> Kansas Medical Center, Kansas City, KS, USA.

>

> Background and purpose: Resveratrol (RES) has been

> shown to prolong lifespan and prevent cancer

> formation. At present, the precise cellular

> mechanisms of RES actions are still not clearly

> understood, and this is the focus of this study.

> Experimental approach: Using human hepatocellular

> carcinoma-derived HepG2 cells as a model, we studied

> RES-induced changes in cell growth, cell cycle

> progression and apoptosis (death). Key results:

>

> RES at lower concentrations induced a strong but

> reversible S-phase delay and mild DNA synthesis

> inhibition, yet without causing apoptotic or

> necrotic cell death.

> At high concentrations, RES induced apoptosis (cell

> death), which is mainly mediated by the

> mitochondrial pathway.

> Overall, RES was a relatively weak apoptotic agent.

> Mechanistically, MEK inhibition was identified as an

> important early signalling event for RES-induced

> apoptosis. In comparison, activation of CDK2 and

> checkpoint kinase 2, and inhibition of

> phosphatidylinositol 3'-kinase/Akt signalling

> pathway contributed to the induction by RES of a

> reversible, non-cytotoxic S-phase delay. Conclusion

> and implications: It is hypothesized that the

> induction of a non-cytotoxic S-phase delay may

> represent a useful mechanistic strategy for lifespan

> prolongation and cancer prevention. When cell cycles

> are selectively slowed down in the S phase, it would

> cumulatively increase the total lifespan of an

> organism if the total numbers of cell divisions of a

> given organism are assumed to remain basically

> constant. Likewise, when cells proceed through the

> cell cycles at a reduced pace during DNA

> replication, it may allow cells more time to repair

> the damaged DNA, and thereby reduce the chances for

> mutagenesis and tumor initiation.

>

>

>

> Longevinex�

> 457 W. Allen Ave. Suite 117

> San Dimas, CA 91773

> http://www.longevinex.com <http://www.longevinex.com/>

> http://www.longevinexadvantage.com <http://www.longevinexadvantage.com/>

> (866) 405-4000

>

> If you wish to be removed from our mailing list,

> please click here.

>

> =====================================================

> For info on managing your subscription: http://ppml-info.org/welcome.html

> Need more help? Send email to: prostate-request@...

> <http://us.mc343.mail.yahoo.com/mc/compose?to=prostate-request@...

> .org>

>

> __________ Information fr�n ESET NOD32 Antivirus, version av

> virussignaturdatabas 4217 (20090704) __________

>

> Meddelandet har kontrollerats av ESET NOD32 Antivirus.

>

> http://www.esetscandinavia.com <http://www.esetscandinavia.com/>

>

Reply | Forward

#15902

From: Donald Lytton <dhlytton@...>
Date: Wed Jul 8, 2009 4:58 am
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

donaldlytton

Offline

Send Email

David: I'm still using the same Medpro Prostasol capsules which I bought about 3 years ago. The only new products that I'm taking are Vitamin D and Triveratrol which may be causing the decrease in PSA. Don

From: "tinycamera1" <DavidCohen99@...>
Reply-To: natural_prostate_treatments@yahoogroups.com
Date: Wed, 08 Jul 2009 02:30:15 -0000
To: natural_prostate_treatments@yahoogroups.com
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

Donald:

I had the same experience. The new QP+ seems to be 3 times more potent. I only take one every couple weeks.

