--- In morelife@yahoogroups.com, Paul Wakfer <paul@...> wrote:

[big snip by moderator]

> It is unlikely that an aspirin of only 81 mg (1/4 of one adult-size
> aspirin tablet) will have any negative effects on the digestive
> system. This is even less likely if the aspirin is entericly coated
> (so that it will bypass the stomach still intact), which ours are. We
> also take many other pills and some powders with our 81 mg aspirin in
> the morning, so its concentration is diluted by other things. If taken
> in this manner or with food, I see no reason why anyone over 30 should
> not take two 81 mg aspirins daily as we do. Do not forget that while
> it is true that glucose (and glycation pressure) will be highest right
> after a meal, the blood always contains a large amount of glucose and
> in addition many other glycative chemicals are delayed metabolic
> products. Therefore, glycation is something that is constantly taking
> place in the body. This is true also for the other negative effects
> which aspirin helps to prevent or inhibit. Therefore, I think that it
> is best to have aspirin distributed and a total of 162 mg daily should
> have no negative effects at all, IMO.
>
> --Paul


Hi Paul,

Though, unfortunately in some regards, I became allergic to aspirin
about 20 years ago. From time to time people ask me for health
related advice. I have had some reservations about recommending
regular low dose aspirin due to my past recollection(s) from the
literature that NSAIDs inhibited bone formation. As you point out
most eloquently on many occassions, there are pro and con arguments
about most things. Here is a PUBMED abstract that shows an example
of this contrast.

[I have inserted the journal, title, author and facility information for the
abstract. Please do not omit it from abstracts in future. Doing so removes
important information about the abstract, and prevents those who created the
abstract and article/study from getting credit for their product. --Paul]

J Am Acad Orthop Surg. 2004 May-Jun;12(3):139-43.
Effects of nonsteroidal anti-inflammatory drugs on bone formation and
soft-tissue healing.
Dahners LE, Mullis BH.
Department of Orthopaedics, University of North Carolina School of Medicine,
Chapel Hill, NC 27599-7055, USA.

Nonsteroidal anti-inflammatory drugs continue to be prescribed as
analgesics for patients with healing fractures even though these
drugs diminish bone formation, healing, and remodeling. Inhibition
of bone formation can be clinically useful in preventing heterotopic
ossification in selected clinical situations. In this regard,
naproxen may be more efficacious than the traditional indomethacin,
and short-term administration is as effective as long-term. When
fracture healing or spine fusion is desired, nonsteroidal anti-
inflammatory drugs should be avoided. Some nonsteroidal anti-
inflammatory drugs have a positive effect on soft-tissue healing;
they stimulate collagen synthesis and can increase strength in the
early phases of repair during skin and ligament healing.
Cyclooxygenase-2 inhibitors have an adverse effect on bone healing
and may have an adverse effect on ligament healing. Therefore,
further investigation is necessary to confirm that traditional
nonsteroidal anti-inflammatory drugs may be preferable for the
healing of collagenous tissues.

PMID: 15161166

Maybe you have a more quantitative Pro/Con take on the subject with
respect to bone formation/preservation.

Thanks,

Terry