This is my response to the second part of the original for which the
subject title is still appropriate.

On 01/07/2009 11:30 PM, David Thomas Jackemeyer wrote:
>
> --- In morelife@yahoogroups.com, Paul Wakfer <paul@...> wrote:
> >
> > On 12/31/2008 11:21 AM, David Thomas Jackemeyer wrote:

<big snip of what was previously responded to>

> > > I would like to fast for extended periods, and one 2hr meal per day
> > > has been working fine for me. I would also like to exercise 45 min
> > > per day. BTW, I have completely cut out alcohol from my diet, in
> > > response to the posts related to message 1809 on Morelife Yahoo Group
> > > posted 06/04/08:
> > > http://health.groups.yahoo.com/group/morelife/message/1809
> > >
> > > Question: If I finished my (one per day) meal by noon, to what extent
> > > would exercising seven hours later disturb the important pathways
> > > hypothesized to occur during a long fast period?
> >
> > Exercise will always enhance the beneficial biochemical activities of
> > the fasting state. The time you give appears to be quite ideal.
> > Exercise is best in relation to fasting if done as long as possible
> > after eating, but not so close to sleeping that it will interfere with
> > that important activity - ie it is probably best to end exercise by at
> > least 2 hours before sleep so that the body can wind down and get into
> > a very relaxed state by sleep time.
>
> I was concerned that when exercising, my body might retard autophagic
> response to fasting because of the increased liberation of energy
> stored in liver, muscles, fat, and ingested ingredients (whey
> protein, e.g.). Is this a concern?

I don't think so. If there is a great deal of stored energy, the
autophagic effects of recycling proteins will not be high anyway,
since the energy stores of carbohydrates (and fats, but to a lesser
extent because they are harder to liberate) will tend to be used first
for fuel as they are more easily converted to fuel. WRT, ingested
ingredients, the whole purpose of fasting and exercising in a fasted
state is precisely because there are no longer any ingested
ingredients available - they have all gone past the point where they
can be absorbed.

META: I had hoped that Olafur would respond to this part since he
certainly knows the area.

> If this is viable, are these concerns mitigated if exercise instead
> immediately precedes the 2hr large meal?

That would be an even better time for it. The more deeply fasted state,
the better effect of the exercise on promotion of autophagy. And 2 hrs
should give your body sufficient time to recover before the large meal.

--Paul