--- In morelife@yahoogroups.com, Ólafur Páll Ólafsson
<olafurpall@...>
wrote:
>
> --- In morelife@yahoogroups.com, "David Thomas Jackemeyer"
> <Olehenry1@> wrote:
> >
> > "David Thomas Jackemeyer" <Olehenry1@> wrote:
><snip>
> > You mention intake of alcohol during fasting enhances the
> > potential negatives, above the impact sustained when drinking
> > with foods -- how much worse would you predict?
>
> This is not a simple question to answer because it depends on
> several factors including of course the dose of the alcohol. Also
> the timing of the alcohol intake will effect its positive effects as
> well as its
> negative effects. With respect to the positive effects evidence
> suggests that some of the beneficial effects of moderate alcohol
> consumption are caused by a hormetic effect. This is among others
> supported by the J shaped curve that relates alcohol intake to
> mortality. To get the hormetic benefit the dose consumed must be
> large enough to cause a stress response. But if the dose is too
> large the harm will be more than the benefit from the stress
> response. This is why alcohol is only beneficial in moderation.
> Epidemiological studies suggest that somewhere around 10-40g of
> alcohol a day is the optimal
> dose for reduction in mortality (full text of PMID: 15006414). Note
> that the stress on the body from drinking a dose of alcohol spread
> over the day will be less than the stress of consuming it all in
> one dose. Thus 10g of alcohol might be enough to cause a beneficial
> hormetic response if drunken in a single dose while it may not be
> enough to cause such a response if one were to consume it in
> several small doses over the day, such as when spreading it over
> three meals.
> On the other hand 40g of alcohol is most likely enough to cause a
> beneficial hormetic response even if spread over the day. But
> taking 40g all at once would probably cause a stress response that
> is considerably higher than that needed to cause the beneficial
> hormetic response and might be high enough for the harmful effects
> to outweigh
> the beneficial ones. These numbers of course are just estimates and
> will be very individual. But note that drinking alcohol with a meal
> does spread the dose considerably compared to drinking it on a
> fasting stomach since the meal will slow down its absorption.

I'm not sure I understand the dosage figure (maybe I've mixed up
with the sugar calculation above):
My red wine contains 12% of alcohol (according to its label)
Does 10 g of alcohol a day would equal to 10*100/12 =~ 0.083 liter
(=2,82 fl oz) of wine?
If that's the case, then I assume that my regural intake of wine (I
drink around .2 liter =6.76 fl oz each day ) is within the right
range considering the fact that I drink it with my one meal a day.


> I think that generally, as long as the dose of alcohol is lower to
> compensate for it being less spread through out the day, drinking
> wine in a fasting state will not be more negative than taking it
> with a meal. But this is without taking into account the potential
> of the wine to disturb the fast by increasing glucose and reducing
> gluconeogenesis. That effect alone, even though it will only wary
> for a short time, is a good enough reason for me to think that in
> your case drinking the wine with or right after the meal will be
> more beneficial than drinking it later in the day when you are in a
> fasted state. As Paul mentioned the potential of the wine to
> interrupt important sleep processes is yet another reason not to
> drink it before you go to sleep. In conclusion I agree with Paul's
> advice that it would be better for you to drink the wine with the
> meal or right after eating it.
>
> > [I am away on a trip right now without access to all my research
> > "tools" so I cannot easily give any answer to this at the moment.
> > However, I will later plan to do some work on the metabolism of
> > alcohol and get back to this thread with information on it.
> > OTOH, if
> > Olafur reads this message, perhaps he could answer and save me
> > the effort. --Paul]
>
> Sure Paul. This subject wasn't exactly of much interest to me
> since I myself do not drink alcoholic beverages, nor do I plan to in
> part because I dislike their taste. But I'm always glad to save you
> some of the effort.

I used to dislike the taste of red wine until I was a teenager but my
father has educated my taste and it came gradually. My wife also
used to
dislike the taste of red wine before she met me.
<snip>

François Rose