Skip Lenz sent me this email privately in response to a
thread on splitting 50 mg tablets with any assurance of
even distribution of drug. Due to the fact that in LDN we
are dealing with a small amount of drug and trying to split
a small tablet into ten or more pieces the margin of error
is amplified.

The best use of a 50 mg tablet is to dilute it in 50 ml of
distilled water and shake before each dose is removed to
insure complete and thorough distribution of drug in each dose.

Thanks to Skip for providing this information!

Garnet

-------- Original Message --------
Subject: Re: [lowdosenaltrexone] Re: Question about Rx for
50 mg tablets
Date: Mon, 8 Jun 2009 11:41:13 EDT
From: SLenzrph@...
To: garnet@...


No, it was the result of a clinical study published several
years ago
that showed.
1. medicant distribution was not linear thruout a tablet.
2. cutting was not precise. Even for pharmacists equipped
to tablet split.


Yes I actually do know how a tableting machine works
and the kinetic
profile of powder flow thru. "Some tablets actually
must be tested
for distribution of drug. The range is +/- 5%. Lets
say that you
are making a 4.5mg dose but you got a low end tablet =
4.27mg. Now
lets say that you are using a two ounce bottle to make
it = 60mls.
. So now you take 4.5 mls and you get 3.2mg. Gee I
wonder why it
doesn't work.

Now if you split the tablet you are increasing error by an
unknown
factor. Maybe more, maybe less, who knows.
There are many people who "make their own". I have stopped
arguing with
them. They won't be part of our new survey though.
Dr. Skip






.



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