So, the way that I understand this is that this gene study confirms
what Dr Faustman has been saying for years-that these dieases are
related, and that "training" the cells to make the correct t-cells
will cure these diseases?

Why is this such big news now, if it's already known?

--- In nathanfaustmantrials@yahoogroups.com, Razvan Lefter
<r_lefter@...> wrote:
>
>
> Serious diseases genes revealed
>
A major advance in understanding the genetics
behind several of the world's most common diseases has been
reported.
The landmark Wellcome Trust study analysed DNA from the
blood of 17,000 people to find genetic
differences.
> They found new genetic variants for depression, Crohn's disease,
coronary heart disease, hypertension, rheumatoid arthritis and type
1 and 2 diabetes.
> The remarkable findings, published in
Nature, have been hailed as a new chapter in medical
science.
> It is hoped they will
pave the way for research into new treatments and genetic
tests.
>
>
>


>
By identifying the genes underlying these conditions, our
study should enable scientists to understand better how disease
occurs, which people are most at risk and, in time, to produce more
effective, more personalised treatments
>
Professor Peter
Donnelly

>



> The £9m Wellcome Trust Case
Control Consortium (WTCCC) involved 50 leading research groups
analysing the DNA from 2,000 patients for each of the seven
conditions and 3,000 healthy volunteers.
> Genome-
wide
> They used "gene chips" to scan hundreds of thousands of DNA
markers to identify common genetic differences across the whole
genome.
> Many of the genes identified by the team of 200 scientists were
in parts of the genome not previously thought to be associated with
disease.
> In the future it may be possible to test people for combinations
of genes to find out their lifetime risk of a disease, which would
enable them to modify their lifestyle or undergo screening.
> One of the most exciting finds was a previously unknown gene
common to type 1 diabetes and Crohn's disease, a type of
inflammatory bowel disorder, suggesting that they share similar
biological pathways.
> The team also unexpectedly found a process known as autophagy - a
process of clearing bacteria from within cells - is important in the
development of Crohn's disease.
>
>
>


>
We have taken a big step forward in understanding the genetics
underlying some of the most prevalent diseases affecting human
health
>
Dr Mark
Walport


> And in
type 1 diabetes, they identified several genetic regions that
increase the risk of developing the
condition.
> The WTCCC project has already played a part in recent reports of
an obesity gene, three new genes linked to type 2 diabetes, and a
genetic region on chromosome 9 associated with coronary heart
disease.
> Major
advances
> Professor Peter Donnelly, chair of the WTCCC and professor of
statistical science at Oxford University, said the research was
a "new dawn" and they had learnt more in the past 12 months than
they had in 15 years.
> "If you think of the genome as very long road that you are trying
to find your way along in the dark, previously we have only been
able to turn lights on in a small number of places, but now we can
turn on lights in a large number of places - in this case half a
million lights."
> "Many of the most common diseases are very complex, involving
both 'nature' and 'nurture', genes interacting with our environment
and lifestyles."
> "By identifying the genes underlying these conditions, our study
should enable scientists to understand better how disease occurs,
which people are most at risk and, in time, to produce more
effective, more personalised treatments."
> Dr Mark Walport, director of the Wellcome Trust, added that all
the data are being made publicly available to ensure that scientists
across the globe have immediate access to the results.
> "We have taken a big step forward in understanding the genetics
underlying some of the most prevalent diseases affecting human
health."
> Matt Hunt, Science Information Manager at Diabetes UK, said: "The
WTCCC has been an excellent example of collaborative working and has
produced some exciting results about the genetics of Type 1 and Type
2 diabetes."
>
> Story from BBC NEWS:
> http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6724369.stm
>
> Published: 2007/06/06 17:00:04 GMT
>
> © BBC MMVII
>
>
>
> ---------------------------------
> Fussy? Opinionated? Impossible to please? Perfect. Join Yahoo!'s
user panel and lay it on us.
>