From Lynne Murphy at MGH:

"Keep checking our website www.faustmanlab.org for updated
information. We will also be informing all individuals in our
database when the clinical trial is about to start. I think we are
planning for early 2008."

I believe this is for the BCG arm of the trial only. They have yet
to identify the second agent, to make this "cure" permanent.

Possibly another 10 to 15 years to identify the second agent?


--- In nathanfaustmantrials@yahoogroups.com, "imcimc1"
<curtieimc@...> wrote:
>
>
> Go the below website and lok on the right hand side
under "Contact" and
> it will give you information on who to contact about the trials.
>
> http://www.faustmanlab.org <http://www.faustmanlab.org>
>
>
>
>
> --- In nathanfaustmantrials@yahoogroups.com, "mjspicer51"
> <mjspicer51@> wrote:
> >
> > I am new to this group. I have been waiting for 20+ years to see
a
> > cure or a real hope of a cure...What is happening seems to be
faster
> > than the ADA who seems satisfied with the band aid of using
insulin
> > instead of finding a real cure. How do I get my name on the list
> > for the trials? I have two grandsons who I hope never have to
deal
> > with this desease personally. Thank you, would love to hear from
> > anyone on this situation --- In
> > nathanfaustmantrials@yahoogroups.com, "imcimc1" curtieimc@
> > wrote:
> > >
> > > They have to automate the process. They cannot monitor even a
> > small
> > > group of people effectively day after day during the trial
without
> > > automation. I would rather see this automation process get off
> > the
> > > ground now instead of after phase 1 of the trial is finished.
At
> > > least the are working with some kind of vision and greater
plan in
> > > mind. My fingers are crossed with this one.
> > >
> > > --- In nathanfaustmantrials@yahoogroups.com, "stilltypeone"
> > > <stilltypeone@> wrote:
> > > >
> > > > Sue, thanks for the info. I am still baffled that they chose
to
> > > > spend time and money on the automation process, when it may
be a
> > > > moot point.
> > > > If they can count T cells from hundreds of mice, can they
not do
> > > the
> > > > same for such a small sample of humans?
> > > >
> > > >
> > > > --- In nathanfaustmantrials@yahoogroups.com, Sue root
> > > > <susan_root@> wrote:
> > > > >
> > > > > The procedure to separate and count the targeted T cells
from
> > > > whole blood samples in humans takes 1 ½ days by hand. Seeing
> > that
> > > > they plan to ultimately take blood samples every other day
from
> > the
> > > > patients to monitor the effect, and they will plan to have 40
> > > > patients in the trial with controls, the automation will make
> > this
> > > > possible in a timely manner by decreasing the procedure to
only
> > > > about 6 hrs. More importantly, standardizing dosing in mice
is
> > much
> > > > less of an issue compared to humans, even if we're talking 40
> > people
> > > > > Even though the NOD mouse is the best known animal model
for
> > type
> > > > I diabetes, when dosing in mice, one doesn't have to deal
with
> > > > variables such as body weight. The groups of mice are born at
> > the
> > > > same time, are the same size, and develop diabetes roughly
the
> > same
> > > > time. Therefore, being able to standardize the dosing of BCG
in
> > a
> > > > group of humans with such variables, will be a key factor for
> > > > success.
> > > > > What we do know is that the NOD mice have the same 2
defects
> > > > found in humans with type I diabetes and the treatment that
Dr.
> > > > Faustman used targets and eliminates these defects.
> > > > >
> > > > >
> > > > > stilltypeone <stilltypeone@> wrote:
> > > > > Patsy, I think you are misunderstanding what I am
> > > > inferring.
> > > > > The point I am making is why spend so much time and money
on a
> > > > > automation process that, in the end may end up as useless.
> > Kind
> > > of
> > > > > like the "cart before the horse". Why not do the initial
trial
> > by
> > > > > hand, as the mouse trials were done. If sucessful, then
move
> > on
> > > to
> > > > > scale this up to a larger group trial.
> > > > > I would not expect death from BCG injections, as it is
used in
> > > > huge
> > > > > quantities for bladder cancer.
> > > > > The begining trial as I understand it will be 40
individuals.
> > I
> > > > > consider that "small". I realize that is a relative term.
> > > > > If asking questions is "grumbling" then I am guilty.
> > > > >
> > > > > --- In nathanfaustmantrials@yahoogroups.com, Patsy Van
Huyck
> > > > > <patsy@> wrote:
> > > > > >
> > > > > > The answer in short is because if a mouse dies, nobody
> > cares.
> > > > > Just
> > > > > > think if the "small human trial" was a failure either
due to
> > > > huge
> > > > > > complications or due to the lack of results. Do you think
> > that
> > > > > they
> > > > > > would just get to try again with another dose? The assay
is
> > > very
> > > > > > important so that the trial can be successful, and we can
> > then
> > > > > move to
> > > > > > the next stage.
> > > > > >
> > > > > > We all want the cure to have been in 2002, but dealing
with
> > the
> > > > > FDA is
> > > > > > tediously slow. Grumbling isn't going to get the research
> > done
> > > > > any more
> > > > > > quickly.
> > > > > >
> > > > > > Patsy
> > > > > >
> > > > > > >
> > > > > > > Re: NEJM Correspondence
> > > > > > >
> > > > >
> > > >
> > >
> >
<http://groups.yahoo.com/group/nathanfaustmantrials/message/245;_ylc=
> > > > >
> > > >
> > >
> >
X3oDMTJxMmg3MXB1BF9TAzk3MzU5NzE1BGdycElkAzE2NDEyMTQ1BGdycHNwSWQDMTcwN
> > > > >
> > > >
> > >
> >
TA2MTY2MgRtc2dJZAMyNDUEc2VjA2Rtc2cEc2xrA3Ztc2cEc3RpbWUDMTE3MDU4NDUyMQ
> > > > > -->
> > > > > > >
> > > > > > >
> > > > > > >
> > > > > > > Posted by: "stilltypeone" stilltypeone@
> > > > > > > <mailto:stilltypeone@?Subject=%20Re%3A%20NEJM%
> > > > > 20Correspondence>
> > > > > > > stilltypeone <http://profiles.yahoo.com/stilltypeone>
> > > > > > >
> > > > > > >
> > > > > > > Sat Feb 3, 2007 6:57 pm (PST)
> > > > > > >
> > > > > > > Sue, can we agree that these trials will not proceed
until
> > > > > > > the "automated assay" is completed?
> > > > > > > Did Faustman have this automated assay during the mouse
> > > trials?
> > > > > > > I am guessing the answer is no.
> > > > > > > So, why the need for automation for a small human
trial?
> > > > > >
> > > > >
> > > >
> > >
> >
>