&nbsp; Use of vitamin D in clinical practice

Also for a vitamin D supplement with Boron and colloidal minerals, for arthritis, bone disorders, auto-immune disorders click here

Please Note: This product is not yet available. Estimated availability February 2009

The Significance of Vitamin D Supplementation

John Claydon D.Hom

The importance of vitamin D is often over-looked. Vitamin D is a hormone like substance that is manufactured in the skin in response to sunlight exposure. Failure to obtain a least a few minutes a day of direct sunlight exposure on the skin (The Sun will not be high enough in the sky to enable UVB rays to get through to generate vitamin D in the skin for several months a year in northern climates such as northern Europe, UK, northern USA) etc will result in a deficiency of vitamin D. Deficiencies have now been linked to a multiple array of diseases and a greatly increased incidence of cancer. These diseases include arthritis, muscle weakness, multiple sclerosis, and other auto-immune disorders. In fact studies have now indicated that mortality from all causes is significantly increased in vitamin D deficient persons. This is not surprising when one considers the multitude of biochemical reactions that cannot complete without vitamin D. Even the failure to integrate calcium and magnesium that was established to be a result of vitamin D deficiency has far reaching implications for getting the health right.

One can take a broad-spectrum of nutrients and be conscientious about ones diet, but failure to address the Vitamin D issue will result in health problems, and is so commonly overlooked. This is especially true of the elderly and persons who already have compromised health, who tend not to venture outside much. This problem has been compounded by false information about the actual amount of vitamin D that we need. There have been warnings by health authorities in the past, not to take more than about 800 IU a day...but that sort of dose is obtained just from partial exposure to the sun when it is high in the sky for a few minutes. Much research has now found that larger supplemental doses are required to overcome vitamin D deficiency syndrome.

The general advice based on this knowledge and client experience, also clinical trails is to supplement initially with around 2000IU-4000IU per day for a few months, thereafter about 2000 IU is usually sufficient. Vitamin D is stored in the body. So for example, if you are exposed to strong sunlight without sunscreen for 30 minutes a day for a few weeks then the body will store enough vitamin D to last possibly a couple months.

Safety Issues (For fuller information see main article below)

In the past there were reports of toxicity of higher doses. Further investigation has found that most or all of these where for Vitamin D2, ergocalciferol. Vitamin D3 or cholecalciferol is the form natural to the body. And is not toxic, in doses below 10,000 IU.

In very rare cases persons can be hypersensitive to Vitamin D, and is usually confined to persons with such conditions are sarcoidosis, oat cell carcinoma of the lung, and non�Hodgkin's lymphoma�although other illness, such as primary hyperparathyroidism, can cause the syndrome. Periodic measurements of 25(OH)D levels and serum calcium will alert the physician to the need to do more tests, such as 1,25(OH)2D3 or PTH. For full details of safety, dose and therapeutic potential see full product information linked below.

Example Directions (for 2,000 IU capsules) Click here for order information

Vitamin D is required on a daily basis unless you expose at least face and bare arms to the sun out of doors, when the sun is at least 50 degrees above the horizon, for at least ten minutes each day, without sunscreen. In Northern countries such as the UK this is not possible for about six months a year. In the absence of the above suggested use is:

Adults Below the age of 50, typically one capsule daily.

Adults over the age of 50, typically two capsules daily

Children under the age of one, if not receiving sunlight as described, typically half a capsule daily. (Capsule may be opened and contents of half mixed with feed) Use proportionally less if Vitamin D is already added to formula feed. Vitamin D supplementation is not needed for babies if the mother is breast feeding and obtaining 4000-6000 IU Vitamin D from all sources, e.g. from sun exposure or taking this supplement.

Children 1 to 4 years old if not receiving the described sunlight typically one capsule every other day.

Children 4 to 10 years one capsules daily.

For housebound individuals with chronic health disorders higher doses are required, eg. 3 capsules daily for the first 6 months then 2 capsules daily.

Do not exceed stated dose, unless under medical supervision, i.e. have blood tested for 25(OH)D, and seeing what you need to do to keep your level around 50 ng/ml. This is a sensible measure for all suffering from long term Chronic health disorders.

Use of vitamin D in clinical practice

Alternative Medicine Review, March, 2008 by John J. Cannell, Bruce W. Hollis

The recent discovery from a meta-analysis of 18 randomized controlled trials that supplemental cholecalciferol (vitamin D) significantly reduces all-cause mortality emphasizes the medical, ethical, and legal implications of promptly diagnosing and adequately treating vitamin D deficiency. Not only are such deficiencies common, and probably the rule, vitamin D deficiency is implicated in most of the diseases of civilization. Vitamin D's final metabolic product is a potent, pleiotropic, repair and maintenance, seco-steroid hormone that targets more than 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. One of the most important genes vitamin D up-regulates is for cathelicidin, a naturally occurring broad-spectrum antibiotic.

Natural vitamin D levels, those found in humans living in a sun-rich environment, are between 40-70 ng/mL, levels obtained by few modern humans. Assessing serum 25-hydroxy-vitamin D (25(OH)D) is the only way to make the diagnosis and to assure treatment is adequate and safe. Three treatment modalities exist for vitamin D deficiency: sunlight, artificial ultraviolet B (UVB) radiation, and vitamin D supplementation. Treatment of vitamin D deficiency in otherwise healthy patients with 2,000-7,000 IU vitamin [D.sub.3] per day should be sufficient to maintain year-round 25(OH)D levels between 40-70 ng/mL. In those with serious illnesses associated with vitamin D deficiency, such as cancer, heart disease, multiple sclerosis, diabetes, autism, and a host of other illnesses, doses should be sufficient to maintain year-round 25(OH)D levels between 55-70 ng/ mL. Vitamin D-deficient patients with serious illness should not only be supplemented more aggressively than the well, they should have more frequent monitoring of serum 25(OH) D and serum calcium. Vitamin D should always be adjuvant treatment in patients with serious illnesses and never replace standard treatment. Theoretically, pharmacological doses of vitamin D (2,000 IU/kg/day for three days) may produce enough of the naturally occurring antibiotic cathelicidin to cure common viral respiratory infections, such as influenza and the common cold, but such a theory awaits further science. (Altern Med Rev 2008; 13(1):6-20)

Introduction

A recent meta-analysis of 18 randomized controlled trials (RCT) found that cholecalciferol (vitamin D) significantly reduced total mortality. (1) This discovery is all the more remarkable because of the relatively low doses of vitamin D used (mean close 528 IU (13 mcg)) and because the finding persisted across a number of subgroup analyses. In spite of the low doses used and the short duration of the trials, vitamin D's mortality reduction was seven percent. (2) Indeed, the recent discovery that statins significantly increase 25-hydroxy-vitamin D (25(OH)D) levels raise the possibility that some--or all--of the mortality reduction of statins may be mediated through increases in vitamin D levels. (3,4)

Lappe et al recently reported the first RCT of vitamin D in preventing internal cancers and found a 60-percent reduction in such cancers by increasing baseline 25(OH)D levels from 29 ng/mL to 38 ng/mL with 1,100 IU (28 mcg) per day. (5) Baseline and treatment-induced serum 25(OH)D levels were strong and independent predictors of cancer risk. Lappe et al's study left open the possibility that higher doses and higher treatment-induced 25(OH)D levels might prevent even more cancers. (Note that 25(OH)D levels are reported in the literature as either ng/mL or nmol/L; 1.0 ng/mL equals 2.5 nmol/L.)