David

--- In natural_prostate_treatments@yahoogroups.com <mailto:natural_prostate_treatments%40yahoogroups.com> , Donald Lytton <dhlytton@...> wrote:
>
> Hi Shel. Your e-mail reminded me of something.
>
> I posted this e mail 12/9/08.
>
> "Hi : I had a prostatectomy in 1991 and they didn't get all the cancer out.
> I started on PC Spes when it came out and now I'm on Prostasol from Medpro.
> My strategy is to let my PSA drift slightly up to keep my testostrone at a
> reasonable amount ( betwwen 500 and 600).
>
> Last spring my PSA was 1.1 on 5 to 6 Prostasol capsules per week. I stayed
> on this amount and expected my PSA to drift up to 1.3 to 1.5. Much to my
> surprise, my Psa, taken on Nov. 26, 2008 was undetectable. I went back to
> the lab to check my testosterone and Vitamin D. My testosterone was only 38
> and my Vitamin D was 73.9 ng/ml. I take 2000IUs of Vit. D per day.
>
> It didn't make any sense that my testosterone should be so low on the same
> dosage of Prostasol. It's possible that since I'm 78 I'm producing less
> testerone.
>
> I'm only going to take 2 prostasol capsules per week and see what happens in
> 3 months.
>
> If anyone has an explanation, I'd love to hear it. Don Lytton"
>
> Since then, I've dropped it to two per week and then one per week and it is
> still undetectable. I'm now taking one capsule evry other week and I'll
> report the results in 2 months.
>
> I thought it might be the Vitamin D, as I had been taking Longevinex for
> about a year earlier with no unusual results. But about the middle of
> September 2008 ( 2 months before my Nov 26 PSA test), I started taking a
> supplement called Triveratrol Plus sold by Dr. Julian Whitaker.
>
> Each capsule contains 150mg Aloe Vera extract, 100mg tumeric extract, 50mg
> trans resveratrol extract from Japanese knotwood root and 40 mg red wine
> polyphenols from grapes. I take two per day.
>
> I have no idea whether it's the Triveratrol Plus that's causing my
> undetectable PSA, or maybe it's combination with Vit D. Or it could be a
> fluke. Unfortunately, you can't prove anything with one person's data. I
> thought I'd throw this information into the mix. Don
>
>
>
>
>
> From: shel litt <shellitt@...>
> Reply-To: natural_prostate_treatments@yahoogroups.com <mailto:natural_prostate_treatments%40yahoogroups.com>
> Date: Mon, 6 Jul 2009 06:32:25 -0700 (PDT)
> To: hope <HOPE-list@yahoogroups.com <mailto:HOPE-list%40yahoogroups.com> >
> Cc: PC-ACT@yahoogroups.com <mailto:PC-ACT%40yahoogroups.com>
> Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill
> cancer (??) - (longevinex)
>
>
>
>
>
> Has anyone here tried Longevinex? (i was told by someone long ago that Dr
> Myers recommends it, but cannot recall context.)
>
> -Shel
>
> Subject: Dose determines whether resveratrol
> produces longevity or kills cancer
> All followers of resveratrol science take note! In
> the study abstract below, researchers describe how
> resveratrol affects the cell cycle, that is,
> cellular events leading to its division and
> duplication (replication). The S-phase (synthesis
> phase) of the cell cycle is when DNA synthesis or
> replication occurs.
>
> In modest doses, resveratrol causes the S-phase cell
> cycle to proceed in slow gear, giving more time for
> DNA to be repaired, producing longevity. In mega-
> doses, resveratrol accelerates the S-phase cell
> cycle and increases cellular death, thus inducing
> mutated tumor cells to die (apoptosis).
>
> Advice to consume mega-dose resveratrol (more than
> 300 mg) appears to be ill advised. Other studies
> confirm that mega-dose resveratrol (as little as 360
> milligrams for a 160 lb human) shortened the lives
> of laboratory animals on a standard calorie diet.
>
> The widespread false notion that the equivalent of
> 1000 glasses of red wine is needed to produce the
> same effect as pure resveratrol in the laboratory
> should be dismissed. It has been shown that 3-5
> glasses of red wine, providing 180-300 mg of daily
> polyphenolic molecules (resveratrol, quercetin,
> ferulic acid, malvidin, catechin, kaempferol, gallic
> acid) produces unusual health and longevity in
> French wine-drinking populations. Copyright 2009
> Bill Sardi, Resveratrol Partners LLC
>
> For the full text of this report, email Bill Sardi at
> bsardi@... <http://us.mc343.mail.yahoo.com/mc/compose?to=bsardi@...>
>
>
> British Journal Pharmacology 2009 Jun 25. [Epub
> ahead of print]
>
>
>
> Induction of a reversible, non-cytotoxic S-phase
> delay by resveratrol: implications for a mechanism
> of lifespan prolongation and cancer protection.
> Zhou R, Fukui M, Choi HJ Zhu BT.
> Department of Pharmacology, Toxicology and
> Therapeutics, School of Medicine, University of
> Kansas Medical Center, Kansas City, KS, USA.
>
> Background and purpose: Resveratrol (RES) has been
> shown to prolong lifespan and prevent cancer
> formation. At present, the precise cellular
> mechanisms of RES actions are still not clearly
> understood, and this is the focus of this study.
> Experimental approach: Using human hepatocellular
> carcinoma-derived HepG2 cells as a model, we studied
> RES-induced changes in cell growth, cell cycle
> progression and apoptosis (death). Key results:
>
> RES at lower concentrations induced a strong but
> reversible S-phase delay and mild DNA synthesis
> inhibition, yet without causing apoptotic or
> necrotic cell death.
> At high concentrations, RES induced apoptosis (cell
> death), which is mainly mediated by the
> mitochondrial pathway.
> Overall, RES was a relatively weak apoptotic agent.
> Mechanistically, MEK inhibition was identified as an
> important early signalling event for RES-induced
> apoptosis. In comparison, activation of CDK2 and
> checkpoint kinase 2, and inhibition of
> phosphatidylinositol 3'-kinase/Akt signalling
> pathway contributed to the induction by RES of a
> reversible, non-cytotoxic S-phase delay. Conclusion
> and implications: It is hypothesized that the
> induction of a non-cytotoxic S-phase delay may
> represent a useful mechanistic strategy for lifespan
> prolongation and cancer prevention. When cell cycles
> are selectively slowed down in the S phase, it would
> cumulatively increase the total lifespan of an
> organism if the total numbers of cell divisions of a
> given organism are assumed to remain basically
> constant. Likewise, when cells proceed through the
> cell cycles at a reduced pace during DNA
> replication, it may allow cells more time to repair
> the damaged DNA, and thereby reduce the chances for
> mutagenesis and tumor initiation.
>
>
>
> Longevinex�
> 457 W. Allen Ave. Suite 117
> San Dimas, CA 91773
> http://www.longevinex.com <http://www.longevinex.com/>
> http://www.longevinexadvantage.com <http://www.longevinexadvantage.com/>
> (866) 405-4000
>
> If you wish to be removed from our mailing list,
> please click here.
>
> =====================================================
> For info on managing your subscription: http://ppml-info.org/welcome.html
> Need more help? Send email to: prostate-request@...
> <http://us.mc343.mail.yahoo.com/mc/compose?to=prostate-request@...
> .org>
>
> __________ Information fr�n ESET NOD32 Antivirus, version av
> virussignaturdatabas 4217 (20090704) __________
>
> Meddelandet har kontrollerats av ESET NOD32 Antivirus.
>
> http://www.esetscandinavia.com <http://www.esetscandinavia.com/>
>

