Your letter made me think of 2 questions.
1. Does nephritis have to do with mito disorders?
2. Does acidosis cause bladder and/or kidney infections?
Linda S.

-----Original Message-----
From: Paul Benke <pbenke@...>
To: iem-family@onelist.com <iem-family@onelist.com>
Date: Monday, August 16, 1999 3:02 PM
Subject: Re: [iem-family] Liver transplantation for MMA-children?


>From: Paul Benke <pbenke@...>
>
>
>Would recommend strongly AGAINST considering liver transplant unless there
>are some unusual circumstances; althought the tranplant would be
>potentially curative, at least 20-30 per cent will die because of the
>transplant, and about 20-30 per cent have problems, such as graft versus
>host, which can require lots of problems and hospital stays, and only 1/2
>do extremely well, and fade away with a normal life. Liver transplantation
>requires lots of attention, pain, and hospital care early on.
>
>Would strongly urge that attention be paid to the chronic acidosis, as well
>as to carnitine, and special diet, since many children have progressive
>renal disease and loss of nephrons starting in the teenage years, and I
>think that attention to acidosis may help forestall this complication and
>the need for a renal transplant.
>
>pbenke
>Paul J. Benke, M.D., Ph.D.
>Box 016820, Mailman Ctr.
>University of Miami Sch. Medicine
>Miami, FL 33101
>
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