Besides cancer, vitamin D deficiency is associated with cardiovascular disease, hypertension, stroke, diabetes, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, osteoporosis, periodontal disease, macular degeneration, mental illness, propensity to fall, and chronic pain. (6-10) A recent review presented considerable evidence that influenza epidemics, and perhaps even the common cold, are brought on by seasonal deficiencies in antimicrobial peptides (AMP), such as cathelicidin, secondary to seasonal deficiencies in vitamin D. (11) Results of an RCT support the theory, finding 2,000 IU of vitamin D/day for one year virtually eliminated self-reported incidence of colds and influenza (Figure 1). (12) Even the current triple childhood epidemics of autism (13) (Figure 2), asthma, (14) and type 1 diabetes, (15) all of which blossomed after sun-avoidance advice became widespread, might be the tragic and iatrogenic sequela of gestational or early childhood vitamin D deficiencies brought on by medical advice to avoid the sun. (Most sun screens are absorbed into the skin and blood and are quite likely toxic. Use of coconut oil is ideal, it protects skin from burning and does not block the crucially beneficial ultra-violet A and B. ed)

Claims that vitamin D may help prevent such a wide variety of diseases seem incredible until one realizes vitamin D is not a vitamin; rather, it is the only known substrate for a potent, pleiotropic, repair and maintenance, seco-steroid hormone with a single endocrine function, but multiple autocrine functions. Previously, many practitioners thought vitamin D's activity was principally its endocrine function--the regulation of serum calcium--and was thus mainly involved in bone metabolism. Indeed, the classic endocrine function of vitamin D begins when the kidney hydroxylates 25(OH)D into 1,25[(OH).sub.2]D, which then acts, both directly and indirectly, to maintain serum calcium.

However, in the last ten years, it has become clear the vitamin D steroid hormone system includes more than the classic endocrine pathway used to preserve calcium economy. (16) The enzyme that further hydroxylates 25(OH)D to 1,25[(OH).sub.2]D (activated vitamin D, the steroid hormone) is present in a wide variety of human tissues other than kidney. 1,25[(OH).sub.2]D is autonomously made in tissues and directly affects numerous cells via its autocrine, and presumed paracrine, functions. (17) Most organs show evidence of end organ responsiveness to 1,25[(OH).sub.2]D. (18) Like all steroid hormones, 1,25[(OH).sub.2]D acts as a molecular switch, activating more than 200 target genes, thereby regulating gene expression. Thus, locally produced 1,25[(OH).sub.2]D exists in most tissues of the body, is under autonomous autocrine control, and has as many mechanisms of action as genes it targets. This explains why the same substance may have a role in preventing cancer, influenza, autism, asthma, multiple sclerosis, and cardiovascular disease, not just curing rickets and osteomalacia (Figure 3).

Such claims leave practitioners with understandable skepticism and multiple questions. Is vitamin D a cure-all? When should I recommend vitamin D? How much should I prescribe? What form of vitamin D should I use? How much do children need? How much do pregnant or breastfeeding women need? Is it appropriate to use higher doses of vitamin D as adjuvant treatment for any of the above diseases? How do I interpret vitamin D blood tests and which tests should I order? What is the risk of toxicity?

Another way to ask many of these questions is, "What is an ideal 25(OH)D level?" Levels needed to optimize intestinal calcium absorption (34 ng/mL) (19) are lower than those needed to optimize neuromuscular performance (38 ng/mL). (20) Recent pooled meta-analyses estimate 25(OH)D levels of 52 ng/mL are needed to effect a 50-percent reduction in the incidence of breast cancer. (21) Although some experts believe the lower limit of adequate 25(OH)D levels is in the low 30s, (22,23) others recommend a lower limit of 40 ng/mL; (24,25) there is certainly no scientific consensus.

Ideal levels are unknown but are probably close to levels present when the human genome evolved in sub-equatorial Africa. Natural levels, such as those found at the end of summer in 30 young men who spent the summer working outdoors, were around 50 ng/mL; (26) however, these levels are obtained by only a small fraction of people. (27) Furthermore, despite such summertime levels, at the end of winter 25(OH)D levels in 50 percent of these men dropped to less than 30 ng/mL, indicating a sun-induced level of 50 ng/mL at the end of summer is inadequate to maintain such a level during wintertime.

Another way to ask the "ideal 25(OH)D" question involves understanding vitamin D's unique pharmacokinetics. Unlike any other steroid hormone system, the substrate concentrations for the liver production of 25(OH)D are absolutely rate limiting. This means the liver enzymes that initially hydroxylate vitamin D to form 25(OH)D and the enzyme in tissue that generates 1,25[(OH).sub.2]D operate below their Michaelis-Menten constants throughout the full range of modern human substrate concentrations; i.e., the reactions follow first-order mass action kinetics. (28) The more vitamin D that is ingested, the more is converted into 25(OH)D, and the more is converted into 1,25[(OH).sub.2]D in the tissues. The reaction appears to be uncontrolled; an aberrant, totally unique, and potentially dangerous situation for a steroid hormone system. Imagine, for example, if cortisol, testosterone, progesterone, or estradiol levels were entirely dependent on the intake of their substrate, cholesterol.

Hollis et al recently explained this conundrum and concluded very few humans obtain enough vitamin D even if they take several thousand units per day. (29) Hollis et al studied the pharmacokinetics of the parent compound, vitamin D, and its first metabolic product, 25(OH)D, in two groups; Hawaiians with significant sun exposure and lactating women receiving 6,400 IU of supplemental vitamin D per day. They found 25(OH)D levels had to exceed a minimum of 40 ng/ mL, and often 50 ng/mL, to begin to detect the parent compound in the blood and begin to normalize the kinetics of 25(OH)D production. In other words, when 25(OH)D levels > 40 ng/mL were achieved, the parent compound began to be detectable in the blood, the reactions became saturable and controlled (like other steroid hormone systems), and thus levels above 40 ng/mL appear to represent the lower limit of "normal" 25(OH) D levels.

This implies virtually everyone has a chronic 25(OH)D substrate deficiency, at least in the winter, and the absence of the parent vitamin D compound (cholecalciferol) in the blood means all available vitamin D is used for metabolic needs and none of it is stored. Because of this, most individuals have chronic substrate starvation, functional vitamin D deficiency, and thus, perhaps, higher risk for the "diseases of civilization."

The ideal 25(OH)D level continues to be debated in scientific circles and consensus awaits further science. However, do we wait for science to complete its work with highly seasonal 25(OH)D levels (Figure 4) that reflect sunlight deprivation, levels where vitamin D steroid pharmacokinetics are aberrant, or is it safer to wait with levels normally achieved by humans in a sunrich environment, levels where vitamin D's kinetics are normalized (>40 ng/mL)?

Once a practitioner is comfortable with ideal 25(OH)D levels being above 40 ng/mL, the answers to the questions posed above become fairly simple. Healthy humans should be supplemented with enough vitamin D or exposed to enough ultraviolet B (UVB) radiation to achieve natural 25(OH)D levels (40-70 ng/mL) year-round, whether they are infants, children, pregnant women, lactating women, healthy young adults, or the elderly.

What role vitamin D has in treating--rather than preventing--disease is largely unknown, but given vitamin D's genetic mechanism of action, it may have a significant role. For example, vitamin D reduces cellular proliferation, induces differentiation, induces apoptosis, and prevents angioneogenesis, each a laudable goal in cancer treatment. A simple risk-versus-benefit analysis suggests patients with a potentially fatal cancer (see below) may think it wise to maintain 25(OH)D levels in the high end of natural ranges (55-70 ng/mL), ranges that assure vitamin D's kinetics are normalized. While the RCTs needed to clarify vitamin D's role in the treatment of disease are being conducted, a strong case already exists for adequately diagnosing and aggressively treating vitamin D deficiency. (22,25,30)

Adult vitamin D deficiency is the rule rather than the exception in industrialized nations. (31-33) A high number of otherwise healthy children and adolescents are also vitamin D deficient. (34,35) Rickets, a disease of the industrial revolution, is being diagnosed more frequently, (36) especially in breast-fed infants. (37) Alarmingly, given mounting animal data that gestational vitamin D deficiency causes subtle but irreversible brain damage in mammalian offspring, (38,39) severe deficiencies are common in newborn infants and pregnant women, especially African-Americans. (40) A population-based study of 2,972 U.S. women of childbearing age found 42 percent of African-American women had 25(OH)D levels below 15 ng/mL, and 12 percent had levels below 10 ng/mL. (41)

More Articles of Interest

Physical examination is usually unremarkable but may reveal undue pain on sternal or tibial pressure if deficiency is severe. The vast majority of cases appear normal on exam, although frequent infections, autoimmune illness, diabetes, cancer, heart disease, major depression, and a host of other "diseases of civilization" may be warning signs that deficiency has been present for many years. (22,25)

The aged may be wheelchair-bound secondary to vitamin D deficiency-induced myopathy, yet they typically recover mobility after treatment. (50) The recent strong association of low mood and cognitive impairment in the aged with vitamin D deficiency (51) suggests depressed mood and/or impaired cognition may be presenting symptoms. A blinded intervention trial found 4,000 IU vitamin D per day improved the mood of endocrinology outpatients, (52) but there are no interventional studies of its effects on cognition.

