In a message dated 98-06-17 22:41:43 EDT, you write:
<<
All of this is most confusing. Please tell me if this combo is
successful for crack cocaine addiction. I need bigtime help..I've got
to get my life put back together, I'm 29 and going down fast. Suzanne
>>
I would definitely look into Ibogaine, Ayahuasca, and GHB for help. If you
feel that your very spirit has been harmed or changed through your addiction,
then look more closely at Ibogaine or Ayahuasca.
If you need some added push to get off -- look at crackhead Bob -- a chronic
visitor to the Howard Stern show. He was smoking crack, then had a stroke.
Then he started smoking again and had another stroke and was smoking while he
was stroking! Now he is partially paralyzed and millions of radio and TV fans
look at him and laugh.
-Michael Pinchera
Rev. MeO
All of this is most confusing. Please tell me if this combo is
successful for crack cocaine addiction. I need bigtime help..I've got
to get my life put back together, I'm 29 and going down fast. Suzanne
>From ibogaine@... Wed Jun 17 07:11:55 1998
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>Subject: Re: Coronaridine, Voacangine, Ibogaine : natural sources
(long)
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>
>I know of another 2 people who beat narcotic addiction with Potassium
GHB/
>Lactone combo. I know any information not pertaining to ibogaine is
barely
>tolerated by some people in this group but this is more than a fluke.
I was
>thinking that I would have to be a real shmuck to have a possible cure
and not
>let everyone in on it. In fact if you will pay for postage I will give
2
>ounces to anyone in this group. 2 ounces is about 10-15 doses and
shipping
>should be about 5-7 bucks. If it works I will send more but I will
have to
>charge you for large quantities. Still much cheeper than other things.
E-
>mail me and let me know if you are interested. I will also include the
dose
>regimine I found to be most successful. ought to at least give it a
try.
>Later---Phos www.juredivino.com E-mail me at phosphagas@...
>
______________________________________________________
Get Your Private, Free Email at http://www.hotmail.com
I awake in a hostile enviroment...
The acid rain burns into my skull much like hot oil on a stick of
butter, disssolving holes into my brain, systematically eating my
physical memory nodes. Yet I remain conscious. The acid screams through
my head, the acrid stench of flesh and bone enveloping me as I dissolve
into acidic vapor, what little remains puddles into toxicity on the
ground where I once stood. The remains ignite into flame and my soul
rises into a luminescant plasma; a phoenix rising from the inferno.
The plasma, waxing & waning in intensity, throbbing and morphing in
form, is random. I slowly begin to gain control and I take on various
shapes at will. My outer surface is a complex network of energy forming
an intricate grid of geometry. Fiery red, green and blue pulses form the
vertices, a psychedelic grid. This begins to take on a familar pattern
and I slowly recogonize this as a map, of the universe. I sense an
infinite knowledge of divine origin coalescing with-in me. At first it
seems to come from an external source, then I realise it is being
revealed from inside of me, from the roots of my being. I am not alone
in this being, as I am ALL and All is ONE. The remembering begins. Tens
of thousands of memories from past lifetimes flood my consciousness in
code-like graphical representation. Mathematical equations of light,
color, pattern and intensity project themselves across the liquid skin
of my human form, raised in relief, an eternity of consciousness
embossed on the surafce of my soul. Within, infinite sacred geometry
spins its divine dance; a blueprint of the universe.
Although my phisical body has been shed, sound/touch/sight/smell are
amplified a thousand fold, overlapping to create a myriad of new and
strange sensations. I begin to accelerate through time/space, and I find
myself speeding at an enourmous rate thru the universe: my own
consciousness. Stars, Quazars, Aquaintances and Lovers blur by, fleeting
glimpses of Past, Present and Future which combine into an
all-enveloping eternity. Time is just an illusion...
Trailing behind me is an all-familar, vaporous, glowing, bubbling tracer
that sparkles and reflects the surounding geometry of the cosmos. I
plunge headfirst into a vast nebulah, dissolving and dispersing into the
gaseous cosmic cloud, dis-incarnating into the building blocks of life.
Still conscious....
crystaline formations swirl in an ever increasing intensity around my
being,
and I momentarily (as if there is a measurment of time) fear being
shredded
by the razor sharp edges, forgetting I am no longer confined to a
physical body. The Crystals quickly shape an immense crystalized sphere
in which I am trapped. Feeling imprisonment, I reach out to test the
strength of the softly glowing sphere walls and the entire structure
dissolves into countless pinpoints of radiant light. I observe my spirit
body go through the same transformation countless times; crystalizing
and disolving into light. This becomes dizzying and my attention becomes
focused on an approaching shimmering surface, wet in appearance and very
reflective. I gaze towards my previously embossed 'skin' and see that
it, too has taken on this wet surface, and I feel physicality setting
in, I touch my chest with my hand and I am alarmed to see it sink into
my flesh, as the stench of rotting muck rises from the gaping sludge, I
spiral towards the approaching surface, my body weighted and distorted
by the gravitational pull.
Merging with the primordial goo, I sink fast and fear suffocation, but
the fear is instantly dispersed with the sensation of gravity and
pressure increasing and decreasing concurrently. I take on form and
dissolve in unity, evolving through eons of evolution in all expanding
now.
Knowledge pours into my soul in the form of light, which is interpreted
as more geometric equations. focusing on any given geometric pattern
only causes it to change into a completely new pattern, made of
spiraling spheres covered with transparent lace made of fractal
patterns, very reflective and liquid in form. Multi Threaded DNA Strands
dance around my field of vision, which as far as I can tell has a 360
degree range.
An infinity of graphical representations continue to show me knowledge,
much of which I can but begin to grasp, even though my awareness has
expanded a million fold. I expereince being many different life forms;
animals, plants, sentinent beings of light and matter, all dancing
within an eternal movenment of learning, and Love is the lesson.
DH
I was told _ervatamia orientalis_ is a ibogaine subsitute. However you need
like 1 kilo of leaves to get 1 dose.....
If large quantititys became available and extracts made. I dont think it
would be that big of a deal. I think we should let those poor little iboga
tree's grow and utilize bushes or shrubs of the same family.
Anyone else heard of anyone using _ervatamia orientalis_?
