The full article seems slightly easier to read and contains a helpful
conclusion.

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T5P-47MH7Y4-F-F&_cdi=5\
008&_orig=browse&_coverDate=01%2F31%2F2003&_sk=999329998&view=c&wchp=dGLbVtb-lSz\
tb&_acct=C000054413&_version=1&_userid=1749566&md5=b3f2e139599b8bf0ec398167c4672\
3b2&ie=f.pdf


--- opopieca <opopieca@...> wrote:
> Hello,
>
> I am wondering if someone can translate the below abstract so I might
>
> better understand it. Unfortunatly my background in software
> engineering is of no use... and it leaves me wondering do we really
> sound like this when we talk about our field??
>
> Thanks
>
> Owen
>
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=12826690&dopt=Abstract
>
> Abstract:
>
> J Androl. 2003 Jul-Aug;24(4):501-9. Links
>
>
> Status of Spermatogenesis and Sperm Parameters in Langur Monkeys
> Following Long-term Vas Occlusion With Styrene Maleic Anhydride.
>
> Mishra PK, Manivannan B, Pathak N, Sriram S, Bhande SS, Panneerdoss
> S, Lohiya NK.
>
> Reproductive Physiology Section, Department of Zoology, University of
>
> Rajasthan, Jaipur, India.
>
> Vas occlusion by styrene maleic anhydride (SMA), trade name RISUG
> (one of the promising male contraceptive procedures currently in
> phase III clinical trials), at 60 mg/vas deferens dissolved in 120
> micro L dimethyl sulphoxide (DMSO) at up to a 540-day study period
> caused severe oligospermia in the first 2 to 3 ejaculations and
> uniform azoospermia in the subsequent ejaculations without toxicity
> in langur monkeys. The ejaculated spermatozoa were
> necroasthenoteratozoospermic, suggesting instant sterility. Routine
> hematology and clinical chemistry parameters and the serum
> testosterone and sperm antibody titers remained unchanged from their
> pretreatment values until 540 days vas occlusion. Histology of testes
>
> revealed continued spermatogenesis throughout the study period. The
> stages of spermatogenesis appeared normal until 300 days of vas
> occlusion. At 360 days of vas occlusion, germ cells appeared in the
> lumen. Degeneration of seminiferous epithelium was evident in some of
>
> the tubules. Following 420 days of vas occlusion, the central portion
>
> of the testis showed regressed seminiferous tubules depicting various
>
> shapes and devoid of germ cells, which continued until 540 days of
> vas occlusion. Ultrastructure of the testes after 540 days of vas
> occlusion revealed vacuolization in the cytoplasm of Sertoli cells
> and degenerative features in the membranes of the spermatocytes and
> spermatids in the affected seminiferous tubules. The sub-cellular
> features of the normal tubules were similar to those of controls. The
>
> results suggest focal degeneration of seminiferous epithelium in the
> central portion of the testis following long-term vas occlusion with
> SMA.
>
>
>


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