Even without physical signs or symptoms, the physician should screen those at risk. Obtaining and properly interpreting a serum 25(OH)D level is the only way to make the diagnosis. A 25(OH)D level should be obtained at least twice yearly on any patient at risk, once in the early spring for the nadir and once in the late summer for a peak level. (53) We recommend 25(OH)D levels be kept above 40 ng/mL year-round (Figure 5).

It is crucial to remember that serum 1,25[(OH).sub.2]D levels play no role in diagnosing vitamin D deficiency. The kidney tightly controls serum 1,25[(OH).sub.2]D levels, which are often normal or even elevated in vitamin D deficiency. Therefore, a patient with normal or high 1,25[(OH).sub.2]D serum levels but low 25(OH)D levels is vitamin D deficient despite high serum levels of the active hormone. Practitioners who rely on serum 1,25[(OH).sub.2]D levels to make the diagnosis of vitamin D deficiency will routinely miss it. (25)

Treatment of Vitamin D Deficiency

Three options exist for treatment of vitamin D deficiency: sunlight, artificial UVB light, and vitamin D supplements. An exposure of 10-15 minutes of full-body summer noon-day sun or artificial UVB radiation (such as tanning beds) will input more than 10,000 IU of vitamin D into the systemic circulation of most light-skinned adults. One or two such exposures per week should maintain 25(OH)D levels in an ideal range, but adequacy should be assured by 25(OH)D blood levels. Those who choose UVB light for vitamin D repletion, from either sunlight or artificial sources, should avoid sunburn, which is associated with malignant melanoma. Furthermore, they should understand that regular UV exposure ages the skin and increases the risk of nonmelanoma skin cancers.

For the full article Click Here

For Vitamin D Supplement click here

Information from The Vitamin D council

How Much Vitamin D?

If you refuse to see a physician, or can't find a knowledgeable one, purchase the 1000 IU/day vitamin D3 cholecalciferol pills that are available over-the-counter in North America. Take an average of two pills a day (50 ug or 2,000 IU) year around if you have some sun exposure. If you have little or no sun exposure, you will need to take more than 2,000 IU per day, how much more depends on your latitude of residence, skin pigmentation, and body weight. Generally speaking, the further you live away from the equator, the darker your skin, and the more you weigh, the more you will have to take to maintain healthy blood levels. For example, Dr. Cannell lives at latitude 32 degrees, weighs 220 pounds, and has fair skin. In the late fall and winter he takes 5,000 IU per day, in the early fall and spring he takes 2,000 IU per day, and in the summer he regularly sunbathes for a few minutes most days, and thus takes no vitamin D most days in the summer. The only way you can know how much you vitamin D you need to take is by repeatedly getting your blood tested, called a 25(OH)D test, and seeing what you need to do to keep your level around 50 ng/mL.

Infants and Children

Infants and children under the age of one, should obtain a total of 1,000 IU (25 mcg) per day from their formula, sun exposure, or supplements. As most breast milk contains little or no vitamin D, breast-fed babies should take 1,000 IU per day as a supplement unless they are exposed to sunlight. The only exception to this are lactating mothers who either get enough sun exposure or take enough vitamin D (usually 4,000�6,000 IU per day) to produce breast milk that is rich in vitamin D. Formula fed babies should take an extra 600 IU per day until they are weaned and then take 1,000 IU a day, as advised below.

Children over the age of 1 year, and less than 4 years of age, should take 1,500 IU vitamin D per day, depending on body weight, latitude or residence, skin pigmentation, and sun exposure.

Children over the age of 4, and less than 10 years of age, should take 2,000 IU per day, unless they get significant sun exposure. On the days they are outside in the sun, they do not need to take any; in the winter they will need to take 2,000 IU every day.

Children over the age of 10 years old should follow instructions for adults detailed above.

Vitamin D Upper Limit

If you absolutely avoid the sun, you should have your 25(OH)D level measured and remember that a maximum of two pills a day (50 ug or 2,000 IU) is the upper limit (UL) currently listed by the Food and Nutrition Board as the amount not to exceed unless under the care of a physician. When it comes to vitamin D, the right amount is good, but a lot is not better and can be dangerous. However, 2,000 IU a day is simply not enough for many people to get the full benefit of vitamin D, nor is it enough to keep vitamin D levels around 50 ng/mL, especially in the winter.

Maintaining 25(OH)D Levels

If you are suffering from any of the diseases associated with vitamin D deficiency you need to be under the care of a knowledgeable physician. Your physician needs to replete your vitamin D system with sunlight, artificial light, oral vitamin D, or a combination of the three, while treating your vitamin D deficiency illnesses using conventional means. Regardless of the method used, we believe your physician should be certain your 25(OH)D levels are maintained between 35�65 ng/mL.

For those who do not fear the sun, judiciously expose as much skin as possible to direct midday sunlight for 1/4 the time it takes for one's skin to turn red during those months when the proper ultraviolet light occurs at one's latitude (usually late spring, summer and early fall). Do not get sunburned. Vitamin D production is already maximized before your skin turns pink and further exposure does not increase levels of vitamin D but may increase your risk of skin cancer. Black patients may need five to ten times longer in the sun than white patients, depending on skin type. After several months of judicious sun exposure, a 25(OH)D level should again be obtained to ensure levels between 35�65 ng/mL.

Several artificial light sources are commercially available that provide the proper wavelength for vitamin D production. Sperti makes a good UVB lamp and even has data available on the vitamin D production of its sunlamps.

As far as vitamin D supplements are concerned, we believe cholecalciferol is the preferred oral form of vitamin D, as it is the compound your skin makes naturally when you go in the sun. It is more potent and perhaps even safer than the synthetic analog, ergocalciferol, in more common use. Cholecalciferol is 1.7 times more efficient at raising 25(OH)D levels than is ergocalciferol.

Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth R. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr. 1998 Oct;68(4):854�8.

Calcitriol Contraindicated in VDDS (Vitamin D deficiency syndrome)

Ergocalciferol (vit D2) has been used safely by physicians for years (However vitamin D3, is better absorbed are the safest form ed) for a variety of indications. Unfortunately, when doctors don't prescribe ergocalciferol, they sometimes prescribe calcitriol or newer analogs of calcitriol, costing thousands of times more than cholecalciferol. Calcitriol, and its analogs, are contraindicated in vitamin D deficiency because they may cause hypercalcemia and they fail to address the real problem: low stores of 25(OH)D. Cholecalciferol repletes the vitamin D system by filling up your vitamin D tank with 25(OH)D, the vitamin D fuel. Vieth R. The pharmacology of vitamin D, including fortification strategies. In:Feldman D, Glorieux F, eds. Vitamin D, Chapter 61, in press, 2nd ed. Academic Press, San Diego.

Giving calcitriol, or its analogs, for vitamin D deficiency is like shooting ether into your engine to keep your car running. In addition, they pose a significant risk of hypercalcemia (high blood calcium). If you have a simple vitamin D deficiency and your doctor insists on prescribing calcitriol or an expensive analog of vitamin D (other than cholecalciferol or ergocalciferol), find another doctor.