Reply | Forward

#15903

From: "tinycamera1" <DavidCohen99@...>
Date: Wed Jul 8, 2009 1:56 pm
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

tinycamera1

Offline

Send Email

Yes, Vitamin D works big time.  That could be the trick.



David







--- In natural_prostate_treatments@yahoogroups.com, Donald Lytton <dhlytton@...>

wrote:

>

> David:  I'm still using the same Medpro Prostasol capsules which I bought

> about 3 years ago.  The only new products that I'm taking are Vitamin D and

> Triveratrol which may be causing the decrease in PSA.  Don

>

> From: "tinycamera1" <DavidCohen99@...>

> Reply-To: natural_prostate_treatments@yahoogroups.com

> Date: Wed, 08 Jul 2009 02:30:15 -0000

> To: natural_prostate_treatments@yahoogroups.com

> Subject: Re: [NTPC  Yahoo Group] resveratrol produces longevity and can kill

> cancer (??) - (longevinex)

>

>

>

>

>

> Donald:

>

> I had the same experience.  The new QP+ seems to be 3 times more potent.  I

> only take one every couple weeks.

>

> David

>

> --- In natural_prostate_treatments@yahoogroups.com

> <mailto:natural_prostate_treatments%40yahoogroups.com> , Donald Lytton

> <dhlytton@> wrote:

> >

> > Hi Shel.  Your e-mail reminded me of something.

> >

> > I posted this e mail 12/9/08.

> >

> > "Hi :  I had a prostatectomy in 1991 and they didn't get all the cancer out.

