It's only big news if you actually do something with the
information. So far no one has! Faustman has been well funded, and
I suspect that her job is done.
All we can do is wait for the next "in 5 year" therapy!

--- In nathanfaustmantrials@yahoogroups.com, "Paul Mullens"
<skywriter41@...> wrote:
>
> So, the way that I understand this is that this gene study
confirms
> what Dr Faustman has been saying for years-that these dieases are
> related, and that "training" the cells to make the correct t-cells
> will cure these diseases?
>
> Why is this such big news now, if it's already known?
>
> --- In nathanfaustmantrials@yahoogroups.com, Razvan Lefter
> <r_lefter@> wrote:
> >
> >
> > Serious diseases genes revealed
>
>
> A major advance in understanding the genetics
> behind several of the world's most common diseases has been
>
reported.
> The landmark Wellcome Trust study analysed DNA from
the
> blood of 17,000 people to find genetic
> differences.
> > They found new genetic variants for depression, Crohn's
disease,
> coronary heart disease, hypertension, rheumatoid arthritis and
type
> 1 and 2 diabetes.
> > The remarkable findings, published in
> Nature, have been hailed as a new chapter in medical
> science.
> > It is hoped they
will
> pave the way for research into new treatments and genetic
> tests.
> >
> >
>
>
>

>
>
>
> By identifying the genes underlying these conditions, our
> study should enable scientists to understand better how disease
> occurs, which people are most at risk and, in time, to produce
more
> effective, more personalised treatments
>
>
> Professor Peter
>
Donnelly
>
>
>
>

>

>
> > The £9m Wellcome Trust Case
> Control Consortium (WTCCC) involved 50 leading research groups
> analysing the DNA from 2,000 patients for each of the seven
> conditions and 3,000 healthy volunteers.
> > Genome-
> wide
> > They used "gene chips" to scan hundreds of thousands of DNA
> markers to identify common genetic differences across the whole
> genome.
> > Many of the genes identified by the team of 200 scientists were
> in parts of the genome not previously thought to be associated
with
> disease.
> > In the future it may be possible to test people for
combinations
> of genes to find out their lifetime risk of a disease, which would
> enable them to modify their lifestyle or undergo screening.
> > One of the most exciting finds was a previously unknown gene
> common to type 1 diabetes and Crohn's disease, a type of
> inflammatory bowel disorder, suggesting that they share similar
> biological pathways.
> > The team also unexpectedly found a process known as autophagy -
a
> process of clearing bacteria from within cells - is important in
the
> development of Crohn's disease.
> >
> >
>
>
>

>
>
>
> We have taken a big step forward in understanding the
genetics
> underlying some of the most prevalent diseases affecting human
> health
>
>
> Dr Mark
>
Walport
>

>
> > And in
> type 1 diabetes, they identified several genetic regions that
> increase the risk of developing the
> condition.
> > The WTCCC project has already played a part in recent reports
of
> an obesity gene, three new genes linked to type 2 diabetes, and a
> genetic region on chromosome 9 associated with coronary heart
> disease.
> > Major
> advances
> > Professor Peter Donnelly, chair of the WTCCC and professor of
> statistical science at Oxford University, said the research was
> a "new dawn" and they had learnt more in the past 12 months than
> they had in 15 years.
> > "If you think of the genome as very long road that you are
trying
> to find your way along in the dark, previously we have only been
> able to turn lights on in a small number of places, but now we can
> turn on lights in a large number of places - in this case half a
> million lights."
> > "Many of the most common diseases are very complex, involving
> both 'nature' and 'nurture', genes interacting with our
environment
> and lifestyles."
> > "By identifying the genes underlying these conditions, our
study
> should enable scientists to understand better how disease occurs,
> which people are most at risk and, in time, to produce more
> effective, more personalised treatments."
> > Dr Mark Walport, director of the Wellcome Trust, added that all
> the data are being made publicly available to ensure that
scientists
> across the globe have immediate access to the results.
> > "We have taken a big step forward in understanding the genetics
> underlying some of the most prevalent diseases affecting human
> health."
> > Matt Hunt, Science Information Manager at Diabetes UK,
said: "The
> WTCCC has been an excellent example of collaborative working and
has
> produced some exciting results about the genetics of Type 1 and
Type
> 2 diabetes."
> >
> > Story from BBC NEWS:
> > http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6724369.stm
> >
> > Published: 2007/06/06 17:00:04 GMT
> >
> > © BBC MMVII
> >
> >
> >
> > ---------------------------------
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> >
>