Gentle Moderators,

I have a question: Do you think that there is more benefit from
taking resveratrol in higher dosages, let's say once or twice per
day, or in lower amounts more often throughout the day? Someone
else I was talking to raised the point that larger doses might more
effectively raise serum levels and better influence the SIRT1 gene
(and other possible mechanisms of benefit). I heard from a person
whom asked him directly that Dr. Sinclair takes four Longevinex
(40mg per capsule) per dose (160mg), and does so twice per day
(320mg total). Do you think he's taking the larger doses for
convenience, or perhaps for a more positive benefit than spreading
them out more often?

Disclosure: I have been taking two Longevinex per day (morning &
night) for about 18 months now. I will likely double my dosage very
soon.

Scott Miller
(DukeNukem at ImmInst.com)

[I am not aware of any experimental evidence that has answered or is relevant to
this question. The mice were simply fed the resveratrol in their food. The
biology of supplementation is far too complex to have any great hope to provide
a valid answer to such a question for many nutrients without doing comparative
experiments, so I think it is really not beneficial to speculate. I expect that
Sinclair is taking it that way with meals for convenience. That is the way that
I am taking it now within capsules containing other supplements (total of 62mg
daily) and plan to take it when I increase my dosage (to 182mg daily) by using
LEF's 20 mg stand alone resveratrol product. --Paul]

[The details of how the mice actually eat their food is not provided, although
the food was given ad lib (as much as they wanted to eat). Maybe one of the
group can provide the information of how mice in a laboratory being fed ad lib
actually consume the food given. **Kitty]

[I have not seen any evidence either that might provide an answer to this
question. Personally if I were taking resveratrol I'd take it with food as I do
with most of the supplements I take. -°Olafur]