Hypersensitivity Not Toxicity

Vitamin D hypersensitivity syndromes are often mistaken for vitamin D toxicity. This rare syndrome occurs when abnormal tissue subvert the kidney's normal regulation of endocrine 1,25(OH)2D3 (calcitriol) production. Aberrant tissues, usually granulomatous in nature, convert 25(OH)D into 1,25(OH)2D3 causing high blood calcium. The most common of such conditions are sarcoidosis, oat cell carcinoma of the lung, and non�Hodgkin's lymphoma�although other illness, such as primary hyperparathyroidism, can cause the syndrome. Periodic measurements of 25(OH)D levels and serum calcium will alert the physician to the need to do more tests, such as 1,25(OH)2D3 or PTH.

Toxicity is simply not a concern in doses below 10,000 units a day. Restoring physiological serum levels of 25(OH)D will help many more patients than it will hurt.

John Jacob Cannell MD Executive Director. For more information from the Vitamin D council click here

Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level

Vieth R, Chan PC, MacFarlane GD.

Mount Sinai Hospital, Toronto, Ontario, Canada. rvieth@...

BACKGROUND: The Food and Nutrition Board of the National Academy of Sciences states that 95 microg vitamin D/d is the lowest observed adverse effect level (LOAEL).

OBJECTIVE: Our objective was to assess the efficacy and safety of prolonged vitamin D3 intakes of 25 and 100 microg (1000 and 4000 IU)/d. Efficacy was based on the lowest serum 25-hydroxyvitamin D [25(OH)D] concentration achieved by subjects taking vitamin D3; potential toxicity was monitored by measuring serum calcium concentrations and by calculating urinary calcium-creatinine ratios. DESIGN: Healthy men and women (n = 61) aged 41 +/- 9 y (mean +/- SD) were randomly assigned to receive either 25 or 100 microg vitamin D3/d for 2-5 mo, starting between January and February. Serum 25(OH)D was measured by radioimmunoassay.

RESULTS: Baseline serum 25(OH)D was 40.7 +/- 15.4 nmol/L (mean +/- SD). From 3 mo on, serum 25(OH)D plateaued at 68.7 +/- 16.9 nmol/L in the 25-microg/d group and at 96.4 +/- 14.6 nmol/L in the 100-microg/d group. Summertime serum 25(OH)D concentrations in 25 comparable subjects not taking vitamin D3 were 46.7 +/- 17.8 nmol/L. The minimum and maximum plateau serum 25(OH)D concentrations in subjects taking 25 and 100 microg vitamin D3/d were 40 and 100 nmol/L and 69 and 125 nmol/L, respectively. Serum calcium and urinary calcium excretion did not change significantly at either dosage during the study. CONCLUSIONS: The 100-microg/d dosage of vitamin D3 effectively increased 25(OH)D to high-normal concentrations in practically all adults and serum 25(OH)D remained within the physiologic range; therefore, we consider 100 microg vitamin D3/d to be a safe intake.

For a another full article on vitamin D please see The Healing Power of Sunlight & Vitamin D

#2233

From: ANNE <anne_white53@...>
Date: Mon Feb 9, 2009 12:25 pm
Subject: Fw: The Healthy Newsletter - February 2009 note: Dr. Hull has MS

naturalrulesus

Offline

----On Mon, 2/9/09, Dr. Janet Starr Hull healthynews@... wrote:

From: Dr. Janet Starr Hull healthynews@...

DR. JANET STARR HULL'S HEALTHY NEWSLETTER
http://m1e.net/c?57512829-XpY/qYZeVIM1Q%403967944-Cf.darpBt3t8s
February 2009
Publisher: Dr. Janet Starr Hull, Ph.D., CN
By Subscription Only.
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INTRO
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Hi anne,
Splenda safety concerns are back in the news, so February's Healthy
Newsletter has some new articles and research to update your sweetener files. We have some
great feedback from clients who have used the French Green Clay so I thought I would write another article about the FGC.
Also, I have been asked by several clients from all over the USA if I am seeing
clients again. I had stopped seeing clients when I was researching and writing my Splenda book, and never reopened my office, but due to the number of recent requests to council with me in person, I decided to start taking clients again.
All the best in health!
Dr. Janet Starr Hull, Ph.D., CN
View this issue online:
http://m1e.net/c?57512829-JzclcvVYa26Ok%403967945-ZCbZUs4a99TmA
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IN THIS ISSUE
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=> Healthy Feedback
=> The Secret Of My French Green Clay - What I Learned From The Soviets
=> SIMPLIFY YOUR LIFE
=> WEIRD SCIENCE: How Splenda Was Discovered
=> Q & A with Dr. Hull
=> Did You Know?
=> This Month's Healthy Recipe
=> Featured Article: New Splenda Study Reveals Harmful Effects
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HEALTHY FEEDBACK
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Dear Dr. Janet, Thank you so much for all you do! I truly appreciate the newsletter and look forward to its arrival always. You are so very
inspirational and encouraging, just by the amount of work you put into the newsletter. Your knowledge, education, integrity and honesty are quite evident....
Continue Reading
http://m1e.net/c?57512829-38y9sw/r9mFS.%403967946-MjAXuXF.wYkT6
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THE SECRET OF MY FRENCH GREEN CLAY - WHAT I LEARNED FROM THE SOVIETS
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I wasn't always a Doctor of Nutrition. Emerging from a background in International Studies, Environmental Engineering and Toxicology, and Hazardous Waste and Emergency Response, I developed my unique approach to natural healing
by merging all three disciplines. I am a geologist, international geographer, licensed Environmental Hazardous Waste Specialist, and fire...
Continue Reading
http://m1e.net/c?57512829-6JoaOB8IK/aSY%403967947-4D06Axq3AdyFc
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SIMPLIFY YOUR LIFE
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Have you noticed people are crabbier lately? Some people are overly sensitive
to criticism, and most are becoming more insecure with their jobs and relationships. The economy is at a low in America, and people are stressed
about that, for sure. More and more people are on medications of various...
Continue Reading
http://m1e.net/c?57512829-Qc8.kTV7NhQzA%403967948-q6GXSdtSZmT92
-----------------------------------------------------------------
WEIRD SCIENCE: HOW SPLENDA WAS DISCOVERED
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The following article comes from my book, Splenda: Is it Safe Or Not? It seems that each of the artificial sweeteners have been discovered by accident, and sucralose is no exception. It is yet another strange "fortuitous
discovery" of yet another chemical sweetener. In 1976, Tate & Lyle, a British...
Continue Reading
http://m1e.net/c?57512829-nD05v4BE080hc%403967949-eRoocOK3721mA
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Q & A WITH DR. HULL
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Perfect pH: Q: Your main page says perfect pH is 6.4. You might want to get
that corrected. It's the first line result in a Google search. I almost did not
look at your site because of it. A: This is correct - 6.4. In my professional opinion, perfect body...
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http://m1e.net/c?57512829-mMnp904waFMns%403967950-F4onzTxmQXdlo
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DID YOU KNOW?
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A giraffe has the same number of bones in its neck as a human. They can also clean their ears with their half meter long tongue. Oysters can change from one
gender to another and back again depending on which is best for mating. Sapphires and rubies are both made...
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http://m1e.net/c?57512829-waIYnFM0LeTu.%403967951-skOExyhT6QxXg
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THIS MONTH'S HEALTHY RECIPE
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This month we have recipes for easy, healthy "South of the Border"
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#2232

From: Crystals MS TM LDN Website <angelindisguise67@...>
Date: Sun Feb 8, 2009 8:58 pm
Subject: Crystal's MS, TM and LDN Website - Added a Language Translator - Pass It Along!!!

angelindisgu...

Offline

http://www.freewebs.com/crystalangel6267/index.htm

Hi Everyone,

Just wanted to let everyone know I added a Language Translator to my website (Crystal�s MS, TM and LDN Website) so other people that speak different languages and from other Countries can read it and pass it along. Thought it would be a good idea�.I had one that did just English to Italian but found one that does Arabic, Chinese, Dutch, English, French, German, Italian, Japanese, Korean, Polish, Portuguese, Russian and Spanish. Let me know what you think? If it works I�ll put it on my other sites.

May there be a miracle in YOUR life today and may you have the EYES to see it.