Turiyan
HSL123@... wrote:
>
> In a message dated, Wed, Jun 17, 1998 13:06 EDT,
> dana@... (Rob G.) writes:
>
> >Howard,
>
> >A woman called me today and said that a friend of hers was >possibly dosed
> with
> >out his knowledge. Base no longer has almost any effect on >him after about
> one
> >minute he goes into a state more like being on narcotics than >a stimulent.
> He has
> >also had a great deal of gastro intestional problems.
>
> >The things she is seeking are
>
> >Is there any lab test for the presence of metabolites or >residuals?
> >Is there info about similar experiences.
> >Is there any one who can advise on what this person should >do?
>
> >Her name is XXXXX XXXXX #XXX-XXX-XXXX
>
> Dear Rob,
>
> First, this message should have been sent as a private email as you identified
> persons without their permission to a list of possibly 100s of persons. That
> is a matter of breached medical confidentiality. Setting that issue aside, I
> spoke to both parties involved and whatever they were given it is not
> Ibogaine. I suggested they contact Guilford pharmaceuticals to determine if
> an early test batch of their cocaine vaccine may have been stolen and
In a message dated, Wed, Jun 17, 1998 13:06 EDT,
dana@... (Rob G.) writes:
>Howard,
>A woman called me today and said that a friend of hers was >possibly dosed
with
>out his knowledge. Base no longer has almost any effect on >him after about
one
>minute he goes into a state more like being on narcotics than >a stimulent.
He has
>also had a great deal of gastro intestional problems.
>The things she is seeking are
>Is there any lab test for the presence of metabolites or >residuals?
>Is there info about similar experiences.
>Is there any one who can advise on what this person should >do?
>Her name is XXXXX XXXXX #XXX-XXX-XXXX
Dear Rob,
First, this message should have been sent as a private email as you identified
persons without their permission to a list of possibly 100s of persons. That
is a matter of breached medical confidentiality. Setting that issue aside, I
spoke to both parties involved and whatever they were given it is not
Ibogaine. I suggested they contact Guilford pharmaceuticals to determine if
an early test batch of their cocaine vaccine may have been stolen and given to
these people and also suggested they contact Dr. Carlo Contoreggi at NIDA's
Intramural Program in Baltimore as both may provide extensive testing. The
symptoms in the male have been ongoing for two years and in the female for a
year, since she began a relationship with the male. There are no indications
from any of the primary or long term effects that this is an Ibogaine or
ibogaine-like substance. Both parties may have been dosed, if that is the
case, without their knowledge and that is something that is ethically wrong.
Howard
dana wrote:
>
> Howard,
>
> A woman called me today and said that a friend of hers was possibly dosed with
> out his knowledge.
It is my opinion that one would know within an hour if they were dosed,
for the Ibo experience isn't one to slip by unoticed...
DH
Howard,
A woman called me today and said that a friend of hers was possibly dosed with
out his knowledge. Base no longer has almost any effect on him after about one
minute he goes into a state more like being on narcotics than a stimulent. He
has
also had a great deal of gastro intestional problems.
The things she is seeking are
Is there any lab test for the presence of metabolites or residuals?
Is there info about similar experiences.
Is there any one who can advise on what this person should do?
Her name is Brenda Dewitt #508-999-0698
Rob G CNW
List,
Iboga Foundation was contacted by a medical student who was visiting Gabon
and brought back a few kilos of powdered Iboga root bark. He extracted
Ibogaine as described in Amon Knut's book IBOGA, and checked it at the
University lab (gas chromatograph and something else, I forgot). He claims
that he has quite pure Ibogaine, flavoured with some other Iboga alkaloids.
He's not on Internet yet, so he asked if I could tell you that he wants to
sell 3 grams, 500 DM/g. Anyone interested (from countries where Iboga is
legal) should mail me address or phone number and he'll contact you.
I'm quite amazed that nobody knows exsact vibration of Ibogaine molecule...
Marko
I know of another 2 people who beat narcotic addiction with Potassium GHB/
Lactone combo. I know any information not pertaining to ibogaine is barely
tolerated by some people in this group but this is more than a fluke. I was
thinking that I would have to be a real shmuck to have a possible cure and not
let everyone in on it. In fact if you will pay for postage I will give 2
ounces to anyone in this group. 2 ounces is about 10-15 doses and shipping
should be about 5-7 bucks. If it works I will send more but I will have to
charge you for large quantities. Still much cheeper than other things. E-
mail me and let me know if you are interested. I will also include the dose
regimine I found to be most successful. ought to at least give it a try.
Later---Phos www.juredivino.com E-mail me at phosphagas@...
Karl Naeher wrote:
>
> Anyone who is interested in getting powdered iboga-root or
> rootbark-shavings can contact me via e-mail or call: 39-3356563973
Dear Karl,
Tried to contact you at your e-mail adress, I failed.
I import my Iboga from Central west Africa from a person that mentioned
a Karl.
I wondered if it was you.
her name is Hortense.
If you also guide people through Bwiticeremonies, sure like to contact
you.
Frans Scheerder
At 05:48 PM 6/7/98 EDT, parcival@... (Dirk Teunis) wrote:
DT>In a message of 03 Jun 98 Chris Jenks wrote to Multiple recipients of list:
CJ> of voacangine were minuscule - only about 0.04%! A whole kilogram of
CJ> trunk bark would produce no more than 400 mg of voacangine! =
DT>Is it the same for root bark ?
According to this French paper I have, by an unknown author, trunk bark
contains 5.9% alkaloid and root bark contains 9.2% alkaloid. These two
alkaloid mixtures were separated into fractions, and the fraction
containing voacangine consists of 0.19% of the trunk bark and 0.11% of the
root bark. One of these fractions (37 g) was purified to give voacangine (8
g), and this is where my figure of 0.04% voacangine from trunk bark came
from, although I assumed that the voacangine-containing fractions from
trunk bark and root bark would contain similar proportions of voacangine.
Where did the rest of the alkaloid go? The predominant fraction from trunk
bark (2.7%) gives voacorine on purification, and the predominant fraction
from trunk bark (4.6%) gives voacamine and vobtusine.
DT>-Tabernanthe pubescens (6)
DT> trunc bark : 0.7% ibogaine
DT> root bark : 0.3% voacangine, 2.6% ibogaine
Really 2.6% ibogaine? That is about as good as T. iboga! According to Van
Beek's review:
van Beek, T. A.; Verpoorte, R.; Svendsen, A. Baerheim; Leeuwenberg, A. J.
