Forget about the fundraisers jumping on board at that point. IF BCG
halts the autoimmune attach I would like to see the government step
in an recognize that curing major disease is with our reach and let
them DO SOMETHING to advance the research!!!

--- In nathanfaustmantrials@yahoogroups.com, "rmccully2000"
<rmccully2000@...> wrote:
>
>
> Perhaps if BCG is successful in temporarily halting the autoimmune
> attack, then millions of the research money raised would start
> funnelling into the search for the second compound? Hopefully the
> fundraising machines will jump on board at that point.
>
> Regardless, even if it did take that long for a permanent solution,
> this would still be 10 - 15 years that my son will not have to take
> insulin, count carbs, wear sensors and insulin pumps, carry
glucagon,
> meters, strips, poker and glucose tabs, go to the nurse as often,
> etc. etc. etc.
>
> Becky, Mom to Mason, 7
>
> --- In nathanfaustmantrials@yahoogroups.com, "stilltypeone"
> <stilltypeone@> wrote:
> >
> > From Lynne Murphy at MGH:
> >
> > "Keep checking our website www.faustmanlab.org for updated
> > information. We will also be informing all individuals in our
> > database when the clinical trial is about to start. I think we
are
> > planning for early 2008."
> >
> > I believe this is for the BCG arm of the trial only. They have
yet
> > to identify the second agent, to make this "cure" permanent.
> >
> > Possibly another 10 to 15 years to identify the second agent?
> >
> >
> > --- In nathanfaustmantrials@yahoogroups.com, "imcimc1"
> > <curtieimc@> wrote:
> > >
> > >
> > > Go the below website and lok on the right hand side
> > under "Contact" and
> > > it will give you information on who to contact about the trials.
> > >
> > > http://www.faustmanlab.org <http://www.faustmanlab.org>
> > >
> > >
> > >
> > >
> > > --- In nathanfaustmantrials@yahoogroups.com, "mjspicer51"
> > > <mjspicer51@> wrote:
> > > >
> > > > I am new to this group. I have been waiting for 20+ years to
> see
> > a
> > > > cure or a real hope of a cure...What is happening seems to be
> > faster
> > > > than the ADA who seems satisfied with the band aid of using
> > insulin
> > > > instead of finding a real cure. How do I get my name on the
list
> > > > for the trials? I have two grandsons who I hope never have to
> > deal
> > > > with this desease personally. Thank you, would love to hear
from
> > > > anyone on this situation --- In
> > > > nathanfaustmantrials@yahoogroups.com, "imcimc1" curtieimc@
> > > > wrote:
> > > > >
> > > > > They have to automate the process. They cannot monitor even
a
> > > > small
> > > > > group of people effectively day after day during the trial
> > without
> > > > > automation. I would rather see this automation process get
off
> > > > the
> > > > > ground now instead of after phase 1 of the trial is
finished.
> > At
> > > > > least the are working with some kind of vision and greater
> > plan in
> > > > > mind. My fingers are crossed with this one.
> > > > >
> > > > > --- In nathanfaustmantrials@yahoogroups.com, "stilltypeone"
> > > > > <stilltypeone@> wrote:
> > > > > >
> > > > > > Sue, thanks for the info. I am still baffled that they
> chose
> > to
> > > > > > spend time and money on the automation process, when it
may
> > be a
> > > > > > moot point.
> > > > > > If they can count T cells from hundreds of mice, can they
> > not do
> > > > > the
> > > > > > same for such a small sample of humans?
> > > > > >
> > > > > >
> > > > > > --- In nathanfaustmantrials@yahoogroups.com, Sue root
> > > > > > <susan_root@> wrote:
> > > > > > >
> > > > > > > The procedure to separate and count the targeted T
cells
> > from
> > > > > > whole blood samples in humans takes 1 ½ days by hand.
Seeing
> > > > that
> > > > > > they plan to ultimately take blood samples every other
day
> > from
> > > > the
> > > > > > patients to monitor the effect, and they will plan to
have
> 40
> > > > > > patients in the trial with controls, the automation will
> make
> > > > this
> > > > > > possible in a timely manner by decreasing the procedure
to
> > only
> > > > > > about 6 hrs. More importantly, standardizing dosing in
mice
> > is
> > > > much
> > > > > > less of an issue compared to humans, even if we're
talking
> 40
> > > > people
> > > > > > > Even though the NOD mouse is the best known animal
model
> > for
> > > > type
> > > > > > I diabetes, when dosing in mice, one doesn't have to deal
> > with
> > > > > > variables such as body weight. The groups of mice are
born
> at
> > > > the
> > > > > > same time, are the same size, and develop diabetes
roughly
> > the
> > > > same
> > > > > > time. Therefore, being able to standardize the dosing of
> BCG
> > in
> > > > a
> > > > > > group of humans with such variables, will be a key factor
> for
> > > > > > success.