From My Heart to Yours
Love, Hugs & Blessings,
Crystal
LDN_Users Group Owner

Diagnosed November 2004 with Secondary Progressive MS, Transverse Myelitis and an Advocate for LDN!! 3 years on LDN with Skip's Pharmacy.....No Relapses.....

Crystal's MS,TM & LDN Website
http://www.freewebs.com/crystalangel6267/index.htm

LDN Website
http://ww.ldninfo.org/

Crystal's LDN Support Group
http://health.groups.yahoo.com/group/LDN_Users/

LDN MySpace

http://www.myspace.com/lowdosenaltrexone

Cris - Case Health - Health Success Stories
http://casehealth.com/case/about.html

Crystal's LDN Gift Shop
http://www.cafepress.com/crystalldngifts

Skip's Compounding Pharmacy
http://www.skipspharmacy.com/

#2231

From: "info_getuspk" <nazpieces@...>
Date: Sat Feb 7, 2009 8:03 am
Subject: Online Nursing Degrees

info_getuspk

Offline

Online Nursing Degrees
Nursing career all over the world is thought to be an excellent and rewarding profession. The job opportunities in the field of nursing are enormous. Nursing is an extensive field.
GED
AIU Online Degrees
Life Experience Credit
Online Paralegal Degrees
Learn Chinese
CELTA

Reply | Forward | Messages in this Topic (3)

#2230

From: "tbayuk" <tbayuk@...>
Date: Fri Feb 6, 2009 2:00 pm
Subject: Fw: Study sheds new light on role of vitamin D in MS

tmbayuk

Offline

----- Original Message -----

From: Cabbie54@...

To: Upstate_NY_GRC@yahoogroups.com ; nataliamarcu@... ; Shaky036@... ; wnyselfadvocates@yahoogroups.com ; cricketshaven@yahoogroups.com ; MSchat@... ; MENDOZARJML@... ; SAVAPET@... ; marleneu@... ; tbayuk@... ; NoClue915@... ; Reno2430@... ; red857@... ; Acoma45@... ; DebbMCC@... ; SCalabria@... ; NDPMultipleSclerosisCaucus@yahoogroups.com ; fhinman@... ; adler.jmadler.jayne33@... ; HOUSLOCK@... ; abkenned@... ; Martha_Lightfoot@... ; zdum@... ; rochester_disabled@yahoogroups.com ; PWhipple@...

Sent: Thursday, February 05, 2009 7:43 PM

Subject: Study sheds new light on role of vitamin D in MS

Study sheds new light on role of vitamin D in MS
05 February 2009

A team of researchers have demonstrated a direct link between a
particular genetic variant and vitamin D which can determine an
individual's risk of developing MS.

The new evidence emerged from a study published in the journal PLoS
Genetics which found that the most important gene implicated in
susceptibility to MS, the variant gene DRB1 can be switched on by
vitamin D in laboratory experiments.

The researchers claimed that a lack of this vitamin alters the DRB1
gene, a gene that has a direct role in the functioning of a healthy
immune system.

Leading the study, George Ebers, Professor of Clinical Neurology at
the University of Oxford, suggested that a lack of vitamin D during
pregnancy and in the early years of life could increase the risk of
developing the condition later in life.

Chief Executive of the MS Trust, Pam Macfarlane, commented, 'This is
a interesting study which adds to the growing evidence of a link
between vitamin D and the risk of developing MS. A number of studies
over the years have also suggested this connection and hopefully
these results will encourage further investigation.'

Reference

Ramagopalan SV, Maugeri NJ, Handunnetthi L et al.
Expression of the multiple sclerosis associated MHC Class II Allele
HLA-DRB1*1501 is regulated by vitamin D.
PLoS Genet 2009; Genet 5(2) e1000369.
doi:10.1371/journal.pgen.1000369.
Access full article on PLoS Genetics

--- In lowdosenaltrexone@yahoogroups.com, "mgalda1999"
<mgalda1999@...> wrote:
>
> Check this out - New Study Results !!! Spread the news ---
>
>
http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20090205/Vitamin_D
_
> 090205/20090205?hub=TopStories
>

Reply to sender | Reply to group | Reply via web post
Messages in this topic (2)

3a.

Who's never won? Biggest Grammy Award surprises of all time on AOL Music.

#2229

From: "info_getuspk" <nazpieces@...>
Date: Wed Feb 4, 2009 5:52 am
Subject: MBA Programs Worldwide

info_getuspk

Offline

EQUIS Accreditation: a level of quality

MBA Programs Worldwide
The MBA is by its nature a general management qualification. An MBA program usually consists of a core curriculum covering the functional areas of management, including information systems, finance and accounting, and human resources, to name a few.

AMBA � the Association of MBA's

AACSB International

#2228

From: "info_getuspk" <nazpieces@...>
Date: Tue Feb 3, 2009 10:58 am
Subject: A+ Certification E Study Course

info_getuspk

Offline

A+ Certification E Study Course
A+ certification E Study course for aspiring IT professionals, computer specialists, computer technicians and working adults interested in launch a career in computers.
Online Bachelors Degree
Bridal Consultant
Appliance Repair Courses
Online Computer Science Training

#2227

From: "info_getuspk" <nazpieces@...>
Date: Mon Feb 2, 2009 5:24 am
Subject: MBA Admission FAQ

info_getuspk

Offline

Top-Ten Job Hunting Fallacies
MBA Degree

MBA Admission FAQ

Apply as soon as possible, however, because for most programs, decisions are made on a rolling basis and applications are evaluated in the order of their arrival.
MBA Academics
MBA Courses

Executive MBA Program

#2226

From: "John Donnelly" <john@...>
Date: Sun Feb 1, 2009 3:17 am
Subject: Database

johncarneint

Offline

Hi All

I am new to this group, I would like to ask you all to fill in a questionnaire on LDN at www.ldn-database.carnebeach.com I started this database with a few others from the yahoo group and would really appreciate your help. So we can all help others.

Thanks a million

John

#2225

From: Crystals MS TM LDN Website <angelindisguise67@...>
Date: Sat Jan 31, 2009 1:12 am
Subject: LDN Stops or Slows the Progression

angelindisgu...

Offline

A lot of people think that LDN is going to take all their symptoms away and some think that LDN will take them back before they were diagnosed with MS or any other autoimmune disorder and cancer they have. Yes LDN stops or slows your progression but it�s not a cure and LDN affects everyone different as like anything else does.

I was rereading through Mary Anne Boyle Bradley�s book �Up the Creek with a Paddle� which I suggest you buy and read if you haven�t and in one section where Mary was talking to Dr. Bihari about her husband�s MS, Dr Bihari insisted to Mary that LDN is NOT A CURE for MS and he stated that LDN would Remove The Last 3 Months Worth Of Damage if Noel (Mary�s husband) was lucky, but it seemed to be universal in Stopping Disease Progression.

Mary goes on to say that she tells Dr. Bihari about her uncle that has Parkinson�s disease. Dr Bihari told Mary that although Parkinson�s was medically documented with unknown etiology, he believed that Parkinson�s was also an autoimmune disease. Dr. Bihari told Mary that because of his success with HIV, Aids and MS, he started branching out in diseases. Dr. Bihari explained that he was very thankful for the internet because it made it possible for him to reach so many more people than ever before. Dr. Bihari was excited and told Mary at that time he had 3 Parkinson�s patients on LDN for over a year and that although it was too early then for him to say for sure that it worked, he assured Mary that it was too early then for him to say for sure that it worked and assured Mary that it looked very promising. If nothing else, Dr. Bihari insisted LDN was worth a try for Parkinson�s based on the fact that there are No Side Effects and It Is A Very Inexpensive Therapy.

Dr. Bihari explains that ANY Doctor could prescribe LDN for their patients and told Mary that he was delighted to share his information with her and wished her well. Dr. Bihari just asked that the LDN be compounded as described on the LDN Website (www.ldninfo.org). Dr. Bihari assured Mary that it was an easy thing to do and that any compounding pharmacy could do it IF instructed PROPERLY but it was important that it was compounded correctly for LDN to work!!!