M. and Bisset, N. G. "Tabernaemontana L. (Apocynaceae): A review of its
taxonomy, phytochemistry, ethnobotany and pharmacology.", Journal of
Ethnopharmacology, (1984), 10(1), 1-156.
the Tabernaemontana pubescens plant grows in Australia and Moluccas. The
respective references are:
L. J. Webb (1952) Australian Phytochemical Survey, part 2. C. S. I. R. O.
(Melbourne), Bulletin no. 268, 23.
N. G. Bisset (Dec. 1957) Proceedings of the Symposium on Phytochemistry,
Kuala Lumpur, Unesco Science Cooperation Office for South East Asia, p. 125.
Yours Truly,
Chris
just checking my system . sorry to waste space.
***************************************************
Please note that the iafrica server is having trouble temporarily so if
you don't get a reply to your mail within a reasonable time,
send it again. Sorry for the inconvenience.
Dan ethnobotany@...
***************************************************
Dear Howard,
thanks for posting all those useful drug sense think pieces and contact URLs
relating to the UN session. I have forwarded them to anyone I can think of
that counts in these parts, including the British government (who, despite
paying close attention to their e-mail, are highly unlikely to take any of
the ideas onboard).
If you get time, could you post a brief description of the UN session demo,
for those of us outside the US?
Thanks a lot!
SW
Calyx was passed over once again by the DPF in the latest round of grant
funding. This really puts me in a bad position because there is really no
disk space left to continue operating in the manner we're operating in
now. Meanwhile David Borden refuses to publicly acknowledge that Calyx
has provided DRCNet with listproc service since 1995 at no charge while
they continue to rake in the grant money and share not a cent of it.
I still don't make a salary from Calyx so I am not in a position to go
spending hundreds of dollars on more disk space.
this sucks. Just thought I would vent a tiny bit. sorry.
----------------------------------------------------------------------------
Nicholas Merrill 24 Hour pager: 917-381-0500 Voice: 212-966-1900
President / CEO http://www.calyx.net Fax : 212-966-3965
Calyx Internet Access 13-17 Laight St. NYC, NY 10013 Email: nick@...
----------------------------------------------------------------------------
In a message dated 6/10/98 10:56:03 AM Mountain Daylight Time, ssrski@...
writes:
<< << Forgive Me When I Whine
-----------
Today upon a bus I saw a lovely girl with shining hair. I envied
her...she
seemed so gay...and oh, I wished I were so fair. When suddenly she rose
to
leave I saw her hobble down the aisle. She had one foot and wore a
crutch,
but as she passed, a smile...Oh, God, forgive me when I whine...I have
two
feet...the World is mine.
And when I stopped to buy some sweets, the lad who served me had such
charm,
he seemed to radiate good cheer, his manner was so kind and warm. I
said,
"It's nice to deal with you, such courtesy I seldom find." He turned
and
said, "Oh thank you ma'am" and then I saw he was blind...Oh, God, forgive
me
when I whine...I have two eyes...the World is mine.
Then, walking down the street I saw a child who seemed sad and blue. He
stood
and watched the others play, it seemed he knew not what to do. I stopped
a
moment, then I said, "Why don't you join the others, dear?" He looked
ahead
without a word...and then I knew he could not hear...Oh, God, forgive me
when
I whine...I have two ears...the World is mine.
With feet to take me where I go, with eyes to see the sunset glow, with
ears
to hear what I should know, I'm blessed indeed...the World is mine.
Oh, God, forgive me when I whine.
>>
Wednesday, June 10, 1998
Press Advisory
Contact: Robert MacDonald at (212) 677-7180
(800) 811-9416 (pager)
NGOs and International Citizens Groups Denounce UN Drug Summit
A coalition of U.S. and foreign drug policy organizations will be holding
a press conference in Ralph Bunche Park next to the United Nations to
present criticism of the Special Session. The press conference will be
held on:
Wednesday June 10th
11:00am until 12:00 noon
Ralph BunchPark
located at 44th Street and First Avenue.
In attendance will be Dr. David Wintzki (Switzerland), Martin Barriuso
(Spain), Marco Capato (Italy), Dr. Harry Levine (Queens College, New York
City) and others from the drug treatment and policy community. The
participants will be able to answer questions in English, Spanish, Italian,
German, and French.
On this concluding day of the Special Session on Narcotics, these doctors,
treatment providers, and human rights activists are holding a press
conference to express their concern at the misguided effort and resources
that the UN intends to implement to create a "Drug Free World"
The following organizations have endorsed the event: Cures-Not-Wars, Harm
Reduction Coalition, DRCNet, Marijuana Reform Party of New York,
Trans-National Radical Party, Bridgeport Needle Exchange, New York State
CAN, NYC Medical Marijuana Buyers Club, Marijuana Policy Project;
Environmental Action Coalition, New York State Libertarian Party, Michael
Harrington Center of CUNY, FACTuality, and Friends of Ibogaine.
###
<http://www.drugsense.org/crazy/htm> (For more)
"Drug Crazy: How We Got Into This Mess and How We can Get Out," is a gripping
and
dramatic review of the drug war over the last 100 years. It is being published
by Random
House. From the opening scene, a shoot out between police and drug gangs in
Chicago,
the book draws you in with human stories, amazing revelations and the whole
sordid
history of the drug war.
"Drug Crazy" will capture the imagination of the public, convince many that
prohibition
will never work, and open a dialogue on drug policy at a level we have never
seen
before.
The author is Mike Gray, best known as the writer of the screenplay of "The
China
Syndrone" (Jane Fonda, Jack Lemmon, Michael Douglas) which forever altered the
public view concerning nuclear energy. "Drug Crazy" could do the same thing to
the war
on drugs.
"Drug Crazy" is fascinating, informative, scary and rewarding. Everyone who
has seen an
advance copy is enthusiastic about its potential to open people's minds and
change
opinion.
published by Random House.
Source: Ottawa Citizen, Editorial
Contact: letters@...
Website: http://www.ottawacitizen.com/
Pubdate: Monday 08 June 1998
WAR ON REASON
Today in New York City, an act of almost indescribable stupidity will be
committed. Eighteen years after Ronald Reagan announced he would stamp out
drugs, the "War on Drugs" will be declared once again.
This time the United Nations will play the fool, with an announcement of
the most ambitious international anti-drug program ever. Representatives
from 130 nations, plus 30 heads of state, including US president Bill
Clinton, will be there to applaud.
