Hello,

I am wondering if someone can translate the below abstract so I might
better understand it. Unfortunatly my background in software
engineering is of no use... and it leaves me wondering do we really
sound like this when we talk about our field??

Thanks

Owen


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=12826690&dopt=Abstract

Abstract:

J Androl. 2003 Jul-Aug;24(4):501-9. Links


Status of Spermatogenesis and Sperm Parameters in Langur Monkeys
Following Long-term Vas Occlusion With Styrene Maleic Anhydride.

Mishra PK, Manivannan B, Pathak N, Sriram S, Bhande SS, Panneerdoss
S, Lohiya NK.

Reproductive Physiology Section, Department of Zoology, University of
Rajasthan, Jaipur, India.

Vas occlusion by styrene maleic anhydride (SMA), trade name RISUG
(one of the promising male contraceptive procedures currently in
phase III clinical trials), at 60 mg/vas deferens dissolved in 120
micro L dimethyl sulphoxide (DMSO) at up to a 540-day study period
caused severe oligospermia in the first 2 to 3 ejaculations and
uniform azoospermia in the subsequent ejaculations without toxicity
in langur monkeys. The ejaculated spermatozoa were
necroasthenoteratozoospermic, suggesting instant sterility. Routine
hematology and clinical chemistry parameters and the serum
testosterone and sperm antibody titers remained unchanged from their
pretreatment values until 540 days vas occlusion. Histology of testes
revealed continued spermatogenesis throughout the study period. The
stages of spermatogenesis appeared normal until 300 days of vas
occlusion. At 360 days of vas occlusion, germ cells appeared in the
lumen. Degeneration of seminiferous epithelium was evident in some of
the tubules. Following 420 days of vas occlusion, the central portion
of the testis showed regressed seminiferous tubules depicting various
shapes and devoid of germ cells, which continued until 540 days of
vas occlusion. Ultrastructure of the testes after 540 days of vas
occlusion revealed vacuolization in the cytoplasm of Sertoli cells
and degenerative features in the membranes of the spermatocytes and
spermatids in the affected seminiferous tubules. The sub-cellular
features of the normal tubules were similar to those of controls. The
results suggest focal degeneration of seminiferous epithelium in the
central portion of the testis following long-term vas occlusion with
SMA.