The following abstract seems to address, to some degree, the
question about Sinclair not having done the experimental combination
of mice being fed a standard diet plus resveratrol.

[The question referred to above is within the message at:
http://groups.yahoo.com/group/morelife/message/1267 --Paul]

Cell Metab. 2008 Jul 2. [Epub ahead of print]
Resveratrol Delays Age-Related Deterioration and Mimics
Transcriptional Aspects of Dietary Restriction without Extending Life
Span.
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N,
Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y,
Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y,
Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS,
Ungvari Z, Sinclair DA, de Cabo R.
Laboratory of Experimental Gerontology, National Institute on Aging, National
Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD
21224, USA.

A small molecule that safely mimics the ability of dietary
restriction (DR) to delay age-related diseases in laboratory animals
is greatly sought after. We and others have shown that resveratrol
mimics effects of DR in lower organisms. In mice, we find that
resveratrol induces gene expression patterns in multiple tissues
that parallel those induced by DR and every-other-day feeding.
Moreover, resveratrol-fed elderly mice show a marked reduction in
signs of aging, including reduced albuminuria, decreased
inflammation, and apoptosis in the vascular endothelium, increased
aortic elasticity, greater motor coordination, reduced cataract
formation, and preserved bone mineral density. However, mice fed a
standard diet did not live longer when treated with resveratrol
beginning at 12 months of age. Our findings indicate that
resveratrol treatment has a range of beneficial effects in mice but
does not increase the longevity of ad libitum-fed animals when
started midlife.

PMID: 18599363

Terry