Thank you for thinking of me, and I really appreciate the prayers!! =)

 

I'm not sure what the ANA results mean, as mine did not give ranges or anything, it just said negative. But I think that's the one that you read about people having speckled or something or other!! And I think it's something that requires blood thinners like Lovenox. Hopefully someone else here will know. I just posted this to someone else about MTHFR, so I hope you don't mind the copy & paste here for you (I'm working myself up from newest to oldest in emails right now)

 

 

I am also heterozygous for MTHFR, and this is what the NP emailed me about my results:

 

MTHFR was positive for 1 copy of C677T and negative (normal) for A1298C.  This means you are heterozygous for MTHFR.  This has NO increased risk or coronary disease and clotting.  This is a common finding in the general population.  Your homocysteine level was normal so therefore no risk for you with clotting.  If you would have has 1 copy for each of the above mutations, then there is some increased risk and treating with blood thinners would be the approach.

 

I also met with a hematologist a couple of weeks ago and he agreed that this alone (hetero for MTHFR) means nothing, and does not require blood thinners. However, I also have a slight Protein S deficiency that my RE put me on 30mg injections of Lovenox for TTC, and will continue through a pregnancy. The hematologist did not feel this was necessary for the slight deficiency I have, seeing as I have never had any blood clots before (although he wants me retested to see if the level comes back low again), but he did not discount my RE's choice to put me on lovenox just to be safe, as he admitted that reproductive medicine is obviously not his specialty, and for all he knows this could help me. He also recommended that if I use this *therapeutic* dose of Lovenox throughout an entire pregnancy, he would want me to also continue through 6 weeks postpartum, as there is an increased risk of blood clots for any woman in the early postpartum weeks.

 

 

 

Also, my intralipids are 20% 100mL, mixed with 500mL of normal saline, to be infused between 2-3 hours. I'm to do 1 infusion per month, a couple days prior to ovulation. If pregnant with 2 good beta's, I would immediately have another infusion. My RE and NP do not prescribe more than this for pregnancy, and the NP said getting me through the 1st trimester seems sufficient - so I don't know if that means they are willing to prescribe at least 2 more infusions to be done at 8 and 12 weeks, or what. I am determined to find a way to do them monthly until at least 24-32 weeks though - I'm a better safe than sorry kind of person and I cannot even imagine if we got that far and then lost the baby - I would always question if monthly infusions would have worked and would never forgive myself for not pushing for it. So I have made my mind up that I will do whatever it takes to make that happen, if we are lucky enough to get pregnant and stay pregnant!! 

 

 

I HTH....and please keep us posted with the rest of your results too, ok!!

 

 

(((HUGS)))

 

Holly 

 

 

 

 

---

From: mjbc07 <mjbc07@yahoo.com>
To: immunologysupport@yahoogroups.com
Sent: Sat, June 26, 2010 5:31:03 PM
Subject: [immunologysupport] Slowly Getting Some Results

 

Well, my recent battery of test results is beginning to come back. Some are normal, some are red-flagged. My ANA was at a 3 last November, but now it is 32?! Not sure what this means. My NK cells were suppressed equally well by IVIG and intralipids, so we may be able to move from IVIG to intralipids (which is really encouraging for me emotionally & financially). I am MTHFR homozygous - does that mean anything??
We're still waiting on the DQa and HLA matching things.

Does anyone know about the MTHFR homo thing?
And if you've done intralipids, what was your dosage & frequency?

Thank you! Reading your messages every day encourages me, even when I am not writing/responding. Someday I will be experienced enough to participate and offer advice. :)
Holly, I am praying for you. And Claudia too. (((hugs)))

~M~