This is taken from Mary Anne Boyle Bradley�s book �Up the Creek with a Paddle� (http://www.marybradleybooks.com/LDN%20Book.htm).

I just don�t want people to get false hopes and think LDN is a quick fix because its not and it takes time for LDN to get into your system and work and the main purpose of LDN is to Stop the Progression and if you get any of the other Benefits from it then that is a Big Bonus��.

Many of these questions can be answered by simply going to www.ldninfo.org and reading the information there.

Symptom improvement is not a guarantee for those with MS. LDN will not reverse the damage already done to your myelin. Though some do experience some symptom relief.

Side effects take to form of sleep disturbances (vivid dreams, waking up, etc.) for the first week or so on the med. Supposedly in 20%-30% of those first taking it. No other side effects, though people with MS also suffering from Candida overgrowth may experience a transitory increase in their MS symptoms for a couple weeks to a couple months.

The protocol for MS is 4.5mg once at night at bedtime between 9PM - 3AM. Unless you have MS and suffer from muscle spasms, then the recommended dose is 3.0mg.

Just my 2 cents�..

#2224

From: "info_getuspk" <nazpieces@...>
Date: Fri Jan 30, 2009 1:49 pm
Subject: Executive MBA Program

info_getuspk

Offline

Executive MBA Program
The Executive MBA program also has a shorter completion (similar to full-time programs), because classes are typically offered during the weekends. (Be careful: some part-time programs use the term "executive" in the name of the program, when they are in fact part-time programs for all intents and purposes.) Executive MBA programs often have minimum work experience requirements and target candidates with significant management experience.
Online MBA & Distance Learning MBA
Full Time MBA Program
The MBA Degree

#2223

From: Crystals MS TM LDN Website <angelindisguise67@...>
Date: Fri Jan 30, 2009 4:06 am
Subject: YouTube LDN Video's

angelindisgu...

Offline

http://www.youtube.com/user/CrystalAngelMSTMLDN

Crystal's YouTube LDN Video's

#2222

From: "info_getuspk" <nazpieces@...>
Date: Mon Jan 26, 2009 7:00 am
Subject: Welcome to MBA Guide Online

info_getuspk

Offline

Distance Learning MBA
MBA Careers

Welcome to MBA Guide Online

How to get into a top MBA program, doing an MBA, and after-MBA career. Also we establish a comprehensive database of business schools worldwide.

Executive MBA Program

The MBA Degree

#2221

From: "info_getuspk" <nazpieces@...>
Date: Fri Jan 23, 2009 1:32 pm
Subject: MBA Internship

info_getuspk

Offline

MBA Internship

The objective of the MBA internship program is to provide practical work experience to students enrolled in the MBA program, to allow students to apply the knowledge gained in their undergraduate education, and to allow students to apply business principles learned in their MBA coursework.
MBA Course
MBA FAQ
MBA Academics
How to Choose a business school?

#2220

From: "info_getuspk" <nazpieces@...>
Date: Thu Jan 22, 2009 9:47 am
Subject: 10,000 Filipinos should move to South Australia

info_getuspk

Offline

10,000 Filipinos should move to South Australia
The Philippine Overseas Employment Administration (POEA) has reported that South Australia needs 10,000 Filipino construction workers, welders, and pipe-fitters to emigrate to Australia in the next decade to contribute to road rehabilitation projects.
Immigration to UK
Qualifying for a Visa
Australia to revise citizenship test

#2219

From: "info_getuspk" <education_us@...>
Date: Tue Jan 20, 2009 6:31 am
Subject: MBA Internship

info_getuspk

Offline

MBA Internship

#2218

From: "nickscole" <nickscole@...>
Date: Mon Jan 19, 2009 9:42 am
Subject: Nutrition Facts : Metabolic Syndrome Away from Apple

nickscole

Offline

Adults who eat apples, apple sauce or drink apple juice have a significantly reduced risk of metabolic syndrome. Metabolic syndrome is thought to double the risk of heart attack and increase the likelihood of developing Type 2 diabetes fivefold. A person may have metabolic syndrome if he or she has a large waist size plus two or more of the following: high blood fat (triglycerides), high blood pressure, elevated fasting blood glucose and low "good" HDL cholesterol. In this new study, researchers took data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES) on food consumption and looked for an association between intake of apples and apple products, overall nutrient intake and various measures related to metabolic syndrome. When compared to adults who didn't eat apples, apple eaters were found to have a 27 percent lower risk of being diagnosed with metabolic syndrome. Apple eaters were also less likely to have high blood pressure and were 21 percent less likely to have a large waist size - two risk factors for metabolic syndrome and heart disease. Overall, apple eaters ate healthier diets than adults who didn't eat apples and had higher intakes of fruit and nutrients found in fruit, including fiber, vitamins A and C, and potassium. Apple eaters were also found to eat less fat, saturated fat, and sugar. A diet that's low in fat and saturated fat is known to be good for heart health. Canada's Food Guide recommends 7 to 8 servings of vegetables and fruits for women and 8 to 10 servings for men. One fresh apple, one-half cup (125 ml) of apple juice, or one-half cup (125 ml) of applesauce counts as one Food Guide serving of vegetables and fruits. A fresh apple with a tablespoon (15 ml) of almonds or a three-quarter cup (175 g) of low-fat yogurt makes a quick and nutritious snack. For more ideas on how to add apples to your diet, check out our October 2000 Featured Food. All research on this web site is the property of Leslie Beck and is protected by copyright. Keep in mind that research on these matters continues daily and is subject to change. The information presented is not intended as a substitute for medical treatment. It is intended to provide ongoing support of your healthy lifestyle practices. Source: Lesliebeck.com Discount Pharmacy Soma Cheap Soma Order Pharmacy Online

#2217

From: "info_getuspk" <education_us@...>
Date: Sun Jan 18, 2009 7:33 am
Subject: Online MBA Degree

info_getuspk

Offline

Online MBA Degree
The courses in this program are designed to build upon a basic understanding of finance, providing a sophisticated body of theoretical knowledge that is applicable to almost anyone's life in today's world.
International Business
e-Business Program
Technology Management
Criminal Justice MBA

#2216

From: "info_getuspk" <education_us@...>
Date: Sat Jan 17, 2009 6:37 am
Subject: Online Social Science Degree Program

info_getuspk

Offline

Online Social Science Degree Program
Online Bachelors Degree, online Masters degree, or online certificate in social science provides you with valuable career skills as well as critical thinking, reasoning and writing skills prized by employers.
Online Human Services Degree Program
Online PhD Degrees and Doctoral Program
Healthcare Management (PhD) Degree Online

#2215

From: "info_getuspk" <education_us@...>
Date: Wed Jan 14, 2009 7:28 am
Subject: Online Distance Schools

info_getuspk

Offline

Online Distance Schools
Whether one wants to obtain a degree in higher education, an MBA, PHD, or simply looking to advance in his career or trying for a new job, these can all be achieved in many ways.
Law Enforcement Training
Online High School Courses

#2214

From: Michelle Bynoe <bria73@...>
Date: Tue Jan 13, 2009 5:10 pm
Subject: FW: Can LDN Really Help Multiple Sclerosis, Rheumatoid Arthritis and Other Autoimmune Diseases?

letsgetmichelle

Offline

http://rss.mercola.com/NL/rss.aspx

I wonder if this is really good news for LDN users. Wouldn't the word getting out mean more expensive, less effective garbage to come??

Live, learn, laugh, love life

    Michelle

From: jm@...
To: bria73@...
Subject: Can LDN Really Help Multiple Sclerosis, Rheumatoid Arthritis and Other Autoimmune Diseases?
Date: Tue, 13 Jan 2009 02:47:40 -0600

Mercola Newsletter

Please use this link if you are having problems reading this newsletter:
http://articles.mercola.com/sites/current.aspx

January 13, 2009 - Issue 1212

The newsletters are also available via RSS:

Two Simple Ways to Make Sure You Get Enough Protein
Without high-quality protein, you cannot create healthy heart and muscle tissue, hormones, enzymes, and many other body structures. Here�s the simple solution: traditional whey, containing all your essential amino acids and our tasty new vegetable-based protein mix.
Get FREE SHIPPING on your ENTIRE ORDER!

