Hi Jane,
Thank you for sharing more information. So if my LAD comes back low
because of never having been pg, then DB would automatically
recommend LIT? Would he recommend donor LIT instead due to the DQ
alpha match? I am really scared of LIT/donor LIT.

He mentioned transfusion in the DB post. Well, I had a complete
exchange transfusion just after birth due to Rh sensitivity (I'm Rh
pos and my mom was Rh neg and I was the 6th baby). Would that
transfusion caused my immune issues at all? I have elevated NK, pos
APA, and DQ alpha match w/dh.

I think the ANA changing over time question I had was something I
concluded from the posts and I thought it was IVIG related so
disregard -- I must have made a wrong conclusion somewhere. It's
probably that immune labs just change over time and possibly due to
recurrent miscarriage.

Anyway, thanks for any more light you can shed on this. You've all
been great. I've been reading all the posts and files.
Hugs to all of you who are struggling and succeeding!
Renee





--- In immunologysupport@yahoogroups.com, "Jane Reed" <edreed@p...>
wrote:
>
> Hi Renee,
>
> You ask good questions and make good points. So you have never been
> pregnant before? If this is true, then you are right, your blocking
> antibodies will be zero, whether you have an immune problem or a DQ
> alpha matching problem or not. Blocking antibodies build up in
> response to a pregnancy. They are automatically zero in virgins and
> in couples who have never had a pregnancy before.
>
> However, an important point to note: Often ladies who "think" they
> have never been pregnant when they have. Couples may have been
losing
> the pregnancies very early, before a positive pregnancy test, in
> these cases the LAD ( blocking antibody ) levels could actually
> moderately high. This is one of the intersting twists of the LAD
> tests, if it shows some elevation in level, this can prove past
> fertility (and past early failed pregnancies) when no other test
has
> shown it before!
>
> So even if you think you have never been pregnant before, ask Dr
> Beer, but there still might be an argument for doing the LAD test
in
> your case. If the numbers are at all elevated ( even if not super
> high) it can prove you have been getting pregnant, just losing the
> pregnancies very early. This could be important piece of
information
> to know.
>
> Regarding the RIP tests and NK Assay, if your tests were last done
in
> 2001, then " yes" I would repeat them. The immune system can change
a
> lot in 4 years.
>
> As to the ANA test turning postive, this can often be caused by
many
> things, not IVIG. Maybe an early failed pregnancy, other immune
> activation? I may be wrong, but I have never heard Dr Beer say the
> ANA test can turn positive as a result of IVIG. I would certainly
ask
> about this
>
> Also see Dr Beer blocking antibody post below.
>
> Hope this helps.
>
> Jane
>
>
> Dr Beer post:
>
> *************
> I am trying to find out if any woman (without children) who has had
> more than one miscarriage has ever had her blocking antibodies come
> back in the normal range (regardless of who did the testing).
>
> THE ONLY WAY THAT THE BLOCKING ANTIBODIES TURN POSITIVE IS FROM A
> PREGNANCY WITH YOUR SPOUSE. IF THERE HAS NEVER BEEN A PREGNANCY
THEN
> THE BLOCKING ANTIBODIES WILL BE NEGATIVE. TRANSFUSIONS IN SOME
WOMEN
> CAUSE THE BLOCKING ANTIBODIES TO BE POSITIVE.
>
> From what I have read about, no woman (without children) has normal
> levels of blocking antibodes if she has had miscarriages, EVEN if
her
> miscarriages were not caused by low blocking antibodies (such as
> chromo. abnormalities or infection or high nk levels, etc). If the
> theory behind LIT is correct, then there should be plenty of women
> out there with normal levels of blocking antibodies after multiple
> losses.
>
> YES THERE ARE.
>
> So, the question out there for those of you who don't have any
> biological children is:
> Have your blocking antibody results come back within the normal
> range? Please give your age, your number of losses, how far you got
> with each pg and your dx.
>
> I AM SURE YOU WILL HEAR FROM SOME OF MY PATIENTS.
>
> I will start: I am 31. Two losses, one at 7wks and one at 10wks
> (twins). Pathology report on twin loss says loss was due to twin to
> twin transfusion. One positive APA (will take heparin) and low
> blocking antibodies. After two treatments of PLIT, I measure:
> B cells - 8.7%
> T cells - .6%
> Also have high nk activity level of 18%.
>
> HAVE YOU HAD DQ ALPHA TESTING TO DETERMINE IF YOU MAY NEED DONOR
LIT?
>
> thanks for your responses.
>
> ****************
>
>
> --- In immunologysupport@yahoogroups.com, "chicrenee" <RNMFA@c...>
> wrote:
> >
> > So does that mean any woman who has not been pg would need LIT?
> Why
> > would I need to do the LAD test if I've never been pg then? I am
> so
> > confused. Thanks for any help you can provide.
> >
> > Also, my RIP and NK tests were done in 2001. Do you think DB
will
> > want to repeat them?
> >
> > I read that some people who were ANA neg become ANA pos after
IVIG
> > txs, why? I've had 3 IVIGs (2 at 40gms each in one day and 1 at
> > 60gms over 2 days).
> >
> > Thank you so much for helping me,
> > Renee
> >
> >
> > --- In immunologysupport@yahoogroups.com, Karin Moser
> > <karinsamira@y...> wrote:
> > > Hi!
> > >
> > > I was told that you have no blocking ABs when you have never
been
> > pregnant, because blocking AB formation is a reaction of your
body
> > specifically to pregnancy.
> > >
> > > Kind regards
> > >
> > > Karinsamira
> > >
> > > chicrenee <RNMFA@c...> wrote:
> > >
> > >
> > > Can you have low blocking antibodies if you have never been pg?
> (DQ
> > > alpha match 1.2/4.1: both me and dh)
> > >
> > >
> > >
> > >
> > >
> > >
> > > **Information in this group not to substitute for medical
advice.
> > Please consult with your physician before undergoing any form of
> > medical treatment**
> > >
> > > Yahoo! Groups Links
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
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