> Clinical trials have been done in South Africa for male contraceptives.
> The University of Cape Town seems to be the main spot. The Department of
> Medical Bioscience's Prof G Van Der Horst seems like a possible person to
> contact for future trials if the Oleanolic acid treatment gets to a
human trial and Zephne van der Spuy, head of the University
> of Cape Town's department of obstetrics and gynaecology may still be
> involved in one. That is through the CDN and here is the email and
requirements I found on their website. I have not found anything more
recent than 2003 in a brief search but the head people all seem to still
work at their universities and should be able to help you. And it
always helps them to know that people are interested. Hope this helps,
Ed. Croom

http://www.crb.ed.ac.uk/CDN/interested.html

CONTRACEPTIVE DEVELOPMENT UNIT

INTERESTED IN TAKING PART?

If you would like to receive further information on participating in one
of our trials in male contraception and you are

· Aged 18 – 45

· fit and healthy

· not taking any regular medication

you can contact us at:
cdn@...
>
> SEPTEMBER GRADUATES FOR 2003
> http://www.uwc.ac.za/students/indexr.htm
>
> PHILOSOPHIAE DOCTOR
> Mdhluli Christopher Mongezi
> Thesis: " Toxicological and Antifertility Investigations of Oleanolic Acid
> in Male Vervet Monkeys (Chlorocebus aethiops)."
> Oleanolic acid, a plant-derived substance with a multitude of biological
> actions, has been investigated in this study. The candidate made major
> breakthroughs in the field of toxicology and male contraception. Firstly,
> Oleanolic acid isolated from cloves has been tested for its safety in a
> primate model, the vervet monkey. It had no detrimental effects on heart,
> liver and kidney enzymes as well as other clinical chemistry parameters.
> Mr. Mdhluli's earlier research, presented at an international conference
> in Montreal and later published, showed that Oleanolic acid causes
> reversible sterility in a rat model. On that basis, tha male contraceptive
> action was also tested in a vervet monkey model. The results showed that
> Oleanolic acid has the potential to be developed as a male contraceptive
> in humans. This is an important scientific breakthrough in the field of
> non-hormonal male contraception. The three external examiners were
> unanimous in their recommendation that the PhD degree be awarded to
> Mongezi Mdhluli. They were particularly complimentary that the study
> represented the first in-depth investigation of the safety of a
> plant-derived contraceptive substance in a primate model. This is
> cutting-edge work.
> Department of Medical Bioscience
> Supervisors: Prof G Van Der Horst
> Dr. J Seier
> Di Caelers
> November 09 2003 at 09:27AM
>
>
>
> All it took was five minutes - with no pain at all - and Maitland father
> Greg Faure found himself at the forefront of global scientific advances to
> offer men a new form of contraception right up there with the women's
> pill.
>
> Part of a group of 20 Cape Town men, Faure is one of the first to put his
> body on the line to advance the cause of male contraception. The female
> contraceptive pill was introduced in the early 1960s, and Faure's stand is
> that a male equivalent has been "a long time coming".
>
> The study will involve 60 men from three other centres - Nigeria, Shanghai
> and Hong Kong - who will try the male "pill" in the form of an implant.
>
> Faure is aware that he is unlikely to benefit from the end product - it'll
> take between seven to nine years before it's likely to be available - but
> he is adamant he wants to do this for the next generation of young men.
>
> 'A long time coming'
> The trial is being driven by Zephne van der Spuy, head of the University
> of Cape Town's department of obstetrics and gynaecology. Her team, based
> at Groote Schuur Hospital, is part of the Contraceptive Development
> Network, established 10 years ago, based in Edinburgh and funded by the
> United Kingdom Department for International Development.
>
> Simply, the aim of the researchers is to secure a hormonal contraceptive
> alternative for men. Previous work has shown the efficacy of a combination
> of testosterone and a progestogen as a contraceptive agent in men.
>
> Richard Anderson, an obstetrician gynaecologist who works in Edinburgh on
> the project and is visiting South Africa, explained that the first study
> involved testosterone pellets - about the size of a grain of rice - being
> inserted under the skin of the stomach. These were replaced every three
> months. In addition, the men took progestogen pills daily.
>
> But because the men complained that they forgot to take their daily doses,
> the new trial has substituted the pills for a long-lasting implant. This
> is inserted under the skin on the inside of the upper arm. Anderson
> explained that the progestogen implant suppressed the hormones that
> normally stimulate the testes.
>
> Men have traditionally enjoyed only three contraception choices - condoms,
> abstinence or a vasectomy - and Faure welcomed the idea that men could
> have other options. "Just because men are in long-term relationships
> doesn't mean they want to have babies. And this will even the balance.
> It'll give men the chance to make their own decision about when they want
> to become a dad," he said.
>
> 'This will even the balance'
> "If you went out there and asked men how many of them actually made the
> decision to become fathers, you'll find that not many did."
>
> Faure is 42 and has two sons, Rowan, 21, and Francois, 18, and a
> five-year-old daughter, Pascal.
>
> "All my friends had vasectomies. But it just wasn't something I wanted
> done. This was so simple. When I heard about it I had no doubt that I
> wanted to be part of seeing this product reach the public," Faure said.
>
> And for those men concerned that the implant may affect their performance
> or virility, Faure's the best person to offer that answer. "Everything's
> much more sensitive, and I'm far more energetic. I like it much better
> this way," he said.
>
> For more information, call Sister Anne Hoffman on (021) 404 3074 or (021)
> 406 6150
>
>
> Van der Spuy, Z.M. 2004. Principal Investigator, Cape Town Branch of
> Contraceptive Development Network.
>
http://www.iol.co.za/general/newsview.php?click_id=677&art_id=iol1069158772360D3\
00&set_id=16
>
>> hi, I have been researching male contraceptive methods for a while
>> now, and all that I come up with is the fact that nothing is available
>> except through clinical trials, and none of these clinical trials are
>> taking place in South Africa. Yes I understand the low-tech heat
>> methods can be tested at home, but i cannot risk using such
>> uncontrolled methods. If there is anyone, anywhere, who can assist me
>> in any way, please email me and let me know.
>> Thanks
>>
>>
>>
>>
>>
>>
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>> Service.
>>
>
>
> Ed Croom
> Graduate Student
> Toxicology Department
> North Carolina State University
> Raleigh, NC 27695
> 919-515-2275
> elcroom@...
>