From: Patrick OShea <pjoshea13@...>
Subject: Re: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex)
To: natural_prostate_treatments@yahoogroups.com
Date: Monday, July 6, 2009, 12:49 PM

Shel,   I have used it (I recently ran out).  I have never been convinced that regular resveratrol is particularly bioavailable.  Seemed to me that Longevinex, although expensive, might almost be cheaper than other brands because of increased bioavailability.  I started out on 1 cap as a replacement for the 4-6 LEF caps I had been taking.  I moved to 4 caps when I read that a higher dose was necessary for apoptosis.   One study, though, had me worried.  It seems that at a dose required to kill cancer cells, Longevinex might actually increase mortality.  A healthy organ is in a homeostatic state in terms of cells.  Apoptosis & cell division must balance.  When the organ is under attack, there is a danger that cell death will race ahead of replacement.  However, the obligatory response to such an event is activation of NFkB, which is anti-apoptotic.  Resveratrol is just one of a number of polyphenols that can inhibit NFkB activation.  Whatever the reason, it seems that increased mortality was due to an unusually high rate of apoptosis during events that did not particularly affect controls.   The obvious concern to the PCa population is what might happen during a mild heart attack.  I raised this issue with Sardi.  I said that it seemed that I should be taking 4 caps to fight PCa - but was that a safe dose?  He replied that, unless fighting active cancer, take a low dose (1-2 caps).  It's a non-reply, but clear enough.   During the year that I was on Longevinex, my PSA continued to rise, but at a slow rate.  I can't say what Longevinex did for me, since I take a lot of other stuff.    When I shifted to 4 caps, I foolishly omitted to have a baseline PSA test.   If you are in good health (apart from PCa), it might be interesting to see what effect 4 caps has on PSA in a 1-2 month period.  I would discontinue Longevinex during times when the body is suffering from viral or bacterial insult - & upon experiencing any medical emergency.   -Patrick Dx04 @ 56 (DRE nodule 2002) |bPSA 3.3 (0.8 when nodule found)| GS=4+3, RP - no LN, no SV, but PSA nadir-0.3. DT=3 months Salvage RT 2005. Again, nadir=0.3. No HB. +AM --- On Mon, 7/6/09, shel litt <shellitt@yahoo. com> wrote: From: shel litt <shellitt@yahoo. com> Subject: [NTPC Yahoo Group] resveratrol produces longevity and can kill cancer (??) - (longevinex) To: "hope" <HOPE-list@yahoogrou ps.com> Cc: PC-ACT@yahoogroups. com Date: Monday, July 6, 2009, 9:32 AM Has anyone here tried Longevinex?  (i was told by someone long ago that Dr Myers recommends it, but cannot recall context.)   -Shel Subject: Dose determines whether resveratrol produces longevity or kills cancer All followers of resveratrol science take note! In the study abstract below, researchers describe how resveratrol affects the cell cycle, that is, cellular events leading to its division and duplication (replication) . The S-phase (synthesis phase) of the cell cycle is when DNA synthesis or replication occurs. In modest doses, resveratrol causes the S-phase cell cycle to proceed in slow gear, giving more time for DNA to be repaired, producing longevity. In mega- doses, resveratrol accelerates the S-phase cell cycle and increases cellular death, thus inducing mutated tumor cells to die (apoptosis). Advice to consume mega-dose resveratrol (more than 300 mg) appears to be ill advised. Other studies confirm that mega-dose resveratrol (as little as 360 milligrams for a 160 lb human) shortened the lives of laboratory animals on a standard calorie diet. The widespread false notion that the equivalent of 1000 glasses of red wine is needed to produce the same effect as pure resveratrol in the laboratory should be dismissed. It has been shown that 3-5 glasses of red wine, providing 180-300 mg of daily polyphenolic molecules (resveratrol, quercetin, ferulic acid, malvidin, catechin, kaempferol, gallic acid) produces unusual health and longevity in French wine-drinking populations. Copyright 2009 Bill Sardi, Resveratrol Partners LLC For the full text of this report, email Bill Sardi at bsardi@... British Journal Pharmacology 2009 Jun 25. [Epub ahead of print] Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection. Zhou R, Fukui M, Choi HJ Zhu BT. Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Background and purpose: Resveratrol (RES) has been shown to prolong lifespan and prevent cancer formation. At present, the precise cellular mechanisms of RES actions are still not clearly understood, and this is the focus of this study. Experimental approach: Using human hepatocellular carcinoma-derived HepG2 cells as a model, we studied RES-induced changes in cell growth, cell cycle progression and apoptosis (death). Key results: RES at lower concentrations induced a strong but reversible S-phase delay and mild DNA synthesis inhibition, yet without causing apoptotic or necrotic cell death. At high concentrations, RES induced apoptosis (cell death), which is mainly mediated by the mitochondrial pathway. Overall, RES was a relatively weak apoptotic agent. Mechanistically, MEK inhibition was identified as an important early signalling event for RES-induced apoptosis. In comparison, activation of CDK2 and checkpoint kinase 2, and inhibition of phosphatidylinosito l 3'-kinase/Akt signalling pathway contributed to the induction by RES of a reversible, non-cytotoxic S-phase delay. Conclusion and implications: It is hypothesized that the induction of a non-cytotoxic S-phase delay may represent a useful mechanistic strategy for lifespan prolongation and cancer prevention. When cell cycles are selectively slowed down in the S phase, it would cumulatively increase the total lifespan of an organism if the total numbers of cell divisions of a given organism are assumed to remain basically constant. Likewise, when cells proceed through the cell cycles at a reduced pace during DNA replication, it may allow cells more time to repair the damaged DNA, and thereby reduce the chances for mutagenesis and tumor initiation.. Longevinex® 457 W. Allen Ave. Suite 117 San Dimas, CA 91773 http://www.longevin ex.com http://www.longevin exadvantage. com (866) 405-4000 If you wish to be removed from our mailing list, please click here. ============ ========= ========= ========= ========= ===== For info on managing your subscription: http://ppml- info.org/ welcome.html Need more help? 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