> > I started on PC Spes when it came out and now I'm on Prostasol from Medpro.

> > My strategy is to let my PSA drift slightly up to keep my testostrone at a

> > reasonable amount ( betwwen 500 and 600).

> >

> > Last spring my PSA was 1.1 on 5 to 6 Prostasol capsules per week.  I stayed

> > on this amount and expected my PSA to drift up to 1.3 to 1.5.  Much to my

> > surprise, my Psa, taken on Nov. 26, 2008 was undetectable.  I went back to

> > the lab to check my testosterone and Vitamin D.  My testosterone was only 38

> > and my Vitamin D was 73.9 ng/ml. I take 2000IUs of Vit. D per day.

> >

> > It didn't make any sense that my testosterone should be so low on the same

> > dosage of Prostasol.  It's possible that since I'm 78 I'm producing less

> > testerone.

> >

> > I'm only going to take 2 prostasol capsules per week and see what happens in

> > 3 months.

> >

> > If anyone has an explanation, I'd love to hear it.  Don Lytton"

> >

> > Since then, I've dropped it to two per week and then one per week and it is

> > still undetectable.  I'm now taking one capsule evry other week and I'll

> > report the results in 2 months.

> >

> > I thought it might be the Vitamin D, as I had been taking Longevinex for

> > about a year earlier with no unusual results.  But about the middle of

> > September 2008 ( 2 months before my Nov 26 PSA test), I started taking a

> > supplement called Triveratrol Plus sold by Dr. Julian Whitaker.

> >

> > Each capsule contains 150mg Aloe Vera extract, 100mg tumeric extract, 50mg

> > trans resveratrol extract from Japanese knotwood root and 40 mg red wine

> > polyphenols from grapes.  I take two per day.

> >

> > I have no idea whether it's the Triveratrol Plus that's causing my

> > undetectable PSA, or maybe it's combination with Vit D.  Or it could be a

> > fluke.  Unfortunately, you can't prove anything with one person's data.  I

> > thought I'd throw this information into the mix.  Don

> >

> >

> >

> >

> >

> > From: shel litt <shellitt@>

> > Reply-To: natural_prostate_treatments@yahoogroups.com

> <mailto:natural_prostate_treatments%40yahoogroups.com>

> > Date: Mon, 6 Jul 2009 06:32:25 -0700 (PDT)

> > To: hope <HOPE-list@yahoogroups.com <mailto:HOPE-list%40yahoogroups.com> >

> > Cc: PC-ACT@yahoogroups.com <mailto:PC-ACT%40yahoogroups.com>

> > Subject: [NTPC  Yahoo Group] resveratrol produces longevity and can kill

> > cancer (??) - (longevinex)

> >

> >

> >

> >

> >

> > Has anyone here tried Longevinex?  (i was told by someone long ago that Dr

> > Myers recommends it, but cannot recall context.)

> >

> > -Shel

> >

> > Subject: Dose determines whether resveratrol

> > produces longevity or kills cancer

> > All followers of resveratrol science take note! In

> > the study abstract below, researchers describe how

> > resveratrol affects the cell cycle, that is,

> > cellular events leading to its division and

> > duplication (replication). The S-phase (synthesis

> > phase) of the cell cycle is when DNA synthesis or

> > replication occurs.

> >

> > In modest doses, resveratrol causes the S-phase cell

> > cycle to proceed in slow gear, giving more time for

> > DNA to be repaired, producing longevity. In mega-

> > doses, resveratrol accelerates the S-phase cell

> > cycle and increases cellular death, thus inducing

> > mutated tumor cells to die (apoptosis).

> >

> > Advice to consume mega-dose resveratrol (more than

> > 300 mg) appears to be ill advised. Other studies

> > confirm that mega-dose resveratrol (as little as 360

> > milligrams for a 160 lb human) shortened the lives

> > of laboratory animals on a standard calorie diet.