> > > > > > > What we do know is that the NOD mice have the same 2
> > defects
> > > > > > found in humans with type I diabetes and the treatment
that
> > Dr.
> > > > > > Faustman used targets and eliminates these defects.
> > > > > > >
> > > > > > >
> > > > > > > stilltypeone <stilltypeone@> wrote:
> > > > > > > Patsy, I think you are misunderstanding what I am
> > > > > > inferring.
> > > > > > > The point I am making is why spend so much time and
money
> > on a
> > > > > > > automation process that, in the end may end up as
useless.
> > > > Kind
> > > > > of
> > > > > > > like the "cart before the horse". Why not do the
initial
> > trial
> > > > by
> > > > > > > hand, as the mouse trials were done. If sucessful, then
> > move
> > > > on
> > > > > to
> > > > > > > scale this up to a larger group trial.
> > > > > > > I would not expect death from BCG injections, as it is
> > used in
> > > > > > huge
> > > > > > > quantities for bladder cancer.
> > > > > > > The begining trial as I understand it will be 40
> > individuals.
> > > > I
> > > > > > > consider that "small". I realize that is a relative
term.
> > > > > > > If asking questions is "grumbling" then I am guilty.
> > > > > > >
> > > > > > > --- In nathanfaustmantrials@yahoogroups.com, Patsy Van
> > Huyck
> > > > > > > <patsy@> wrote:
> > > > > > > >
> > > > > > > > The answer in short is because if a mouse dies, nobody
> > > > cares.
> > > > > > > Just
> > > > > > > > think if the "small human trial" was a failure either
> > due to
> > > > > > huge
> > > > > > > > complications or due to the lack of results. Do you
> think
> > > > that
> > > > > > > they
> > > > > > > > would just get to try again with another dose? The
> assay
> > is
> > > > > very
> > > > > > > > important so that the trial can be successful, and we
> can
> > > > then
> > > > > > > move to
> > > > > > > > the next stage.
> > > > > > > >
> > > > > > > > We all want the cure to have been in 2002, but
dealing
> > with
> > > > the
> > > > > > > FDA is
> > > > > > > > tediously slow. Grumbling isn't going to get the
> research
> > > > done
> > > > > > > any more
> > > > > > > > quickly.
> > > > > > > >
> > > > > > > > Patsy
> > > > > > > >
> > > > > > > > >
> > > > > > > > > Re: NEJM Correspondence
> > > > > > > > >
> > > > > > >
> > > > > >
> > > > >
> > > >
> >
>
<http://groups.yahoo.com/group/nathanfaustmantrials/message/245;_ylc=
> > > > > > >
> > > > > >
> > > > >
> > > >
> >
>
X3oDMTJxMmg3MXB1BF9TAzk3MzU5NzE1BGdycElkAzE2NDEyMTQ1BGdycHNwSWQDMTcwN
> > > > > > >
> > > > > >
> > > > >
> > > >
> >
>
TA2MTY2MgRtc2dJZAMyNDUEc2VjA2Rtc2cEc2xrA3Ztc2cEc3RpbWUDMTE3MDU4NDUyMQ
> > > > > > > -->
> > > > > > > > >
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > Posted by: "stilltypeone" stilltypeone@
> > > > > > > > > <mailto:stilltypeone@?Subject=%20Re%3A%20NEJM%
> > > > > > > 20Correspondence>
> > > > > > > > > stilltypeone
<http://profiles.yahoo.com/stilltypeone>
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > Sat Feb 3, 2007 6:57 pm (PST)
> > > > > > > > >
> > > > > > > > > Sue, can we agree that these trials will not
proceed
> > until
> > > > > > > > > the "automated assay" is completed?
> > > > > > > > > Did Faustman have this automated assay during the
> mouse
> > > > > trials?
> > > > > > > > > I am guessing the answer is no.
> > > > > > > > > So, why the need for automation for a small human
> > trial?
> > > > > > > >
> > > > > > >
> > > > > >
> > > > >
> > > >
> > >
> >
>