First, I know of Dr. Salafia (we're in NY as well, and will deliver at Mt.
Sinai). She's good, but NOT sufficently trained to look at immune issues. Get
back your paraffan blocks or slides from her and sent them to Dr. Beer. I bet
he sees much more than she.

Your heparin dose should probably be 2x a day. However, most on this board take
lovenox. I don't know why (Jane can tell you), but it is the preferred
medicine. You should be on a higher dose than the standard 5000 units 2x a day.
If your dose is 7000 units 2x a day, then you might be ok. But again, DB
prefers Lovenox.

You might want to consider going to Nogales for LIT therapy. It is especially
required if your body does not respond to IVIG (which you probably also need).
I would also repeat your Nk assay somewhere else (finch labs in chicago)....that
non-responsive to ivig makes me concerned.

Finally, if the biopsy or slides reveal NKUs (killer cells that take residence
in the uterus, you may need enbrel or remicade). Others on this board can tell
you more about it (we have no experiecne with it)

My DW (Jodi had 3 losses, including one after a perfect IVF). Our first 2 pg,
we got pg on the first month. Then for some reason we couldn't get pg, and did
the ivf after 8 months and 2 failed IUIs.

After all of this, we discovered DB and got on IVIG, dex, Lovenox, BA, Folgard,
Fish Oil, progesterone, etc. Got pregnant 1st try on IUI with twins. Currently
35 weeks pregnant with b/g twins and getting ready to run from Long Island to
Mt. Sinai at any given moment. Dr. Jon Scher is our high risk ob/gyn, Dr. Beer
is our RI, and Dr. Davis of Cornell Medical is our RE.

Mike


-------Original Message-------
From: aizkraukle2 <nikih@...>
Sent: 06/22/03 12:45 PM
To: immunologysupport@yahoogroups.com
Subject: [immunologysupport] Re: New member (loss ment)

>

Dear Mike,

Thanks for replying.

Just to answer a couple of questions:

The testing that I listed is all that was done.  I have read where
other testing may be indicated and am trying to learn more about them.

We had Dr. Salafia look at our slides.  She didn't have much to look
at since the protocols are different in Latvia. However, she was able
to determine "chronic maternal malperfusion" and some tendencies
toward preeclampsia.  The sample was so small that she couldn't
determine the nature of the problem.  In speaking with Dr. Matzner,
they determined that immune issues were probable in our loss,
however, neither could relate the results directly to the abruption.

I was not taking anything except my thyroid medicine and prenatal
vitamins during pregnancy.  This was our first pregnancy and we
conceived the first month trying.  I had no problems with the
pregnancy...growth normal, u/s normal, so spotting, nothing.....until
the abruption.

The recommended protocol was:
ASA 81 mg, heparin 7500 U, and prednisone 5 mg all 5 days before
ovulation and IVIg 400mg/kg/day for two consecutive days 10 days
prior to ovulation.  Then testing and treatment accordingly
throughout.

I am also worried about the lack of NK suppression by the IVIg....but
don't know what to think about the lack of it stimulating either.

If you have a moment, a quick reminder of your experiences would be
great!

Thanks for your help,
Niki

--- In immunologysupport@yahoogroups.com, Esquire727@M... wrote:
> Not 100% sure about Matzer's testing, but let's give it a try.
>
> Your NK isn't bad, but I'm concerned about "Not supressed with
IVIG".  I think this means the nks were non-responsive to IVIG, which
isn't too good.  It means they are very strong.
>
> You have Hashimotos, which is a hint of other auto-immune
problems.  Further, you have a matching DQ Alpha at 3.0 (meaning you
are more prone to immune aggravation) and you lack blocking
antibodies (meaning the fetus can't protect itself against an attack).
>
> Did you test APAs, ANAs, Protein S, APC Resistence, etc.
>
> Placenta Abruption can be caused by little blood clots behind the
placenta.  You probably need Lovenox and BA.  Also, just because your
NKs were normal, doesn't mean they stay that way. 
>
> Did you have a endo biopsy or have a doctor look at the slides from
the latest m/c?  That would be the most insightful thing you can do
at this point.
>
> I would contact Dr. Beer.  I am not a huge fan of Dr. Matzer (as
many on this board).  You definitely have something going on and need
to fine tune your testing and treatment.
>
> Mike
> -------Original Message-------
> From: aizkraukle2 <nikih@c...>
> Sent: 06/22/03 08:29 AM
> To: immunologysupport@yahoogroups.com
> Subject: [immunologysupport] New member (loss ment)
>
> >



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