Semin Reprod Med 2002 Aug;20(3):297-304


Long-Term Perspectives for 46,XY Patients Affected by Complete
Androgen Insensitivity Syndrome or Congenital Micropenis.

Wisniewski AB, Migeon CJ.

Department of Pediatrics, Division of Pediatric Endocrinology, Johns
Hopkins University School of Medicine, Baltimore, Maryland.

Controversy concerning optimal treatment for individuals affected by
syndromes of abnormal sex differentiation can best be resolved with
knowledge about long-term medical, surgical, and psychosexual
outcomes of patients. Follow-up information has recently been
gathered on older cohorts of the following patient groups: (1) those
affected by complete androgen insensitivity syndrome (CAIS) raised
female and (2) those affected by congenital micropenis raised male or
female. As a group, women with CAIS were satisfied with their female
gender and sexual function. However, a need for better patient
education was identified for this specific population. Most patients
with congenital micropenis, whether raised male or female, were
satisfied with their gender. Regardless of sex of rearing,
dissatisfaction with the appearance and function of the genitalia as
judged by both physicians and subjects was evident. For patients with
congenital micropenis, male sex of rearing was concluded to be
optimal because genital reconstructive surgery is not required with
this choice.

PMID: 12428209 [PubMed - in process]

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