> >

> > The widespread false notion that the equivalent of

> > 1000 glasses of red wine is needed to produce the

> > same effect as pure resveratrol in the laboratory

> > should be dismissed. It has been shown that 3-5

> > glasses of red wine, providing 180-300 mg of daily

> > polyphenolic molecules (resveratrol, quercetin,

> > ferulic acid, malvidin, catechin, kaempferol, gallic

> > acid) produces unusual health and longevity in

> > French wine-drinking populations. Copyright 2009

> > Bill Sardi, Resveratrol Partners LLC

> >

> > For the full text of this report, email Bill Sardi at

> > bsardi@ <http://us.mc343.mail.yahoo.com/mc/compose?to=bsardi@>

> >

> >

> > British Journal Pharmacology 2009 Jun 25. [Epub

> > ahead of print]

> >

> >

> >

> > Induction of a reversible, non-cytotoxic S-phase

> > delay by resveratrol: implications for a mechanism

> > of lifespan prolongation and cancer protection.

> > Zhou R, Fukui M, Choi HJ Zhu BT.

> > Department of Pharmacology, Toxicology and

> > Therapeutics, School of Medicine, University of

> > Kansas Medical Center, Kansas City, KS, USA.

> >

> > Background and purpose: Resveratrol (RES) has been

> > shown to prolong lifespan and prevent cancer

> > formation. At present, the precise cellular

> > mechanisms of RES actions are still not clearly

> > understood, and this is the focus of this study.

> > Experimental approach: Using human hepatocellular

> > carcinoma-derived HepG2 cells as a model, we studied

> > RES-induced changes in cell growth, cell cycle

> > progression and apoptosis (death). Key results:

> >

> > RES at lower concentrations induced a strong but

> > reversible S-phase delay and mild DNA synthesis

> > inhibition, yet without causing apoptotic or

> > necrotic cell death.

> > At high concentrations, RES induced apoptosis (cell

> > death), which is mainly mediated by the

> > mitochondrial pathway.

> > Overall, RES was a relatively weak apoptotic agent.

> > Mechanistically, MEK inhibition was identified as an

> > important early signalling event for RES-induced

> > apoptosis. In comparison, activation of CDK2 and

> > checkpoint kinase 2, and inhibition of

> > phosphatidylinositol 3'-kinase/Akt signalling

> > pathway contributed to the induction by RES of a

> > reversible, non-cytotoxic S-phase delay. Conclusion

> > and implications: It is hypothesized that the

> > induction of a non-cytotoxic S-phase delay may

> > represent a useful mechanistic strategy for lifespan

> > prolongation and cancer prevention. When cell cycles

> > are selectively slowed down in the S phase, it would

> > cumulatively increase the total lifespan of an

> > organism if the total numbers of cell divisions of a

> > given organism are assumed to remain basically

> > constant. Likewise, when cells proceed through the

> > cell cycles at a reduced pace during DNA

> > replication, it may allow cells more time to repair

> > the damaged DNA, and thereby reduce the chances for

> > mutagenesis and tumor initiation.

> >

> >

> >

> > Longevinex�

> > 457 W. Allen Ave. Suite 117

> > San Dimas, CA 91773

> > http://www.longevinex.com <http://www.longevinex.com/>

> > http://www.longevinexadvantage.com <http://www.longevinexadvantage.com/>

> > (866) 405-4000

> >

> > If you wish to be removed from our mailing list,

> > please click here.

> >

> > =====================================================

> > For info on managing your subscription: http://ppml-info.org/welcome.html

> > Need more help? Send email to: prostate-request@

> > <http://us.mc343.mail.yahoo.com/mc/compose?to=prostate-request@

> > .org>

> >

> > __________ Information fr�n ESET NOD32 Antivirus, version av

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#15904

From: jessie huffman <jessie.huffman@...>
Date: Wed Jul 8, 2009 3:56 pm
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

jessie.huffman

Offline

Send Email

Don what is Dr. Julian addy. I may need to try what you are doing someday. So far I am o k but my lower back hurts a lots and I stay constipated a lots. I will be 62 this November. I started urnitating at age 55 on my birthday.

