Not 100% sure about Matzer's testing, but let's give it a try.

Your NK isn't bad, but I'm concerned about "Not supressed with IVIG". I think
this means the nks were non-responsive to IVIG, which isn't too good. It means
they are very strong.

You have Hashimotos, which is a hint of other auto-immune problems. Further,
you have a matching DQ Alpha at 3.0 (meaning you are more prone to immune
aggravation) and you lack blocking antibodies (meaning the fetus can't protect
itself against an attack).

Did you test APAs, ANAs, Protein S, APC Resistence, etc.

Placenta Abruption can be caused by little blood clots behind the placenta. You
probably need Lovenox and BA. Also, just because your NKs were normal, doesn't
mean they stay that way.

Did you have a endo biopsy or have a doctor look at the slides from the latest
m/c? That would be the most insightful thing you can do at this point.

I would contact Dr. Beer. I am not a huge fan of Dr. Matzer (as many on this
board). You definitely have something going on and need to fine tune your
testing and treatment.

Mike
-------Original Message-------
From: aizkraukle2 <nikih@...>
Sent: 06/22/03 08:29 AM
To: immunologysupport@yahoogroups.com
Subject: [immunologysupport] New member (loss ment)

>

I wanted to introduce myself as I have been lingering here for some
time trying to get a handle on my immunology test results.  This
group is very active and experienced so I am hoping to get some
feedback.

I am 32, DH 32.  We lost our first baby, son, at 26 weeks in Jan. 03
due to complications of a placental abruption.  He was born living
after an emergency c-setion but passed away two days later.  We were
told that there was no apparent cause of the abruption and all should
be well next time.  We wanted a second opinion, however.  We live in
Latvia and although there are very good doctors and services here, we
felt assistance from specialists were in our best interest.

We sought the help of Dr. Matzner and were able to visit him in CA.
Test results, April 03:

Total T CD3+ lymphs  86 (range 59.4-84)
Total B CD19+  5 (6.4-22)
Helper/Inducer CD4+  67 (29-59)
Supp/Cytotoxic (CD8+) lymphs, Activated T (CD3), Total NK CD16+56,
Cytotoxic (CD5+) all normal range

NK activation
1:50 8.9 (borderline 8.5-10)
no stimulation with IL2
no suppression with IVIg

Quantitative IgM  30 (42-250)
Quantitative IgG, IgA normal
IgG cardiolipin positive
All others negative

T-cells with IgG  1.1 (negative <30)
B-cells with IgG  8 (negative <30)
lacks blocking antibodies

MTHFR heterozygous

DQ alpha  1.1, 3.0  DH 1.2, 3.0

ATA, ANA normal

Prior to pregnancy I was hypothyroid (Hashimoto's) and had treatment
yet during pregnancy my TSH started falling at about 16 weeks and has
continued to slowly do so to where I am just below the normal range. 
Treatment has been adjusted but we haven't achieved a steady normal
range yet.

Protocol:  IVIg, heparin, baby aspirin and prednisone prior to
ovulation

I would appreciate any comments on my results.  Any thoughts on
vitamins etc...

Also, we are moving to UK by the end of this summer (Sheffield
area).  We are considering becoming patients of Dr. Beer.  Would
anyone in the UK be willing to correspond with us about their
experiences with immune issues in the UK as well as working with Dr.
Beer?

I am sorry this is so long.  I thought it best to get it all out
there.

Kind regards,
Niki





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