The cornerstone of the UN plan will be a program to get farmers in the nine
major drug-producing nations -- Afghanistan, Burma, Laos, Colombia, India,
Mexico, Pakistan, and Vietnam -- to switch from growing plants that produce
illegal drugs to other crops. The stated goal of the UN plan: To eradicate
the world's entire production of heroin, cocaine, and marijuana in 10 years.
Bonne chance, nos amis. The nations being targeted range from merely
corrupt to tyrannical to anarchic. Authority, where it exists, is often
intimately involved in the production and transportation of drugs. Unless
the UN is prepared to pay every farmer to grow soybeans and send
peacekeepers to fight off the guerrillas, police, and soldiers who will be
displeased that their cash-cow has dried up, its war will be lost.
But assume the UN could manage the impossible and turn the nations now
producing the bulk of the world's drugs into exporters of soybeans. Would
that mean victory in the War on Drugs?
Not at all. Cutting the supply of drugs does nothing to reduce the demand
for them. It would mean, however, that some of that demand wouldn't be met,
which would push the value of drugs skyward. That in turn would tempt
criminals, soldiers, police, guerrillas, and farmers in nations elsewhere
in the world to produce their own supply. If it's not Afghanistan and Burma
supplying the drug markets, it will be Nigeria, or Peru, or somewhere else.
Unless the UN can afford to put every farmer in the world on the anti-drug
dole, crop substitution won't work.
Nor will it work even if it is coupled with new programs to lessen the
demand for drugs. Every Western nation, particularly the U.S., has tried to
stifle demand using every imaginable carrot and stick, and met with no more
success than King Canute when he ordered the tides to halt. Demand for
drugs rises and falls largely according to social factors which are
impervious to the efforts of governments.
For all its futility, the UN's quixotic quest will not come cheaply. By one
estimate, the new plan will require $3 to $4 billion US. To put that in
perspective: 2.2 million children under the age of five die in developing
countries each year from diarrhoeal dehydration because they don't have
safe drinking water. How much clean water $3 to $4 billion US could buy can
only be imagined.
There will be other facets to the UN's anti-drug drive, most of which will
be decided over the course of three days of deliberations in the UN General
Assembly. The UN will not, however, discuss alternatives to the War on
Drugs. Mexico, a nation that bears the worst scars of the drug war, first
proposed this conference as a way of assessing what has been done, and
learning from that experience, but other nations, particularly the U.S.,
used the planning stages of the conference to push discussion of
alternatives off the agenda. Non-governmental organizations that asked to
hold a short, small seminar to discuss alternatives to the War on Drugs
were refused permission.
What about Canada? As always, the federal government is clambering onto the
bandwagon and cheering on the war. Since the Trudeau years, it has seldom
given serious thought to drug policy, preferring instead to follow whatever
variation on failure is being proposed.
That, sadly, is true of most of the world's nations. Sense and experience
are ignored, folly is repeated, and the War on Drugs becomes a war on
reason itself.
United Nations To Hold Drug Summit
c The Associated Press
By ROBERT H. REID
UNITED NATIONS (AP) - With demand for illegal drugs rising, leaders
of the world's major drug-producing and drug-consuming nations open
a three-day conference Monday to discuss how to fight the scourge.
President Clinton, who delivers the opening address, has pledged to
cut drug use by half in the United States - the world's leading drug
consumer - by the year 2007.
Latin American leaders say their efforts to curtail drug production and
trafficking will fail unless Americans curb their appetite for drugs. The
presidents of Mexico, Venezuela, Peru and Colombia are expected to
deliver that message at the conference.
The goal of the U.N. General Assembly's ``special session on drugs''
is to endorse target dates for governments to enact legislation on
issues such as money laundering, judicial cooperation, reducing
demand for drugs and stamping out cultivation of illicit crops.
``Around the world, there is a growing consensus that more needs
to be done to understand and reduce the rising demand for drugs,''
the United Nations said in a report.
But critics fear the United Nations is placing too much emphasis
on legal measures, following a path that has largely failed in the
United States, and should consider drugs a health problem.
The conference is expected to approve a plan prepared in March in
Vienna, Austria, setting a target date of 2003 for countries to pass
laws to control money laundering and increase judicial cooperation.
It also sets 2008 as the target for significantly reducing illegal
cultivation of coca, cannabis and opium poppies and for controlling
the spread of amphetamines.
Some critics, however, believe the United Nations should use the
resources of the World Health Organization to develop effective
treatment programs instead.
``Drug policy is a global public health concern,'' said Dr. Alex Wodak,
director of alcohol and drug services at St. Vincent's Hospital in
Sydney, Australia. ``The U.N.'s exaggerated emphasis on interdiction
and criminalization makes it impossible to protect public health.''
In an open letter to U.N. Secretary-General Kofi Annan, about 500
prominent figures from around the world said the ``global war on
drugs is now causing more harm than drug abuse itself.''
``Human rights are violated, environmental assaults perpetrated
and prisons inundated with hundreds of thousands of drug violators,''
the letter said. It called for a drug program based on ``common sense,
science, public health and human rights.''
Among the signers were former U.S. Secretary of State George Shultz,
former U.N. Secretary-General Javier Perez de Cuellar, former
Australian Prime Minister Paul Keating, and former President
Oscar Arias of Costa Rica.
Pino Arlacchi, head of the U.N. drug control office in Vienna, insists
that the United Nations has no intention of promoting a U.S.-style
``war on drugs'' on a global scale.
``For the first time, we have the issue of demand reduction included
at the same level as other components of narcotics control,'' Arlacchi said.
But the U.N. drug office has frowned on novel experiments, such as
Swiss program to prescribe limited amounts of heroin to addicts.
More than two-thirds of the Swiss addicts had been involved in
prostitution, drug trafficking and other criminal activity when they
enrolled in the program. The number dropped to 10 percent, the
study showed.
AP-NY-06-07-98 1720EDT
Copyright 1998 The Associated Press. The information contained in the AP
news report may not be published, broadcast, rewritten or otherwise
distributed
without prior written authority of The Associated Press.