Can LDN Really Help Multiple Sclerosis, Rheumatoid Arthritis and Other Autoimmune Diseases?

This inexpensive drug, normally used for narcotic overdoses, could spell relief for millions when taken in low doses.

Decades-Old Vaccine Mystery Solved -- Why Did RSV Vaccine Make Kids Sick?
Perfect example of how vaccine makers� dabbling can end up with unanticipated negative consequences.

1,000 New Species Found in Largely Unexplored Region
With animals going extinct at unprecedented rates, it's nice to be reminded that some animal species haven't even been discovered.

Berry Compound Reduces Aging Effects
Just how important is eating berries in keeping your mind and body healthy as you age?

Organic and Sustainable Farmers Can Feed the World
Can sustainable farming methods compete with conventional farming in the realm of food production?

Vaccination Escape by Homeschooling? The Simple Truth...

Why it may be necessary to go to extreme lengths to protect your children from unnecessary vaccinations.

A Brand-New Winning Health Combo Just For Women...

You probably already know I recommend Krill Oil as one of the best nutritional products you can add to your diet. But since women have unique health needs, I had Krill For Women with Evening Primrose Oil formulated exclusively for you. You�ll receive all the benefits of pure Krill Oil, plus the added nutritional support specific to your female system.

Are You Full of Toxic Impurities? Find Out Now...

As the 'Go Green' movement gains momentum and you become more environmentally conscious, it's also important to remember your internal environment too. Taking steps to rid your body of harmful toxins is crucial to keeping your body energized and rejuvenated.* That's why I recommend adding nutrient-rich Premium Chlorella to your diet. It helps detoxify and strengthen your body's internal systems.*

Vitamin D Boost and Healthy Skin Tone -- In Just Ten Minutes a Day...

Forget sunlight deprivation forever. Get essential health benefits of the sun's UVA and UVB rays in the comfort and privacy of your own home year round. Plus, support for healthy, young-looking skin. Claim your own rays of sunshine.

Shop online securely from the convenience of your home and save time and money. I guarantee the quality of our products, if you have any problems or concerns, contact customer service at:

	US Phone Orders - Please call 877.985.2695
	Int'l Phone Orders - Please call 847.252.4355

The Real Secret to Getting a Healthy Body: 92% Success Rate
To reach optimal health, you have to be able to overcome your food cravings. Recently, a national magazine tested the exact program I recommend. Of the 50 subjects tested, 92% of them were successful. Surprise -- the technique was hypnosis and the program they tested is the one I have been recommending for over a year! This program is gentle, relaxing, completely congruent with my advice, and most importantly... it works. If you are struggling and still haven't tried this program, then I recommend you read my complete review here.

Learn Bioenergetic Testing From the Leading Expert...

Considered one of the leading experts on heavy metal toxicity, Dr. Dietrich Klinghardt's courses teach non-invasive techniques for detecting and treating the underlying causes of illness.

* These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

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� Copyright Dr. Joseph Mercola, 2008. All Rights Reserved. This content may be copied in full, as long as copyright, contact, and creation information is given, only if used only in a not-for-profit format. If possible, I would also appreciate an endorsement and encouragement to subscribe to the newsletter. If any other use is desired, written permission is required.

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#2213

From: "tbayuk" <tbayuk@...>
Date: Tue Jan 13, 2009 3:40 pm
Subject: LDN

tmbayuk

Offline

Low-dose naltrexone (LDN) could treat patients with Crohn's Disease, Alzheimer�s, ovarian and pancreatic cancers, AIDS, autism and MS, to name just a few.

Naltrexone is a pharmacologically active opioid antagonist. It has primarily been used at fairly high doses to treat opioid and alcohol addiction. But at very low dosages, naltrexone has been found to have immunomodulating properties.

LDN was first used as a therapeutic agent for people with AIDS. It has been proposed for use in people with malignancies, multiple sclerosis, and autoimmune diseases. A recent publication showed a marked improvement in active Crohn�s disease for people using LDN.

Sources:

Integrative Cancer Therapies September 2007;6(3):293-6

Dr. Mercola's Comments:

Some leading experts believe that low-dose naltrexone (LDN) holds great promise for the treatment of millions of people suffering with autoimmune diseases, central nervous system disorders, and even cancer and HIV/AIDS.

It�s extremely low-cost, and appears to be virtually free of detrimental side effects.

So why haven�t you heard about this before?

What is Naltrexone?

Naltrexone (generic name) is a pharmacologically active opioid antagonist, conventionally used to treat drug- and alcohol addiction � normally at doses of 50mg to 300mg. As such, it�s been an FDA approved drug for over two decades.

However, researchers have found that at very low dosages (3 to 4.5 mg), naltrexone has immunomodulating properties that may be able to successfully treat cancer malignancies and a wide range of autoimmune diseases like rheumatoid arthritis, multiple sclerosis (MS), Parkinson�s, fibromyalgia, and Crohn�s disease, just to name a few.

At least one physician, Dr. Jacquelyn McCandless, has even found LDN to have a positive effect on children with autism.

Recently I had the pleasure of interviewing Dr. Burton M. Berkson, MD, for my Inner Circle,expert interview series, and he attested to achieving phenomenal results with low-dose naltrexone (LDN) in both cancer patients and those with autoimmune diseases.

Unfortunately, very few physicians are aware of LDN, and none of the pharmaceutical giants back it, meaning there are no friendly sales reps visiting your doctor talking about the potential benefits of this drug in very low doses.

And why would they?

At an average price of $15 to $40 for a month�s supply, the income potential from LDN doesn�t even come off in the rounding. It�s completely insignificant.

How Does Low-Dose Naltrexone (LDN) Work for Autoimmune Diseases and Cancer?

A growing body of research over the past 20 years indicates that your body�s secretion of endorphins (your internal, natural opioids) play an important, if not central, role in the workings of your immune system.

A review article entitled Opioid Therapy for Chronic Pain, published in a 2003 issue of the New England Journal of Medicine, states:

"Opioid-Induced Immune Modulation: .... Preclinical evidence indicates overwhelmingly that opioids alter the development, differentiation, and function of immune cells, and that both innate and adaptive systems are affected.

Bone marrow progenitor cells, macrophages, natural killer cells, immature thymocytes and T cells, and B cells are all involved.

The relatively recent identification of opioid-related receptors on immune cells makes it even more likely that opioids have direct effects on the immune system."

As explained on the informative website www.lowdosenaltrexone.org, when you take LDN at bedtime -- which blocks your opioid receptors for a few hours in the middle of the night -- it is believed to up-regulate vital elements of your immune system by increasing your body�s production of metenkephalin and endorphins (your natural opioids), hence improving immune function.

In addition to increased endorphin production, Dr. Bernard Bihari (who first discovered LDN as a therapeutic agent for AIDS, in 1985), believes LDNs anti-cancer mechanism is likely due to an increase in:

the number and density of opiate receptors on the tumor cell membranes, making them more responsive to the growth-inhibiting effects of the already present levels of endorphins, which in turn induces apoptosis (cell death) in the cancer cells
the absolute numbers of circulating cytotoxic T cells and natural killer cells, as well as killer cell activity

Dr. Bihari has reportedly treated more than 450 cancer patients with LDN with promising results, including cancers of the bladder, breast, liver, lung, lymph nodes, colon, and rectum.

According to Dr. Bihari, nearly a quarter of his patients had at least a 75 percent reduction in tumor size, and nearly 60 percent of his patients demonstrated disease stability.

Recent Clinical Studies on Safety and Benefits of LDN for Autoimmune Diseases

Although the video above makes it seem as though there are virtually no scientific inquiries into the safety and benefits of LDN, that�s not an entirely accurate assessment. Several studies have been conducted, and more are in the pipeline.