Good Luck

JESSIE HUFFMAN

MSG USAR RET TC

From: Donald Lytton <dhlytton@...>
To: natural_prostate_treatments@yahoogroups.com
Sent: Tuesday, July 7, 2009 6:42:24 PM
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

From: shel litt <shellitt@yahoo. com>
Reply-To: natural_prostate_ treatments@ yahoogroups. com
Date: Mon, 6 Jul 2009 06:32:25 -0700 (PDT)
To: hope <HOPE-list@yahoogrou ps.com>
Cc: PC-ACT@yahoogroups. com
Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

Has anyone here tried Longevinex? (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)

-Shel

Subject: Dose determines whether resveratrol
produces longevity or kills cancer
All followers of resveratrol science take note! In
the study abstract below, researchers describe how
resveratrol affects the cell cycle, that is,
cellular events leading to its division and
duplication (replication) . The S-phase (synthesis
phase) of the cell cycle is when DNA synthesis or
replication occurs.

In modest doses, resveratrol causes the S-phase cell
cycle to proceed in slow gear, giving more time for
DNA to be repaired, producing longevity. In mega-
doses, resveratrol accelerates the S-phase cell
cycle and increases cellular death, thus inducing
mutated tumor cells to die (apoptosis).

Advice to consume mega-dose resveratrol (more than
300 mg) appears to be ill advised. Other studies
confirm that mega-dose resveratrol (as little as 360
milligrams for a 160 lb human) shortened the lives
of laboratory animals on a standard calorie diet.

The widespread false notion that the equivalent of
1000 glasses of red wine is needed to produce the
same effect as pure resveratrol in the laboratory
should be dismissed. It has been shown that 3-5
glasses of red wine, providing 180-300 mg of daily
polyphenolic molecules (resveratrol, quercetin,
ferulic acid, malvidin, catechin, kaempferol, gallic
acid) produces unusual health and longevity in
French wine-drinking populations. Copyright 2009
Bill Sardi, Resveratrol Partners LLC

For the full text of this report, email Bill Sardi at
bsardi@... <http://us.mc343.. mail.yahoo. com/mc/compose? to=bsardi@ aol.com>

British Journal Pharmacology 2009 Jun 25. [Epub
ahead of print]

Induction of a reversible, non-cytotoxic S-phase
delay by resveratrol: implications for a mechanism
of lifespan prolongation and cancer protection.
Zhou R, Fukui M, Choi HJ Zhu BT.
Department of Pharmacology, Toxicology and
Therapeutics, School of Medicine, University of
Kansas Medical Center, Kansas City, KS, USA.

Background and purpose: Resveratrol (RES) has been
shown to prolong lifespan and prevent cancer
formation. At present, the precise cellular
mechanisms of RES actions are still not clearly
understood, and this is the focus of this study.
Experimental approach: Using human hepatocellular
carcinoma-derived HepG2 cells as a model, we studied
RES-induced changes in cell growth, cell cycle
progression and apoptosis (death). Key results:

RES at lower concentrations induced a strong but
reversible S-phase delay and mild DNA synthesis
inhibition, yet without causing apoptotic or
necrotic cell death.
At high concentrations, RES induced apoptosis (cell
death), which is mainly mediated by the
mitochondrial pathway.
Overall, RES was a relatively weak apoptotic agent.
Mechanistically, MEK inhibition was identified as an
important early signalling event for RES-induced
apoptosis. In comparison, activation of CDK2 and
checkpoint kinase 2, and inhibition of
phosphatidylinosito l 3'-kinase/Akt signalling
pathway contributed to the induction by RES of a
reversible, non-cytotoxic S-phase delay. Conclusion
and implications: It is hypothesized that the
induction of a non-cytotoxic S-phase delay may
represent a useful mechanistic strategy for lifespan
prolongation and cancer prevention. When cell cycles
are selectively slowed down in the S phase, it would
cumulatively increase the total lifespan of an
organism if the total numbers of cell divisions of a
given organism are assumed to remain basically
constant. Likewise, when cells proceed through the
cell cycles at a reduced pace during DNA
replication, it may allow cells more time to repair
the damaged DNA, and thereby reduce the chances for
mutagenesis and tumor initiation.

Longevinex�
457 W. Allen Ave.. Suite 117
San Dimas, CA 91773
http://www.longevin ex.com <http://www.longevin ex.com/>
http://www.longevin exadvantage. com <http://www.longevin exadvantage. com/>
(866) 405-4000

If you wish to be removed from our mailing list,
please click here.