In a message of 03 Jun 98 Chris Jenks wrote to Multiple recipients of list:
CJ> While resting in Europe I can upon a sample of V. africana trunk bar=
k
CJ> and decided to analyze and extract it. I found that it did indeed
CJ> contain about 5% alkaloid, but unfortunately it was a complex mixture!=
I
CJ> thought I might have the wrong plant until contacting the lab where
CJ> Goutarel and Janot worked and obtaining a french paper describing the
CJ> extraction of V. africana trunk and root barks. To my dismay, the yiel=
ds
CJ> of voacangine were minuscule - only about 0.04%! A whole kilogram of
CJ> trunk bark would produce no more than 400 mg of voacangine! =
Is it the same for root bark ?
CJ> I still don't understand the
CJ> discrepancy between the patent and the paper, both from the same lab.
CJ> Maybe the alkaloid concentration varies.
In other species it varies with plant organ, not only in concentration also=
=
in composition.
CJ> If only voacangine could be isolated in useful amounts, its
CJ> conversion to ibogaine is a snap - boil it in alcohol with lye, then
CJ> warm it in dilute acid.
This convertion is discribed in several sources (2),(14)
(15min at 50C in 1M HCl)
CJ> The same conversion can be used to prepare
CJ> ibogamine from coronaridine. This latter process may be a lot more
Coronaridine itself is also biologically active, produced analgesia in mice
has CNS and autonomic activity (not specified), a 30mg/kg p.o. dose when
given on the right days prevented pregnancy in rats (estrogenic activity)
(13)
Tabernantine was called a nootropic and a non amphetamine-like stimulant
(11).
CJ> useful because coronaridine is a lot more widespread than ibogamine,=
and
CJ> ibogamine is present in T. iboga - and has therefore been consumed by
CJ> human beings - and has also been successful for treating addiction in
CJ> rats, without tremors even!
Ibogamine just as ibogaine produced bradycardy that's resistant to atropine=
,
as well as central stimulating properties. (13)
Voacangine (among others) was _isolated_ from : (isolated yields mentioned
where possible)
-Ervatamia coronaria var. plena {=3DTabernaemontana divaricata} voacangine
(0.0012%) although used in local folk medicine against cancer the plant no
cytotoxic products were isolated (3)
The latex has the reputation of being very cooling, applied to wounds to
prevent inflammation, used against tooth ache. It's used as a tonic in burm=
a
and afrodisiac in india, said to be a poison, has many more uses (13).
-Tabernaemontana pauciflora {=3DErvatamia blumeana} root, called "lontupak"=
or
"lampada" in Sabah state on Borneo. contained 28g total alkaloids extracted
from 3.8kg fresh root of which 4g turned out to be coronaridine (0.1%)
(analgesic) (4) =
-Tabernaemontana pandacaqui also called called "lontupak" in Sabah state on
Borneo, the major alkaloid was voacangine (analgesic). 250g dried root
yielded 130mg voacangine (0.05%) after repeated chromatography.(4) Juice
used for healing wounds, used buring childbirth (philippines) (13) Extract
has anti-tumor activity(!), 1mg/kg hexane extract produced weakness of limb
and body in mice, *1000mg/kg* massive convulsions and rapid death (13)
-Voacanga schweinfurthii var. puberula (=3DVoacanga puberula) root bark
yielded ibogaine (0.02%), voacangine (0.4%), voacamine (1.4%), the seeds
contian 3.5% tabersonine (5)
Tabersonine at 2mg/kg produce the same hypotensive effect as 0.5mg/kg
reserpine in anesthetised cat(13)
-Tabernanthe pubescens (6)
trunc bark : 0.7% ibogaine
root bark : 0.3% voacangine, 2.6% ibogaine
-Tabernaemontana heyneana yielded coronaridine (0.13%) (antifertility
activity in female rats, estrogenic), voacangine (0.02%) (7). Latex applie=
d
to wounds to prevent inflammation, used against tooth ache, predisposes
women to pregnancy, reliefs diseases and gives strenght, flowers are
analgesic(india) (13) Aqueous ethanolic extract is cytotoxic(!).(13)
-Stemmadenia obovata stem bark yielded voacangine (0.004%) and other
bases(8)
-Trachelospermum jasminoides major alkaloids voacangine (?%),
coronaridine(?%), apparicine(%?) (9). Ibogaine (%?) was also detected (10)
but this might be the result of the extraction procedure that used 10% HCl
which they call pH=3D1 (sic.)
-Pagiantha cerifera was used as a source for ibogaine, voacangine,
coronaridine, voacamine, tabernamine, vobasine,perivine and pagisulfine in=
a
behavioral test on mice. (11)
-Tabernaemontana crassa (=3DT. durissima =3D T.jollyana =3D Conopharyngia=
crassa =3D
C. durissima =3D Gabunia odoratissima) stembark yielded ibogaine (0.03%) wh=
ich
was shown to have weak antibiotic activity (12). The latex is used to dres=
s
and cure wounds, concoctions of leaves is used as a tonic, enema reliefs
back pain, bark juice is instilled in the nouse to relief violent
headaches(africa). (13) Crude ethanolic extract decreased motor activity an=
d
brought about muscle relaxation in mice. A dose of 250mg/kg proved to be
lethal within 30 min (13) [440]
Tabernaemontana species in which ibogaine was _detected_ (13):
T.cerifera l [314], T. contorta sb [205], T. eusepala l,sb,rb [298], T.
eusepaloides rb [324], T. humblotii l,sb,rb [279], l,sb,rb [296](?), T.
lundii l,b,st [225], T. olivacea st [379], T. orientalis l [294], T.
psychotrifolia sb,rb [418], T. quadrangularis r [378]
Tabernaemontana species in which voacangine was _detected_ (13):
T. amblyocarpa st [407], T. amygdalifolia r [412], T.apoda fr[315,335], l
[373], r[301], T. arborea se[391], dried trunk sap[352]; T. attenuata
sb[426]; T. aurantiaca b[171], T. australis st [132], T. cerifera l [314],
T. citrifolia l [371], r[132], T. cofferoides r[361], T. contorta sb[205],
T. divaricata l[281], sb[312], T. eglandulosa sb[205] wp[116], T.
fuchsiifolia sb[200,412], T.heterophylla l[397]; T. heyneana sb,st[396],
r[261], T.humblotii l,sb,rb [296](?), T. killipii sb[300], T. longiflora
sb[199], unk[173], T. longipes se[368], T. lundii l,b,st[225], T. macrocarp=
a
se [337], T. mocquerysii rb [286], T. olivacea st [379]. T.orientalis
l,tw[388], unk[383], T. pachysiphon se [191] sb[205], T. penduliflora
sb[205], T. psorocarpa sb [441], T. psychotrifolia l,sb,rb[418], r[132], T.
