I just took this from the website, but here's what the $11.5M ($10M
from Iacocca Foundation and $1.5M from Dr. F's own fundraising) is
supposed to pay for:

The Nathan/Faustman Project – $10,000,000
Massachusetts General Hospital
Boston, MA
Preparation for a Human Clinical Trial to stop the autoimmune attack
in type 1 diabetes. Grant covers the first three years to develop an
automated system and a new assay needed to accommodate the BCG Human
Clinical Trial due to start in the fall of 2008.

Project 1:
The Faustman lab will standardize the manual separation of T cells
from human blood. Results will be validated with 50 consecutive human
blood samples and then translated to a semi-automated system. During
this time the lab will simultaneously work to standardize T cell death
assays to detect autoreactive T cells in individual human blood
samples and then incorporate the assay into the semi automated system
in preparation for the BCG Human Clinical Trial (BCG/HCT). The assay
will be used for patient selection and efficacy assessment suitable
for treatment of Type 1 diabetes using BCG in the BCG/HCT.

Project 2:
The Faustman lab will continue NOD mouse studies using the same
protocols intended to be approved for the BCG Human Clinical Trial and
will analyze the effects of such treatment on autoreactive T cells
from NOD mice.

Timeline: 18 months

Project 3:
In year two and three of this project, patients with type 1 and type 2
diabetes will be recruited along with age matched controls. Patients
will be initially characterized as to levels of autoreactive T cells
using the assay developed in Project 1. Changes in the levels of
autoreactive T cells in volunteers with type 1 diabetes will be
monitored following BCG treatment.

Hope this helps,
Stacy Lavery
Team Maryland Captain, JLN Campaign
Moderator, Nathan/Faustman Trials Yahoo Group



--- In nathanfaustmantrials@yahoogroups.com, "stilltypeone"
<stilltypeone@...> wrote:
>
> Marc, you said $11.5 mil to REACH human clinical trials. Can you
> clarify, does this INCLUDE the human clinical trials, or does this
> only include all the pre-clinical trial work?
>
>
>
> --- In nathanfaustmantrials@yahoogroups.com, "Marc Davino"
> <marc@> wrote:
> >
> > Hi,
> >
> >
> >
> > Nearly $6 million has been raised to date. Thanks to everyone for
> the
> > generous support.
> >
> >
> >
> > The price tag remains the same to reach human clinical trials -
> $11.5
> > million. The foundation has committed to $10 million and the
> Massachusetts
> > General Hospital has committed to $1.5 million.
> > http://www.iacoccafoundation.org/grants_diabetes_research.html
> describes the
> > Nathan/Faustman project in more detail.
> >
> >
> >
> > Regards,
> >
> >
> >
> > Marc J. Davino
> >
> > Assistant Director, Development and Communications
> >
> > The Iacocca Foundation
> >
> > 17 Arlington Street, 4th Floor
> >
> > Boston, MA 02116
> >
> > 617-267-7747
> >
> > marc@
> >
> > www.iacoccafoundation.org
> >
> >
> >
> > _____
> >
> > From: nathanfaustmantrials@yahoogroups.com
> > [mailto:nathanfaustmantrials@yahoogroups.com] On Behalf Of
> stilltypeone
> > Sent: Monday, October 02, 2006 9:53 PM
> > To: nathanfaustmantrials@yahoogroups.com
> > Subject: [nathanfaustmantrials] Re: Give money now?
> >
> >
> >
> > Marc, how much of the $10 million has The Iacocca Foundation
> raised
> > so far? How many millions will it take to get this into human
> > trials?
> >
> > --- In nathanfaustmantrial <mailto:nathanfaustmantrials%
> 40yahoogroups.com>
> > s@yahoogroups.com, "Marc Davino"
> > <marc@> wrote:
> > >
> > > Good afternoon,
> > >
> > >
> > >
> > > Just to clarify, The Iacocca Foundation has COMMTTED to raising
> > $10 million
> > > for the Nathan/Faustman trial. However, that number has yet to
> be
> > reached
> > > so we need to continue fundraising if we are to reach the goal.
> > >
> > >
> > >
> > > In addition, the foundation is committed to supporting
> additional
> > diabetes
> > > research projects and as such we will continue fundraising.
> > >
> > >
> > >
> > > For both of these reasons, we appreciate all of the generous
> > support we have
> > > received to date, and will receive going forward.
> > >
> > >
> > > Warm regards,
> > >
> > >
> > >
> > > Marc J. Davino
> > >
> > > Assistant Director, Development and Communications
> > >
> > > The Iacocca Foundation
> > >
> > > 17 Arlington Street, 4th Floor
> > >
> > > Boston, MA 02116
> > >
> > > 617-267-7747
> > >
> > > marc@
> > >
> > > www.iacoccafoundation.org
> > >
> > >
> > >
> > > _____
> > >
> > > From: nathanfaustmantrial <mailto:nathanfaustmantrials%
> 40yahoogroups.com>
> > s@yahoogroups.com
> > > [mailto:nathanfaustmantrial
> > <mailto:nathanfaustmantrials%40yahoogroups.com> s@yahoogroups.com]
> On Behalf
> > Of Bernard
> > Farrell
> > > Sent: Monday, October 02, 2006 1:55 PM
> > > To: nathanfaustmantrial <mailto:nathanfaustmantrials%
> 40yahoogroups.com>
> > s@yahoogroups.com
> > > Subject: Re: [nathanfaustmantrials] Give money now?
> > >
> > >
> > >
> > > Joshua
> > >
> > > You may be right overall about giving money. However my belief
> is
> > that all
> > > research could do with more money, it may help speed up building
> of
> > > equipment. I also strongly believe that if this research got a
> lot
> > of
> > > funding others may consider looking into this area, and the more
> > folks
> > > working on a problem area the more likely we are to see
> progress.
> > >
> > > Bernard
> > >
> > > On 10/2/06, Joshua Levy <joshualevy@yahoo. <mailto:joshualevy@>
> > > com> wrote:
> > >
> > >
> > > My questions is: should we give money to this research now? If
> so,
> > > why?
> > >
> > > I know that sounds like a strange question (especially for this
> > board),
> > > but my understanding is this:
> > > 1. The Faustman/Nathan human trials have been funded for $10
> > million
> > > dollars; all the money they asked for.
> > > 2. They are not going to actually start human trials until fall
> > 2008.
> > > 3. This delay is based on pre-clinical work and building
> > equipment, and
> > > will not be sped up by more money.
> > > 4. Even if the trial works, there can not be a follow-on trial
> > until
> > > fall 2009, at the very earliest.
> > >
> > > So if my goal is to cure type-1 as quickly as possible, why
> should
> > I
> > > donate more money to this research right now? Why not wait until
> > 2008
> > > and 2009?
> > >
> > > Joshua Levy
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > > ------------------------------------------------------
> > > Read my blog at:
> > > http://www.bernardf
> > <http://www.bernardf
> <http://www.bernardfarrell.com/blog/blogger.html>
> > arrell.com/blog/blogger.html>
> > > arrell.com/blog/blogger.html
> > >
> >
>