============ ========= ========= ========= ========= =====
For info on managing your subscription: http://ppml- info.org/ welcome.html
Need more help? Send email to: prostate-request@ listserv. acor.org <http://us.mc343. mail.yahoo. com/mc/compose? to=prostate- request@listserv .acor.org>

__________ Information fr�n ESET NOD32 Antivirus, version av virussignaturdataba s 4217 (20090704) __________

Meddelandet har kontrollerats av ESET NOD32 Antivirus.

http://www.esetscan dinavia.com <http://www.esetscan dinavia.com/>

Reply | Forward

#15909

From: Donald Lytton <dhlytton@...>
Date: Thu Jul 9, 2009 12:08 am
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

donaldlytton

Offline

Send Email

Jessie: Here is Dr. Whitaker's website. Don

http://www.drwhitaker.com/default.aspx

From: jessie huffman <jessie.huffman@...>
Reply-To: natural_prostate_treatments@yahoogroups.com
Date: Wed, 8 Jul 2009 08:56:47 -0700 (PDT)
To: natural_prostate_treatments@yahoogroups.com
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

Don what is Dr. Julian addy. I may need to try what you are doing someday. So far I am o k but my lower back hurts a lots and I stay constipated a lots. I will be 62 this November. I started urnitating at age 55 on my birthday.

Good Luck

JESSIE HUFFMAN
MSG USAR RET TC

From: Donald Lytton <dhlytton@...>
To: natural_prostate_treatments@yahoogroups.com
Sent: Tuesday, July 7, 2009 6:42:24 PM
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

Hi Shel. Your e-mail reminded me of something.

I posted this e mail 12/9/08.

"Hi : I had a prostatectomy in 1991 and they didn't get all the cancer out. I started on PC Spes when it came out and now I'm on Prostasol from Medpro. My strategy is to let my PSA drift slightly up to keep my testostrone at a reasonable amount ( betwwen 500 and 600).

Last spring my PSA was 1.1 on 5 to 6 Prostasol capsules per week. I stayed on this amount and expected my PSA to drift up to 1.3 to 1.5. Much to my surprise, my Psa, taken on Nov. 26, 2008 was undetectable. I went back to the lab to check my testosterone and Vitamin D. My testosterone was only 38 and my Vitamin D was 73.9 ng/ml. I take 2000IUs of Vit. D per day.

It didn't make any sense that my testosterone should be so low on the same dosage of Prostasol. It's possible that since I'm 78 I'm producing less testerone.

I'm only going to take 2 prostasol capsules per week and see what happens in 3 months.

If anyone has an explanation, I'd love to hear it. Don Lytton"

Since then, I've dropped it to two per week and then one per week and it is still undetectable. I'm now taking one capsule evry other week and I'll report the results in 2 months.

I thought it might be the Vitamin D, as I had been taking Longevinex for about a year earlier with no unusual results. But about the middle of September 2008 ( 2 months before my Nov 26 PSA test), I started taking a supplement called Triveratrol Plus sold by Dr. Julian Whitaker.

Each capsule contains 150mg Aloe Vera extract, 100mg tumeric extract, 50mg trans resveratrol extract from Japanese knotwood root and 40 mg red wine polyphenols from grapes. I take two per day.

I have no idea whether it's the Triveratrol Plus that's causing my undetectable PSA, or maybe it's combination with Vit D. Or it could be a fluke. Unfortunately, you can't prove anything with one person's data. I thought I'd throw this information into the mix. Don

From: shel litt <shellitt@yahoo. com>
Reply-To: natural_prostate_ treatments@ yahoogroups. com
Date: Mon, 6 Jul 2009 06:32:25 -0700 (PDT)
To: hope <HOPE-list@yahoogrou ps.com <http://ps.com/> >
Cc: PC-ACT@yahoogroups. com
Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)

Has anyone here tried Longevinex? (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)

-Shel

Subject: Dose determines whether resveratrol
produces longevity or kills cancer
All followers of resveratrol science take note! In
the study abstract below, researchers describe how
resveratrol affects the cell cycle, that is,
cellular events leading to its division and
duplication (replication) . The S-phase (synthesis
phase) of the cell cycle is when DNA synthesis or
replication occurs.