quadrangularis r[378], T. retusa se[278],l,sb[264], T. sananho b[338], T.
siphilitica l[311]; T. undulata sb [365], T. wallichiana l,sb[323]
Tabernaemontana species in which Coronaridine was _detected_ (13):
T. affinis rb[304], T. alba se[144], T. albiflora sb[402], T. amblyocarpa
l,st[407], T.amygdalifolia r[412], T. apoda fr[335],
l[322],r[301],,,T.attenuata sb,rb[426], T. bufalina r[435], T. citrifolia
l[371],r[132], T. coffeoides r[361], T. contorta, sb[205], T. crasa se[198]
sb[161] unk[168], T. dichotoma fr[150], rb[186], T.divaricata se[400],
l[281,302] sb[312] st[132] rb[223,408], unk [249], T. eglandulosa
sb[205,277], rb[284], T.fuchsiifolia sb[412], T. heyneana se[193], fr[245],
sb,st[396] b,r[184],r[261], wp[194], T. longipes se[368] l[414] T.lundii
l,b,st [225], T. macrocalyx se[365], T. macrocarpa se[337], T.minutiflora
l[297], T. mocquerysii rb[286], T. mucronata b[180], T.olivacea st[379], T.
orientalist l,tw[388] unk[383], T. pachysiphon sb[205] r[334], T. pandacaqu=
i
b[154,157,167], T. penduliflora sb[205], T. psorocarpa, sb[441], T.
psychotrifolia sb[418] r[132], T. quadrangularis r[378], T.retusa se[278]
l,sb[264], rb[234], T.sananho b[338], T. sessilifolia l,sb,rb[291], T.
siphilitica l[311], T. stellata rb[234], T. undulata se[248],sb[365], T.
wallichiana l,sb[323]
l:leaf; sb: stem bark; rb root bark; st stem; r root; fr fruit; se seed; st
stem; tw twig; unk unknown; wp whole plant. (?)the botanic identity of this
material is uncertain
(3) Perveen Sharma & G. A. Gordell J.Nat.prod. /51/ 528-531 (1988) =
(4) E. Okuyama et al., Chem. Pharm. Bull. (tokyo) /40/ 2075-2079 (1992) =
(5) B. Richard et al., J.Nat.Prod., /46/ 283-284 (1983) =
(6) T. Mulamba et al., J.Nat.Prod., /44/ 184-189 (1981) =
(7) W. E. Meyer et al., J.Pharm.Sci., /62/ 1199-1201 (1973) =
(8) A. Madinaveitia et al., J.Nat.Prod., /59/ 185-189 (1996) =
(9) Atta-ur Rahman et al., Planta Medica, /53/ 57-59 (1987) =
(10) Atta-ur Rahman et al., Planta Medica, /54/ 364 (1988) =
(11) M. Bert et al., Planta Medica, /54/ 191-192 (1988) =
(12) T.A. van Beek et al., Journal of Ethnopharmacology, /14/ 315-318 (1985=
) =
(13) T.A. van Beek et al., Journal of Ethnopharmacology, /10/ 2-156 (1984)
(14) U. Renner et al., Helv. Chim. Acta, /42/ 1572 (1959)
Some of the revevant references cites in (13):
[116] Belgian patent 555 059 (16/2/57)
[132] Journal of the American Chemical Society, /82/ 1142 (1960)
[144] Lloydia, /25/ 222 (1962)
[154] Anales de la Real Academia Farmacia, /31/ 391 (1963)
[157] Journal of the Philippine Pharmaceutical Association, /50/ 321,333 (1=
964)
[167] Chemistry and industry, 2064 (1965)
[171] Australian journal of chemistry, /18/ 927 (1965)
[173] Bulletin de la Societe chimique de belgique, /76/ 300 (1967)
[180] Anales de la real Academia Farmacia, /31/ 3 (1965)
[184] Journal of the Chemical Society : chemical communications, 97 (1966)
[191] Bulletin de la Societe chimique de france, 427 (1966)
[193] Indian Journal of Chemistry, /4/ 99 (1966)
[194] Indian Journal of Chemistry, /4/ 332 (1966)
[199] Helvetica Chimica acta, /50/ 60 (1967)
[200] Anales de la Asociacion Quimica Argentina, /55/ 239 (1967)
[205] Annals Pharmaceutic Francaises, /25/ 379 (1967)
[223] Journal of the institutiion of Chemists, /41/ 5 (1969)
[225] Journal of Organic Chemistry, /34/ 412 (1969)
[234] Annales Pharmaceutiques Francaises, /28/ 127 (1970)
[245] Jounal of the institution of chemists, india, /43/ 69 (1971)
[248] Plantes Medicinales et Phytotherapie, /6/ 228 (1972)
[249] Ahi Accademia Nazionale dei Lincei, Memorie, Classe di scienze Fisich=
e, matematiche e naturali [viii], /52/ 375 (1972)
[261] Journal of Pharmaceutical Sciences, /62/ 1199 (1973)
[264] Phytochemistry, /12/ 2517 (1973)
[277] Bulletin des Societe chimique de France, 1369 (1974)
[278] Phytochemistry, /13/ 280 (1974)
[279] Phytochemistry, /13/ 1969 (1974)
[281] Phytochemistry, /13/ 1621 (1974)
[284] Helvetica Chimica Acta, /58/1001 (1975)
[286] Phytochemistry, /14/ 1649 (1975)
[291] Phytochemistry, /14/ 1120 (1975)
[294] Australian journal of chemistry, /28/ 1813 (1975)
[296] Phytochemistry, /14/ 579 (1975)
[297] Phytochemistry, /14/ 1648 (1975)
[298] Phytochemistry, /14/ 812 (1975)
[300] Dissertation Abstract 35B 3842 (1975)
[301] Rebita CENIC, Ceincias Fisica, /6/ 199 (1975)
[302] Phytochemistry, /14/ 1652 (1975)
[304] Phytochemistry, /15/ 551 (1976)
[311] Tetrahedron letters, 3531 (1976)
[312] Revista Cubana Farmacia, /10/ 31 (1976)
[314] Annales Pharmaceutiques Francais, /34/ 31 (1976)
[315] Revista CENIC, Ceincias Fisicas, /7/ 373 (1976)
[322] Revista CENIC, Ceincias Fisicas, /7/ 365 (1976)
[323] Indian Jounal of Chemistry, /14 B/, 385 (1976)
[324] Journal of the American Chemical Society, /98/ 3645 (1976)
[334] Journal of pharmaceutical Sciences, /66/ 1135 (1977)
[335] Revista CENIC, Ceincias Fisicas, /8/ 61 (1977)
[337] Phytochemistry, /16/ 153 (1977)
[338] Atti Accademia Nazionale dei Lincei, Memorie, clase de Scieze Fisiche=
, Matematiche et Naturali [viii], /62/ 221 (1977)
