Having problems with message search?
Marc,
I hope everyone realizes that the phase I clinical trial is not expected to result in anyone being cured. The low dose(s) of BCG that will be administered during this phase I must first show safety before going onto phase II. No safety issues are expected seeing that BCG has been administered to millions of people and has a good safety track record. The uniqueness of this trial is that the scientists will now have the ability to measure the effect of BCG during phase I based on the automation of the blood assay that they have been working on. At best, we hope that the low doses will have a decreased effect on the targeted autoreacitve T cells in all of the patients. They will be collecting valuable data inlcuding TNF alpha levels and C-peptide that will help them proceed to phase II to increase dosing intensity and/or frequency of BCG with the goal of killing off all of the targeted
autoreactive T cells. I believe that there is a shot at this point of having islet regeneration once all of the targeted T cells have been depleted. We don't know if it will be permanent or last 6months or 20 years. Research for compound 2 is needed to be done as well.
This leads me to a question. Now that the Iacocca goal of $10 million has been raised to take this research through phase I. Is the join lee now campaign going to continue to help raise funds to take the Faustman/Nathan project through phase 2 over the next few years?
Marc Davino <marc@...> wrote:
Hi Scott and others,I hope this finds you well and enjoying the summer. Some of you may have missed my June 29 email so here it is again. It was in response to a posting titled “Awfully quiet on the Faustman front.”Marc-------Greetings from The Iacocca Foundation,oundation. . We will be sending a more formal announcement via our next e-Lee electronic newsletter shortly.org/research_ news_type_ 1_diabetes. html oundation. and sign up there.org/type_ 1_type_2_ diabetes_ research_ contact.html Thank you for your support and passion.Regards,Marc J. DavinoAssistant Director, Development and CommunicationsThe Iacocca Foundation, 4th Floor 17 Arlington Street Boston ,MA 02116 617-267-7747Accelerating the pace and promise of diabetes researchP Please consider the environment before printing this e-mail.
From:nathanfaustmantrial [mailto:s@yahoogroups. com nathanfaustmantrial ] On Behalf Of Scott Strumellos@yahoogroups. com
Sent: Tuesday, July 10, 2007 8:25 PM
To:nathanfaustmantrial s@yahoogroups. com
Subject: [nathanfaustmantrials] Re: I'd like to see a Faustman research blog Forgive me for asking, but what about someone from the Iacocca
Foundation ... they undoubtedly have more info. than we do, and it would
be nice if they could share any news they have on how the plans are
progressing.
--- In nathanfaustmantrials@yahoogroups. , "stacy_lavery"com
<stacy_lavery@...> wrote:
>
> Hi Bernard (and everyone who's feeling like it's been too quiet on the
> Faustman front) -
>
> I'm hearing that ever since Dr. Faustman has had a steady flow of
> funds coming in since last June from the Iacocca Foundation, she has
> been overwhelmingly busy trying to get the work done as quickly as
> possible. She has little to no time to write up weekly or even monthly
> research updates as she has specific progressive goals that must be
> met every 6 months in order to receive the next funding installment
> from the Iacocca Foundation's $10 million pledge.
>
> With this information, along with the latest update on June 21, 2007
> saying that the blood assay seems to be successfully automated, and
> that the trials are expected to actually begin in January 2008, I
> think we can all see that though all seemed to have fallen silent, the
> Faustman lab has been nothing but busy doing exactly what we want them
> to be doing. We want Dr. Faustman to progress toward the cure, and if
> that means less frequent updates, I think that's a valid trade-off.
>
> Take heart - soon we will know if this research will lead to a cure.
> It's never soon enough, but this one is so very close!
>
> Stacy Lavery
> Team MD Captain, JLN Campaign
> Nathan/Faustman Trials Yahoo Group Moderator
>
>
> --- In nathanfaustmantrials@yahoogroups. , "Bernard Farrell"com
> bernard.farrell@ wrote:
> >
> > I sent an e-mail to Dr. Faustman some time ago suggesting that she
> > write a blog letting us know what was happening.
> >
> > Now I don't expect a daily summary of what's happening. But even if
> > she or Dr. Nathan posted something every other week that would let
us
> > know that research is moving forward.
> >
> > Despite the lack of news, I'mr cycling again this year to raise
funds
> > for the research. If you'd like to get involved, consider signing up
> > at http://www.bikethemiles.com/ .
> >
> > Last year I raised $7,500 and this year I'm shooting for $10,000.
I'd
> > REALLY like to know that there's some life in this work.
> >
> > Research folks, please consider a blog.
> >
> > Even if all it said was things like: waiting for some piece of
> > equipment; we had a minor setback...; we made a small
breakthrough...;
> > here's out latest team member; and so on.
> >
> > Bernard
> > http://www.bernardfarrell.com/ blog/blogger. html
> >
>
Offline 
Send Email