In modest doses, resveratrol causes the S-phase cell
cycle to proceed in slow gear, giving more time for
DNA to be repaired, producing longevity. In mega-
doses, resveratrol accelerates the S-phase cell
cycle and increases cellular death, thus inducing
mutated tumor cells to die (apoptosis).

Advice to consume mega-dose resveratrol (more than
300 mg) appears to be ill advised. Other studies
confirm that mega-dose resveratrol (as little as 360
milligrams for a 160 lb human) shortened the lives
of laboratory animals on a standard calorie diet.

The widespread false notion that the equivalent of
1000 glasses of red wine is needed to produce the
same effect as pure resveratrol in the laboratory
should be dismissed. It has been shown that 3-5
glasses of red wine, providing 180-300 mg of daily
polyphenolic molecules (resveratrol, quercetin,
ferulic acid, malvidin, catechin, kaempferol, gallic
acid) produces unusual health and longevity in
French wine-drinking populations. Copyright 2009
Bill Sardi, Resveratrol Partners LLC

For the full text of this report, email Bill Sardi at
bsardi@... <http://us.mc343.. mail.yahoo. com/mc/compose? to=bsardi@ aol.com <http://aol.com/> >

British Journal Pharmacology 2009 Jun 25. [Epub
ahead of print]

Induction of a reversible, non-cytotoxic S-phase
delay by resveratrol: implications for a mechanism
of lifespan prolongation and cancer protection.
Zhou R, Fukui M, Choi HJ Zhu BT.
Department of Pharmacology, Toxicology and
Therapeutics, School of Medicine, University of
Kansas Medical Center, Kansas City, KS, USA.

Background and purpose: Resveratrol (RES) has been
shown to prolong lifespan and prevent cancer
formation. At present, the precise cellular
mechanisms of RES actions are still not clearly
understood, and this is the focus of this study.
Experimental approach: Using human hepatocellular
carcinoma-derived HepG2 cells as a model, we studied
RES-induced changes in cell growth, cell cycle
progression and apoptosis (death). Key results:

RES at lower concentrations induced a strong but
reversible S-phase delay and mild DNA synthesis
inhibition, yet without causing apoptotic or
necrotic cell death.
At high concentrations, RES induced apoptosis (cell
death), which is mainly mediated by the
mitochondrial pathway.
Overall, RES was a relatively weak apoptotic agent.
Mechanistically, MEK inhibition was identified as an
important early signalling event for RES-induced
apoptosis. In comparison, activation of CDK2 and
checkpoint kinase 2, and inhibition of
phosphatidylinosito l 3'-kinase/Akt signalling
pathway contributed to the induction by RES of a
reversible, non-cytotoxic S-phase delay. Conclusion
and implications: It is hypothesized that the
induction of a non-cytotoxic S-phase delay may
represent a useful mechanistic strategy for lifespan
prolongation and cancer prevention. When cell cycles
are selectively slowed down in the S phase, it would
cumulatively increase the total lifespan of an
organism if the total numbers of cell divisions of a
given organism are assumed to remain basically
constant. Likewise, when cells proceed through the
cell cycles at a reduced pace during DNA
replication, it may allow cells more time to repair
the damaged DNA, and thereby reduce the chances for
mutagenesis and tumor initiation.

Longevinex�
457 W. Allen Ave.. Suite 117
San Dimas, CA 91773
http://www.longevin ex.com <http://ex.com/> <http://www.longevin ex.com/ <http://ex.com/> >
http://www.longevin exadvantage. com <http://www.longevin exadvantage. com/>
(866) 405-4000

If you wish to be removed from our mailing list,
please click here.

============ ========= ========= ========= ========= =====
For info on managing your subscription: http://ppml- info.org/ <http://info.org/> welcome.html
Need more help? Send email to: prostate-request@ listserv. acor.org <http://acor.org/> <http://us.mc343. mail.yahoo. com/mc/compose? to=prostate- request@listserv .acor.org>

__________ Information fr�n ESET NOD32 Antivirus, version av virussignaturdataba s 4217 (20090704) __________

Meddelandet har kontrollerats av ESET NOD32 Antivirus.

http://www.esetscan dinavia.com <http://dinavia.com/> <http://www.esetscan dinavia.com/ <http://dinavia.com/> >

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