I was doing a little reading today about citrulline. I haven't yet
concluded if these two articles suggest that citrulline intake should
be avoided, or if perhaps arginine is modified to citrulline and
arginine is the ultimate cause. Still, these two abstracts make me
question the idea of deliberately consuming extra citrulline. These two
articles suggest that citrulline may modify synovial fluid proteins,
and these proteins then provoke an immune-response, which may be part
of the cause of Rheumatoid Arthritis (RA). The second article is a
review on this topic.

PMID: 11665966 - Specific presence of intracellular citrullinated
proteins in rheumatoid arthritis synovium: relevance to antifilaggrin
autoantibodies.

PMID: 15574347 - Citrullinated proteins in rheumatoid arthritis.

--Max Peto