For a more complete list of past and current research, please see the lowdosenaltrexone.org website, but here are a couple of highlights.

LDN for Multiple Sclerosis � Dr. Maira Gironi, an Italian neurological researcher, treated 40 patients affected with Primary Progressive MS (PPMS) with LDN for six months, concluding that LDN was not only safe and well-tolerated, but halted the progression of the disease in all but one patient. The results from this pilot study were published in the journal Multiple Sclerosis in September of last year.

LDN for Crohn�s Disease � The first clinical study of LDN published by a U.S. medical journal was Dr. Jill Smith�s article, Low-Dose Naltrexone Therapy Improves Active Crohn�s Disease, published in the American Journal of Gastroenterology in 2007.

An impressive two-thirds of the patients in her pilot study went into remission, and 89 percent responded to LDN treatment to some degree. She concluded that �LDN therapy appears effective and safe in subjects with active Crohn�s disease.�

Other studies currently underway in various parts of the world, include:

A Phase II placebo-controlled clinical trial on the efficacy of LDN for children and adolescents with Crohn�s disease at Penn State.
A clinical trial of LDN in HIV-infected citizens of Mali�the first scientific study of LDN for HIV/AIDS in Africa�implemented in October 2007.
A study of LDN in the treatment of MS at the University of California, San Francisco, implemented in early 2007.
A clinical trial of LDN in the treatment of fibromyalgia at Stanford Medical Center implemented in October 2007.
A study by the MindBrain Consortium in Akron, Ohio of, especially, the affective changes in MS treated with LDN, begun late 2007.
An animal research study at Penn State of naltrexone in a model of a disease that mimics MS.
Animal research on neurodegeneration at NIEHS, suggesting a protective role for naltrexone.

Side Effects and Cautionary Warnings

So far, the only adverse events reported in clinical studies have been temporary insomnia and vivid dreaming in some patients. However, there are a few cautionary warnings with this drug, as with most others.

According to lowdosenaltrexone.org, if you fall in any of the categories below, you need to take special precautions:

If you use opioid agonists, i.e. narcotic medications such as Ultram (tramadol), morphine, Percocet, Duragesic patch or codeine-containing medication, should not take LDN until such medicine is completely out of your system.
Patients taking thyroid hormone replacement for a diagnosis of Hashimoto�s thyroiditis with hypothyroidism need to begin LDN at the very lowest range (1.5mg for an adult), as LDN may lead to a prompt decrease in the autoimmune disorder, which then may require a rapid reduction in the dose of thyroid hormone replacement in order to avoid symptoms of hyperthyroidism.
People who have received organ transplants and who therefore are taking immunosuppressive medication on a permanent basis are cautioned against the use of LDN because it may act to counter the effect of those medications.

For more information about low-dose naltrexone, LDNers.org is another good resource.

And, if you or someone you love suffers from any of the autoimmune diseases listed in the article links below, please review them for my personal recommendations on how to resolve the underlying problems of your ailment.

Reply | Forward | Messages in this Topic (3)

#2212

From: "info_getuspk" <education_us@...>
Date: Tue Jan 13, 2009 8:17 am
Subject: PhD Degrees Pay

info_getuspk

Offline

PhD Degrees Pay
Though the course of PhD completion is always tiresome and also challenging but the toil of doing PhD is fairly compensated with the perks and facilities one gets afterwards.
Degrees by Subject
Online Human Resources Degree
Online MBA Program
Test Preparation

#2211

From: "info_getuspk" <education_us@...>
Date: Mon Jan 12, 2009 10:52 am
Subject: PERFORMING ARTS

info_getuspk

Offline

Distance Learning Brings the Knowledge of the World to You

PERFORMING ARTS

For the student considering a career as a professional actor, finding the right course of study is key. While today, acting students are fortunate, as theatre and conservatory training programs exist in most major cities, renowned artists and performers across the globe agree.

Religious Education
Qualifying for a Visa
Tax matters for Brits who move to Australia

#2210

From: t eilerman <kteilerman@...>
Date: Sun Jan 11, 2009 5:00 pm
Subject: Neurologist Information (MS patient)

kteilerman

Offline

Hello, all.

I am new to the support group so please bear with me. I am among those dealing with an unsupportive neurologist regarding LDN. I live in southwestern Ohio and am hoping there is someone out there that can provide me with a name of a neurologist that is open minded to this drug. I am not on any of the CRAB drugs and don't plan on going on Copaxone just to satisfy the Dr. to provide me with the LDN script. Dr. Boyd Koffman at the University of Toledo has been brought to my attention as a possibility. Does anyone have any experience with this Dr.? He would be several hours drive for me. I wondered if he would be an option before I spend all the drive time to see him.

Any info is certainly appreciated.

Thanks.

#2209

From: "info_getuspk" <education_us@...>
Date: Fri Jan 9, 2009 3:15 pm
Subject: MBA Programs & Distance Learning MBAs

info_getuspk

Offline

MBA Programs & Distance Learning MBAs
It is recognized by business professionals everywhere as an advanced business degree. Students who wish to get that extra edge in the world of business normally will seek a MBA.
MBA/Management
MBA/Marketing Degree
Online Accounting MBA Program
MBA/International Business

#2208

From: "tbayuk" <tbayuk@...>
Date: Wed Jan 7, 2009 8:34 pm
Subject: Fw: [mscured] Re: do-spirochetes-bacteria-cause-ms?

tmbayuk

Offline

----- Original Message -----

From: shepdog87

To: mscured@yahoogroups.com

Sent: Wednesday, January 07, 2009 3:06 PM

Subject: [mscured] Re: do-spirochetes-bacteria-cause-ms?

No actually MS (toxemia) causes spirochetes.

B�champ and others in the scientific community opposed the germ theory
and advocated the theory of pleomorphism, saying:

� Acidic terrain, not germs, cause disease
� Germs are already in the body by the billions and don't
necessarily have to come from without (although that can sometimes happen)
� Blood is not sterile but can contain many microbial forms
� Germs are pleomorphic, i.e., they can change through many forms
(Dr Gaston Naessens identified a microbe undergoing 16 different
stages of evolution)
� Virtually all diseases are caused by acidic terrain
� Diseases can be prevented or reversed by increasing the
alkalinity of the terrain

Hard as it is to believe, these findings, made over more than a
century ago, have been consistently ignored, censored by silence, or
suppressed throughout all of that time by ruling "opinion-makers",
orthodox (R1) thinkers in mainstream microbiology.

Instead of being welcomed with excitement and open arms, as one would
a friend or lover, the amazing discoveries have been received with a
hostility unusually only meted out to trespassers or imposters.

Shep

Very interesting article. would love to know what everyone thinks.
> Lydia
>
> http://resultsfitness.wordpress.com/2008/12/30/do-spirochetes-bacteria-
> cause-ms-alzheimers-lupus-and-fibromyalgia/
>

#2207

From: Crystals MS TM LDN Website <angelindisguise67@...>
Date: Tue Jan 6, 2009 8:53 pm
Subject: Dr. Bihari is doing ONLY Phone Consultations at this time....

angelindisgu...

Offline

I just called Dr. Bihari's office and Confirmed that he IS doing ONLY Phone Consultations at this time so I have added him to my LDN Prescribing Dr list for Phone Consults.

#2206

From: "info_getuspk" <education_us@...>
Date: Mon Jan 5, 2009 7:01 am
Subject: You want an MBA? You have options

info_getuspk

Offline

You want an MBA? You have options
An MBA will help polish your business and management skills regardless of your background. Whether you are "just thinking about it" or seriously pursuing it, you will find the resources you need to choose the right MBA.
The Scoop on MBA Accreditation
MBA Admission Requirements
Courses in MBA Programs
Paying for MBA Expense

#2205

From: Shirley Lotz <shylotz@...>
Date: Tue Dec 30, 2008 12:38 am
Subject: How to Vote?

shylotz

Offline

Help! Where do I record my vote or see the number of votes recorded? I've gone to change.org twice but only topics and a request for suggestions. No place to vote. Advice appreciated.