Forgot to add,

we went to nogales for LIT at 10weeks of our pregnancy, due to low LAD and
matching DQ alpha at 4.1 (the worst one to match).

Mike
-------Original Message-------
From: aizkraukle2 <nikih@...>
Sent: 06/22/03 12:45 PM
To: immunologysupport@yahoogroups.com
Subject: [immunologysupport] Re: New member (loss ment)

>

Dear Mike,

Thanks for replying.

Just to answer a couple of questions:

The testing that I listed is all that was done.  I have read where
other testing may be indicated and am trying to learn more about them.

We had Dr. Salafia look at our slides.  She didn't have much to look
at since the protocols are different in Latvia. However, she was able
to determine "chronic maternal malperfusion" and some tendencies
toward preeclampsia.  The sample was so small that she couldn't
determine the nature of the problem.  In speaking with Dr. Matzner,
they determined that immune issues were probable in our loss,
however, neither could relate the results directly to the abruption.

I was not taking anything except my thyroid medicine and prenatal
vitamins during pregnancy.  This was our first pregnancy and we
conceived the first month trying.  I had no problems with the
pregnancy...growth normal, u/s normal, so spotting, nothing.....until
the abruption.

The recommended protocol was:
ASA 81 mg, heparin 7500 U, and prednisone 5 mg all 5 days before
ovulation and IVIg 400mg/kg/day for two consecutive days 10 days
prior to ovulation.  Then testing and treatment accordingly
throughout.

I am also worried about the lack of NK suppression by the IVIg....but
don't know what to think about the lack of it stimulating either.

If you have a moment, a quick reminder of your experiences would be
great!

Thanks for your help,
Niki

--- In immunologysupport@yahoogroups.com, Esquire727@M... wrote:
> Not 100% sure about Matzer's testing, but let's give it a try.
>
> Your NK isn't bad, but I'm concerned about "Not supressed with
IVIG".  I think this means the nks were non-responsive to IVIG, which
isn't too good.  It means they are very strong.
>
> You have Hashimotos, which is a hint of other auto-immune
problems.  Further, you have a matching DQ Alpha at 3.0 (meaning you
are more prone to immune aggravation) and you lack blocking
antibodies (meaning the fetus can't protect itself against an attack).
>
> Did you test APAs, ANAs, Protein S, APC Resistence, etc.
>
> Placenta Abruption can be caused by little blood clots behind the
placenta.  You probably need Lovenox and BA.  Also, just because your
NKs were normal, doesn't mean they stay that way. 
>
> Did you have a endo biopsy or have a doctor look at the slides from
the latest m/c?  That would be the most insightful thing you can do
at this point.
>
> I would contact Dr. Beer.  I am not a huge fan of Dr. Matzer (as
many on this board).  You definitely have something going on and need
to fine tune your testing and treatment.
>
> Mike
> -------Original Message-------
> From: aizkraukle2 <nikih@c...>
> Sent: 06/22/03 08:29 AM
> To: immunologysupport@yahoogroups.com
> Subject: [immunologysupport] New member (loss ment)
>
> >



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