Just a note in reply; sorry, do not check info from this list very often. I
would like to say also that I am sorry, but really cannot respond to
individual questions addressed to me; better, they go up on the board, and
there are few biochemical geneticists who have input on occasion.

Does not sound like this 10 year old boy is B-12 responsive. He would have
to be on a low protein/special diet. We now know that renal damage is a
risk for children with MMA. A liver transplant is a big risk, and
experimental, and tough to justify. CHeeRS\

Good luck.

pbenke
At 08:31 AM 8/22/1999 -0400, you wrote:
>My son is 10 years old, has MMa and is B-12 responsive. His MMA levels in
>the urine range from 2,000-5,000 and in his blood 200-350. Although this
>is little info, what is the likelihood that he will need a kidney/liver
>transplant and when does it usually happen agewise?
>
>Please respond.
>
>Lisa Hare
>Worried mother<
>
>Lisa,
>
>Just for your information, I also have a son with MMA who is not B-12
>responsive. He is currently 16 and despite renal damage from the MMA, he
>is doing fine and not in need of a transplant yet.
>
>Conrad Cota
>
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Paul J. Benke, M.D., Ph.D.
Box 016820, Mailman Ctr.
University of Miami Sch. Medicine
Miami, FL 33101