[352] Journal of Pharmaceutical Sciences, /67/ 271 (1978)
[361] Phytochemistry, /17/ 834 (1978)
[365] Fitoterapia /50/ 123 (1979)
[368] Revista Latinoamericana de Quimica, /10/ 185 (1979)
[371] Revista CENIC, Ceincias Fisicas, /10/ 351 (1979)
[373] Revista Cubana Farmacia, /13/ 65 (1979)
[378] Zeitschrift fur Naturforschung, /35 B/, 219 (1980)
[379] Zeitschrift fur Naturforschung, /35 B/, 885 (1980)
[383] Journal of Natural Products, /43/ 514 (1980)
[388] Planta medica, /39/ 180 (1980)
[391] Revista Latinoamericana de Quimica, /11/ 64 (1980)
[396] Phytochemistry, /19/ 1213 (1980)
[397] Acta Chemica Scandinavica, /B 34/ 509 (1980)
[400] Bangladesh Journal of Biological Sciences, /9/ 31 (1980)
CA 97:34 474 (1982)
[402] Tetrahedron Letters, 55 (1980)
[407] Revista Latinoamericana de Quimica, /11/ 132 (1980)
[408] Phytochemistry, /19/ 1209 (1980)
[412] H. Achenbach (1981) personal communication
[414] Revista Latinamericana de Quimica, /12/ 88 (1981)
[418] Journal of Natural Products, /44/ 717 (1981)
[426] Journal of Natural Products, /44/ 459 (1981)
[435] Planta Medica, /44/ 212 (1982)
[440] Journal of etnopharmacology, /5/ 187 (1982)
[441] Planta Medica, /47/ 83 (1983)
deGroeten
Dirk
("`-'"`"`-'")
`( - _ o )'
`(.-Y-.)'
`---'
Convertion of related products into ibogaine
18-methoxyibogaine by reduction with LAH (1)
Voacangine by treatment with K in MeOH (2) =
Voacangine by treatment with Na in MeOH (1) 180mg voacangine was added to=
a
solution of 0.8g sodium in 11ml methanol containing 0.8ml water. The mixtur=
e
was heated for 12h under reflux. After cooling the mixture was diluted with
5 ml water and adjusted to pH 2 with H3PO4. After heating for 5 minutes,
sodium carbonate solution and methylene chloride was added. The organic
phase dried with sodium sulfate and evaporated to give 160mg of a crude
residue . A benzene solution of this material was filtered through alumina
(activity III) and the residue obtained by evaporation was crystallized fro=
m
methanol to give 70mg ibogaine mp 153-154C. =
voacangine by saponisation and decarboxylation (9)
Decarbomethoxylation of voacangine using hydrazine (5),(3) (Y:73%), (7)
reduction of ibogaine lactam with LAH (6),(3)
reduction of iboxygaine tosylate with sodium in ethanol (4) reduction of
iboxygaine tosylate with LAH (y:82%) (3)
Voacryptin by Wolff-Kishner reduction (8) =
(1) jacs /88/ 2532-2535 (1966)
(2) Unites States patent, (November 19, 1957), 2,813,873 (posted to the
ibogaine list) =
(3) JACS /83/ 4805 (1961)
(4) Experientia /15/ 456 (1959)
(5) Helv. Chim. Acta /42/ 1572 (1959)
(6) jacs /80/ 126 (1958)
(7) Experientia, /17/ 106 (1961)
(8) Experientia, /13/ 468 (1957) =
(9) Compt. Rendu, /241/ 986 (1955)
What follows is the isolation of alkaloids as presented by D.F. Dickel et
al. The alkaloids of Tabernanthe iboga part 3. isolation studies, JACS, /80=
/
123-125 (1958)
Ibogaine :
Tabernanthe iboga (96.7kg) was extracted four times by recycling methanol=
at
60-65C through a stationary bed of ground root for 2 hours. The total
extract (1320 l) was evaporated in vacuo to 18l to which was added 9.6l of
water, 28.8l of 15% acetic acid and 1.25 kg of Filter gel. The mixture was
stirred, filtered, and the filter cake was washed with 2.4l of a solution
prepared by mixing 0.18l of acetic acid, 0.8l of methanol and 1.6l of
water.The combined filtrate and washings were extracted twice with 19.2l
portion of petroleum naphtha (b.p. 60-90C). The petroleum naphtha extracts
were backwashed with 3.8l of 15% acetic acid. To the aqueous phase, 25.2l=
of
ethylene dichloride was added followed by 19.1l of ammonium hydroxide over=
a
period of 90 min. The layers were separated and the aqueous phase
re-extracted five times with 12.8l portion of ethylene dichloride. The
extracts were combined and washed with three 25l portions of water, dried
over anhydrous sodium sulfate, filtered, and concentrated to 2.5 l. Ethanol
(2l) was added, the solution again concentrated to 2.5l and a further 6l of
ethanol added. After chilling for 2 days 456g of crude ibogaine was
collected m.p. 140-143C. The filtrate was evaporated to four liters and
chilled overnight yielding a second crop of 474.5g melting at 137-140C. The
filtrate was evaporated to dryness and the dark amorphous residue of 1.16kg
was reserved for the isolation of minor alkaloids.
The crude ibogaine (474g) in 2890ml of ethanol was treated with 50g norite,
filtered, and allowed to crystallize yielding 379g melting at 143.5-146C.=
A
second treatment with norite and crystallization from ethanol yielded309g
melting at 148-149C. This product in 3090ml benzene was filtered through
620g of neutral alumina (activity II) and the column washed with an equal
volume of benzene. Evaporation of the solvent and crystallization of the
residue from 1400ml of ethanol yielded 259g of pure ibogaine melting at
152-153C. Chromatography on paper showed only a trace of impurity. For
analysis a sample was dried overnight in high vacuum at room temperature.
