scottlp2:
> Paul,
>
> I gather you're not concerned about the recent alt-711
> developements?
>
>http://www.corporate-ir.net/ireye/ir_site.zhtml?ticker=ALT&script=416&layout=7&\
item_id=678834
>
> "In December 2004, the company announced that findings of a
> two-year toxicity study indicated that male Sprague Dawley rats
> exposed to high doses of alagebrium over their natural lifetime
> developed dose-related increases in liver cell alterations and
> tumors, and that the liver tumor rate was slightly over the
> expected background rate in this gender and species of rat"
>
> [The problem with this announcement is its lack of precise
> information. "high doses" has no scientific meaning. I and others
> I know are using very low doses (only 1-2 mg/kg daily) and only
> for the latter part of a lifetime. In addition, both Kitty and
> I are taking many liver beneficial nutrients (such as sylibinin,
> N-acetyl cysteine, taurine, etc). I am watching and waiting for
> more information, but until it is forthcoming, my estimate is
> that the benefits are worth the risk. --Paul]

[Micky:] I remember a post in which Paul mentions his liver
enzymes being too high, but could not find it.

[I made a comment about my ALT level with respect to the 10/22/02 blood test
results on the page:
http://morelife.org/personal/health/labtestsintro_paul.html

For some reason, I did not mention it in my comments on the 3/1/04 blood tests.
It appears that I was so busy looking at other parameters that I did not notice
that it had risen further to 52 and then dropped back to 44 a year ago (still
slightly higher than the normal range given for these tests although other
sources give 50 as the upper limit of normal).

Although I would like it to be lower, and I will work on it, this enzyme
elevation is not necessarily related to ALT-711, since I take many other
chemicals (aminoguanidine, metformin, etc) which can elevate liver enzymes that
need to deal with them. According to
http://www.gpnotebook.co.uk/simplepage.cfm?ID=1926234188&linkID=907&cook=no
what I have is "asymptomatic raised aminotransferase levels" (ALT only) and the
recommended approach for any such elevated level under 80 is merely to watch and
wait with at least once yearly testing. This medical site also makes the point
that "Mild hepatic injury tends to increase the ratio of cytoplasmic ALT to AST;
more severe disease reverses the trend". So at most I have mild hepatic injury,
but see below why I may not have any actual injury at all. --Paul]


I could see on morelife.org Paul lab results,
http://morelife.org/personal/health/Bldtests_Paul.xls
which shows elevated ALT (above ref range) since October 2002, though the "rise"
has started earlier. Could be just a coincidence, but it does seem suspicious.

[The fact that it began even before starting ALT-711 shows that it also results
from many other chemicals that I take. A high liver enzyme does not indicate
incipient cancer. It merely implies that the liver is needing to cope with
disposal of a lot of strange chemicals. The liver is thus working harder and
producing more enzymes than normal of which a percentage get leaked out to the
blood (that is the normal manner in which they appear in the blood). I take so
many other anti-cancer substances that I am still not concerned. However, in
order to assess the extent to which these enzyme levels are being affected by
ALT-711, I have decided to get a simple blood chemistry in July (when next in
the US) and then stop ALT-711 completely until October when I am next back there
(for the winter) at which time I will get another test. Kitty will do the same
thing. --Paul]


Kitty's AST numbers as well in range, and much less suggestive of any
problem, but there's a *slight* rise in AST which seems to have occurred at
October 2002 as well.

[Both Kitty's AST and ALT have approximately doubled since she joined me. This
is also a result of taking many strange chemicals and nutrients. --Paul]


Micky.

[Thanks for bringing this to our attention. --Paul]