Ibogaine hydrochloride
To a stirred solution of 100g of ibogaine in 1000ml of acetone, 51ml of
aqueous HCl(1:1) was added dropwise. Crystalline ibogaine hydrochloride
separated immediately. The product was filtered and washed with acetone;
yield 1.8.5g m.p. 299-300C [alpha]D -63 degrees (ethanol), -49 degrees
(water)
A further 56g ibogaine was obtained from 717g (of above 1.16kg of residue).
After chromatography a fraction containing 4% tabernanthine and ibogaine wa=
s
obtained, they were separated by precipitating ibogaine.HCl from acetone in
which tabernanthine.HCl is more soluble.
Bringing the total isolated ibogaine yield at about 1%.
Other products isolated (as opposed to detected) ibogamine and its
hydroxyindolenine, the hydroxyindolenine derivative of ibogaine and
iboquine, gabonine, kisantine, demethoxyiboluteine, iboluteine, voacangine
(0.65g from 4kg root powder), kimvuline.
deGroeten
Dirk
("`-'"`"`-'")
`( - _ o )'
`(.-Y-.)'
`---'
Brain Res 1997 Mar 28;752(1-2):250-254
Effects of ibogaine on the development of tolerance to antinociceptive action
of mu-, delta- and
kappa-opioid receptor agonists in mice.
Cao YJ, Bhargava HN
Department of Pharmaceutics and Pharmacodynamics, The University of Illinois
at Chicago, 60612, USA.
The effects of ibogaine, an alkaloid isolated from the bark of the African
shrub, Tabernanthe iboga, on the development of tolerance to the
antinociception action of
morphine, U-50,488H and [D-Pen2,D-Pen5]enkephalin (DPDPE), which are mu-,
kappa- and delta-opioid receptor agonists, respectively, were determined in
male
Swiss-Webster mice. Mice were rendered tolerant to opioid receptor agonists by
injecting morphine (20 mg/kg, s.c.), U-50,488H (25 mg/kg, i.p.) or DPDPE (20
microg/mouse, i.c.v.) twice a day for 4 days. Ibogaine (20, 40 or 80 mg/kg,
i.p.) given twice a day for 4 days did not alter the tail-flick latency.
Ibogaine (40 or 80 mg/kg,
i.p.) injected 10 min before each injection of morphine inhibited the
development of tolerance to the antinociceptive action of morphine, however,
the lower dose of ibogaine
(20 mg/kg, i.p.) was ineffective. Ibogaine (20, 40 or 80 mg/kg, i.p.) given
prior to the injection of U-50,488H or DPDPE did not modify the development of
tolerance to their
antinociceptive action. It is concluded that ibogaine inhibits selectively the
development of tolerance to the antinociceptive action of mu- but not kappa-
or delta-opioid
receptor agonists in mice.
Am I the only one who hasnt had any email for a couple of days.
Not only that, but although it has been since January that
one could obtain root bark by mail (legally in all but a few
countries), no reports of results have made it to this list.
Bill Ross
Am I the only one who hasnt had any email for a
couple of days. Usually I can count on the Ibogaine
group at the very least. I miss you.
dgoldenone
----------
> From: HSL123@...
> To: Multiple recipients of list <ibogaine@...>
> Subject: IBOGAINE AND OTHER U.N. PROTESTS, MONDAY, JUNE 8
> Date: Friday, June 05, 1998 8:10 PM
>
> For Immediate Release
>
> PROTEST - Clinton's Drug War policy proposal to the U.N.
>
> WHERE: Dag Hammarskjold Plaza @47th &1st ave.
> WHEN: Monday June 8th
> TIME: 9am to 2:30pm
>
> Clinton arrives at the U.N. at 10:00 am and adresses the assembly at
> 11:00 am. Be there for Clinton's arrival.
>
> Protest the internationalization of the U.S.'s drug policy.
>
> Organizations in attendance: Cures not Wars, Harm Reduction Coalition,
Drug
> Reform Coalition ,Marijuana Reform Party, Trans National Radical Party,
> Bridgeport Needle Exchange,
> New York State Cannabis Action Committee., NYC Medical Marijuana Buyers
Club,
> Environmental Action Coalition, New York State Libertarians, Michael
> Harrington Center of CUNY, Friends of Ibogaine.
>
> GENERAL AND CONTACT INFORMATION FOR THE EVENT:
>
> For more information:
> Contact Cures not Wars at 212-677-7180 or page Robert MacDonald at
> 1-800-811-9416
> email: curenotwar@...
>
> We still need a few persons to hold placards supporting Ibogaine and
> methadone. Please contact me via email if you are in NY or are going to
be in
> NY. Please leave your telephone number. I will not be able to get back
to
> you till Sunday as I will be attending the First International Conference
on
> Heroin Maintenance on Saturday at the NY Acad. of Medicine.
>
> Thanks
>
> Howard
For Immediate Release
PROTEST - Clinton's Drug War policy proposal to the U.N.
WHERE: Dag Hammarskjold Plaza @47th &1st ave.
WHEN: Monday June 8th
TIME: 9am to 2:30pm
Clinton arrives at the U.N. at 10:00 am and adresses the assembly at
11:00 am. Be there for Clinton's arrival.
Protest the internationalization of the U.S.'s drug policy.
Organizations in attendance: Cures not Wars, Harm Reduction Coalition, Drug
Reform Coalition ,Marijuana Reform Party, Trans National Radical Party,
Bridgeport Needle Exchange,
New York State Cannabis Action Committee., NYC Medical Marijuana Buyers Club,
Environmental Action Coalition, New York State Libertarians, Michael
Harrington Center of CUNY, Friends of Ibogaine.
GENERAL AND CONTACT INFORMATION FOR THE EVENT:
For more information:
Contact Cures not Wars at 212-677-7180 or page Robert MacDonald at
1-800-811-9416
email: curenotwar@...
We still need a few persons to hold placards supporting Ibogaine and
methadone. Please contact me via email if you are in NY or are going to be in
NY. Please leave your telephone number. I will not be able to get back to
you till Sunday as I will be attending the First International Conference on
Heroin Maintenance on Saturday at the NY Acad. of Medicine.
Thanks
Howard